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Items: 1 to 50 of 54

1.

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency.

Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A.

EMBO J. 2018 May 15;37(10). pii: e96553. doi: 10.15252/embj.201796553. Epub 2018 Apr 9.

2.

Mitigating effect of EUK-207 on radiation-induced cognitive impairments.

Raber J, Davis MJ, Pfankuch T, Rosenthal R, Doctrow SR, Moulder JE.

Behav Brain Res. 2017 Mar 1;320:457-463. doi: 10.1016/j.bbr.2016.10.038. Epub 2016 Oct 24.

3.

Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage.

Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Medhora M, Hill RP.

Int J Radiat Oncol Biol Phys. 2014 Jul 15;89(4):722-8. doi: 10.1016/j.ijrobp.2014.03.048. Epub 2014 May 24.

4.

Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice.

Kash JC, Xiao Y, Davis AS, Walters KA, Chertow DS, Easterbrook JD, Dunfee RL, Sandouk A, Jagger BW, Schwartzman LM, Kuestner RE, Wehr NB, Huffman K, Rosenthal RA, Ozinsky A, Levine RL, Doctrow SR, Taubenberger JK.

Free Radic Biol Med. 2014 Feb;67:235-47. doi: 10.1016/j.freeradbiomed.2013.10.014. Epub 2013 Oct 17.

5.

Investigations of antioxidant-mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin.

Jelveh S, Kaspler P, Bhogal N, Mahmood J, Lindsay PE, Okunieff P, Doctrow SR, Bristow RG, Hill RP.

Int J Radiat Biol. 2013 Aug;89(8):618-27. doi: 10.3109/09553002.2013.782450. Epub 2013 Apr 23.

PMID:
23484491
6.

Mitigation of radiation-induced lung injury with EUK-207 and genistein: effects in adolescent rats.

Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Hill RP.

Radiat Res. 2013 Feb;179(2):125-34. doi: 10.1667/RR2954.1. Epub 2012 Dec 13.

7.

A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin.

Doctrow SR, Lopez A, Schock AM, Duncan NE, Jourdan MM, Olasz EB, Moulder JE, Fish BL, Mäder M, Lazar J, Lazarova Z.

J Invest Dermatol. 2013 Apr;133(4):1088-96. doi: 10.1038/jid.2012.410. Epub 2012 Nov 29. Erratum in: J Invest Dermatol. 2013 Jun;133(6):1691.

8.

Effects of alpha-lipoic acid on associative and spatial memory of sham-irradiated and 56Fe-irradiated C57BL/6J male mice.

Villasana LE, Rosenthal RA, Doctrow SR, Pfankuch T, Zuloaga DG, Garfinkel AM, Raber J.

Pharmacol Biochem Behav. 2013 Jan;103(3):487-93. doi: 10.1016/j.pbb.2012.09.021. Epub 2012 Oct 7.

9.

Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation.

Gao F, Fish BL, Szabo A, Doctrow SR, Kma L, Molthen RC, Moulder JE, Jacobs ER, Medhora M.

Radiat Res. 2012 Nov;178(5):468-80. doi: 10.1667/RR2953.1. Epub 2012 Sep 28.

10.

Mitigation of lung injury after accidental exposure to radiation.

Mahmood J, Jelveh S, Calveley V, Zaidi A, Doctrow SR, Hill RP.

Radiat Res. 2011 Dec;176(6):770-80. Epub 2011 Oct 20.

11.

Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion.

Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS.

Circulation. 2011 Aug 16;124(7):806-13. doi: 10.1161/CIRCULATIONAHA.110.003418. Epub 2011 Jul 25.

12.

Mitigation of radiation-induced lung injury by genistein and EUK-207.

Mahmood J, Jelveh S, Calveley V, Zaidi A, Doctrow SR, Hill RP.

Int J Radiat Biol. 2011 Aug;87(8):889-901. doi: 10.3109/09553002.2011.583315. Epub 2011 Jun 15.

13.

Salen Mn complexes mitigate radiation injury in normal tissues.

Rosenthal RA, Fish B, Hill RP, Huffman KD, Lazarova Z, Mahmood J, Medhora M, Molthen R, Moulder JE, Sonis ST, Tofilon PJ, Doctrow SR.

Anticancer Agents Med Chem. 2011 May 1;11(4):359-72. Review.

14.

Superoxide dismutase mimics.

Rosenthal RA, Doctrow SR, Callaway WB.

Antioxid Redox Signal. 2011 Mar 15;14(6):1173; author reply 1174-6. doi: 10.1089/ars.2010.3758. No abstract available.

15.

Novel synthetic SOD/catalase mimetics can mitigate capillary endothelial cell apoptosis caused by ionizing radiation.

Vorotnikova E, Rosenthal RA, Tries M, Doctrow SR, Braunhut SJ.

Radiat Res. 2010 Jun;173(6):748-59. doi: 10.1667/RR1948.1.

16.

Orally available Mn porphyrins with superoxide dismutase and catalase activities.

Rosenthal RA, Huffman KD, Fisette LW, Damphousse CA, Callaway WB, Malfroy B, Doctrow SR.

J Biol Inorg Chem. 2009 Aug;14(6):979-91. doi: 10.1007/s00775-009-0550-4. Epub 2009 Jun 6.

17.

A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease.

Brazier MW, Doctrow SR, Masters CL, Collins SJ.

Free Radic Biol Med. 2008 Jul 15;45(2):184-92. doi: 10.1016/j.freeradbiomed.2008.04.006. Epub 2008 Apr 16.

PMID:
18455516
18.

Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.

Peng J, Peng L, Stevenson FF, Doctrow SR, Andersen JK.

J Neurosci. 2007 Jun 27;27(26):6914-22.

19.

Using superoxide dismutase/catalase mimetics to manipulate the redox environment of neural precursor cells.

Limoli CL, Giedzinski E, Baure J, Doctrow SR, Rola R, Fike JR.

Radiat Prot Dosimetry. 2006;122(1-4):228-36. Epub 2006 Dec 13.

PMID:
17166877
20.

Oxidative neuropathology and putative chemical entities for Alzheimer's disease: neuroprotective effects of salen-manganese catalytic anti-oxidants.

Rupniak HT, Joy KA, Atkin C, Brown G, Barnes JC, Doctrow SR, Malfroy B, Wong T, Anderson IK, Molloy CR, Mills GI, Soden P.

Neurotox Res. 2000;2(2-3):167-78.

PMID:
16787839
21.

Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging.

Zhang HJ, Doctrow SR, Oberley LW, Kregel KC.

J Appl Physiol (1985). 2006 Apr;100(4):1385-91. Epub 2005 Oct 27.

22.
23.

Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment.

Melov S, Wolf N, Strozyk D, Doctrow SR, Bush AI.

Free Radic Biol Med. 2005 Jan 15;38(2):258-61.

PMID:
15607908
24.

Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress.

Zhang HJ, Doctrow SR, Xu L, Oberley LW, Beecher B, Morrison J, Oberley TD, Kregel KC.

FASEB J. 2004 Oct;18(13):1547-9. Epub 2004 Aug 19.

PMID:
15319374
25.

SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness.

Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd A, Doctrow SR, Burakoff SJ.

Blood. 2004 Oct 15;104(8):2565-73. Epub 2004 Jun 17.

26.

Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice.

Browne SE, Roberts LJ 2nd, Dennery PA, Doctrow SR, Beal MF, Barlow C, Levine RL.

Free Radic Biol Med. 2004 Apr 1;36(7):938-42.

PMID:
15019978
27.
28.

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics.

Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, Baudry M.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8526-31. Epub 2003 Jun 18.

29.

Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species.

Liu R, Liu W, Doctrow SR, Baudry M.

J Neurochem. 2003 Apr;85(2):492-502.

30.

Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies.

Doctrow SR, Huffman K, Marcus CB, Tocco G, Malfroy E, Adinolfi CA, Kruk H, Baker K, Lazarowych N, Mascarenhas J, Malfroy B.

J Med Chem. 2002 Sep 26;45(20):4549-58.

PMID:
12238934
31.
32.

Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics.

Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman K, Wallace DC, Malfroy B.

J Neurosci. 2001 Nov 1;21(21):8348-53.

34.

6,6'-Bis(2-hydroxyphenyl)-2,2'-bipyridine manganese(III) complexes: a novel series of superoxide dismutase and catalase mimetics.

Giblin GM, Box PC, Campbell IB, Hancock AP, Roomans S, Mills GI, Molloy C, Tranter GE, Walker AL, Doctrow SR, Huffman K, Malfroy B.

Bioorg Med Chem Lett. 2001 Jun 4;11(11):1367-70.

PMID:
11378356
36.

Extension of life-span with superoxide dismutase/catalase mimetics.

Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ.

Science. 2000 Sep 1;289(5484):1567-9.

37.
38.
39.

Role of oxidant stress and iron delocalization in acidosis-induced intestinal epithelial hyperpermeability.

Gonzalez PK, Doctrow SR, Malfroy B, Fink MP.

Shock. 1997 Aug;8(2):108-14.

PMID:
9261900
40.

Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites.

Malfroy B, Doctrow SR, Orr PL, Tocco G, Fedoseyeva EV, Benichou G.

Cell Immunol. 1997 Apr 10;177(1):62-8.

PMID:
9140096
41.

A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication.

Cruikshank WW, Doctrow SR, Falvo MS, Huffman K, Maciaszek J, Viglianti G, Raina J, Kornfeld H, Malfroy B.

J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Mar 1;14(3):193-203.

PMID:
9117450
42.

Salen-manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy.

Doctrow SR, Huffman K, Marcus CB, Musleh W, Bruce A, Baudry M, Malfroy B.

Adv Pharmacol. 1997;38:247-69. Review. No abstract available.

PMID:
8895812
43.

Role of oxidant stress in the adult respiratory distress syndrome: evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury.

Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP.

Shock. 1996;6 Suppl 1:S23-6. Review.

PMID:
8828094
44.

EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine.

Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP.

J Pharmacol Exp Ther. 1995 Nov;275(2):798-806.

PMID:
7473169
45.

The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells.

Doctrow SR, Abelleira SM, Curry LA, Heller-Harrison R, Kozarich JW, Malfroy B, McCarroll LA, Morgan KG, Morrow AR, Musso GF, et al.

J Pharmacol Exp Ther. 1994 Oct;271(1):229-37.

PMID:
7965719
46.

Regulation of growth-plate chondrocytes by insulin-like growth-factor I and basic fibroblast growth factor.

Trippel SB, Wroblewski J, Makower AM, Whelan MC, Schoenfeld D, Doctrow SR.

J Bone Joint Surg Am. 1993 Feb;75(2):177-89.

PMID:
8423178
47.

Blood-brain barrier penetration and in vivo activity of an NGF conjugate.

Friden PM, Walus LR, Watson P, Doctrow SR, Kozarich JW, Bäckman C, Bergman H, Hoffer B, Bloom F, Granholm AC.

Science. 1993 Jan 15;259(5093):373-7.

PMID:
8420006
48.

Interaction of basic fibroblast growth factor with bovine growth plate chondrocytes.

Trippel SB, Whelan MC, Klagsbrun M, Doctrow SR.

J Orthop Res. 1992 Sep;10(5):638-46.

PMID:
1323648
49.

The tight-junction-specific protein ZO-1 is a component of the human and rat blood-brain barriers.

Watson PM, Anderson JM, Vanltallie CM, Doctrow SR.

Neurosci Lett. 1991 Aug 5;129(1):6-10.

PMID:
1922971
50.

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