Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 116


SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.

Leiris S, Coelho A, Castandet J, Bayet M, Lozano C, Bougnon J, Bousquet J, Everett M, Lemonnier M, Sprynski N, Zalacain M, Pallin TD, Cramp MC, Jennings N, Raphy G, Jones MW, Pattipati R, Shankar B, Sivasubrahmanyam R, Soodhagani AK, Juventhala RR, Pottabathini N, Pothukanuri S, Benvenuti M, Pozzi C, Mangani S, De Luca F, Cerboni G, Docquier JD, Davies DT.

ACS Infect Dis. 2019 Jan 11;5(1):131-140. doi: 10.1021/acsinfecdis.8b00246. Epub 2018 Nov 30.


Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization.

Pasero C, D'Agostino I, De Luca F, Zamperini C, Deodato D, Truglio GI, Sannio F, Del Prete R, Ferraro T, Visaggio D, Mancini A, Guglielmi MB, Visca P, Docquier JD, Botta M.

J Med Chem. 2018 Oct 25;61(20):9162-9176. doi: 10.1021/acs.jmedchem.8b00619. Epub 2018 Oct 11.


Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily.

Iannelli F, Santoro F, Santagati M, Docquier JD, Lazzeri E, Pastore G, Cassone M, Oggioni MR, Rossolini GM, Stefani S, Pozzi G.

Front Microbiol. 2018 Jul 31;9:1670. doi: 10.3389/fmicb.2018.01670. eCollection 2018.


Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam.

Pozzi C, Di Pisa F, De Luca F, Benvenuti M, Docquier JD, Mangani S.

ChemMedChem. 2018 Jul 18;13(14):1437-1446. doi: 10.1002/cmdc.201800213. Epub 2018 Jun 20.


Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae.

Everett M, Sprynski N, Coelho A, Castandet J, Bayet M, Bougnon J, Lozano C, Davies DT, Leiris S, Zalacain M, Morrissey I, Magnet S, Holden K, Warn P, De Luca F, Docquier JD, Lemonnier M.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e00074-18. doi: 10.1128/AAC.00074-18. Print 2018 May.


An update on β-lactamase inhibitor discovery and development.

Docquier JD, Mangani S.

Drug Resist Updat. 2018 Jan;36:13-29. doi: 10.1016/j.drup.2017.11.002. Epub 2017 Nov 7. Review.


Deciphering Multifactorial Resistance Phenotypes in Acinetobacter baumannii by Genomics and Targeted Label-free Proteomics.

Cecchini T, Yoon EJ, Charretier Y, Bardet C, Beaulieu C, Lacoux X, Docquier JD, Lemoine J, Courvalin P, Grillot-Courvalin C, Charrier JP.

Mol Cell Proteomics. 2018 Mar;17(3):442-456. doi: 10.1074/mcp.RA117.000107. Epub 2017 Dec 19.


Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases.

Santucci M, Spyrakis F, Cross S, Quotadamo A, Farina D, Tondi D, De Luca F, Docquier JD, Prieto AI, Ibacache C, Blázquez J, Venturelli A, Cruciani G, Costi MP.

Sci Rep. 2017 Dec 18;7(1):17716. doi: 10.1038/s41598-017-17399-7.


Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents.

Zamperini C, Maccari G, Deodato D, Pasero C, D'Agostino I, Orofino F, De Luca F, Dreassi E, Docquier JD, Botta M.

Sci Rep. 2017 Aug 15;7(1):8251. doi: 10.1038/s41598-017-08749-6.


Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol.

Maccari G, Deodato D, Fiorucci D, Orofino F, Truglio GI, Pasero C, Martini R, De Luca F, Docquier JD, Botta M.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3332-3336. doi: 10.1016/j.bmcl.2017.06.016. Epub 2017 Jun 10.


Genetic and biochemical characterisation of CTX-M-37 extended-spectrum β-lactamase from an Enterobacter cloacae clinical isolate from Mongolia.

Lee K, Yong D, Jeong SH, Tulgaa K, Docquier JD, Rossolini GM, Chong Y.

J Glob Antimicrob Resist. 2017 Sep;10:3-7. doi: 10.1016/j.jgar.2017.03.007. Epub 2017 Jun 3.


1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases.

Sevaille L, Gavara L, Bebrone C, De Luca F, Nauton L, Achard M, Mercuri P, Tanfoni S, Borgianni L, Guyon C, Lonjon P, Turan-Zitouni G, Dzieciolowski J, Becker K, Bénard L, Condon C, Maillard L, Martinez J, Frère JM, Dideberg O, Galleni M, Docquier JD, Hernandez JF.

ChemMedChem. 2017 Jun 21;12(12):972-985. doi: 10.1002/cmdc.201700186. Epub 2017 Jun 12.


Chryseobacterium gleum in a man with prostatectomy in Senegal: a case report and review of the literature.

Arouna O, Deluca F, Camara M, Fall B, Fall B, Ba Diallo A, Docquier JD, Mboup S.

J Med Case Rep. 2017 Apr 24;11(1):118. doi: 10.1186/s13256-017-1269-4. Review.


Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota.

Gudeta DD, Bortolaia V, Pollini S, Docquier JD, Rossolini GM, Amos GC, Wellington EM, Guardabassi L.

Front Microbiol. 2016 Dec 26;7:1985. doi: 10.3389/fmicb.2016.01985. eCollection 2016.


Effect of High N-Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens.

Landini G, Di Maggio T, Sergio F, Docquier JD, Rossolini GM, Pallecchi L.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7513-7517. Print 2016 Dec.


Structure-based approach for identification of novel phenylboronic acids as serine-β-lactamase inhibitors.

Sgrignani J, De Luca F, Torosyan H, Docquier JD, Duan D, Novati B, Prati F, Colombo G, Grazioso G.

J Comput Aided Mol Des. 2016 Oct;30(10):851-861. Epub 2016 Sep 8.


Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and Its Complexes with Moxalactam and Imipenem.

Pozzi C, De Luca F, Benvenuti M, Poirel L, Nordmann P, Rossolini GM, Mangani S, Docquier JD.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7189-7199. Print 2016 Dec.


Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors.

Brindisi M, Brogi S, Giovani S, Gemma S, Lamponi S, De Luca F, Novellino E, Campiani G, Docquier JD, Butini S.

J Enzyme Inhib Med Chem. 2016;31(sup1):98-109. Epub 2016 Apr 28.


Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound.

Deodato D, Maccari G, De Luca F, Sanfilippo S, Casian A, Martini R, D'Arezzo S, Bonchi C, Bugli F, Posteraro B, Vandeputte P, Sanglard D, Docquier JD, Sanguinetti M, Visca P, Botta M.

J Med Chem. 2016 Apr 28;59(8):3854-66. doi: 10.1021/acs.jmedchem.6b00018. Epub 2016 Apr 19.


Biochemical Characterization of CPS-1, a Subclass B3 Metallo-β-Lactamase from a Chryseobacterium piscium Soil Isolate.

Gudeta DD, Pollini S, Docquier JD, Bortolaia V, Rossolini GM, Guardabassi L.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1869-73. doi: 10.1128/AAC.01924-15.


Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece.

Papagiannitsis CC, Pollini S, De Luca F, Rossolini GM, Docquier JD, Hrabák J.

Antimicrob Agents Chemother. 2015 Dec;59(12):7811-4. doi: 10.1128/AAC.01935-15. Epub 2015 Sep 14.


Structure-Function Relationships of Class D Carbapenemases.

Docquier JD, Mangani S.

Curr Drug Targets. 2016;17(9):1061-71. Review.


OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant.

Antonelli A, D'Andrea MM, Vaggelli G, Docquier JD, Rossolini GM.

J Antimicrob Chemother. 2015 Oct;70(10):2749-56. doi: 10.1093/jac/dkv181. Epub 2015 Jun 30.


Biochemical characterization of the POM-1 metallo-β-lactamase from Pseudomonas otitidis.

Borgianni L, De Luca F, Thaller MC, Chong Y, Rossolini GM, Docquier JD.

Antimicrob Agents Chemother. 2015 Mar;59(3):1755-8. doi: 10.1128/AAC.03843-14. Epub 2014 Dec 15.


Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity.

Maccari G, Sanfilippo S, De Luca F, Deodato D, Casian A, Dasso Lang MC, Zamperini C, Dreassi E, Rossolini GM, Docquier JD, Botta M.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5525-9. doi: 10.1016/j.bmcl.2014.09.081. Epub 2014 Oct 14.


Editorial overview: anti-infectives: towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need.

Docquier JD, Cusi MG.

Curr Opin Pharmacol. 2014 Oct;18:iv-vi. doi: 10.1016/j.coph.2014.10.004. Epub 2014 Oct 22. No abstract available.


Molecular basis of selective inhibition and slow reversibility of avibactam against class D carbapenemases: a structure-guided study of OXA-24 and OXA-48.

Lahiri SD, Mangani S, Jahić H, Benvenuti M, Durand-Reville TF, De Luca F, Ehmann DE, Rossolini GM, Alm RA, Docquier JD.

ACS Chem Biol. 2015 Feb 20;10(2):591-600. doi: 10.1021/cb500703p. Epub 2014 Dec 4.


Occurrence of conjugative IncF-type plasmids harboring the blaCTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia.

Lahlaoui H, De Luca F, Maradel S, Ben-Haj-Khalifa A, Ben Hamouda H, Kheder M, Ben Moussa M, Rossillini GM, Docquier JD.

Pediatr Res. 2015 Jan;77(1-1):107-10. doi: 10.1038/pr.2014.153. Epub 2014 Oct 8.


Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-lactamases.

Lahiri SD, Mangani S, Durand-Reville T, Benvenuti M, De Luca F, Sanyal G, Docquier JD.

Antimicrob Agents Chemother. 2013 Jun;57(6):2496-505. doi: 10.1128/AAC.02247-12. Epub 2013 Feb 25.


FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy.

Pollini S, Maradei S, Pecile P, Olivo G, Luzzaro F, Docquier JD, Rossolini GM.

Antimicrob Agents Chemother. 2013 Jan;57(1):410-6. doi: 10.1128/AAC.01953-12. Epub 2012 Oct 31.


Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases.

Hayre JK, Xu G, Borgianni L, Taylor GL, Andrew PW, Docquier JD, Oggioni MR.

BMC Biochem. 2012 Oct 2;13:19. doi: 10.1186/1471-2091-13-19.


Regulation of neuraminidase expression in Streptococcus pneumoniae.

Gualdi L, Hayre JK, Gerlini A, Bidossi A, Colomba L, Trappetti C, Pozzi G, Docquier JD, Andrew P, Ricci S, Oggioni MR.

BMC Microbiol. 2012 Sep 11;12:200. doi: 10.1186/1471-2180-12-200.


[Carbapenem resistance in Pseudomonas aeruginosa isolates: an example of interaction between different mechanisms].

Santella G, Pollini S, Docquier JD, Almuzara M, Gutkind G, Rossolini GM, Radice M.

Rev Panam Salud Publica. 2011 Dec;30(6):545-8. Spanish.


Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design.

De Luca F, Benvenuti M, Carboni F, Pozzi C, Rossolini GM, Mangani S, Docquier JD.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18424-9. doi: 10.1073/pnas.1110530108. Epub 2011 Oct 31.


Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea.

Lee K, Yum JH, Yong D, Jeong SH, Rossolini GM, Docquier JD, Chong Y.

Antimicrob Agents Chemother. 2011 Dec;55(12):5930-2. doi: 10.1128/AAC.05341-11. Epub 2011 Sep 12.


Structure of the extended-spectrum β-lactamase TEM-72 inhibited by citrate.

Docquier JD, Benvenuti M, Calderone V, Rossolini GM, Mangani S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):303-6. doi: 10.1107/S1744309110054680. Epub 2011 Feb 18.


Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4.

Lassaux P, Traoré DA, Loisel E, Favier A, Docquier JD, Sohier JS, Laurent C, Bebrone C, Frère JM, Ferrer JL, Galleni M.

Antimicrob Agents Chemother. 2011 Mar;55(3):1248-55. doi: 10.1128/AAC.01486-09. Epub 2010 Dec 13.


Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States.

Borgianni L, Prandi S, Salden L, Santella G, Hanson ND, Rossolini GM, Docquier JD.

Antimicrob Agents Chemother. 2011 Jan;55(1):140-5. doi: 10.1128/AAC.00858-10. Epub 2010 Nov 1.


Purification and biochemical characterization of IMP-13 metallo-beta-lactamase.

Santella G, Docquier JD, Gutkind G, Rossolini GM, Radice M.

Antimicrob Agents Chemother. 2011 Jan;55(1):399-401. doi: 10.1128/AAC.00421-10. Epub 2010 Oct 25.


Intercontinental dissemination of IMP-13-producing Pseudomonas aeruginosa belonging in sequence type 621.

Santella G, Pollini S, Docquier JD, Mereuta AI, Gutkind G, Rossolini GM, Radice M.

J Clin Microbiol. 2010 Nov;48(11):4342-3. doi: 10.1128/JCM.00614-10. Epub 2010 Sep 15. No abstract available.


Improved performance of the modified Hodge test with MacConkey agar for screening carbapenemase-producing Gram-negative bacilli.

Lee K, Kim CK, Yong D, Jeong SH, Yum JH, Seo YH, Docquier JD, Chong Y.

J Microbiol Methods. 2010 Nov;83(2):149-52. doi: 10.1016/j.mimet.2010.08.010. Epub 2010 Aug 27.


High-resolution crystal structure of the subclass B3 metallo-beta-lactamase BJP-1: rational basis for substrate specificity and interaction with sulfonamides.

Docquier JD, Benvenuti M, Calderone V, Stoczko M, Menciassi N, Rossolini GM, Mangani S.

Antimicrob Agents Chemother. 2010 Oct;54(10):4343-51. doi: 10.1128/AAC.00409-10. Epub 2010 Aug 9.


Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-beta-lactamases.

Lee K, Kim CK, Hong SG, Choi J, Song S, Koh E, Yong D, Jeong SH, Yum JH, Docquier JD, Rossolini GM, Chong Y.

Int J Antimicrob Agents. 2010 Sep;36(3):259-63. doi: 10.1016/j.ijantimicag.2010.05.018.


Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding.

Borgianni L, Vandenameele J, Matagne A, Bini L, Bonomo RA, Frère JM, Rossolini GM, Docquier JD.

Antimicrob Agents Chemother. 2010 Aug;54(8):3197-204. doi: 10.1128/AAC.01336-09. Epub 2010 May 24.


Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates.

Docquier JD, Benvenuti M, Calderone V, Giuliani F, Kapetis D, De Luca F, Rossolini GM, Mangani S.

Antimicrob Agents Chemother. 2010 May;54(5):2167-74. doi: 10.1128/AAC.01517-09. Epub 2010 Feb 9.


Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes.

De Luca F, Giraud-Morin C, Rossolini GM, Docquier JD, Fosse T.

Antimicrob Agents Chemother. 2010 Apr;54(4):1547-54. doi: 10.1128/AAC.01252-09. Epub 2010 Feb 1.


BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa.

Poirel L, Docquier JD, De Luca F, Verlinde A, Ide L, Rossolini GM, Nordmann P.

Antimicrob Agents Chemother. 2010 Jan;54(1):533-5. doi: 10.1128/AAC.00859-09. Epub 2009 Nov 2.


IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso.

Zeba B, De Luca F, Dubus A, Delmarcelle M, Simporé J, Nacoulma OG, Rossolini GM, Frère JM, Docquier JD.

Antimicrob Agents Chemother. 2009 Oct;53(10):4320-6. doi: 10.1128/AAC.01607-08. Epub 2009 Aug 3.


Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases.

Docquier JD, Calderone V, De Luca F, Benvenuti M, Giuliani F, Bellucci L, Tafi A, Nordmann P, Botta M, Rossolini GM, Mangani S.

Chem Biol. 2009 May 29;16(5):540-7. doi: 10.1016/j.chembiol.2009.04.010.


Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora.

Stoczko M, Frère JM, Rossolini GM, Docquier JD.

Antimicrob Agents Chemother. 2008 Jul;52(7):2473-9. doi: 10.1128/AAC.01062-07. Epub 2008 Apr 28.

Supplemental Content

Loading ...
Support Center