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Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.

Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, Law A, Sangesland M, Gat-Viks I, Digard P, Vasudevan S, Lingwood D, Dockrell DH, Doench JG, Baillie JK, Hacohen N.

Nat Commun. 2020 Jan 9;11(1):164. doi: 10.1038/s41467-019-13965-x.


The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.

Kitchen GB, Cunningham PS, Poolman TM, Iqbal M, Maidstone R, Baxter M, Bagnall J, Begley N, Saer B, Hussell T, Matthews LC, Dockrell DH, Durrington HJ, Gibbs JE, Blaikley JF, Loudon AS, Ray DW.

Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1543-1551. doi: 10.1073/pnas.1915932117. Epub 2020 Jan 3.


Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation.

Rahman A, Henry KM, Herman KD, Thompson AA, Isles HM, Tulotta C, Sammut D, Rougeot JJ, Khoshaein N, Reese AE, Higgins K, Tabor C, Sabroe I, Zuercher WJ, Savage CO, Meijer AH, Whyte MK, Dockrell DH, Renshaw SA, Prince LR.

Elife. 2019 Oct 15;8. pii: e50990. doi: 10.7554/eLife.50990.


Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease.

Hughes BM, Burton CS, Reese A, Jabeen MF, Wright C, Willis J, Khoshaein N, Marsh EK, Peachell P, Sun SC, Dockrell DH, Marriott HM, Sabroe I, Condliffe AM, Prince LR.

Front Immunol. 2019 Jul 31;10:1721. doi: 10.3389/fimmu.2019.01721. eCollection 2019.


Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages.

Belchamber KBR, Singh R, Batista CM, Whyte MK, Dockrell DH, Kilty I, Robinson MJ, Wedzicha JA, Barnes PJ, Donnelly LE; COPD-MAP consortium.

Eur Respir J. 2019 Oct 10;54(4). pii: 1802244. doi: 10.1183/13993003.02244-2018. Print 2019 Oct.


Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia.

Preston JA, Bewley MA, Marriott HM, McGarry Houghton A, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, Whyte MKB, Shapiro SD, Dockrell DH.

Am J Respir Crit Care Med. 2019 Jul 1;200(1):84-97. doi: 10.1164/rccm.201804-0646OC.


Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold.

Sabroe I, Ho A, Dockrell DH.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1451-1452. doi: 10.1164/rccm.201812-2283ED. No abstract available.


Human skin commensals augment Staphylococcus aureus pathogenesis.

Boldock E, Surewaard BGJ, Shamarina D, Na M, Fei Y, Ali A, Williams A, Pollitt EJG, Szkuta P, Morris P, Prajsnar TK, McCoy KD, Jin T, Dockrell DH, van Strijp JAG, Kubes P, Renshaw SA, Foster SJ.

Nat Microbiol. 2018 Aug;3(8):881-890. doi: 10.1038/s41564-018-0198-3. Epub 2018 Jul 16.


Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC.


HIV gp120 in the Lungs of Antiretroviral Therapy-treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci.

Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M, Dockrell DH.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1604-1615. doi: 10.1164/rccm.201708-1755OC.


Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.


Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis.

Salamaga B, Prajsnar TK, Jareño-Martinez A, Willemse J, Bewley MA, Chau F, Ben Belkacem T, Meijer AH, Dockrell DH, Renshaw SA, Mesnage S.

PLoS Pathog. 2017 Jul 24;13(7):e1006526. doi: 10.1371/journal.ppat.1006526. eCollection 2017 Jul.


Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.

Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):845-855. doi: 10.1164/rccm.201608-1714OC.


Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.


Facing new challenges to promote long-term health for people living with HIV.

Dockrell DH.

Curr Opin Infect Dis. 2017 Feb;30(1):1-3. doi: 10.1097/QCO.0000000000000338. No abstract available.


Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

Bewley MA, Belchamber KB, Chana KK, Budd RC, Donaldson G, Wedzicha JA, Brightling CE, Kilty I, Donnelly LE, Barnes PJ, Singh D, Whyte MK, Dockrell DH; COPDMAP.

PLoS One. 2016 Sep 28;11(9):e0163139. doi: 10.1371/journal.pone.0163139. eCollection 2016.


The therapeutic potential of epigenetic manipulation during infectious diseases.

Cole J, Morris P, Dickman MJ, Dockrell DH.

Pharmacol Ther. 2016 Nov;167:85-99. doi: 10.1016/j.pharmthera.2016.07.013. Epub 2016 Aug 9. Review.


Analysis of histone post translational modifications in primary monocyte derived macrophages using reverse phase×reverse phase chromatography in conjunction with porous graphitic carbon stationary phase.

Minshull TC, Cole J, Dockrell DH, Read RC, Dickman MJ.

J Chromatogr A. 2016 Jul 1;1453:43-53. doi: 10.1016/j.chroma.2016.05.025. Epub 2016 May 7.


Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.

Thomas MR, Outteridge SN, Ajjan RA, Phoenix F, Sangha GK, Faulkner RE, Ecob R, Judge HM, Khan H, West LE, Dockrell DH, Sabroe I, Storey RF.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2562-70. doi: 10.1161/ATVBAHA.115.306528. Epub 2015 Oct 29.


Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages.

Jubrail J, Morris P, Bewley MA, Stoneham S, Johnston SA, Foster SJ, Peden AA, Read RC, Marriott HM, Dockrell DH.

Cell Microbiol. 2016 Jan;18(1):80-96. doi: 10.1111/cmi.12485. Epub 2015 Sep 2.


The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts.

Cole J, Aberdein J, Jubrail J, Dockrell DH.

Adv Microb Physiol. 2014;65:125-202. doi: 10.1016/bs.ampbs.2014.08.004. Epub 2014 Nov 4. Review.


Editorial: RSV: a new box of delights for an old enemy.

Sabroe I, Dockrell DH, Culley FJ.

J Leukoc Biol. 2014 Dec;96(6):945-7. doi: 10.1189/jlb.4CE0714-341R. No abstract available.


Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation.

Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MK, Dockrell DH.

mBio. 2014 Oct 7;5(5):e01710-14. doi: 10.1128/mBio.01710-14.


Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

Prince LR, Maxwell NC, Gill SK, Dockrell DH, Sabroe I, McGreal EP, Kotecha S, Whyte MK.

PLoS One. 2014 Aug 12;9(8):e103059. doi: 10.1371/journal.pone.0103059. eCollection 2014.


Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα.

Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H, Francis S, Martinecz B, Nieswandt B, Rothwell NJ, Allan SM.

Ann Neurol. 2014 May;75(5):670-83. doi: 10.1002/ana.24146. Epub 2014 Apr 14.


Successful use of Fendrix in HIV-infected non-responders to standard hepatitis B vaccines.

de Silva TI, Green ST, Cole J, Stone BJ, Dockrell DH, Vedio AB.

J Infect. 2014 Apr;68(4):397-9. doi: 10.1016/j.jinf.2013.12.009. Epub 2013 Dec 31. No abstract available.


Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR.

Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207. Epub 2013 Nov 6.


The yin and the yang of immunosuppression with inhaled corticosteroids.

Sabroe I, Postma D, Heijink I, Dockrell DH.

Thorax. 2013 Dec;68(12):1085-7. doi: 10.1136/thoraxjnl-2013-203773. Epub 2013 Aug 8. No abstract available.


Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing.

Aberdein JD, Cole J, Bewley MA, Marriott HM, Dockrell DH.

Clin Exp Immunol. 2013 Nov;174(2):193-202. doi: 10.1111/cei.12170. Review.


Clostridium difficile infection in patients with HIV/AIDS.

Collini PJ, Kuijper E, Dockrell DH.

Curr HIV/AIDS Rep. 2013 Sep;10(3):273-82. doi: 10.1007/s11904-013-0162-z. Review.


Low concordance with HIV testing guidelines in a retrospective review of intensive care practice.

Dodd MC, Collini PJ, Dockrell DH.

Thorax. 2013 Nov;68(11):1072-4. doi: 10.1136/thoraxjnl-2012-202871. Epub 2013 Mar 7.


Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.

Chaudhuri N, Jary H, Lea S, Khan N, Piddock KC, Dockrell DH, Donaldson K, Duffin R, Singh D, Parker LC, Sabroe I.

PLoS One. 2012;7(12):e51107. doi: 10.1371/journal.pone.0051107. Epub 2012 Dec 7.


Mechanistic links between acute respiratory tract infections and acute coronary syndromes.

Bazaz R, Marriott HM, Francis SE, Dockrell DH.

J Infect. 2013 Jan;66(1):1-17. doi: 10.1016/j.jinf.2012.09.009. Epub 2012 Oct 6.


Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.

Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MK, Walmsley SR, Higgins KR, Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC, Sabroe I.

J Leukoc Biol. 2013 Jan;93(1):7-19. doi: 10.1189/jlb.0512250. Epub 2012 Aug 17.


Pneumococcal pneumonia: mechanisms of infection and resolution.

Dockrell DH, Whyte MKB, Mitchell TJ.

Chest. 2012 Aug;142(2):482-491. doi: 10.1378/chest.12-0210. Review.


Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

Daigneault M, De Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MK, Dockrell DH.

PLoS Pathog. 2012;8(7):e1002814. doi: 10.1371/journal.ppat.1002814. Epub 2012 Jul 19.


A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.

Marriott HM, Daigneault M, Thompson AA, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MK, Dockrell DH.

Thorax. 2012 Nov;67(11):985-92. doi: 10.1136/thoraxjnl-2012-201591. Epub 2012 Jun 26.


Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AA, Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DH, Whyte MK.

Thorax. 2012 Sep;67(9):796-803. doi: 10.1136/thoraxjnl-2011-200863. Epub 2012 Apr 11.


Clostridium difficile infection in HIV-seropositive individuals and transplant recipients.

Collini PJ, Bauer M, Kuijper E, Dockrell DH.

J Infect. 2012 Feb;64(2):131-47. doi: 10.1016/j.jinf.2011.12.003. Epub 2011 Dec 9. Review.


Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.

Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJ, Iannelli F, Pozzi G, Mitchell TJ, Whyte MK, Sabroe I, Dockrell DH.

Infect Immun. 2012 Mar;80(3):1140-9. doi: 10.1128/IAI.05697-11. Epub 2011 Dec 12.


Evolving controversies and challenges in the management of opportunistic infections in HIV-seropositive individuals.

Dockrell DH, Edwards S, Fisher M, Williams I, Nelson M.

J Infect. 2011 Sep;63(3):177-86. doi: 10.1016/j.jinf.2011.05.022. Epub 2011 Jun 6. Review.


TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.

McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH, Whyte MK.

J Leukoc Biol. 2011 Nov;90(5):855-65. doi: 10.1189/jlb.0211062. Epub 2011 May 11.


Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.

Bewley MA, Pham TK, Marriott HM, Noirel J, Chu HP, Ow SY, Ryazanov AG, Read RC, Whyte MK, Chain B, Wright PC, Dockrell DH.

Mol Cell Proteomics. 2011 Jun;10(6):M111.008193. doi: 10.1074/mcp.M111.008193. Epub 2011 Apr 7.


Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK.

J Clin Invest. 2011 Mar;121(3):1053-63. doi: 10.1172/JCI43273. Epub 2011 Feb 7.


A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MK, Dockrell DH.

PLoS Pathog. 2011 Jan 27;7(1):e1001262. doi: 10.1371/journal.ppat.1001262.


Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.

Collini P, Noursadeghi M, Sabroe I, Miller RF, Dockrell DH.

Curr Mol Med. 2010 Nov;10(8):727-40. Review.


Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.

Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MK, Dockrell DH.

J Immunol. 2010 Sep 1;185(5):2968-79. doi: 10.4049/jimmunol.1000805. Epub 2010 Jul 23.


The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.

Daigneault M, Preston JA, Marriott HM, Whyte MK, Dockrell DH.

PLoS One. 2010 Jan 13;5(1):e8668. doi: 10.1371/journal.pone.0008668.


Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management.

Checkley AM, Chiodini PL, Dockrell DH, Bates I, Thwaites GE, Booth HL, Brown M, Wright SG, Grant AD, Mabey DC, Whitty CJ, Sanderson F; British Infection Society and Hospital for Tropical Diseases.

J Infect. 2010 Jan;60(1):1-20. doi: 10.1016/j.jinf.2009.11.003.


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