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Items: 1 to 50 of 318


Multi-target heteroleptic palladium bisphosphonate complexes.

Cipriani M, Rostán S, León I, Li ZH, Gancheff JS, Kemmerling U, Olea Azar C, Etcheverry S, Docampo R, Gambino D, Otero L.

J Biol Inorg Chem. 2020 Mar 30. doi: 10.1007/s00775-020-01779-y. [Epub ahead of print]


Isolation and Characterization of Acidocalcisomes from Trypanosomatids.

Huang G, Moreno SNJ, Docampo R.

Methods Mol Biol. 2020;2116:673-688. doi: 10.1007/978-1-0716-0294-2_40.


CRISPR/Cas9 Technology Applied to the Study of Proteins Involved in Calcium Signaling in Trypanosoma cruzi.

Lander N, Chiurillo MA, Docampo R.

Methods Mol Biol. 2020;2116:177-197. doi: 10.1007/978-1-0716-0294-2_13.


The Mitochondrial Calcium Uniporter Interacts with Subunit c of the ATP Synthase of Trypanosomes and Humans.

Huang G, Docampo R.

mBio. 2020 Mar 17;11(2). pii: e00268-20. doi: 10.1128/mBio.00268-20.


A CRISPR/Cas9-riboswitch-Based Method for Downregulation of Gene Expression in Trypanosoma cruzi.

Lander N, Cruz-Bustos T, Docampo R.

Front Cell Infect Microbiol. 2020 Feb 27;10:68. doi: 10.3389/fcimb.2020.00068. eCollection 2020.


Synthesis and in vitro evaluation of new 5-substituted 6-nitroimidazooxazoles as antikinetoplastid agents.

Mathias F, Cohen A, Kabri Y, Negrão NW, Crozet MD, Docampo R, Azas N, Vanelle P.

Eur J Med Chem. 2020 Apr 1;191:112146. doi: 10.1016/j.ejmech.2020.112146. Epub 2020 Feb 14.


Catching protein polyphosphorylation in the act.

Docampo R.

J Biol Chem. 2020 Feb 7;295(6):1452-1453. doi: 10.1074/jbc.H120.012632.


Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii.

Galaka T, Falcone BN, Li C, Szajnman SH, Moreno SNJ, Docampo R, Rodriguez JB.

Bioorg Med Chem. 2019 Aug 15;27(16):3663-3673. doi: 10.1016/j.bmc.2019.07.004. Epub 2019 Jul 4.


The acidocalcisome inositol-1,4,5-trisphosphate receptor of Trypanosoma brucei is stimulated by luminal polyphosphate hydrolysis products.

Potapenko E, Negrão NW, Huang G, Docampo R.

J Biol Chem. 2019 Jul 5;294(27):10628-10637. doi: 10.1074/jbc.RA119.007906. Epub 2019 May 28.


Functional analysis and importance for host cell infection of the Ca2+-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi.

Chiurillo MA, Lander N, Bertolini MS, Vercesi AE, Docampo R.

Mol Biol Cell. 2019 Jul 1;30(14):1676-1690. doi: 10.1091/mbc.E19-03-0152. Epub 2019 May 15.


MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca2+ Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi.

Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R.

mBio. 2019 May 7;10(3). pii: e00348-19. doi: 10.1128/mBio.00348-19.


NUDIX hydrolases with inorganic polyphosphate exo- and endopolyphosphatase activities in the glycosome, cytosol and nucleus of Trypanosoma brucei.

Cordeiro CD, Ahmed MA, Windle B, Docampo R.

Biosci Rep. 2019 May 17;39(5). pii: BSR20190894. doi: 10.1042/BSR20190894. Print 2019 May 31.


Pyrophosphate Stimulates the Phosphate-Sodium Symporter of Trypanosoma brucei Acidocalcisomes and Saccharomyces cerevisiae Vacuoles.

Potapenko E, Cordeiro CD, Huang G, Docampo R.

mSphere. 2019 Apr 3;4(2). pii: e00045-19. doi: 10.1128/mSphere.00045-19.


Genome Editing by CRISPR/Cas9 in Trypanosoma cruzi.

Lander N, Chiurillo MA, Docampo R.

Methods Mol Biol. 2019;1955:61-76. doi: 10.1007/978-1-4939-9148-8_5.


Further insights of selenium-containing analogues of WC-9 against Trypanosoma cruzi.

Chao MN, Lorenzo-Ocampo MV, Szajnman SH, Docampo R, Rodriguez JB.

Bioorg Med Chem. 2019 Apr 1;27(7):1350-1361. doi: 10.1016/j.bmc.2019.02.039. Epub 2019 Feb 19.


5-Diphosphoinositol pentakisphosphate (5-IP7) regulates phosphate release from acidocalcisomes and yeast vacuoles.

Potapenko E, Cordeiro CD, Huang G, Storey M, Wittwer C, Dutta AK, Jessen HJ, Starai VJ, Docampo R.

J Biol Chem. 2018 Dec 7;293(49):19101-19112. doi: 10.1074/jbc.RA118.005884. Epub 2018 Oct 12.


Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi.

Lander N, Chiurillo MA, Bertolini MS, Storey M, Vercesi AE, Docampo R.

J Biol Chem. 2018 Nov 9;293(45):17402-17417. doi: 10.1074/jbc.RA118.004498. Epub 2018 Sep 19.


Inorganic polyphosphate interacts with nucleolar and glycosomal proteins in trypanosomatids.

Negreiros RS, Lander N, Huang G, Cordeiro CD, Smith SA, Morrissey JH, Docampo R.

Mol Microbiol. 2018 Dec;110(6):973-994. doi: 10.1111/mmi.14131. Epub 2018 Oct 18.


Membrane Proteins in Trypanosomatids Involved in Ca2+ Homeostasis and Signaling.

Ramakrishnan S, Docampo R.

Genes (Basel). 2018 Jun 19;9(6). pii: E304. doi: 10.3390/genes9060304. Review.


Acidocalcisome-Mitochondrion Membrane Contact Sites in Trypanosoma brucei.

Ramakrishnan S, Asady B, Docampo R.

Pathogens. 2018 Mar 22;7(2). pii: E33. doi: 10.3390/pathogens7020033.


Detection of Weakly Expressed Trypanosoma cruzi Membrane Proteins Using High-Performance Probes.

Cruz-Bustos T, Moreno SNJ, Docampo R.

J Eukaryot Microbiol. 2018 Jul;65(5):722-728. doi: 10.1111/jeu.12517. Epub 2018 Mar 30.


An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi.

Cruz-Bustos T, Potapenko E, Storey M, Docampo R.

mSphere. 2018 Jan 17;3(1). pii: e00377-17. doi: 10.1128/mSphere.00377-17. eCollection 2018 Jan-Feb.


Ibandronate metal complexes: solution behavior and antiparasitic activity.

Demoro B, Rostán S, Moncada M, Li ZH, Docampo R, Olea Azar C, Maya JD, Torres J, Gambino D, Otero L.

J Biol Inorg Chem. 2018 Mar;23(2):303-312. doi: 10.1007/s00775-018-1535-y. Epub 2018 Jan 18.


The mitochondrial calcium uniporter complex in trypanosomes.

Lander N, Chiurillo MA, Bertolini MS, Docampo R, Vercesi AE.

Cell Biol Int. 2018 Jun;42(6):656-663. doi: 10.1002/cbin.10928. Epub 2018 Jan 25. Review.


A Riboswitch-based Inducible Gene Expression System for Trypanosoma brucei.

Cruz-Bustos T, Ramakrishnan S, Cordeiro CD, Ahmed MA, Docampo R.

J Eukaryot Microbiol. 2018 May;65(3):412-421. doi: 10.1111/jeu.12493. Epub 2018 Jan 13.


ZooBank Registration Requirement.

Docampo R.

J Eukaryot Microbiol. 2017 Nov;64(6):728. doi: 10.1111/jeu.12477. No abstract available.


Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation.

Chao MN, Storey M, Li C, Rodríguez MG, Di Salvo F, Szajnman SH, Moreno SNJ, Docampo R, Rodriguez JB.

Bioorg Med Chem. 2017 Dec 15;25(24):6435-6449. doi: 10.1016/j.bmc.2017.10.016. Epub 2017 Oct 16.


Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei.

Zhuo Y, Cordeiro CD, Hekmatyar SK, Docampo R, Prestegard JH.

J Biol Chem. 2017 Nov 3;292(44):18161-18168. doi: 10.1074/jbc.M117.807495. Epub 2017 Sep 8.


The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes.

Cordeiro CD, Saiardi A, Docampo R.

Mol Microbiol. 2017 Oct;106(2):319-333. doi: 10.1111/mmi.13766. Epub 2017 Aug 22.


Endogenous C-terminal Tagging by CRISPR/Cas9 in Trypanosoma cruzi.

Lander N, Chiurillo MA, Vercesi AE, Docampo R.

Bio Protoc. 2017 May 20;7(10). pii: e2299. doi: 10.21769/BioProtoc.2299.


Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi.

Chiurillo MA, Lander N, Bertolini MS, Storey M, Vercesi AE, Docampo R.

mBio. 2017 May 9;8(3). pii: e00574-17. doi: 10.1128/mBio.00574-17.


Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites.

Galaka T, Ferrer Casal M, Storey M, Li C, Chao MN, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.

Molecules. 2017 Jan 4;22(1). pii: E82. doi: 10.3390/molecules22010082.


Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii.

Chao MN, Li C, Storey M, Falcone BN, Szajnman SH, Bonesi SM, Docampo R, Moreno SN, Rodriguez JB.

ChemMedChem. 2016 Dec 16;11(24):2690-2702. doi: 10.1002/cmdc.201600505. Epub 2016 Nov 25.


CRISPR/Cas9-mediated endogenous C-terminal Tagging of Trypanosoma cruzi Genes Reveals the Acidocalcisome Localization of the Inositol 1,4,5-Trisphosphate Receptor.

Lander N, Chiurillo MA, Storey M, Vercesi AE, Docampo R.

J Biol Chem. 2016 Dec 2;291(49):25505-25515. Epub 2016 Oct 28.


Genome Editing by CRISPR/Cas9: A Game Change in the Genetic Manipulation of Protists.

Lander N, Chiurillo MA, Docampo R.

J Eukaryot Microbiol. 2016 Sep;63(5):679-90. doi: 10.1111/jeu.12338. Epub 2016 Jul 15. Review.


Acidocalcisomes of eukaryotes.

Docampo R, Huang G.

Curr Opin Cell Biol. 2016 Aug;41:66-72. doi: 10.1016/ Epub 2016 Apr 25. Review.


Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets.

Yang Y, Ko TP, Chen CC, Huang G, Zheng Y, Liu W, Wang I, Ho MR, Hsu ST, O'Dowd B, Huff HC, Huang CH, Docampo R, Oldfield E, Guo RT.

ACS Chem Biol. 2016 May 20;11(5):1362-71. doi: 10.1021/acschembio.5b00724. Epub 2016 Mar 4.


Polyphosphate and acidocalcisomes.

Lander N, Cordeiro C, Huang G, Docampo R.

Biochem Soc Trans. 2016 Feb;44(1):1-6. doi: 10.1042/BST20150193. Review.


The origin and evolution of the acidocalcisome and its interactions with other organelles.

Docampo R.

Mol Biochem Parasitol. 2016 Sep - Oct;209(1-2):3-9. doi: 10.1016/j.molbiopara.2015.10.003. Epub 2015 Oct 30. Review.


Proteomic analysis of acidocalcisomes of Trypanosoma brucei uncovers their role in phosphate metabolism, cation homeostasis, and calcium signaling.

Huang G, Docampo R.

Commun Integr Biol. 2015 May 6;8(2):e1017174. doi: 10.1080/19420889.2015.1017174. eCollection 2015 Mar-Apr.


In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei.

Yang G, Zhu W, Wang Y, Huang G, Byun SY, Choi G, Li K, Huang Z, Docampo R, Oldfield E, No JH.

ACS Infect Dis. 2015 Aug 14;1(8):388-98. doi: 10.1021/acsinfecdis.5b00068. Epub 2015 Jul 31.


Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors.

Li K, Wang Y, Yang G, Byun S, Rao G, Shoen C, Yang H, Gulati A, Crick DC, Cynamon M, Huang G, Docampo R, No JH, Oldfield E.

ACS Infect Dis. 2015 May 8;1(5):215-221.


TcPho91 is a contractile vacuole phosphate sodium symporter that regulates phosphate and polyphosphate metabolism in Trypanosoma cruzi.

Jimenez V, Docampo R.

Mol Microbiol. 2015 Sep;97(5):911-25. doi: 10.1111/mmi.13075. Epub 2015 Jun 25.


Rab32 is essential for maintaining functional acidocalcisomes, and for growth and infectivity of Trypanosoma cruzi.

Niyogi S, Jimenez V, Girard-Dias W, de Souza W, Miranda K, Docampo R.

J Cell Sci. 2015 Jun 15;128(12):2363-73. doi: 10.1242/jcs.169466. Epub 2015 May 11.


Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii.

Chao MN, Matiuzzi CE, Storey M, Li C, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.

ChemMedChem. 2015 Jun;10(6):1094-108. doi: 10.1002/cmdc.201500100. Epub 2015 Apr 27.


A novel role of Rab11 in trafficking GPI-anchored trans-sialidase to the plasma membrane of Trypanosoma cruzi.

Niyogi S, Docampo R.

Small GTPases. 2015;6(1):8-10. doi: 10.4161/21541248.2014.978712.


Ca2+ Regulation of Trypanosoma brucei Phosphoinositide Phospholipase C.

King-Keller S, Moore CA, Docampo R, Moreno SN.

Eukaryot Cell. 2015 May;14(5):486-94. doi: 10.1128/EC.00019-15. Epub 2015 Mar 13.


SQ109, a new drug lead for Chagas disease.

Veiga-Santos P, Li K, Lameira L, de Carvalho TM, Huang G, Galizzi M, Shang N, Li Q, Gonzalez-Pacanowska D, Hernandez-Rodriguez V, Benaim G, Guo RT, Urbina JA, Docampo R, de Souza W, Oldfield E.

Antimicrob Agents Chemother. 2015 Apr;59(4):1950-61. doi: 10.1128/AAC.03972-14. Epub 2015 Jan 12.

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