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Working Towards a Blood-Derived Gene Expression Biomarker Specific for Alzheimer's Disease.

Patel H, Iniesta R, Stahl D, Dobson RJB, Newhouse SJ.

J Alzheimers Dis. 2020 Feb 11. doi: 10.3233/JAD-191163. [Epub ahead of print]


On classifying sepsis heterogeneity in the ICU: insight using machine learning.

Ibrahim ZM, Wu H, Hamoud A, Stappen L, Dobson RJB, Agarossi A.

J Am Med Inform Assoc. 2020 Mar 1;27(3):437-443. doi: 10.1093/jamia/ocz211.


Efficient Reuse of Natural Language Processing Models for Phenotype-Mention Identification in Free-text Electronic Medical Records: A Phenotype Embedding Approach.

Wu H, Hodgson K, Dyson S, Morley KI, Ibrahim ZM, Iqbal E, Stewart R, Dobson RJ, Sudlow C.

JMIR Med Inform. 2019 Dec 17;7(4):e14782. doi: 10.2196/14782.


Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data.

Bean DM, Teo J, Wu H, Oliveira R, Patel R, Bendayan R, Shah AM, Dobson RJB, Scott PA.

PLoS One. 2019 Nov 25;14(11):e0225625. doi: 10.1371/journal.pone.0225625. eCollection 2019.


UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER.

Denaxas S, Gonzalez-Izquierdo A, Direk K, Fitzpatrick NK, Fatemifar G, Banerjee A, Dobson RJB, Howe LJ, Kuan V, Lumbers RT, Pasea L, Patel RS, Shah AD, Hingorani AD, Sudlow C, Hemingway H.

J Am Med Inform Assoc. 2019 Dec 1;26(12):1545-1559. doi: 10.1093/jamia/ocz105.


C9orf72 intermediate expansions of 24-30 repeats are associated with ALS.

Iacoangeli A, Al Khleifat A, Jones AR, Sproviero W, Shatunov A, Opie-Martin S; Alzheimer’s Disease Neuroimaging Initiative, Morrison KE, Shaw PJ, Shaw CE, Fogh I, Dobson RJ, Newhouse SJ, Al-Chalabi A.

Acta Neuropathol Commun. 2019 Jul 17;7(1):115. doi: 10.1186/s40478-019-0724-4.


Differential gene expression analysis in blood of first episode psychosis patients.

Leirer DJ, Iyegbe CO, Di Forti M, Patel H, Carra E, Fraietta S, Colizzi M, Mondelli V, Quattrone D, Lally J, Ajnakina O, Lee SH, Curtis CJ, Breen G, Pariante C, Aitchison K, Dazzan P, Murray RM, Dobson RJB, Newhouse SJ.

Schizophr Res. 2019 Jul;209:88-97. doi: 10.1016/j.schres.2019.05.011. Epub 2019 May 19.


Transcriptomic analysis of probable asymptomatic and symptomatic alzheimer brains.

Patel H, Hodges AK, Curtis C, Lee SH, Troakes C, Dobson RJB, Newhouse SJ.

Brain Behav Immun. 2019 Aug;80:644-656. doi: 10.1016/j.bbi.2019.05.009. Epub 2019 May 4.


DNAscan: personal computer compatible NGS analysis, annotation and visualisation.

Iacoangeli A, Al Khleifat A, Sproviero W, Shatunov A, Jones AR, Morgan SL, Pittman A, Dobson RJ, Newhouse SJ, Al-Chalabi A.

BMC Bioinformatics. 2019 Apr 27;20(1):213. doi: 10.1186/s12859-019-2791-8.


A Meta-Analysis of Alzheimer's Disease Brain Transcriptomic Data.

Patel H, Dobson RJB, Newhouse SJ.

J Alzheimers Dis. 2019;68(4):1635-1656. doi: 10.3233/JAD-181085.


ALSgeneScanner: a pipeline for the analysis and interpretation of DNA sequencing data of ALS patients.

Iacoangeli A, Al Khleifat A, Sproviero W, Shatunov A, Jones AR, Opie-Martin S, Naselli E, Topp SD, Fogh I, Hodges A, Dobson RJ, Newhouse SJ, Al-Chalabi A.

Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):207-215. doi: 10.1080/21678421.2018.1562553. Epub 2019 Mar 5.


A patient flow simulator for healthcare management education.

Bean DM, Taylor P, Dobson RJB.

BMJ Simul Technol Enhanc Learn. 2019 Jan;5(1):46-48. doi: 10.1136/bmjstel-2017-000251. Epub 2017 Oct 7.


In response to Ballantyne and Schaefer's 'Consent and the ethical duty to participate in health data research'.

Hepgul N, Sleeman KE, Firth AM, Johnston A, Teo JTH, Bernal W, Dobson RJB, Higginson IJ.

J Med Ethics. 2019 May;45(5):351-352. doi: 10.1136/medethics-2018-105271. Epub 2019 Jan 7.


Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.

Carbajosa G, Malki K, Lawless N, Wang H, Ryder JW, Wozniak E, Wood K, Mein CA, Dobson RJB, Collier DA, O'Neill MJ, Hodges AK, Newhouse SJ.

Neurobiol Aging. 2018 Sep;69:151-166. doi: 10.1016/j.neurobiolaging.2018.04.019. Epub 2018 May 17.


Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer.

Jacobsen A, Bosch LJW, Martens-de Kemp SR, Carvalho B, Sillars-Hardebol AH, Dobson RJ, de Rinaldis E, Meijer GA, Abeln S, Heringa J, Fijneman RJA, Feenstra KA.

Sci Rep. 2018 May 14;8(1):7522. doi: 10.1038/s41598-018-24982-z.


A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations.

Kiddle SJ, Voyle N, Dobson RJB.

J Alzheimers Dis. 2018;64(s1):S289-S297. doi: 10.3233/JAD-179904. Review.


How to improve the standardization and the diagnostic performance of the fecal egg count reduction test?

Levecke B, Kaplan RM, Thamsborg SM, Torgerson PR, Vercruysse J, Dobson RJ.

Vet Parasitol. 2018 Apr 15;253:71-78. doi: 10.1016/j.vetpar.2018.02.004. Epub 2018 Feb 9.


Author Correction: Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records.

Bean DM, Wu H, Iqbal E, Dzahini O, Ibrahim ZM, Broadbent M, Stewart R, Dobson RJB.

Sci Rep. 2018 Mar 6;8(1):4284. doi: 10.1038/s41598-018-22521-4.


SemEHR: A general-purpose semantic search system to surface semantic data from clinical notes for tailored care, trial recruitment, and clinical research.

Wu H, Toti G, Morley KI, Ibrahim ZM, Folarin A, Jackson R, Kartoglu I, Agrawal A, Stringer C, Gale D, Gorrell G, Roberts A, Broadbent M, Stewart R, Dobson RJB.

J Am Med Inform Assoc. 2018 May 1;25(5):530-537. doi: 10.1093/jamia/ocx160.


Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records.

Bean DM, Wu H, Iqbal E, Dzahini O, Ibrahim ZM, Broadbent M, Stewart R, Dobson RJB.

Sci Rep. 2017 Nov 27;7(1):16416. doi: 10.1038/s41598-017-16674-x. Erratum in: Sci Rep. 2018 Mar 6;8(1):4284.


ADEPt, a semantically-enriched pipeline for extracting adverse drug events from free-text electronic health records.

Iqbal E, Mallah R, Rhodes D, Wu H, Romero A, Chang N, Dzahini O, Pandey C, Broadbent M, Stewart R, Dobson RJB, Ibrahim ZM.

PLoS One. 2017 Nov 9;12(11):e0187121. doi: 10.1371/journal.pone.0187121. eCollection 2017.


Network analysis of patient flow in two UK acute care hospitals identifies key sub-networks for A&E performance.

Bean DM, Stringer C, Beeknoo N, Teo J, Dobson RJB.

PLoS One. 2017 Oct 2;12(10):e0185912. doi: 10.1371/journal.pone.0185912. eCollection 2017.


Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort.

Baker E, Iqbal E, Johnston C, Broadbent M, Shetty H, Stewart R, Howard R, Newhouse S, Khondoker M, Dobson RJB.

PLoS One. 2017 Jun 7;12(6):e0178562. doi: 10.1371/journal.pone.0178562. eCollection 2017.


Corrigendum: Characterisation of mental health conditions in social media using Informed Deep Learning.

Gkotsis G, Oellrich A, Velupillai S, Liakata M, Hubbard TJP, Dobson RJB, Dutta R.

Sci Rep. 2017 May 16;7:46813. doi: 10.1038/srep46813. No abstract available.


Automated PDF highlighting to support faster curation of literature for Parkinson's and Alzheimer's disease.

Wu H, Oellrich A, Girges C, de Bono B, Hubbard TJ, Dobson RJ.

Database (Oxford). 2017 Jan 1;2017(1). doi: 10.1093/database/bax027.


Characterisation of mental health conditions in social media using Informed Deep Learning.

Gkotsis G, Oellrich A, Velupillai S, Liakata M, Hubbard TJ, Dobson RJ, Dutta R.

Sci Rep. 2017 Mar 22;7:45141. doi: 10.1038/srep45141. Erratum in: Sci Rep. 2017 May 16;7:46813.


Analysis of diagnoses extracted from electronic health records in a large mental health case register.

Kovalchuk Y, Stewart R, Broadbent M, Hubbard TJ, Dobson RJ.

PLoS One. 2017 Feb 16;12(2):e0171526. doi: 10.1371/journal.pone.0171526. eCollection 2017.


Natural language processing to extract symptoms of severe mental illness from clinical text: the Clinical Record Interactive Search Comprehensive Data Extraction (CRIS-CODE) project.

Jackson RG, Patel R, Jayatilleke N, Kolliakou A, Ball M, Gorrell G, Roberts A, Dobson RJ, Stewart R.

BMJ Open. 2017 Jan 17;7(1):e012012. doi: 10.1136/bmjopen-2016-012012.


Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease.

Kim M, Nevado-Holgado A, Whiley L, Snowden SG, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Thambisetty M, Dobson RJB, Powell JF, Lupton MK, Simmons A, Velayudhan L, Lovestone S, Proitsi P, Legido-Quigley C.

J Alzheimers Dis. 2017;60(3):809-817. doi: 10.3233/JAD-160645.


Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid.

Voyle N, Patel H, Folarin A, Newhouse S, Johnston C, Visser PJ, Dobson RJ, Kiddle SJ; EDAR and DESCRIPA study groups and the Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2017;55(4):1417-1427. doi: 10.3233/JAD-160707.


Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis.

Proitsi P, Kim M, Whiley L, Simmons A, Sattlecker M, Velayudhan L, Lupton MK, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Powell JF, Dobson RJ, Legido-Quigley C.

Alzheimers Dement. 2017 Feb;13(2):140-151. doi: 10.1016/j.jalz.2016.08.003. Epub 2016 Sep 28.


Late gadolinium enhancement and adverse outcomes in a contemporary cohort of adult survivors of tetralogy of Fallot.

Dobson RJ, Mordi I, Danton MH, Walker NL, Walker HA, Tzemos N.

Congenit Heart Dis. 2017 Jan;12(1):58-66. doi: 10.1111/chd.12403. Epub 2016 Aug 24.


Alzheimer's disease: are blood and brain markers related? A systematic review.

Khan AT, Dobson RJ, Sattlecker M, Kiddle SJ.

Ann Clin Transl Neurol. 2016 May 11;3(6):455-62. doi: 10.1002/acn3.313. eCollection 2016 Jun.


A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data.

Kerz M, Folarin A, Meleckyte R, Watt FM, Dobson RJ, Danovi D.

J Biomol Screen. 2016 Oct;21(9):887-96. doi: 10.1177/1087057116652064. Epub 2016 Jun 2.


Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.

Allen GI, Amoroso N, Anghel C, Balagurusamy V, Bare CJ, Beaton D, Bellotti R, Bennett DA, Boehme KL, Boutros PC, Caberlotto L, Caloian C, Campbell F, Chaibub Neto E, Chang YC, Chen B, Chen CY, Chien TY, Clark T, Das S, Davatzikos C, Deng J, Dillenberger D, Dobson RJ, Dong Q, Doshi J, Duma D, Errico R, Erus G, Everett E, Fardo DW, Friend SH, Fröhlich H, Gan J, St George-Hyslop P, Ghosh SS, Glaab E, Green RC, Guan Y, Hong MY, Huang C, Hwang J, Ibrahim J, Inglese P, Iyappan A, Jiang Q, Katsumata Y, Kauwe JS, Klein A, Kong D, Krause R, Lalonde E, Lauria M, Lee E, Lin X, Liu Z, Livingstone J, Logsdon BA, Lovestone S, Ma TW, Malhotra A, Mangravite LM, Maxwell TJ, Merrill E, Nagorski J, Namasivayam A, Narayan M, Naz M, Newhouse SJ, Norman TC, Nurtdinov RN, Oyang YJ, Pawitan Y, Peng S, Peters MA, Piccolo SR, Praveen P, Priami C, Sabelnykova VY, Senger P, Shen X, Simmons A, Sotiras A, Stolovitzky G, Tangaro S, Tateo A, Tung YA, Tustison NJ, Varol E, Vradenburg G, Weiner MW, Xiao G, Xie L, Xie Y, Xu J, Yang H, Zhan X, Zhou Y, Zhu F, Zhu H, Zhu S; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2016 Jun;12(6):645-53. doi: 10.1016/j.jalz.2016.02.006. Epub 2016 Apr 11.


Microduplications at the pseudoautosomal SHOX locus in autism spectrum disorders and related neurodevelopmental conditions.

Tropeano M, Howley D, Gazzellone MJ, Wilson CE, Ahn JW, Stavropoulos DJ, Murphy CM, Eis PS, Hatchwell E, Dobson RJ, Robertson D, Holder M, Irving M, Josifova D, Nehammer A, Ryten M, Spain D, Pitts M, Bramham J, Asherson P, Curran S, Vassos E, Breen G, Flinter F, Ogilvie CM, Collier DA, Scherer SW, McAlonan GM, Murphy DG.

J Med Genet. 2016 Aug;53(8):536-47. doi: 10.1136/jmedgenet-2015-103621. Epub 2016 Apr 12.


Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins.

Voyle N, Kim M, Proitsi P, Ashton NJ, Baird AL, Bazenet C, Hye A, Westwood S, Chung R, Ward M, Rabinovici GD, Lovestone S, Breen G, Legido-Quigley C, Dobson RJ, Kiddle SJ; Alzheimer's Disease Neuroimaging Initiative.

Transl Psychiatry. 2016 Jan 26;6:e719. doi: 10.1038/tp.2015.205.


Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease.

Sattlecker M, Khondoker M, Proitsi P, Williams S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Dobson RJ.

J Alzheimers Dis. 2016;49(4):1105-14. doi: 10.3233/JAD-140669.


A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis.

Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Hodges A, Kiddle S, Dobson RJ.

J Alzheimers Dis. 2016;49(3):659-69. doi: 10.3233/JAD-150440.


No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease.

Chiam JT, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Hodges A, Lovestone S, Newhouse S, Dobson RJ, Kiddle SJ, Sattlecker M.

J Alzheimers Dis. 2015;47(3):741-50. doi: 10.3233/JAD-150289.


Identification of Adverse Drug Events from Free Text Electronic Patient Records and Information in a Large Mental Health Case Register.

Iqbal E, Mallah R, Jackson RG, Ball M, Ibrahim ZM, Broadbent M, Dzahini O, Stewart R, Johnston C, Dobson RJ.

PLoS One. 2015 Aug 14;10(8):e0134208. doi: 10.1371/journal.pone.0134208. eCollection 2015.


Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes.

Kiddle SJ, Steves CJ, Mehta M, Simmons A, Xu X, Newhouse S, Sattlecker M, Ashton NJ, Bazenet C, Killick R, Adnan J, Westman E, Nelson S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Curtis C, Breen G, Williams SC, Lovestone S, Spector TD, Dobson RJ.

Transl Psychiatry. 2015 Jun 16;5:e584. doi: 10.1038/tp.2015.78.


Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology.

Voyle N, Baker D, Burnham SC, Covin A, Zhang Z, Sangurdekar DP, Tan Hehir CA, Bazenet C, Lovestone S, Kiddle S, Dobson RJ; AIBL research group.

J Alzheimers Dis. 2015;46(4):947-61. doi: 10.3233/JAD-150020.


Exploring the role of drug-metabolising enzymes in antidepressant side effects.

Hodgson K, Tansey KE, Uher R, Dernovšek MZ, Mors O, Hauser J, Souery D, Maier W, Henigsberg N, Rietschel M, Placentino A, Craig IW, Aitchison KJ, Farmer AE, Dobson RJ, McGuffin P.

Psychopharmacology (Berl). 2015 Jul;232(14):2609-17. doi: 10.1007/s00213-015-3898-x. Epub 2015 Mar 12.


Blood protein predictors of brain amyloid for enrichment in clinical trials?

Ashton NJ, Kiddle SJ, Graf J, Ward M, Baird AL, Hye A, Westwood S, Wong KV, Dobson RJ, Rabinovici GD, Miller BL, Rosen HJ, Torres A, Zhang Z, Thurfjell L, Covin A, Hehir CT, Baker D, Bazenet C, Lovestone S; AIBL Research Group.

Alzheimers Dement (Amst). 2015 Mar 29;1(1):48-60. doi: 10.1016/j.dadm.2014.11.005. eCollection 2015 Mar.


CohortExplorer: A Generic Application Programming Interface for Entity Attribute Value Database Schemas.

Dixit A, Dobson RJ.

JMIR Med Inform. 2014 Dec 1;2(2):e32. doi: 10.2196/medinform.3339.


Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease.

Proitsi P, Kim M, Whiley L, Pritchard M, Leung R, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Sham P, Lovestone S, Powell JF, Dobson RJ, Legido-Quigley C.

Transl Psychiatry. 2015 Jan 13;5:e494. doi: 10.1038/tp.2014.127.


Are blood-based protein biomarkers for Alzheimer's disease also involved in other brain disorders? A systematic review.

Chiam JT, Dobson RJ, Kiddle SJ, Sattlecker M.

J Alzheimers Dis. 2015;43(1):303-14. doi: 10.3233/JAD-140816. Review.


Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology.

Sattlecker M, Kiddle SJ, Newhouse S, Proitsi P, Nelson S, Williams S, Johnston C, Killick R, Simmons A, Westman E, Hodges A, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S; AddNeuroMed Consortium, Dobson RJ.

Alzheimers Dement. 2014 Nov;10(6):724-34. doi: 10.1016/j.jalz.2013.09.016. Epub 2014 Apr 25.


Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana.

Kotze AC, Dobson RJ, Humphries D, Wilson M, Cappello M.

Int J Parasitol Drugs Drug Resist. 2014 Jan 31;4(1):64-70. doi: 10.1016/j.ijpddr.2014.01.001. eCollection 2014 Apr.

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