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Items: 30


Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-Based Subtypes.

Zhang L, MacIsaac KD, Zhou T, Huang PY, Xin C, Dobson JR, Yu K, Chiang DY, Fan Y, Pelletier M, Wang Y, Jaeger S, Krishnamurthy Radhakrishnan V, JeBailey L, Skewes-Cox P, Zhang J, Fang W, Huang Y, Zhao H, Zhao Y, Li E, Peng B, Huang A, Dranoff G, Hammerman PS, Engelman J, Bitter H, Zeng YX, Yao Y.

Mol Cancer Res. 2017 Dec;15(12):1722-1732. doi: 10.1158/1541-7786.MCR-17-0134. Epub 2017 Aug 29.


A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors.

Geoerger B, Bourdeaut F, DuBois SG, Fischer M, Geller JI, Gottardo NG, Marabelle A, Pearson ADJ, Modak S, Cash T, Robinson GW, Motta M, Matano A, Bhansali SG, Dobson JR, Parasuraman S, Chi SN.

Clin Cancer Res. 2017 May 15;23(10):2433-2441. doi: 10.1158/1078-0432.CCR-16-2898. Epub 2017 Apr 21.


Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition.

Hong D, Messier TL, Tye CE, Dobson JR, Fritz AJ, Sikora KR, Browne G, Stein JL, Lian JB, Stein GS.

Oncotarget. 2017 Mar 14;8(11):17610-17627. doi: 10.18632/oncotarget.15381.


A Phase I Study of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) in Patients with Advanced Solid Tumors and Lymphomas.

Infante JR, Cassier PA, Gerecitano JF, Witteveen PO, Chugh R, Ribrag V, Chakraborty A, Matano A, Dobson JR, Crystal AS, Parasuraman S, Shapiro GI.

Clin Cancer Res. 2016 Dec 1;22(23):5696-5705. Epub 2016 Aug 19.


The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation.

Wu Q, Madany P, Dobson JR, Schnabl JM, Sharma S, Smith TC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Muthuswami R, Imbalzano AN, Nickerson JA.

Oncotarget. 2016 Jun 21;7(25):38270-38281. doi: 10.18632/oncotarget.9505.


Identifying Nuclear Matrix-Attached DNA Across the Genome.

Dobson JR, Hong D, Barutcu AR, Wu H, Imbalzano AN, Lian JB, Stein JL, van Wijnen AJ, Nickerson JA, Stein GS.

J Cell Physiol. 2017 Jun;232(6):1295-1305. doi: 10.1002/jcp.25596. Epub 2017 Jan 5.


Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation.

Kuzu G, Kaye EG, Chery J, Siggers T, Yang L, Dobson JR, Boor S, Bliss J, Liu W, Jogl G, Rohs R, Singh ND, Bulyk ML, Tolstorukov MY, Larschan E.

PLoS Genet. 2016 Jul 14;12(7):e1006120. doi: 10.1371/journal.pgen.1006120. eCollection 2016 Jul.


Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Fei F, Firestone B, Fodor M, Fridrich C, Gao H, Grunenfelder D, Hao HX, Jacob J, Ho S, Hsiao K, Kang ZB, Karki R, Kato M, Larrow J, La Bonte LR, Lenoir F, Liu G, Liu S, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Price E, Quinn C, Shakya S, Shultz MD, Slisz J, Venkatesan K, Wang P, Warmuth M, Williams S, Yang G, Yuan J, Zhang JH, Zhu P, Ramsey T, Keen NJ, Sellers WR, Stams T, Fortin PD.

Nature. 2016 Jul 7;535(7610):148-52. Epub 2016 Jun 29.


The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, Browne G, Colby JL, Winter GE, Bradner JE, Pratap J, Sluder G, Bhargava R, Chiosea SI, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Nickerson JA, Imbalzano AN.

J Cell Physiol. 2015 Nov;230(11):2683-94. doi: 10.1002/jcp.24991.


Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1.

Zhang X, Wu H, Dobson JR, Browne G, Hong D, Akech J, Languino LR, Stein GS, Lian JB.

J Cell Biochem. 2015 Sep;116(9):2098-108. doi: 10.1002/jcb.25167.


Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes.

Leiserson MD, Vandin F, Wu HT, Dobson JR, Eldridge JV, Thomas JL, Papoutsaki A, Kim Y, Niu B, McLellan M, Lawrence MS, Gonzalez-Perez A, Tamborero D, Cheng Y, Ryslik GA, Lopez-Bigas N, Getz G, Ding L, Raphael BJ.

Nat Genet. 2015 Feb;47(2):106-14. doi: 10.1038/ng.3168. Epub 2014 Dec 15.


hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3.

Dobson JR, Taipaleenmäki H, Hu YJ, Hong D, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Pratap J.

Cancer Cell Int. 2014 Aug 2;14:73. doi: 10.1186/s12935-014-0073-0. eCollection 2014.


The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter.

Barutcu AR, Tai PW, Wu H, Gordon JA, Whitfield TW, Dobson JR, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS.

Nucleic Acids Res. 2014;42(16):10360-72. doi: 10.1093/nar/gku712. Epub 2014 Aug 12.


Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis.

Wu H, Whitfield TW, Gordon JA, Dobson JR, Tai PW, van Wijnen AJ, Stein JL, Stein GS, Lian JB.

Genome Biol. 2014 Mar 21;15(3):R52. doi: 10.1186/gb-2014-15-3-r52.


Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine.

Raphael BJ, Dobson JR, Oesper L, Vandin F.

Genome Med. 2014 Jan 30;6(1):5. doi: 10.1186/gm524. eCollection 2014. Review.


A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation.

Ali SA, Dobson JR, Lian JB, Stein JL, van Wijnen AJ, Zaidi SK, Stein GS.

J Cell Sci. 2012 Jun 1;125(Pt 11):2732-9. doi: 10.1242/jcs.100909. Epub 2012 Mar 5.


Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility.

Leong DT, Lim J, Goh X, Pratap J, Pereira BP, Kwok HS, Nathan SS, Dobson JR, Lian JB, Ito Y, Voorhoeve PM, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ.

Breast Cancer Res. 2010;12(5):R89. doi: 10.1186/bcr2762. Epub 2010 Oct 28.


Usefulness of multimodality cardiac imaging in the diagnosis of a right atrial angiosarcoma.

Vaidya OU, Dobson JR 3rd, Wible BC, Main ML.

J Am Soc Echocardiogr. 2010 Jul;23(7):792.e3-4. doi: 10.1016/j.echo.2010.01.010. Epub 2010 Mar 25.


Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes.

Ali SA, Zaidi SK, Dobson JR, Shakoori AR, Lian JB, Stein JL, van Wijnen AJ, Stein GS.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4165-9. doi: 10.1073/pnas.1000620107. Epub 2010 Feb 16.


Strongyloides stercoralis eosinophilic granulomatous enterocolitis.

Gutierrez Y, Bhatia P, Garbadawala ST, Dobson JR, Wallace TM, Carey TE.

Am J Surg Pathol. 1996 May;20(5):603-12.


Fallibility of transthoracic needle biopsy of anterior mediastinal masses.

Robinson LA, Dobson JR, Bierman PJ.

Thorax. 1995 Oct;50(10):1114-6.


Benign mediastinal teratoma masquerading as a large multiloculated effusion.

Robinson LA, Rikkers LF, Dobson JR.

Ann Thorac Surg. 1994 Aug;58(2):545-8.


Frequency, extent, and distribution of endomyocardial adipose tissue: Morphometric analysis of endomyocardial biopsy specimens from 241 patients.

Dembinski AS, Dobson JR 3rd, Wilson JE, Radio SJ, Miles RR, Sears TD, McManus BM.

Cardiovasc Pathol. 1994 Jan-Mar;3(1):33-41. doi: 10.1016/1054-8807(94)90005-1.


Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers.

Rennard SI, Daughton D, Fujita J, Oehlerking MB, Dobson JR, Stahl MG, Robbins RA, Thompson AB.

Eur Respir J. 1990 Jul;3(7):752-9.


Personality disorder: a challenge for the future.

Dobson JR.

N Z Med J. 1975 Jan 22;81(532):59-61.


Therapeutic abortion.

Dobson JR, Werry JS, Gluckman L.

N Z Med J. 1971 Oct;74(473):274. No abstract available.


Lysergide and chromosomes.

Fitzgerald PH, Dobson JR.

Lancet. 1968 May 11;1(7550):1036-7. No abstract available.


Integration of psychiatric concepts.

Dobson JR.

N Z Nurs J. 1965 Dec;58(12):12-3. No abstract available.


Group psychotherapy.


N Z Med J. 1958 Jun;57(319):251-5. No abstract available.


Childhood psychoses.


N Z Med J. 1957 Dec;56(316):647-53. No abstract available.


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