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Items: 1 to 50 of 113

1.

Conventional and Specific-Pathogen Free Rats Respond Differently to Anesthesia and Surgical Trauma.

Letson HL, Morris J, Biros E, Dobson GP.

Sci Rep. 2019 Jun 28;9(1):9399. doi: 10.1038/s41598-019-45871-z.

2.

ALM Fluid Therapy Leads to 72 hr Survival After Hemorrhagic Shock: a Model for Studying Differential Gene Expression and Extending Biological Time.

Letson HL, Morris J, Biros E, Dobson GP.

J Trauma Acute Care Surg. 2019 Jun 24. doi: 10.1097/TA.0000000000002397. [Epub ahead of print]

PMID:
31162330
3.

The role of invasive monitoring in the resuscitation of major burns: a systematic review and meta-analysis.

Davenport LM, Dobson GP, Letson HL.

Int J Burns Trauma. 2019 Apr 15;9(2):28-40. eCollection 2019.

4.

Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution.

McCutchan A, Dobson GP, Stewart N, Letson HL, Grant AL, Jovanovic IA, Hazratwala K, Wilkinson M, McEwen P, Morris J.

J Exp Orthop. 2019 Apr 15;6(1):16. doi: 10.1186/s40634-019-0185-5.

5.

The CNS theory of osteoarthritis: Opportunities beyond the joint.

Morris JL, Letson HL, Gillman R, Hazratwala K, Wilkinson M, McEwen P, Dobson GP.

Semin Arthritis Rheum. 2019 Mar 16. pii: S0049-0172(19)30012-5. doi: 10.1016/j.semarthrit.2019.03.008. [Epub ahead of print] Review.

PMID:
30982553
6.

Specific pathogen-free (SPF) animal status as a variable in biomedical research: Have we come full circle?

Dobson GP, Letson HL, Biros E, Morris J.

EBioMedicine. 2019 Mar;41:42-43. doi: 10.1016/j.ebiom.2019.02.038. Epub 2019 Feb 23. No abstract available.

7.

Response to letter to the editor.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2019 Feb;86(2):376. doi: 10.1097/TA.0000000000002107. No abstract available.

PMID:
30376545
9.

Tranexamic acid is associated with selective increase in inflammatory markers following total knee arthroplasty (TKA): a pilot study.

Grant AL, Letson HL, Morris JL, McEwen P, Hazratwala K, Wilkinson M, Dobson GP.

J Orthop Surg Res. 2018 Jun 18;13(1):149. doi: 10.1186/s13018-018-0855-5.

10.

Defining the osteoarthritis patient: back to the future.

Dobson GP, Letson HL, Grant A, McEwen P, Hazratwala K, Wilkinson M, Morris JL.

Osteoarthritis Cartilage. 2018 Aug;26(8):1003-1007. doi: 10.1016/j.joca.2018.04.018. Epub 2018 May 25. Review.

PMID:
29775734
11.
12.

Adenosine, lidocaine, and Mg2+ (ALM) resuscitation fluid protects against experimental traumatic brain injury.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2018 Jun;84(6):908-916. doi: 10.1097/TA.0000000000001874.

PMID:
29554045
13.

Clinical relevance of a p value: Does tranexamic acid save lives after trauma or postpartum hemorrhage?

Dobson GP, Doma K, Letson HL.

J Trauma Acute Care Surg. 2018 Mar;84(3):532-536. doi: 10.1097/TA.0000000000001779. Review. No abstract available.

PMID:
29462114
14.

Clinical relevance of a p-value: Does TXA save lives after trauma or post-partum hemorrhage?

Dobson GP, Doma K, Letson HL.

J Trauma Acute Care Surg. 2017 Dec 28. doi: 10.1097/TA.0000000000001779. [Epub ahead of print] No abstract available.

PMID:
29283963
15.

The Adenosine Hypothesis Revisited: Modulation of Coupling between Myocardial Perfusion and Arterial Compliance.

Dobson GP, Arsyad A, Letson HL.

Front Physiol. 2017 Oct 20;8:824. doi: 10.3389/fphys.2017.00824. eCollection 2017.

16.

Tranexamic acid for post-partum haemorrhage in the WOMAN trial.

Letson HL, Dobson GP.

Lancet. 2017 Sep 30;390(10102):1581-1582. doi: 10.1016/S0140-6736(17)31947-5. Epub 2017 Sep 28. No abstract available.

PMID:
28980953
17.

Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg2+ infusion to dampen the stress response.

Davenport L, Letson HL, Dobson GP.

Innate Immun. 2017 Jul;23(5):482-494. doi: 10.1177/1753425917718921.

PMID:
28691873
18.

Tranexamic acid leads to paradoxical coagulation changes during cardiac surgery: a pilot rotational thromboelastometry study.

Sharma R, Letson HL, Smith S, Dobson GP.

J Surg Res. 2017 Sep;217:100-112. doi: 10.1016/j.jss.2017.05.006. Epub 2017 May 8.

PMID:
28602219
19.

3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours "drip" infusion reduces noncompressible hemorrhage by 60% in a rat model.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2017 Jun;82(6):1063-1072. doi: 10.1097/TA.0000000000001454.

PMID:
28520687
20.

Evaluation of adenosine, lidocaine, and magnesium for enhancement of platelet function during storage.

Bynum JA, Taylor AS, Peltier GC, McIntosh CS, Meledeo MA, Dobson GP, Cap AP.

J Trauma Acute Care Surg. 2017 Jul;83(1 Suppl 1):S9-S15. doi: 10.1097/TA.0000000000001479.

PMID:
28383470
21.

An ex vivo comparison of adenosine and lidocaine solution and University of Wisconsin solution for hypothermic machine perfusion of porcine kidneys: potential for development.

Hamaoui K, Aftab A, Gowers S, Boutelle M, Cook T, Rudd D, Dobson GP, Papalois V.

J Surg Res. 2017 Feb;208:219-229. doi: 10.1016/j.jss.2016.08.068. Epub 2016 Sep 12.

PMID:
27993213
22.

Buprenorphine Analgesia Leads to Coagulopathy and Increased Plasma Fibrinogen in Healthy Rats: Implications For Small Animal Research.

Griffin MJ, Letson HL, Dobson GP.

Shock. 2017 Jul;48(1):78-84. doi: 10.1097/SHK.0000000000000821.

PMID:
27984521
24.
25.

Adenosine relaxation in isolated rat aortic rings and possible roles of smooth muscle Kv channels, KATP channels and A2a receptors.

Arsyad A, Dobson GP.

BMC Pharmacol Toxicol. 2016 May 23;17(1):23. doi: 10.1186/s40360-016-0067-8.

26.

Superior Myocardial Protection Using "Polarizing" Adenosine, Lidocaine, and Mg2+ Cardioplegia in Humans.

Onorati F, Dobson GP, San Biagio L, Abbasciano R, Fanti D, Covajes C, Menon T, Gottin L, Biancari F, Mazzucco A, Faggian G.

J Am Coll Cardiol. 2016 Apr 12;67(14):1751-3. doi: 10.1016/j.jacc.2015.12.071. No abstract available.

27.

Differential contributions of platelets and fibrinogen to early coagulopathy in a rat model of hemorrhagic shock.

Letson HL, Dobson GP.

Thromb Res. 2016 May;141:58-65. doi: 10.1016/j.thromres.2016.03.007. Epub 2016 Mar 7.

PMID:
26970714
28.

Adenosine, lidocaine, and Mg2+ (ALM): From cardiac surgery to combat casualty care--Teaching old drugs new tricks.

Dobson GP, Letson HL.

J Trauma Acute Care Surg. 2016 Jan;80(1):135-45. doi: 10.1097/TA.0000000000000881. Review.

PMID:
26683400
29.

Addressing the Global Burden of Trauma in Major Surgery.

Dobson GP.

Front Surg. 2015 Sep 3;2:43. doi: 10.3389/fsurg.2015.00043. eCollection 2015. Review.

30.

Mechanisms of early trauma-induced coagulopathy: The clot thickens or not?

Dobson GP, Letson HL, Sharma R, Sheppard FR, Cap AP.

J Trauma Acute Care Surg. 2015 Aug;79(2):301-9. doi: 10.1097/TA.0000000000000729.

PMID:
26218701
31.

Correction of acute traumatic coagulopathy with small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ occurs within 5 minutes: a ROTEM analysis.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2015 Apr;78(4):773-83. doi: 10.1097/TA.0000000000000587.

PMID:
25807406
32.

Adenosine, lidocaine and Mg2+ improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model.

Granfeldt A, Letson HL, Dobson GP, Shi W, Vinten-Johansen J, Tønnesen E.

Crit Care. 2014 Dec 11;18(6):682. doi: 10.1186/s13054-014-0682-y.

33.

Addressing the global burden of sepsis: importance of a systems-based approach.

Dobson GP.

Crit Care Med. 2014 Dec;42(12):e797-8. doi: 10.1097/CCM.0000000000000595. No abstract available.

PMID:
25402302
34.

The August Krogh principle: seeking unity in diversity.

Dobson GP.

Shock. 2014 Nov;42(5):480. doi: 10.1097/SHK.0000000000000229. No abstract available.

PMID:
25320913
35.

Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis.

Griffin MJ, Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2014 Sep;77(3):471-8. doi: 10.1097/TA.0000000000000361.

PMID:
25159253
36.

Pulmonary function after hemorrhagic shock and resuscitation in a porcine model.

Nielsen TK, Hvas CL, Dobson GP, Tønnesen E, Granfeldt A.

Acta Anaesthesiol Scand. 2014 Sep;58(8):1015-24. doi: 10.1111/aas.12355. Epub 2014 Jun 24.

PMID:
24961485
37.

Small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation.

Granfeldt A, Letson HL, Hyldebrandt JA, Wang ER, Salcedo PA, Nielsen TK, Tønnesen E, Vinten-Johansen J, Dobson GP.

Crit Care Med. 2014 May;42(5):e329-44. doi: 10.1097/CCM.0000000000000225.

PMID:
24557427
38.

Optimization of the rodent model of polymicrobial sepsis.

Griffin M, Letson HL, Dobson GP.

Int Immunopharmacol. 2014 Apr;19(2):405. doi: 10.1016/j.intimp.2014.01.016. Epub 2014 Jan 29. No abstract available.

PMID:
24485942
39.

The Bellamy challenge: it's about time.

Dobson GP, Letson HL, Tadaki D.

J R Army Med Corps. 2014 Mar;160(1):9-15. doi: 10.1136/jramc-2013-000145. Epub 2013 Oct 18. Review.

PMID:
24142962
40.

Hemodynamic rescue and ECG stability during chest compressions using adenosine and lidocaine after 8-minute asphyxial hypoxia in the rat.

Djabir Y, Dobson GP.

Am J Emerg Med. 2013 Nov;31(11):1539-45. doi: 10.1016/j.ajem.2013.05.044. Epub 2013 Sep 21.

PMID:
24060325
41.

Hyperkalemic cardioplegia for adult and pediatric surgery: end of an era?

Dobson GP, Faggian G, Onorati F, Vinten-Johansen J.

Front Physiol. 2013 Aug 28;4:228. doi: 10.3389/fphys.2013.00228. eCollection 2013. Review.

42.

The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest.

Granfeldt A, Shi W, Schmarkey SL, Jiang R, Bone CC, Cline JM, Wogensen L, Dobson GP, Tønnesen E, Vinten-Johansen J.

Resuscitation. 2013 Nov;84(11):1611-8. doi: 10.1016/j.resuscitation.2013.07.001. Epub 2013 Jul 11.

PMID:
23851192
43.

Adenosine, lidocaine, and Mg2+ (ALM™) increases survival and corrects coagulopathy after eight-minute asphyxial cardiac arrest in the rat.

Djabir Y, Letson HL, Dobson GP.

Shock. 2013 Sep;40(3):222-32. doi: 10.1097/SHK.0b013e3182a03566.

PMID:
23846412
44.

Acute coagulopathy of trauma in the rat. Shock 39: 440-446, 2013.

Letson HL, Dobson GP.

Shock. 2013 Jul;40(1):74. doi: 10.1097/SHK.0b013e318296e18e. No abstract available.

PMID:
23770764
45.

Adenosine-procaine cardioplegia and adenosine-lidocaine cardioplegia: Two sides of the same coin?

Vinten-Johansen J, Dobson GP.

J Thorac Cardiovasc Surg. 2013 Jun;145(6):1684-5. doi: 10.1016/j.jtcvs.2013.01.049. No abstract available.

46.

Adenocaine and Mg(2+) reduce fluid requirement to maintain hypotensive resuscitation and improve cardiac and renal function in a porcine model of severe hemorrhagic shock*.

Granfeldt A, Nielsen TK, Sølling C, Hyldebrandt JA, Frøkiær J, Wogensen L, Dobson GP, Vinten-Johansen J, Tønnesen E.

Crit Care Med. 2012 Nov;40(11):3013-25. doi: 10.1097/CCM.0b013e31825fd4ed.

PMID:
22926331
47.

Reversal of acute coagulopathy during hypotensive resuscitation using small-volume 7.5% NaCl adenocaine and Mg2+ in the rat model of severe hemorrhagic shock.

Letson HL, Pecheniuk NM, Mhango LP, Dobson GP.

Crit Care Med. 2012 Aug;40(8):2417-22. doi: 10.1097/CCM.0b013e31825334c3.

PMID:
22809911
48.

Small animal model species are not created equal.

Dobson GP.

Crit Care Med. 2012 Feb;40(2):711; author reply 711-2. doi: 10.1097/CCM.0b013e31823c8965. No abstract available.

PMID:
22249074
49.
50.

The nondepolarizing, normokalemic cardioplegia formulation adenosine-lidocaine (adenocaine) exerts anti-neutrophil effects by synergistic actions of its components.

Shi W, Jiang R, Dobson GP, Granfeldt A, Vinten-Johansen J.

J Thorac Cardiovasc Surg. 2012 May;143(5):1167-75. doi: 10.1016/j.jtcvs.2011.06.045. Epub 2011 Nov 12.

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