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Items: 1 to 50 of 706

1.

Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of zinc ions.

Mannini B, Habchi J, Chia SKR, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M.

ACS Chem Neurosci. 2018 Jul 9. doi: 10.1021/acschemneuro.8b00141. [Epub ahead of print]

PMID:
29986583
2.

Basosquamous Carcinoma: A Single Centre Clinicopathological Evaluation and Proposal of an Evidence-Based Protocol.

Oldbury JW, Wain RAJ, Abas S, Dobson CM, Iyer SS.

J Skin Cancer. 2018 Jun 3;2018:6061395. doi: 10.1155/2018/6061395. eCollection 2018.

3.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Jun 28. doi: 10.1021/acschembio.8b00466. [Epub ahead of print]

PMID:
29953201
4.

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.

Brown JWP, Meisl G, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C.

Chem Commun (Camb). 2018 Jul 10;54(56):7854-7857. doi: 10.1039/c8cc03002b.

PMID:
29951679
5.

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR.

Cell Rep. 2018 Jun 19;23(12):3492-3500. doi: 10.1016/j.celrep.2018.05.074.

6.

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

Zhang Y, Yates EV, Hong L, Saar KL, Meisl G, Dobson CM, Knowles TPJ.

Chem Sci. 2018 Feb 9;9(14):3503-3507. doi: 10.1039/c7sc04331g. eCollection 2018 Apr 14.

7.

Cooperative Assembly of Hsp70 Subdomain Clusters.

Wright MA, Aprile FA, Bellaiche MMJ, Michaels TCT, Müller T, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ.

Biochemistry. 2018 Jul 3;57(26):3641-3649. doi: 10.1021/acs.biochem.8b00151. Epub 2018 May 29.

PMID:
29763298
8.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
9.

Correction to 'Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species'.

Needham LM, Weber J, Fyfe JWB, Kabia OM, Do DT, Klimont E, Zhang Y, Rodrigues M, Dobson CM, Gandhi S, Bohndiek SE, Snaddon TN, Lee SF.

R Soc Open Sci. 2018 Mar 28;5(3):180308. doi: 10.1098/rsos.180308. eCollection 2018 Mar.

10.

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM.

Protein Sci. 2018 Jul;27(7):1262-1274. doi: 10.1002/pro.3412.

PMID:
29603451
11.

Molecular determinants of the interaction of EGCG with ordered and disordered proteins.

Fusco G, Sanz-Hernandez M, Ruggeri FS, Vendruscolo M, Dobson CM, De Simone A.

Biopolymers. 2018 Mar 30:e23117. doi: 10.1002/bip.23117. [Epub ahead of print]

PMID:
29603125
12.

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S.

Nat Chem. 2018 May;10(5):523-531. doi: 10.1038/s41557-018-0023-x. Epub 2018 Mar 26.

PMID:
29581486
13.

Microfluidic approaches for probing amyloid assembly and behaviour.

Herling TW, Levin A, Saar KL, Dobson CM, Knowles TPJ.

Lab Chip. 2018 Mar 27;18(7):999-1016. doi: 10.1039/c7lc01241a. Review.

PMID:
29527600
14.

Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.

Needham LM, Weber J, Fyfe JWB, Kabia OM, Do DT, Klimont E, Zhang Y, Rodrigues M, Dobson CM, Ghandi S, Bohndiek SE, Snaddon TN, Lee SF.

R Soc Open Sci. 2018 Feb 7;5(2):171399. doi: 10.1098/rsos.171399. eCollection 2018 Feb. Erratum in: R Soc Open Sci. 2018 Mar 28;5(3):180308.

15.

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ.

Annu Rev Phys Chem. 2018 Apr 20;69:273-298. doi: 10.1146/annurev-physchem-050317-021322. Epub 2018 Feb 28.

PMID:
29490200
16.

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.

Perni M, Challa PK, Kirkegaard JB, Limbocker R, Koopman M, Hardenberg MC, Sormanni P, Müller T, Saar KL, Roode LWY, Habchi J, Vecchi G, Fernando N, Casford S, Nollen EAA, Vendruscolo M, Dobson CM, Knowles TPJ.

J Neurosci Methods. 2018 Aug 1;306:57-67. doi: 10.1016/j.jneumeth.2018.02.005. Epub 2018 Feb 13.

PMID:
29452179
17.

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.

Cox D, Whiten DR, Brown JWP, Horrocks MH, San Gil R, Dobson CM, Klenerman D, van Oijen AM, Ecroyd H.

J Biol Chem. 2018 Mar 23;293(12):4486-4497. doi: 10.1074/jbc.M117.813865. Epub 2018 Jan 30.

PMID:
29382725
18.

Biophotonics of Native Silk Fibrils.

Shimanovich U, Pinotsi D, Shimanovich K, Yu N, Bolisetty S, Adamcik J, Mezzenga R, Charmet J, Vollrath F, Gazit E, Dobson CM, Schierle GK, Holland C, Kaminski CF, Knowles TPJ.

Macromol Biosci. 2018 Apr;18(4):e1700295. doi: 10.1002/mabi.201700295. Epub 2018 Jan 29.

PMID:
29377575
19.

Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.

Yang J, Dear AJ, Michaels TCT, Dobson CM, Knowles TPJ, Wu S, Perrett S.

J Am Chem Soc. 2018 Feb 21;140(7):2493-2503. doi: 10.1021/jacs.7b10439. Epub 2018 Feb 7.

20.

Optical Structural Analysis of Individual α-Synuclein Oligomers.

Varela JA, Rodrigues M, De S, Flagmeier P, Gandhi S, Dobson CM, Klenerman D, Lee SF.

Angew Chem Int Ed Engl. 2018 Apr 23;57(18):4886-4890. doi: 10.1002/anie.201710779. Epub 2018 Mar 23.

21.

Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.

Gang H, Galvagnion C, Meisl G, Müller T, Pfammatter M, Buell AK, Levin A, Dobson CM, Mu B, Knowles TPJ.

Anal Chem. 2018 Mar 6;90(5):3284-3290. doi: 10.1021/acs.analchem.7b04820. Epub 2018 Feb 13.

PMID:
29313342
22.

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.

Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D.

ACS Chem Biol. 2018 Mar 16;13(3):636-646. doi: 10.1021/acschembio.7b01039. Epub 2018 Jan 17.

PMID:
29300447
23.

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.

Fusco G, Chen SW, Williamson PTF, Cascella R, Perni M, Jarvis JA, Cecchi C, Vendruscolo M, Chiti F, Cremades N, Ying L, Dobson CM, De Simone A.

Science. 2017 Dec 15;358(6369):1440-1443. doi: 10.1126/science.aan6160.

24.

Inhibiting the Ca2+ Influx Induced by Human CSF.

Drews A, De S, Flagmeier P, Wirthensohn DC, Chen WH, Whiten DR, Rodrigues M, Vincke C, Muyldermans S, Paterson RW, Slattery CF, Fox NC, Schott JM, Zetterberg H, Dobson CM, Gandhi S, Klenerman D.

Cell Rep. 2017 Dec 12;21(11):3310-3316. doi: 10.1016/j.celrep.2017.11.057.

25.

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ.

Chem Sci. 2017 Oct 1;8(10):7087-7097. doi: 10.1039/c7sc01965c. Epub 2017 Aug 31.

26.

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.

Perni M, Aprile FA, Casford S, Mannini B, Sormanni P, Dobson CM, Vendruscolo M.

Sci Rep. 2017 Nov 8;7(1):15045. doi: 10.1038/s41598-017-13755-9.

27.

Clusterin protects neurons against intracellular proteotoxicity.

Gregory JM, Whiten DR, Brown RA, Barros TP, Kumita JR, Yerbury JJ, Satapathy S, McDade K, Smith C, Luheshi LM, Dobson CM, Wilson MR.

Acta Neuropathol Commun. 2017 Nov 7;5(1):81. doi: 10.1186/s40478-017-0481-1.

28.

Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.

Ahn M, Waudby CA, Bernardo-Gancedo A, De Genst E, Dhulesia A, Salvatella X, Christodoulou J, Dobson CM, Kumita JR.

Sci Rep. 2017 Nov 3;7(1):15018. doi: 10.1038/s41598-017-14739-5.

29.

Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.

Villadiego J, Labrador-Garrido A, Franco JM, Leal-Lasarte M, De Genst EJ, Dobson CM, Pozo D, Toledo-Aral JJ, Roodveldt C.

Glia. 2018 Jan;66(1):191-205. doi: 10.1002/glia.23237. Epub 2017 Oct 11.

PMID:
29024008
30.

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.

Mason TO, Michaels TCT, Levin A, Dobson CM, Gazit E, Knowles TPJ, Buell AK.

J Am Chem Soc. 2017 Nov 15;139(45):16134-16142. doi: 10.1021/jacs.7b00229. Epub 2017 Oct 23.

PMID:
28994295
31.

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.

Meisl G, Yang X, Dobson CM, Linse S, Knowles TPJ.

Chem Sci. 2017 Jun 1;8(6):4352-4362. doi: 10.1039/c7sc00215g. Epub 2017 Apr 26.

32.

Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sánchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi A, Hornemann S.

Anal Chem. 2017 Nov 21;89(22):12306-12313. doi: 10.1021/acs.analchem.7b03279. Epub 2017 Nov 1.

33.

Gradient-free determination of isoelectric points of proteins on chip.

Łapińska U, Saar KL, Yates EV, Herling TW, Müller T, Challa PK, Dobson CM, Knowles TPJ.

Phys Chem Chem Phys. 2017 Aug 30;19(34):23060-23067. doi: 10.1039/c7cp01503h.

PMID:
28817152
34.

Sequential Release of Proteins from Structured Multishell Microcapsules.

Shimanovich U, Michaels TCT, De Genst E, Matak-Vinkovic D, Dobson CM, Knowles TPJ.

Biomacromolecules. 2017 Oct 9;18(10):3052-3059. doi: 10.1021/acs.biomac.7b00351. Epub 2017 Sep 7.

PMID:
28792742
35.

Silk micrococoons for protein stabilisation and molecular encapsulation.

Shimanovich U, Ruggeri FS, De Genst E, Adamcik J, Barros TP, Porter D, Müller T, Mezzenga R, Dobson CM, Vollrath F, Holland C, Knowles TPJ.

Nat Commun. 2017 Jul 19;8:15902. doi: 10.1038/ncomms15902.

36.

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.

Hanspal MA, Dobson CM, Yerbury JJ, Kumita JR.

Biochim Biophys Acta. 2017 Nov;1863(11):2762-2771. doi: 10.1016/j.bbadis.2017.07.007. Epub 2017 Jul 13. Review.

37.

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.

Cremades N, Dobson CM.

Neurobiol Dis. 2018 Jan;109(Pt B):178-190. doi: 10.1016/j.nbd.2017.07.009. Epub 2017 Jul 12. Review.

38.

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.

Chia S, Flagmeier P, Habchi J, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8005-8010. doi: 10.1073/pnas.1700239114. Epub 2017 Jul 11.

39.

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.

Aprile FA, Sormanni P, Perni M, Arosio P, Linse S, Knowles TPJ, Dobson CM, Vendruscolo M.

Sci Adv. 2017 Jun 21;3(6):e1700488. doi: 10.1126/sciadv.1700488. eCollection 2017 Jun.

40.

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.

Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D.

BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6.

41.

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.

Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26.

42.

Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies.

Elia F, Cantini F, Chiti F, Dobson CM, Bemporad F.

Biophys J. 2017 Jun 20;112(12):2540-2551. doi: 10.1016/j.bpj.2017.05.011.

43.

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.

Munke A, Persson J, Weiffert T, De Genst E, Meisl G, Arosio P, Carnerup A, Dobson CM, Vendruscolo M, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6444-6449. doi: 10.1073/pnas.1700407114. Epub 2017 Jun 5.

44.

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.

Chiti F, Dobson CM.

Annu Rev Biochem. 2017 Jun 20;86:27-68. doi: 10.1146/annurev-biochem-061516-045115. Epub 2017 May 12. Review.

PMID:
28498720
45.

Amyloid-like Fibrils from an α-Helical Transmembrane Protein.

Stroobants K, Kumita JR, Harris NJ, Chirgadze DY, Dobson CM, Booth PJ, Vendruscolo M.

Biochemistry. 2017 Jun 27;56(25):3225-3233. doi: 10.1021/acs.biochem.7b00157. Epub 2017 Jun 12.

46.

Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein.

Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Schierle GSK, Vendruscolo M, Veglia G, Dobson CM, De Simone A.

Nat Commun. 2017 May 11;8:15667. doi: 10.1038/ncomms15667. No abstract available.

47.

Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates.

Flagmeier P, De S, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D.

Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7750-7754. doi: 10.1002/anie.201700966. Epub 2017 May 5.

48.

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3935-E3943. doi: 10.1073/pnas.1613854114. Epub 2017 Apr 10.

49.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2017 Feb 23;168(5):944. doi: 10.1016/j.cell.2016.12.041. No abstract available.

50.

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N.

Biochemistry. 2017 Mar 7;56(9):1177-1180. doi: 10.1021/acs.biochem.6b01178. Epub 2017 Feb 23.

PMID:
28230968

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