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Items: 1 to 50 of 63

1.

KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons.

You Z, Zhang Z, Blagg BSJ, Dobrowsky RT.

Exp Neurol. 2019 Mar;313:88-97. doi: 10.1016/j.expneurol.2018.12.006. Epub 2018 Dec 15.

PMID:
30557564
2.

Synthesis and evaluation of a ring-constrained Hsp90 C-terminal inhibitor that exhibits neuroprotective activity.

Zhang Z, You Z, Dobrowsky RT, Blagg BSJ.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2701-2704. doi: 10.1016/j.bmcl.2018.03.071. Epub 2018 Mar 26.

PMID:
29759728
3.

Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects.

Forsberg LK, Anyika M, You Z, Emery S, McMullen M, Dobrowsky RT, Blagg BSJ.

Eur J Med Chem. 2018 Jan 1;143:1428-1435. doi: 10.1016/j.ejmech.2017.10.038. Epub 2017 Oct 18.

4.

Targeting Heat Shock Protein 70 to Ameliorate c-Jun Expression and Improve Demyelinating Neuropathy.

Zhang X, Li C, Fowler SC, Zhang Z, Blagg BSJ, Dobrowsky RT.

ACS Chem Neurosci. 2018 Feb 21;9(2):381-390. doi: 10.1021/acschemneuro.7b00377. Epub 2017 Nov 9.

5.

Diverging Novobiocin Anti-Cancer Activity from Neuroprotective Activity through Modification of the Amide Tail.

Ghosh S, Liu Y, Garg G, Anyika M, McPherson NT, Ma J, Dobrowsky RT, Blagg BS.

ACS Med Chem Lett. 2016 Jul 5;7(8):813-8. doi: 10.1021/acsmedchemlett.6b00224. eCollection 2016 Aug 11.

6.

Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy.

Dobrowsky RT.

Curr Diab Rep. 2016 Aug;16(8):71. doi: 10.1007/s11892-016-0769-8. Review.

7.

Promoting Neuronal Tolerance of Diabetic Stress: Modulating Molecular Chaperones.

Emery SM, Dobrowsky RT.

Int Rev Neurobiol. 2016;127:181-210. doi: 10.1016/bs.irn.2016.03.001. Epub 2016 Apr 5. Review.

8.

Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.

Ghosh S, Shinogle HE, Galeva NA, Dobrowsky RT, Blagg BS.

J Biol Chem. 2016 Apr 15;291(16):8309-23. doi: 10.1074/jbc.M115.688374. Epub 2016 Feb 12.

9.

Development of Noviomimetics as C-Terminal Hsp90 Inhibitors.

Anyika M, McMullen M, Forsberg LK, Dobrowsky RT, Blagg BS.

ACS Med Chem Lett. 2015 Dec 9;7(1):67-71. doi: 10.1021/acsmedchemlett.5b00331. eCollection 2016 Jan 14.

10.

The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.

Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L.

Cell Stem Cell. 2016 Feb 4;18(2):214-28. doi: 10.1016/j.stem.2015.11.001. Epub 2015 Nov 25.

11.

Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons.

Ma J, Pan P, Anyika M, Blagg BS, Dobrowsky RT.

ACS Chem Neurosci. 2015 Sep 16;6(9):1637-48. doi: 10.1021/acschemneuro.5b00165. Epub 2015 Jul 22.

12.

Hsp90 C-terminal inhibitors exhibit antimigratory activity by disrupting the Hsp90╬▒/Aha1 complex in PC3-MM2 cells.

Ghosh S, Shinogle HE, Garg G, Vielhauer GA, Holzbeierlein JM, Dobrowsky RT, Blagg BS.

ACS Chem Biol. 2015 Feb 20;10(2):577-90. doi: 10.1021/cb5008713. Epub 2014 Dec 3.

13.

Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy.

Ma J, Farmer KL, Pan P, Urban MJ, Zhao H, Blagg BS, Dobrowsky RT.

J Pharmacol Exp Ther. 2014 Feb;348(2):281-92. doi: 10.1124/jpet.113.210435. Epub 2013 Nov 21.

14.
15.

Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun.

Li C, Ma J, Zhao H, Blagg BS, Dobrowsky RT.

ASN Neuro. 2012 Dec 6;4(7):e00102. doi: 10.1042/20120047.

16.

Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach?

Farmer KL, Li C, Dobrowsky RT.

Pharmacol Rev. 2012 Oct;64(4):880-900. doi: 10.1124/pr.111.005314. Epub 2012 Aug 10. Review.

17.

Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity.

Kusuma BR, Zhang L, Sundstrom T, Peterson LB, Dobrowsky RT, Blagg BS.

J Med Chem. 2012 Jun 28;55(12):5797-812. doi: 10.1021/jm300544c. Epub 2012 Jun 15.

18.

Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy.

Urban MJ, Pan P, Farmer KL, Zhao H, Blagg BS, Dobrowsky RT.

Exp Neurol. 2012 May;235(1):388-96. doi: 10.1016/j.expneurol.2012.03.005. Epub 2012 Mar 20.

19.

C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons.

Zhang L, Zhao H, Blagg BS, Dobrowsky RT.

J Proteome Res. 2012 Apr 6;11(4):2581-93. doi: 10.1021/pr300056m. Epub 2012 Mar 28.

20.

Heat shock response and insulin-associated neurodegeneration.

Urban MJ, Dobrowsky RT, Blagg BS.

Trends Pharmacol Sci. 2012 Mar;33(3):129-37. doi: 10.1016/j.tips.2011.11.001. Epub 2011 Dec 13. Review.

21.

Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes.

Chowdhury SK, Dobrowsky RT, Fernyhough P.

Mitochondrion. 2011 Nov;11(6):845-54. doi: 10.1016/j.mito.2011.06.007. Epub 2011 Jul 2. Review.

22.

Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats.

Akude E, Zherebitskaya E, Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P.

Diabetes. 2011 Jan;60(1):288-97. doi: 10.2337/db10-0818. Epub 2010 Sep 28.

23.

Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replication in vivo.

Haenchen SD, Utter JA, Bayless AM, Dobrowsky RT, Davido DJ.

J Neurovirol. 2010 Oct;16(5):405-9. doi: 10.3109/13550284.2010.513030.

24.

Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice.

Urban MJ, Li C, Yu C, Lu Y, Krise JM, McIntosh MP, Rajewski RA, Blagg BS, Dobrowsky RT.

ASN Neuro. 2010 Aug 11;2(4):e00040. doi: 10.1042/AN20100015.

25.

Fluorogenic Tagging of Peptide and Protein 3-Nitrotyrosine with 4-(Aminomethyl)-benzenesulfonic Acid for Quantitative Analysis of Protein Tyrosine Nitration.

Sharov VS, Dremina ES, Galeva NA, Gerstenecker GS, Li X, Dobrowsky RT, Stobaugh JF, Sch├Âneich C.

Chromatographia. 2010 Jan 1;71(1-2):37-53.

26.

Dopamine D(2) receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse.

Oien DB, Ortiz AN, Rittel AG, Dobrowsky RT, Johnson MA, Levant B, Fowler SC, Moskovitz J.

J Neurochem. 2010 Jul;114(1):51-61. doi: 10.1111/j.1471-4159.2010.06721.x. Epub 2010 Mar 31.

27.

Hyperglycemia alters the schwann cell mitochondrial proteome and decreases coupled respiration in the absence of superoxide production.

Zhang L, Yu C, Vasquez FE, Galeva N, Onyango I, Swerdlow RH, Dobrowsky RT.

J Proteome Res. 2010 Jan;9(1):458-71. doi: 10.1021/pr900818g.

28.

Caveolin-1 and altered neuregulin signaling contribute to the pathophysiological progression of diabetic peripheral neuropathy.

McGuire JF, Rouen S, Siegfreid E, Wright DE, Dobrowsky RT.

Diabetes. 2009 Nov;58(11):2677-86. doi: 10.2337/db09-0594. Epub 2009 Aug 12.

29.

Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination.

Yu C, Rouen S, Dobrowsky RT.

Glia. 2008 Jun;56(8):877-87. doi: 10.1002/glia.20662.

30.

p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide.

Seyb KI, Ansar S, Li G, Bean J, Michaelis ML, Dobrowsky RT.

J Mol Neurosci. 2007;31(1):23-35.

PMID:
17416967
31.

Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice.

Christianson JA, Ryals JM, Johnson MS, Dobrowsky RT, Wright DE.

Neuroscience. 2007 Mar 2;145(1):303-13. Epub 2006 Dec 16.

32.
33.

Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis.

Ilsley JN, Nakanishi M, Flynn C, Belinsky GS, De Guise S, Adib JN, Dobrowsky RT, Bonventre JV, Rosenberg DW.

Cancer Res. 2005 Apr 1;65(7):2636-43.

34.

Altered neurotrophism in diabetic neuropathy: spelunking the caves of peripheral nerve.

Dobrowsky RT, Rouen S, Yu C.

J Pharmacol Exp Ther. 2005 May;313(2):485-91. Epub 2004 Dec 17. Review.

PMID:
15608075
35.

Nerve growth factor blocks the glucose-induced down-regulation of caveolin-1 expression in Schwann cells via p75 neurotrophin receptor signaling.

Tan W, Rouen S, Barkus KM, Dremina YS, Hui D, Christianson JA, Wright DE, Yoon SO, Dobrowsky RT.

J Biol Chem. 2003 Jun 20;278(25):23151-62. Epub 2003 Apr 5.

36.

Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases beta-amyloid toxicity in cortical neurons.

Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G, Michaelis ML, Dobrowsky RT.

J Neurochem. 2003 Jan;84(2):347-62.

37.

Tau neurofibrillary pathology and microtubule stability.

Michaelis ML, Dobrowsky RT, Li G.

J Mol Neurosci. 2002 Dec;19(3):289-93. Review.

PMID:
12540054
38.

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids.

Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA.

J Biol Chem. 2003 Mar 21;278(12):10297-303. Epub 2003 Jan 13.

39.
40.

Inhibition of ceramide production reverses TNF-induced insulin resistance.

Grigsby RJ, Dobrowsky RT.

Biochem Biophys Res Commun. 2001 Oct 12;287(5):1121-4.

PMID:
11587538
41.

Analysis of sphingomyelin and ceramide levels and the enzymes regulating their metabolism in response to cell stress.

Dobrowsky RT, Kolesnick RN.

Methods Cell Biol. 2001;66:135-65. No abstract available.

PMID:
11396001
42.
43.

p75 neurotrophin receptor signaling: mechanisms for neurotrophic modulation of cell stress?

Dobrowsky RT, Carter BD.

J Neurosci Res. 2000 Aug 1;61(3):237-43. Review.

PMID:
10900070
44.

Sphingolipid signalling domains floating on rafts or buried in caves?

Dobrowsky RT.

Cell Signal. 2000 Feb;12(2):81-90. Review.

PMID:
10679576
45.

Analysis of sphingomyelin hydrolysis in caveolar membranes.

Dobrowsky RT, Gazula VR.

Methods Enzymol. 2000;311:184-93. No abstract available.

PMID:
10563324
46.

Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways.

Bilderback TR, Gazula VR, Lisanti MP, Dobrowsky RT.

J Biol Chem. 1999 Jan 1;274(1):257-63.

47.

Coupling of the p75 neurotrophin receptor to sphingolipid signaling.

Dobrowsky RT, Carter BD.

Ann N Y Acad Sci. 1998 Jun 19;845:32-45. Review.

PMID:
9668341
48.

Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae.

Bilderback TR, Grigsby RJ, Dobrowsky RT.

J Biol Chem. 1997 Apr 18;272(16):10922-7.

49.

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.

Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV.

Nature. 1996 Oct 24;383(6602):716-9.

PMID:
8878481
50.

Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors.

Dobrowsky RT, Jenkins GM, Hannun YA.

J Biol Chem. 1995 Sep 22;270(38):22135-42.

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