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Items: 1 to 50 of 74

1.

Biochemical Characterization of Isoniazid-resistant Mycobacterium tuberculosis: Can the Analysis of Clonal Strains Reveal Novel Targetable Pathways?

Nieto R LM, Mehaffy C, Islam MN, Fitzgerald B, Belisle J, Prenni J, Dobos K.

Mol Cell Proteomics. 2018 Sep;17(9):1685-1701. doi: 10.1074/mcp.RA118.000821. Epub 2018 May 29.

PMID:
29844232
2.

Interplay of strain and race/ethnicity in the innate immune response to M. tuberculosis.

Nahid P, Jarlsberg LG, Kato-Maeda M, Segal MR, Osmond DH, Gagneux S, Dobos K, Gold M, Hopewell PC, Lewinsohn DM.

PLoS One. 2018 May 22;13(5):e0195392. doi: 10.1371/journal.pone.0195392. eCollection 2018.

3.

Structural determinants in a glucose-containing lipopolysaccharide from Mycobacterium tuberculosis critical for inducing a subset of protective T cells.

De P, McNeil M, Xia M, Boot CM, Hesser DC, Denef K, Rithner C, Sours T, Dobos KM, Hoft D, Chatterjee D.

J Biol Chem. 2018 Jun 22;293(25):9706-9717. doi: 10.1074/jbc.RA118.002582. Epub 2018 May 1.

4.

Protein Digestion, Ultrafiltration, and Size Exclusion Chromatography to Optimize the Isolation of Exosomes from Human Blood Plasma and Serum.

Diaz G, Bridges C, Lucas M, Cheng Y, Schorey JS, Dobos KM, Kruh-Garcia NA.

J Vis Exp. 2018 Apr 13;(134). doi: 10.3791/57467.

PMID:
29708539
5.

Cytokine-Mediated Systemic Adverse Drug Reactions in a Drug-Drug Interaction Study of Dolutegravir With Once-Weekly Isoniazid and Rifapentine.

Brooks KM, George JM, Pau AK, Rupert A, Mehaffy C, De P, Dobos KM, Kellogg A, McLaughlin M, McManus M, Alfaro RM, Hadigan C, Kovacs JA, Kumar P.

Clin Infect Dis. 2018 Jul 2;67(2):193-201. doi: 10.1093/cid/ciy082.

PMID:
29415190
6.

The N-terminal peptide moiety of the Mycobacterium tuberculosis 19 kDa lipoprotein harbors RP105-agonistic properties.

Schultz TE, Wiesmüller KH, Lucas M, Dobos KM, Baxter AG, Blumenthal A.

J Leukoc Biol. 2018 Feb;103(2):311-319. doi: 10.1002/JLB.2MA0517-190RR. Epub 2018 Jan 9.

PMID:
29345364
7.

Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications.

Russell TM, Green LS, Rice T, Kruh-Garcia NA, Dobos K, De Groote MA, Hraha T, Sterling DG, Janjic N, Ochsner UA.

J Clin Microbiol. 2017 Oct;55(10):3072-3088. doi: 10.1128/JCM.00469-17. Epub 2017 Aug 9.

8.

HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells.

Harriff MJ, Wolfe LM, Swarbrick G, Null M, Cansler ME, Canfield ET, Vogt T, Toren KG, Li W, Jackson M, Lewinsohn DA, Dobos KM, Lewinsohn DM.

Sci Rep. 2017 Jul 4;7(1):4622. doi: 10.1038/s41598-017-04894-0.

9.

Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundance Mycobacterium tuberculosis peptides in human serum.

Mehaffy C, Dobos KM, Nahid P, Kruh-Garcia NA.

Clin Proteomics. 2017 Jun 5;14:21. doi: 10.1186/s12014-017-9156-y. eCollection 2017.

10.

Changes in the Membrane-Associated Proteins of Exosomes Released from Human Macrophages after Mycobacterium tuberculosis Infection.

Diaz G, Wolfe LM, Kruh-Garcia NA, Dobos KM.

Sci Rep. 2016 Nov 29;6:37975. doi: 10.1038/srep37975.

11.

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC.

Nieto R LM, Mehaffy C, Creissen E, Troudt J, Troy A, Bielefeldt-Ohmann H, Burgos M, Izzo A, Dobos KM.

PLoS One. 2016 Nov 28;11(11):e0166807. doi: 10.1371/journal.pone.0166807. eCollection 2016.

12.

RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA).

Oestreicher U, Samaga D, Ainsbury E, Antunes AC, Baeyens A, Barrios L, Beinke C, Beukes P, Blakely WF, Cucu A, De Amicis A, Depuydt J, De Sanctis S, Di Giorgio M, Dobos K, Dominguez I, Duy PN, Espinoza ME, Flegal FN, Figel M, Garcia O, Monteiro Gil O, Gregoire E, Guerrero-Carbajal C, Güçlü İ, Hadjidekova V, Hande P, Kulka U, Lemon J, Lindholm C, Lista F, Lumniczky K, Martinez-Lopez W, Maznyk N, Meschini R, M'kacher R, Montoro A, Moquet J, Moreno M, Noditi M, Pajic J, Radl A, Ricoul M, Romm H, Roy L, Sabatier L, Sebastià N, Slabbert J, Sommer S, Stuck Oliveira M, Subramanian U, Suto Y, Que T, Testa A, Terzoudi G, Vral A, Wilkins R, Yanti L, Zafiropoulos D, Wojcik A.

Int J Radiat Biol. 2017 Jan;93(1):20-29. doi: 10.1080/09553002.2016.1233370. Epub 2016 Oct 21.

PMID:
27766931
13.

RENEB accident simulation exercise.

Brzozowska B, Ainsbury E, Baert A, Beaton-Green L, Barrios L, Barquinero JF, Bassinet C, Beinke C, Benedek A, Beukes P, Bortolin E, Buraczewska I, Burbidge C, De Amicis A, De Angelis C, Della Monaca S, Depuydt J, De Sanctis S, Dobos K, Domene MM, Domínguez I, Facco E, Fattibene P, Frenzel M, Monteiro Gil O, Gonon G, Gregoire E, Gruel G, Hadjidekova V, Hatzi VI, Hristova R, Jaworska A, Kis E, Kowalska M, Kulka U, Lista F, Lumniczky K, Martínez-López W, Meschini R, Moertl S, Moquet J, Noditi M, Oestreicher U, Orta Vázquez ML, Palma V, Pantelias G, Montoro Pastor A, Patrono C, Piqueret-Stephan L, Quattrini MC, Regalbuto E, Ricoul M, Roch-Lefevre S, Roy L, Sabatier L, Sarchiapone L, Sebastià N, Sommer S, Sun M, Suto Y, Terzoudi G, Trompier F, Vral A, Wilkins R, Zafiropoulos D, Wieser A, Woda C, Wojcik A.

Int J Radiat Biol. 2017 Jan;93(1):75-80. doi: 10.1080/09553002.2016.1206230. Epub 2016 Aug 25.

PMID:
27559844
14.

A Subset of Protective γ9δ2 T Cells Is Activated by Novel Mycobacterial Glycolipid Components.

Xia M, Hesser DC, De P, Sakala IG, Spencer CT, Kirkwood JS, Abate G, Chatterjee D, Dobos KM, Hoft DF.

Infect Immun. 2016 Aug 19;84(9):2449-62. doi: 10.1128/IAI.01322-15. Print 2016 Sep.

15.

Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis.

Nandakumar S, Kannanganat S, Dobos KM, Lucas M, Spencer JS, Amara RR, Plikaytis BB, Posey JE, Sable SB.

Sci Rep. 2016 May 13;6:25837. doi: 10.1038/srep25837.

16.

Longitudinal whole genome analysis of pre and post drug treatment Mycobacterium tuberculosis isolates reveals progressive steps to drug resistance.

Datta G, Nieto LM, Davidson RM, Mehaffy C, Pederson C, Dobos KM, Strong M.

Tuberculosis (Edinb). 2016 May;98:50-5. doi: 10.1016/j.tube.2016.02.004. Epub 2016 Feb 26.

17.

Age-related effects of X-ray irradiation on mouse hippocampus.

Casciati A, Dobos K, Antonelli F, Benedek A, Kempf SJ, Bellés M, Balogh A, Tanori M, Heredia L, Atkinson MJ, von Toerne C, Azimzadeh O, Saran A, Sáfrány G, Benotmane MA, Linares-Vidal MV, Tapio S, Lumniczky K, Pazzaglia S.

Oncotarget. 2016 May 10;7(19):28040-58. doi: 10.18632/oncotarget.8575.

18.

Comparing isogenic strains of Beijing genotype Mycobacterium tuberculosis after acquisition of Isoniazid resistance: A proteomics approach.

Nieto R LM, Mehaffy C, Dobos KM.

Proteomics. 2016 May;16(9):1376-80. doi: 10.1002/pmic.201500403. Epub 2016 Apr 13.

19.

Membrane-Bound PenA β-Lactamase of Burkholderia pseudomallei.

Randall LB, Dobos K, Papp-Wallace KM, Bonomo RA, Schweizer HP.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1509-14. doi: 10.1128/AAC.02444-15.

20.

RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.

Yu CH, Micaroni M, Puyskens A, Schultz TE, Yeo JC, Stanley AC, Lucas M, Kurihara J, Dobos KM, Stow JL, Blumenthal A.

J Immunol. 2015 Oct 15;195(8):3890-900. doi: 10.4049/jimmunol.1500017. Epub 2015 Sep 14.

21.

Access to Preventive Health Care in Severely Disabled Women with Multiple Sclerosis.

Dobos K, Healy B, Houtchens M.

Int J MS Care. 2015 Jul-Aug;17(4):200-5. doi: 10.7224/1537-2073.2013-046.

22.

The presence of a galactosamine substituent on the arabinogalactan of Mycobacterium tuberculosis abrogates full maturation of human peripheral blood monocyte-derived dendritic cells and increases secretion of IL-10.

Wheat WH, Dhouib R, Angala SK, Larrouy-Maumus G, Dobos K, Nigou J, Spencer JS, Jackson M.

Tuberculosis (Edinb). 2015 Jul;95(4):476-89. doi: 10.1016/j.tube.2015.04.002. Epub 2015 May 14.

23.

Pathogenic nontuberculous mycobacteria resist and inactivate cathelicidin: implication of a novel role for polar mycobacterial lipids.

Honda JR, Hess T, Malcolm KC, Ovrutsky AR, Bai X, Irani VR, Dobos KM, Chan ED, Flores SC.

PLoS One. 2015 May 18;10(5):e0126994. doi: 10.1371/journal.pone.0126994. eCollection 2015.

24.

Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans.

Hoxmeier JC, Thompson BD, Broeckling CD, Small P, Foy BD, Prenni J, Dobos KM.

Sci Rep. 2015 Mar 18;5:9242. doi: 10.1038/srep09242.

25.

Fractionation and analysis of mycobacterial proteins.

Lucas MC, Wolfe LM, Hazenfield RM, Kurihara J, Kruh-Garcia NA, Belisle J, Dobos KM.

Methods Mol Biol. 2015;1285:47-75. doi: 10.1007/978-1-4939-2450-9_4.

PMID:
25779310
26.

Deciphering the role of exosomes in tuberculosis.

Kruh-Garcia NA, Wolfe LM, Dobos KM.

Tuberculosis (Edinb). 2015 Jan;95(1):26-30. doi: 10.1016/j.tube.2014.10.010. Epub 2014 Nov 21. Review.

PMID:
25496995
27.

Detection of Mycobacterium tuberculosis peptides in the exosomes of patients with active and latent M. tuberculosis infection using MRM-MS.

Kruh-Garcia NA, Wolfe LM, Chaisson LH, Worodria WO, Nahid P, Schorey JS, Davis JL, Dobos KM.

PLoS One. 2014 Jul 31;9(7):e103811. doi: 10.1371/journal.pone.0103811. eCollection 2014.

28.

The human antibody response to the surface of Mycobacterium tuberculosis.

Perley CC, Frahm M, Click EM, Dobos KM, Ferrari G, Stout JE, Frothingham R.

PLoS One. 2014 Jun 11;9(2):e98938. doi: 10.1371/journal.pone.0098938. eCollection 2014.

29.

HspX vaccination and role in virulence in the guinea pig model of tuberculosis.

Wieczorek AE, Troudt JL, Knabenbauer P, Taylor J, Pavlicek RL, Karls R, Hess A, Davidson RM, Strong M, Bielefeldt-Ohmann H, Izzo AA, Dobos KM.

Pathog Dis. 2014 Aug;71(3):315-25. doi: 10.1111/2049-632X.12147. Epub 2014 Feb 24.

30.

O-mannosylation of the Mycobacterium tuberculosis adhesin Apa is crucial for T cell antigenicity during infection but is expendable for protection.

Nandakumar S, Kannanganat S, Dobos KM, Lucas M, Spencer JS, Fang S, McDonald MA, Pohl J, Birkness K, Chamcha V, Ramirez MV, Plikaytis BB, Posey JE, Amara RR, Sable SB.

PLoS Pathog. 2013;9(10):e1003705. doi: 10.1371/journal.ppat.1003705. Epub 2013 Oct 10.

31.

Antigen 85 variation across lineages of Mycobacterium tuberculosis-implications for vaccine and biomarker success.

Kruh-Garcia NA, Murray M, Prucha JG, Dobos KM.

J Proteomics. 2014 Jan 31;97:141-50. doi: 10.1016/j.jprot.2013.07.005. Epub 2013 Jul 24.

32.

A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.

Wolfe LM, Veeraraghavan U, Idicula-Thomas S, Schürer S, Wennerberg K, Reynolds R, Besra GS, Dobos KM.

Mol Cell Proteomics. 2013 Jun;12(6):1644-60. doi: 10.1074/mcp.M112.025635. Epub 2013 Mar 5.

33.

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.

Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, Hutt J, Lyons CR, Dobos KM, Deretic V.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3168-76. doi: 10.1073/pnas.1210500109. Epub 2012 Oct 23.

34.

Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis.

Bisson GP, Mehaffy C, Broeckling C, Prenni J, Rifat D, Lun DS, Burgos M, Weissman D, Karakousis PC, Dobos K.

J Bacteriol. 2012 Dec;194(23):6441-52. doi: 10.1128/JB.01013-12. Epub 2012 Sep 21.

35.

HspX-mediated protection against tuberculosis depends on its chaperoning of a mycobacterial molecule.

Taylor JL, Wieczorek A, Keyser AR, Grover A, Flinkstrom R, Karls RK, Bielefeldt-Ohmann H, Dobos KM, Izzo AA.

Immunol Cell Biol. 2012 Nov;90(10):945-54. doi: 10.1038/icb.2012.34. Epub 2012 Jul 17.

36.

Purified protein derivatives of tuberculin--past, present, and future.

Yang H, Kruh-Garcia NA, Dobos KM.

FEMS Immunol Med Microbiol. 2012 Dec;66(3):273-80. doi: 10.1111/j.1574-695X.2012.01002.x. Epub 2012 Aug 1. Review.

37.

Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2.

Péterfia B, Füle T, Baghy K, Szabadkai K, Fullár A, Dobos K, Zong F, Dobra K, Hollósi P, Jeney A, Paku S, Kovalszky I.

PLoS One. 2012;7(6):e39474. doi: 10.1371/journal.pone.0039474. Epub 2012 Jun 26.

38.

Deciphering the proteome of the in vivo diagnostic reagent "purified protein derivative" from Mycobacterium tuberculosis.

Cho YS, Dobos KM, Prenni J, Yang H, Hess A, Rosenkrands I, Andersen P, Ryoo SW, Bai GH, Brennan MJ, Izzo A, Bielefeldt-Ohmann H, Belisle JT.

Proteomics. 2012 Apr;12(7):979-91. doi: 10.1002/pmic.201100544.

39.

Epidemiologic consequences of microvariation in Mycobacterium tuberculosis.

Mathema B, Kurepina N, Yang G, Shashkina E, Manca C, Mehaffy C, Bielefeldt-Ohmann H, Ahuja S, Fallows DA, Izzo A, Bifani P, Dobos K, Kaplan G, Kreiswirth BN.

J Infect Dis. 2012 Mar 15;205(6):964-74. doi: 10.1093/infdis/jir876. Epub 2012 Feb 7.

40.

Prospective on Mycobacterium tuberculosis proteomics.

Mehaffy MC, Kruh-Garcia NA, Dobos KM.

J Proteome Res. 2012 Jan 1;11(1):17-25. doi: 10.1021/pr2008658. Epub 2011 Oct 19. Review.

PMID:
21988637
41.

Assessment of vaccine testing at three laboratories using the guinea pig model of tuberculosis.

Grover A, Troudt J, Arnett K, Izzo L, Lucas M, Strain K, McFarland C, Hall Y, McMurray D, Williams A, Dobos K, Izzo A.

Tuberculosis (Edinb). 2012 Jan;92(1):105-11. doi: 10.1016/j.tube.2011.09.003. Epub 2011 Oct 1.

42.

Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection.

Yang H, Troudt J, Grover A, Arnett K, Lucas M, Cho YS, Bielefeldt-Ohmann H, Taylor J, Izzo A, Dobos KM.

Infect Immun. 2011 Feb;79(2):716-23. doi: 10.1128/IAI.00486-10. Epub 2010 Dec 6.

43.

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.

Ioerger TR, Feng Y, Chen X, Dobos KM, Victor TC, Streicher EM, Warren RM, Gey van Pittius NC, Van Helden PD, Sacchettini JC.

BMC Genomics. 2010 Nov 26;11:670. doi: 10.1186/1471-2164-11-670.

44.

Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo.

Kruh NA, Troudt J, Izzo A, Prenni J, Dobos KM.

PLoS One. 2010 Nov 11;5(11):e13938. doi: 10.1371/journal.pone.0013938.

45.

Proteomic definition of the cell wall of Mycobacterium tuberculosis.

Wolfe LM, Mahaffey SB, Kruh NA, Dobos KM.

J Proteome Res. 2010 Nov 5;9(11):5816-26. doi: 10.1021/pr1005873. Epub 2010 Sep 29.

46.

Proteomic analysis identifies highly antigenic proteins in exosomes from M. tuberculosis-infected and culture filtrate protein-treated macrophages.

Giri PK, Kruh NA, Dobos KM, Schorey JS.

Proteomics. 2010 Sep;10(17):3190-202. doi: 10.1002/pmic.200900840.

47.

Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.

Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR Jr, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC.

J Bacteriol. 2010 Jul;192(14):3645-53. doi: 10.1128/JB.00166-10. Epub 2010 May 14.

48.

Descriptive proteomic analysis shows protein variability between closely related clinical isolates of Mycobacterium tuberculosis.

Mehaffy C, Hess A, Prenni JE, Mathema B, Kreiswirth B, Dobos KM.

Proteomics. 2010 May;10(10):1966-84. doi: 10.1002/pmic.200900836.

49.

Immunoproteomic identification of human T cell antigens of Mycobacterium tuberculosis that differentiate healthy contacts from tuberculosis patients.

Deenadayalan A, Heaslip D, Rajendiran AA, Velayudham BV, Frederick S, Yang HL, Dobos K, Belisle JT, Raja A.

Mol Cell Proteomics. 2010 Mar;9(3):538-49. doi: 10.1074/mcp.M900299-MCP200. Epub 2009 Dec 22.

50.

IFNgamma response to Mycobacterium tuberculosis, risk of infection and disease in household contacts of tuberculosis patients in Colombia.

del Corral H, París SC, Marín ND, Marín DM, López L, Henao HM, Martínez T, Villa L, Barrera LF, Ortiz BL, Ramírez ME, Montes CJ, Oquendo MC, Arango LM, Riaño F, Aguirre C, Bustamante A, Belisle JT, Dobos K, Mejía GI, Giraldo MR, Brennan PJ, Robledo J, Arbeláez MP, Rojas CA, García LF.

PLoS One. 2009 Dec 14;4(12):e8257. doi: 10.1371/journal.pone.0008257.

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