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Items: 12

1.

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.

Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL.

PLoS One. 2016 Mar 10;11(3):e0150602. doi: 10.1371/journal.pone.0150602. eCollection 2016.

2.

An Aggregation Advisor for Ligand Discovery.

Irwin JJ, Duan D, Torosyan H, Doak AK, Ziebart KT, Sterling T, Tumanian G, Shoichet BK.

J Med Chem. 2015 Sep 10;58(17):7076-87. doi: 10.1021/acs.jmedchem.5b01105. Epub 2015 Aug 28.

3.

Colloidal aggregation and the in vitro activity of traditional Chinese medicines.

Duan D, Doak AK, Nedyalkova L, Shoichet BK.

ACS Chem Biol. 2015 Apr 17;10(4):978-88. doi: 10.1021/cb5009487. Epub 2015 Feb 9.

4.

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.

Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17.

5.

Colloidal drug formulations can explain "bell-shaped" concentration-response curves.

Owen SC, Doak AK, Ganesh AN, Nedyalkova L, McLaughlin CK, Shoichet BK, Shoichet MS.

ACS Chem Biol. 2014 Mar 21;9(3):777-84. doi: 10.1021/cb4007584. Epub 2014 Jan 15.

6.

Structure-based discovery of antagonists of nuclear receptor LRH-1.

Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ.

J Biol Chem. 2013 Jul 5;288(27):19830-44. doi: 10.1074/jbc.M112.411686. Epub 2013 May 10.

7.

Colloidal aggregation causes inhibition of G protein-coupled receptors.

Sassano MF, Doak AK, Roth BL, Shoichet BK.

J Med Chem. 2013 Mar 28;56(6):2406-14. doi: 10.1021/jm301749y. Epub 2013 Mar 12.

8.

Large-scale prediction and testing of drug activity on side-effect targets.

Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, Jenkins JL, Lavan P, Weber E, Doak AK, Côté S, Shoichet BK, Urban L.

Nature. 2012 Jun 10;486(7403):361-7. doi: 10.1038/nature11159.

9.

Colloidal aggregation affects the efficacy of anticancer drugs in cell culture.

Owen SC, Doak AK, Wassam P, Shoichet MS, Shoichet BK.

ACS Chem Biol. 2012 Aug 17;7(8):1429-35. doi: 10.1021/cb300189b. Epub 2012 Jun 8.

10.

Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4.

Mysinger MM, Weiss DR, Ziarek JJ, Gravel S, Doak AK, Karpiak J, Heveker N, Shoichet BK, Volkman BF.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5517-22. doi: 10.1073/pnas.1120431109. Epub 2012 Mar 19.

11.

Colloid formation by drugs in simulated intestinal fluid.

Doak AK, Wille H, Prusiner SB, Shoichet BK.

J Med Chem. 2010 May 27;53(10):4259-65. doi: 10.1021/jm100254w.

12.

Identification and characterization of subpopulations of Pax3 and Pax7 expressing cells in developing chick somites and limb buds.

Galli LM, Knight SR, Barnes TL, Doak AK, Kadzik RS, Burrus LW.

Dev Dyn. 2008 Jul;237(7):1862-74. doi: 10.1002/dvdy.21585.

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