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Recycling of single-stranded DNA-binding protein by the bacterial replisome.

Spenkelink LM, Lewis JS, Jergic S, Xu ZQ, Robinson A, Dixon NE, van Oijen AM.

Nucleic Acids Res. 2019 Feb 15. pii: gkz090. doi: 10.1093/nar/gkz090. [Epub ahead of print]


Tuning recombinant protein expression to match secretion capacity.

Horga LG, Halliwell S, Castiñeiras TS, Wyre C, Matos CFRO, Yovcheva DS, Kent R, Morra R, Williams SG, Smith DC, Dixon N.

Microb Cell Fact. 2018 Dec 22;17(1):199. doi: 10.1186/s12934-018-1047-z.


Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens.

McGrath AE, Martyn AP, Whittell LR, Dawes FE, Beck JL, Dixon NE, Kelso MJ, Oakley AJ.

J Struct Biol. 2018 Dec;204(3):396-405. doi: 10.1016/j.jsb.2018.10.008. Epub 2018 Oct 23.


Structure-activity relationships of pyrazole-4-carbodithioates as antibacterials against methicillin-resistant Staphylococcus aureus.

Majed H, Johnston T, Kelso C, Monachino E, Jergic S, Dixon NE, Mylonakis E, Kelso MJ.

Bioorg Med Chem Lett. 2018 Dec 1;28(22):3526-3528. doi: 10.1016/j.bmcl.2018.09.038. Epub 2018 Oct 3.


Bacterial replisomes.

Xu ZQ, Dixon NE.

Curr Opin Struct Biol. 2018 Dec;53:159-168. doi: 10.1016/ Epub 2018 Oct 4. Review.


Design of DNA rolling-circle templates with controlled fork topology to study mechanisms of DNA replication.

Monachino E, Ghodke H, Spinks RR, Hoatson BS, Jergic S, Xu ZQ, Dixon NE, van Oijen AM.

Anal Biochem. 2018 Sep 15;557:42-45. doi: 10.1016/j.ab.2018.07.008. Epub 2018 Jul 18.


Rationalizing Context-Dependent Performance of Dynamic RNA Regulatory Devices.

Kent R, Halliwell S, Young K, Swainston N, Dixon N.

ACS Synth Biol. 2018 Jul 20;7(7):1660-1668. doi: 10.1021/acssynbio.8b00041. Epub 2018 Jun 29.


Rational Design of a 310 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.

Wegener KL, McGrath AE, Dixon NE, Oakley AJ, Scanlon DB, Abell AD, Bruning JB.

Chemistry. 2018 Aug 6;24(44):11325-11331. doi: 10.1002/chem.201801734. Epub 2018 Jul 19.


Lignolytic-consortium omics analyses reveal novel genomes and pathways involved in lignin modification and valorization.

Moraes EC, Alvarez TM, Persinoti GF, Tomazetto G, Brenelli LB, Paixão DAA, Ematsu GC, Aricetti JA, Caldana C, Dixon N, Bugg TDH, Squina FM.

Biotechnol Biofuels. 2018 Mar 22;11:75. doi: 10.1186/s13068-018-1073-4. eCollection 2018.


Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction.

Chilingaryan Z, Headey SJ, Lo ATY, Xu ZQ, Otting G, Dixon NE, Scanlon MJ, Oakley AJ.

Antibiotics (Basel). 2018 Feb 22;7(1). pii: E14. doi: 10.3390/antibiotics7010014.


Salzburg Global Seminar Session 565-'Better Health Care: how do we learn about improvement?'

Massoud MR, Kimble LE, Goldmann D, Ovretveit J, Dixon N.

Int J Qual Health Care. 2018 Apr 20;30(suppl_1):1-4. doi: 10.1093/intqhc/mzy020.


Translation Stress Positively Regulates MscL-Dependent Excretion of Cytoplasmic Proteins.

Morra R, Del Carratore F, Muhamadali H, Horga LG, Halliwell S, Goodacre R, Breitling R, Dixon N.

MBio. 2018 Jan 30;9(1). pii: e02118-17. doi: 10.1128/mBio.02118-17.


What is all this fuss about Tus? Comparison of recent findings from biophysical and biochemical experiments.

Berghuis BA, Raducanu VS, Elshenawy MM, Jergic S, Depken M, Dixon NE, Hamdan SM, Dekker NH.

Crit Rev Biochem Mol Biol. 2018 Feb;53(1):49-63. doi: 10.1080/10409238.2017.1394264. Epub 2017 Nov 6. Review.


Dynamics of Proofreading by the E. coli Pol III Replicase.

Park J, Jergic S, Jeon Y, Cho WK, Lee R, Dixon NE, Lee JB.

Cell Chem Biol. 2018 Jan 18;25(1):57-66.e4. doi: 10.1016/j.chembiol.2017.09.008. Epub 2017 Nov 2.


Response to Hines and Alper.

Dixon N, Morgan M, Equils O.

Am J Infect Control. 2017 Dec 1;45(12):1413-1414. doi: 10.1016/j.ajic.2017.08.035. Epub 2017 Nov 1. No abstract available.


Optimization of Membrane Protein Production Using Titratable Strains of E. coli.

Morra R, Young K, Casas-Mao D, Dixon N, Bird LE.

Methods Mol Biol. 2017;1586:83-107. doi: 10.1007/978-1-4939-6887-9_6.


Single-molecule visualization of fast polymerase turnover in the bacterial replisome.

Lewis JS, Spenkelink LM, Jergic S, Wood EA, Monachino E, Horan NP, Duderstadt KE, Cox MM, Robinson A, Dixon NE, van Oijen AM.

Elife. 2017 Apr 22;6. pii: e23932. doi: 10.7554/eLife.23932.


Foam soap is not as effective as liquid soap in eliminating hand microbial flora.

Dixon N, Morgan M, Equils O.

Am J Infect Control. 2017 Jul 1;45(7):813-814. doi: 10.1016/j.ajic.2017.01.020. Epub 2017 Feb 28.


NMR Spectroscopic Assignment of Backbone and Side-Chain Protons in Fully Protonated Proteins: Microcrystals, Sedimented Assemblies, and Amyloid Fibrils.

Stanek J, Andreas LB, Jaudzems K, Cala D, Lalli D, Bertarello A, Schubeis T, Akopjana I, Kotelovica S, Tars K, Pica A, Leone S, Picone D, Xu ZQ, Dixon NE, Martinez D, Berbon M, El Mammeri N, Noubhani A, Saupe S, Habenstein B, Loquet A, Pintacuda G.

Angew Chem Int Ed Engl. 2016 Dec 12;55(50):15504-15509. doi: 10.1002/anie.201607084. Epub 2016 Nov 16.


IMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis.

Dixon N, Fowler RC, Yoshizumi A, Horiyama T, Ishii Y, Harrison L, Geyer CN, Moland ES, Thomson K, Hanson ND.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6418-21. doi: 10.1128/AAC.02945-15. Print 2016 Oct.


Are cancer-related decision aids appropriate for socially disadvantaged patients? A systematic review of US randomized controlled trials.

Enard KR, Dolan Mullen P, Kamath GR, Dixon NM, Volk RJ.

BMC Med Inform Decis Mak. 2016 Jun 6;16:64. doi: 10.1186/s12911-016-0303-6.


The E. coli DNA Replication Fork.

Lewis JS, Jergic S, Dixon NE.

Enzymes. 2016;39:31-88. doi: 10.1016/bs.enz.2016.04.001. Epub 2016 May 13.


Weak and Transient Protein Interactions Determined by Solid-State NMR.

Dannatt HR, Felletti M, Jehle S, Wang Y, Emsley L, Dixon NE, Lesage A, Pintacuda G.

Angew Chem Int Ed Engl. 2016 Jun 1;55(23):6638-41. doi: 10.1002/anie.201511609. Epub 2016 Apr 21.


The treatment of uncertainties in reactive pollution dispersion models at urban scales.

Tomlin AS, Ziehn T, Goodman P, Tate JE, Dixon NS.

Faraday Discuss. 2016 Jul 18;189:567-87. doi: 10.1039/c5fd00159e.


Exchange between Escherichia coli polymerases II and III on a processivity clamp.

Kath JE, Chang S, Scotland MK, Wilbertz JH, Jergic S, Dixon NE, Sutton MD, Loparo JJ.

Nucleic Acids Res. 2016 Feb 29;44(4):1681-90. doi: 10.1093/nar/gkv1375. Epub 2015 Dec 10.


Probing molecular choreography through single-molecule biochemistry.

van Oijen AM, Dixon NE.

Nat Struct Mol Biol. 2015 Dec;22(12):948-52. doi: 10.1038/nsmb.3119.


Metabolomic analysis of riboswitch containing E. coli recombinant expression system.

Muhamadali H, Xu Y, Morra R, Trivedi DK, Rattray NJ, Dixon N, Goodacre R.

Mol Biosyst. 2016 Feb;12(2):350-61. doi: 10.1039/c5mb00624d.


Dual transcriptional-translational cascade permits cellular level tuneable expression control.

Morra R, Shankar J, Robinson CJ, Halliwell S, Butler L, Upton M, Hay S, Micklefield J, Dixon N.

Nucleic Acids Res. 2016 Feb 18;44(3):e21. doi: 10.1093/nar/gkv912. Epub 2015 Sep 23.


Replisome speed determines the efficiency of the Tus-Ter replication termination barrier.

Elshenawy MM, Jergic S, Xu ZQ, Sobhy MA, Takahashi M, Oakley AJ, Dixon NE, Hamdan SM.

Nature. 2015 Sep 17;525(7569):394-8. doi: 10.1038/nature14866. Epub 2015 Aug 31.


Strand separation establishes a sustained lock at the Tus-Ter replication fork barrier.

Berghuis BA, Dulin D, Xu ZQ, van Laar T, Cross B, Janissen R, Jergic S, Dixon NE, Depken M, Dekker NH.

Nat Chem Biol. 2015 Aug;11(8):579-85. doi: 10.1038/nchembio.1857. Epub 2015 Jul 6.


Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch.

Wu MC, Lowe PT, Robinson CJ, Vincent HA, Dixon N, Leigh J, Micklefield J.

J Am Chem Soc. 2015 Jul 22;137(28):9015-21. doi: 10.1021/jacs.5b03405. Epub 2015 Jul 9.


Protein residue linking in a single spectrum for magic-angle spinning NMR assignment.

Andreas LB, Stanek J, Le Marchand T, Bertarello A, Cala-De Paepe D, Lalli D, Krejčíková M, Doyen C, Öster C, Knott B, Wegner S, Engelke F, Felli IC, Pierattelli R, Dixon NE, Emsley L, Herrmann T, Pintacuda G.

J Biomol NMR. 2015 Jul;62(3):253-61. doi: 10.1007/s10858-015-9956-1. Epub 2015 Jun 16.


Two mechanisms coordinate replication termination by the Escherichia coli Tus-Ter complex.

Pandey M, Elshenawy MM, Jergic S, Takahashi M, Dixon NE, Hamdan SM, Patel SS.

Nucleic Acids Res. 2015 Jul 13;43(12):5924-35. doi: 10.1093/nar/gkv527. Epub 2015 May 24.


Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs.

Yin Z, Whittell LR, Wang Y, Jergic S, Ma C, Lewis PJ, Dixon NE, Beck JL, Kelso MJ, Oakley AJ.

J Med Chem. 2015 Jun 11;58(11):4693-702. doi: 10.1021/acs.jmedchem.5b00232. Epub 2015 May 28.


Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.

Srivastava M, Duan G, Kershaw NJ, Athanasopoulos V, Yeo JH, Ose T, Hu D, Brown SH, Jergic S, Patel HR, Pratama A, Richards S, Verma A, Jones EY, Heissmeyer V, Preiss T, Dixon NE, Chong MM, Babon JJ, Vinuesa CG.

Nat Commun. 2015 Feb 20;6:6253. doi: 10.1038/ncomms7253.


Schneiderian-Type Papilloma of the Middle Ear: A Review of the Literature.

Schaefer N, Chong J, Griffin A, Little A, Gochee P, Dixon N.

Int Surg. 2015 Jun;100(6):989-93. doi: 10.9738/INTSURG-D-14-00242.1. Epub 2015 Jan 7. Review.


Structure and function of a spectrin-like regulator of bacterial cytokinesis.

Cleverley RM, Barrett JR, Baslé A, Bui NK, Hewitt L, Solovyova A, Xu ZQ, Daniel RA, Dixon NE, Harry EJ, Oakley AJ, Vollmer W, Lewis RJ.

Nat Commun. 2014 Nov 18;5:5421. doi: 10.1038/ncomms6421.


An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase.

James LR, Xu ZQ, Sluyter R, Hawksworth EL, Kelso C, Lai B, Paterson DJ, de Jonge MD, Dixon NE, Beck JL, Ralph SF, Dillon CT.

J Inorg Biochem. 2015 Jan;142:28-38. doi: 10.1016/j.jinorgbio.2014.09.013. Epub 2014 Sep 28.


Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.

DeBaun MR, Gordon M, McKinstry RC, Noetzel MJ, White DA, Sarnaik SA, Meier ER, Howard TH, Majumdar S, Inusa BP, Telfer PT, Kirby-Allen M, McCavit TL, Kamdem A, Airewele G, Woods GM, Berman B, Panepinto JA, Fuh BR, Kwiatkowski JL, King AA, Fixler JM, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Dixon N, Gonzalez CE, Kalinyak KA, Quinn CT, Strouse JJ, Miller JP, Lehmann H, Kraut MA, Ball WS Jr, Hirtz D, Casella JF.

N Engl J Med. 2014 Aug 21;371(8):699-710. doi: 10.1056/NEJMoa1401731.


AtfA, a new factor in global regulation of transcription in Acinetobacter spp.

Withers R, Doherty GP, Jordan M, Yang X, Dixon NE, Lewis PJ.

Mol Microbiol. 2014 Sep;93(6):1130-43. doi: 10.1111/mmi.12723. Epub 2014 Jul 31.


Loading dynamics of a sliding DNA clamp.

Cho WK, Jergic S, Kim D, Dixon NE, Lee JB.

Angew Chem Int Ed Engl. 2014 Jun 23;53(26):6768-71. doi: 10.1002/anie.201403063. Epub 2014 May 22.


Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis.

Kath JE, Jergic S, Heltzel JM, Jacob DT, Dixon NE, Sutton MD, Walker GC, Loparo JJ.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7647-52. doi: 10.1073/pnas.1321076111. Epub 2014 May 13.


DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs.

Yin Z, Wang Y, Whittell LR, Jergic S, Liu M, Harry E, Dixon NE, Kelso MJ, Beck JL, Oakley AJ.

Chem Biol. 2014 Apr 24;21(4):481-487. doi: 10.1016/j.chembiol.2014.02.009. Epub 2014 Mar 13.


Bound or free: interaction of the C-terminal domain of Escherichia coli single-stranded DNA-binding protein (SSB) with the tetrameric core of SSB.

Su XC, Wang Y, Yagi H, Shishmarev D, Mason CE, Smith PJ, Vandevenne M, Dixon NE, Otting G.

Biochemistry. 2014 Apr 1;53(12):1925-34. doi: 10.1021/bi5001867. Epub 2014 Mar 18.


Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach.

Yin Z, Whittell LR, Wang Y, Jergic S, Liu M, Harry EJ, Dixon NE, Beck JL, Kelso MJ, Oakley AJ.

J Med Chem. 2014 Mar 27;57(6):2799-806. doi: 10.1021/jm500122r. Epub 2014 Mar 18.


Generation of orthogonally selective bacterial riboswitches by targeted mutagenesis and in vivo screening.

Vincent HA, Robinson CJ, Wu MC, Dixon N, Micklefield J.

Methods Mol Biol. 2014;1111:107-29. doi: 10.1007/978-1-62703-755-6_8.


Two new hemoglobin variants: Hb Tallahassee [α3(A1)Ser→Tyr; HBA2: c.11C>A] and Hb madison-NC [β119(GH2)Gly→Ser; HBB: c.358G>A].

Kutlar F, Unguru Y, Dixon N, Patel N, Bailey L, Zhuang L, Carmichael H, Kutlar A.

Hemoglobin. 2014;38(3):207-10. doi: 10.3109/03630269.2014.881371. Epub 2014 Jan 29.


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