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The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly.

Looker O, Blanch AJ, Liu B, Nunez-Iglesias J, McMillan PJ, Tilley L, Dixon MWA.

PLoS Pathog. 2019 May 9;15(5):e1007761. doi: 10.1371/journal.ppat.1007761. eCollection 2019 May.


Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells.

Akter J, Khoury DS, Aogo R, Lansink LIM, SheelaNair A, Thomas BS, Laohamonthonkul P, Pernold CPS, Dixon MWA, Soon MSF, Fogg LG, Engel JA, Elliott T, Sebina I, James KR, Cromer D, Davenport MP, Haque A.

PLoS Pathog. 2019 Feb 27;15(2):e1007599. doi: 10.1371/journal.ppat.1007599. eCollection 2019 Feb.


Multimodal analysis of Plasmodium knowlesi-infected erythrocytes reveals large invaginations, swelling of the host cell, and rheological defects.

Liu B, Blanch AJ, Namvar A, Carmo O, Tiash S, Andrew D, Hanssen E, Rajagopal V, Dixon MWA, Tilley L.

Cell Microbiol. 2019 May;21(5):e13005. doi: 10.1111/cmi.13005. Epub 2019 Feb 11.


Inadvertent Intravitreous Ink Injection from Subconjunctival Tattooing Causing Intraocular Inflammation and Retinal Trauma.

Dixon MW, Harocopos GJ, Li AS, Liu JC, Rajagopal R.

Ophthalmol Retina. 2018 Oct;2(10):1080-1082. doi: 10.1016/j.oret.2018.04.017. Epub 2018 Jun 7. No abstract available.


A new Python library to analyse skeleton images confirms malaria parasite remodelling of the red blood cell membrane skeleton.

Nunez-Iglesias J, Blanch AJ, Looker O, Dixon MW, Tilley L.

PeerJ. 2018 Feb 15;6:e4312. doi: 10.7717/peerj.4312. eCollection 2018.


Erythrocyte β spectrin can be genetically targeted to protect mice from malaria.

Lelliott PM, Huang HM, Dixon MW, Namvar A, Blanch AJ, Rajagopal V, Tilley L, Coban C, McMorran BJ, Foote SJ, Burgio G.

Blood Adv. 2017 Dec 12;1(26):2624-2636. doi: 10.1182/bloodadvances.2017009274. eCollection 2017 Dec 12.


Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development.

Parkyn Schneider M, Liu B, Glock P, Suttie A, McHugh E, Andrew D, Batinovic S, Williamson N, Hanssen E, McMillan P, Hliscs M, Tilley L, Dixon MWA.

PLoS Pathog. 2017 Oct 6;13(10):e1006659. doi: 10.1371/journal.ppat.1006659. eCollection 2017 Oct.


Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria.

Huang HM, Bauer DC, Lelliott PM, Dixon MWA, Tilley L, McMorran BJ, Foote SJ, Burgio G.

G3 (Bethesda). 2017 Sep 7;7(9):3133-3144. doi: 10.1534/g3.117.300079.


The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.

Charnaud SC, Dixon MWA, Nie CQ, Chappell L, Sanders PR, Nebl T, Hanssen E, Berriman M, Chan JA, Blanch AJ, Beeson JG, Rayner JC, Przyborski JM, Tilley L, Crabb BS, Gilson PR.

PLoS One. 2017 Jul 21;12(7):e0181656. doi: 10.1371/journal.pone.0181656. eCollection 2017.


An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes.

Batinovic S, McHugh E, Chisholm SA, Matthews K, Liu B, Dumont L, Charnaud SC, Schneider MP, Gilson PR, de Koning-Ward TF, Dixon MWA, Tilley L.

Nat Commun. 2017 Jul 10;8:16044. doi: 10.1038/ncomms16044.


Initiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection.

Farid R, Dixon MW, Tilley L, McCarthy JS.

J Infect Dis. 2017 Apr 1;215(7):1167-1174. doi: 10.1093/infdis/jix035.


CTNNB1 mutation associated with familial exudative vitreoretinopathy (FEVR) phenotype.

Dixon MW, Stem MS, Schuette JL, Keegan CE, Besirli CG.

Ophthalmic Genet. 2016 Dec;37(4):468-470. Epub 2016 Mar 11. No abstract available.


Plasmodium species: master renovators of their host cells.

de Koning-Ward TF, Dixon MW, Tilley L, Gilson PR.

Nat Rev Microbiol. 2016 Aug;14(8):494-507. doi: 10.1038/nrmicro.2016.79. Epub 2016 Jul 4. Review.


A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability.

da Silva FL, Dixon MW, Stack CM, Teuscher F, Taran E, Jones MK, Lovas E, Tilley L, Brown CL, Trenholme KR, Dalton JP, Gardiner DL, Skinner-Adams TS.

Exp Parasitol. 2016 Oct;169:13-21. doi: 10.1016/j.exppara.2016.06.013. Epub 2016 Jun 30.


Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages.

Dearnley M, Chu T, Zhang Y, Looker O, Huang C, Klonis N, Yeoman J, Kenny S, Arora M, Osborne JM, Chandramohanadas R, Zhang S, Dixon MW, Tilley L.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4800-5. doi: 10.1073/pnas.1520194113. Epub 2016 Apr 11.


Contrasting Inducible Knockdown of the Auxiliary PTEX Component PTEX88 in P. falciparum and P. berghei Unmasks a Role in Parasite Virulence.

Chisholm SA, McHugh E, Lundie R, Dixon MW, Ghosh S, O'Keefe M, Tilley L, Kalanon M, de Koning-Ward TF.

PLoS One. 2016 Feb 17;11(2):e0149296. doi: 10.1371/journal.pone.0149296. eCollection 2016.


Ethics of Placebo Procedures in Ophthalmic Surgical Trials.

Dixon MW, Besirli CG.

JAMA Ophthalmol. 2016 Jan;134(1):11-2. doi: 10.1001/jamaophthalmol.2015.4650. No abstract available.


Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein-5 marks the gametocyte ring stage.

Tibúrcio M, Dixon MW, Looker O, Younis SY, Tilley L, Alano P.

Malar J. 2015 Aug 28;14:334. doi: 10.1186/s12936-015-0853-6.


A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking.

McHugh E, Batinovic S, Hanssen E, McMillan PJ, Kenny S, Griffin MD, Crawford S, Trenholme KR, Gardiner DL, Dixon MW, Tilley L.

Mol Microbiol. 2015 Dec;98(6):1101-14. doi: 10.1111/mmi.13201. Epub 2015 Sep 25.


Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite.

Zhang Y, Huang C, Kim S, Golkaram M, Dixon MW, Tilley L, Li J, Zhang S, Suresh S.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6068-73. doi: 10.1073/pnas.1505584112. Epub 2015 Apr 27.


Bio-sensing with butterfly wings: naturally occurring nano-structures for SERS-based malaria parasite detection.

Garrett NL, Sekine R, Dixon MW, Tilley L, Bambery KR, Wood BR.

Phys Chem Chem Phys. 2015 Sep 7;17(33):21164-8. doi: 10.1039/c4cp04930f. Epub 2014 Dec 10.


Red blood cells polarize green laser light revealing hemoglobin's enhanced non-fundamental Raman modes.

Marzec KM, Perez-Guaita D, de Veij M, McNaughton D, Baranska M, Dixon MW, Tilley L, Wood BR.

Chemphyschem. 2014 Dec 15;15(18):3963-8. doi: 10.1002/cphc.201402598. Epub 2014 Sep 26.


Organization and function of an actin cytoskeleton in Plasmodium falciparum gametocytes.

Hliscs M, Millet C, Dixon MW, Siden-Kiamos I, McMillan P, Tilley L.

Cell Microbiol. 2015 Feb;17(2):207-25. doi: 10.1111/cmi.12359. Epub 2014 Oct 31.


A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite.

Tran PN, Brown SH, Mitchell TW, Matuschewski K, McMillan PJ, Kirk K, Dixon MW, Maier AG.

Nat Commun. 2014 Sep 8;5:4773. doi: 10.1038/ncomms5773.


Diagnosing malaria infected cells at the single cell level using focal plane array Fourier transform infrared imaging spectroscopy.

Wood BR, Bambery KR, Dixon MW, Tilley L, Nasse MJ, Mattson E, Hirschmugl CJ.

Analyst. 2014 Oct 7;139(19):4769-74. doi: 10.1039/c4an00989d.


Detection and quantification of early-stage malaria parasites in laboratory infected erythrocytes by attenuated total reflectance infrared spectroscopy and multivariate analysis.

Khoshmanesh A, Dixon MW, Kenny S, Tilley L, McNaughton D, Wood BR.

Anal Chem. 2014 May 6;86(9):4379-86. doi: 10.1021/ac500199x. Epub 2014 Apr 17.


Examining participant engagement in an information technology-based physical activity and nutrition intervention for men: the manup randomized controlled trial.

Short CE, Vandelanotte C, Dixon MW, Rosenkranz R, Caperchione C, Hooker C, Karunanithi M, Kolt GS, Maeder A, Ding H, Taylor P, Duncan MJ.

JMIR Res Protoc. 2014 Jan 3;3(1):e2. doi: 10.2196/resprot.2776.


Infection related hospitalizations after prostate biopsy in a statewide quality improvement collaborative.

Womble PR, Dixon MW, Linsell SM, Ye Z, Montie JE, Lane BR, Miller DC, Burks FN; Michigan Urological Surgery Improvement Collaborative.

J Urol. 2014 Jun;191(6):1787-92. doi: 10.1016/j.juro.2013.12.026. Epub 2013 Dec 15.


The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth.

Matthews K, Kalanon M, Chisholm SA, Sturm A, Goodman CD, Dixon MW, Sanders PR, Nebl T, Fraser F, Haase S, McFadden GI, Gilson PR, Crabb BS, de Koning-Ward TF.

Mol Microbiol. 2013 Sep;89(6):1167-86. doi: 10.1111/mmi.12334. Epub 2013 Aug 15.


Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum.

MacRae JI, Dixon MW, Dearnley MK, Chua HH, Chambers JM, Kenny S, Bottova I, Tilley L, McConville MJ.

BMC Biol. 2013 Jun 13;11:67. doi: 10.1186/1741-7007-11-67.


Temporal evaluation of commitment to sexual development in Plasmodium falciparum.

Peatey CL, Dixon MW, Gardiner DL, Trenholme KR.

Malar J. 2013 Apr 22;12:134. doi: 10.1186/1475-2875-12-134.


Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum.

McMillan PJ, Millet C, Batinovic S, Maiorca M, Hanssen E, Kenny S, Muhle RA, Melcher M, Fidock DA, Smith JD, Dixon MW, Tilley L.

Cell Microbiol. 2013 Aug;15(8):1401-18. doi: 10.1111/cmi.12125. Epub 2013 Mar 14.


Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?

Dixon MW, Dearnley MK, Hanssen E, Gilberger T, Tilley L.

Trends Parasitol. 2012 Nov;28(11):471-8. doi: 10.1016/ Epub 2012 Aug 30. Review.


Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes.

Dearnley MK, Yeoman JA, Hanssen E, Kenny S, Turnbull L, Whitchurch CB, Tilley L, Dixon MW.

J Cell Sci. 2012 Apr 15;125(Pt 8):2053-63. doi: 10.1242/jcs.099002. Epub 2012 Feb 10.


Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum.

Hanssen E, Knoechel C, Dearnley M, Dixon MW, Le Gros M, Larabell C, Tilley L.

J Struct Biol. 2012 Feb;177(2):224-32. doi: 10.1016/j.jsb.2011.09.003. Epub 2011 Sep 16.


Genetic ablation of a Maurer's cleft protein prevents assembly of the Plasmodium falciparum virulence complex.

Dixon MW, Kenny S, McMillan PJ, Hanssen E, Trenholme KR, Gardiner DL, Tilley L.

Mol Microbiol. 2011 Aug;81(4):982-93. doi: 10.1111/j.1365-2958.2011.07740.x. Epub 2011 Jul 7.


The Plasmodium falciparum-infected red blood cell.

Tilley L, Dixon MW, Kirk K.

Int J Biochem Cell Biol. 2011 Jun;43(6):839-42. doi: 10.1016/j.biocel.2011.03.012. Epub 2011 Mar 31. Review.


Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum.

Yeoman JA, Hanssen E, Maier AG, Klonis N, Maco B, Baum J, Turnbull L, Whitchurch CB, Dixon MW, Tilley L.

Eukaryot Cell. 2011 Apr;10(4):556-64. doi: 10.1128/EC.00244-10. Epub 2011 Jan 14.


Effect of antimalarial drugs on Plasmodium falciparum gametocytes.

Peatey CL, Skinner-Adams TS, Dixon MW, McCarthy JS, Gardiner DL, Trenholme KR.

J Infect Dis. 2009 Nov 15;200(10):1518-21. doi: 10.1086/644645.


REX1 and Pf62: are they one and the same?

Gardiner DL, Woodcroft BJ, Dixon MW, Ralph SA, Trenholme KR.

Parasitol Res. 2009 Apr;104(5):967-8. doi: 10.1007/s00436-009-1382-4. Review. No abstract available.


A green fluorescent protein-based assay for determining gametocyte production in Plasmodium falciparum.

Dixon MW, Peatey CL, Gardiner DL, Trenholme KR.

Mol Biochem Parasitol. 2009 Feb;163(2):123-6. doi: 10.1016/j.molbiopara.2008.10.004. Epub 2008 Nov 5.


Targeted mutagenesis of the ring-exported protein-1 of Plasmodium falciparum disrupts the architecture of Maurer's cleft organelles.

Hanssen E, Hawthorne P, Dixon MW, Trenholme KR, McMillan PJ, Spielmann T, Gardiner DL, Tilley L.

Mol Microbiol. 2008 Aug;69(4):938-53. doi: 10.1111/j.1365-2958.2008.06329.x. Epub 2008 Jun 28.


Targeting of the ring exported protein 1 to the Maurer's clefts is mediated by a two-phase process.

Dixon MW, Hawthorne PL, Spielmann T, Anderson KL, Trenholme KR, Gardiner DL.

Traffic. 2008 Aug;9(8):1316-26. doi: 10.1111/j.1600-0854.2008.00768.x. Epub 2008 May 19.


Sex in Plasmodium: a sign of commitment.

Dixon MW, Thompson J, Gardiner DL, Trenholme KR.

Trends Parasitol. 2008 Apr;24(4):168-75. doi: 10.1016/ Epub 2008 Mar 14. Review.


The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

Teuscher F, Lowther J, Skinner-Adams TS, Spielmann T, Dixon MW, Stack CM, Donnelly S, Mucha A, Kafarski P, Vassiliou S, Gardiner DL, Dalton JP, Trenholme KR.

J Biol Chem. 2007 Oct 19;282(42):30817-26. Epub 2007 Aug 20.


Selective permeabilization of the host cell membrane of Plasmodium falciparum-infected red blood cells with streptolysin O and equinatoxin II.

Jackson KE, Spielmann T, Hanssen E, Adisa A, Separovic F, Dixon MW, Trenholme KR, Hawthorne PL, Gardiner DL, Gilberger T, Tilley L.

Biochem J. 2007 Apr 1;403(1):167-75.


Reliable transfection of Plasmodium falciparum using non-commercial plasmid mini preparations.

Spielmann T, Dixon MW, Hernandez-Valladares M, Hannemann M, Trenholme KR, Gardiner DL.

Int J Parasitol. 2006 Oct;36(12):1245-8. Epub 2006 Jul 28.


Development of a taxonomy to describe massage treatments for musculoskeletal pain.

Sherman KJ, Dixon MW, Thompson D, Cherkin DC.

BMC Complement Altern Med. 2006 Jun 23;6:24. Review.


A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell.

Spielmann T, Hawthorne PL, Dixon MW, Hannemann M, Klotz K, Kemp DJ, Klonis N, Tilley L, Trenholme KR, Gardiner DL.

Mol Biol Cell. 2006 Aug;17(8):3613-24. Epub 2006 Jun 7.


Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis.

Gardiner DL, Dixon MW, Spielmann T, Skinner-Adams TS, Hawthorne PL, Ortega MR, Kemp DJ, Trenholme KR.

Mol Biochem Parasitol. 2005 Apr;140(2):153-60. Epub 2005 Jan 19.


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