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Items: 1 to 50 of 307

1.

Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome.

Dixit VM.

Cell Death Differ. 2019 Feb 8. doi: 10.1038/s41418-019-0294-9. [Epub ahead of print]

PMID:
30737474
2.

TBK1 and IKKε restrain cell death.

Heger K, Dixit VM.

Nat Cell Biol. 2018 Dec;20(12):1330-1331. doi: 10.1038/s41556-018-0239-4. No abstract available.

PMID:
30482939
3.

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.

Newton K, Dugger DL, Sengupta-Ghosh A, Ferrando RE, Chu F, Tao J, Lam W, Haller S, Chan S, Sa S, Dunlap D, Eastham-Anderson J, Ngu H, Hung J, French DM, Webster JD, Bolon B, Liu J, Reja R, Kummerfeld S, Chen YJ, Modrusan Z, Lewcock JW, Dixit VM.

Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11244-11249. doi: 10.1073/pnas.1805033115. Epub 2018 Oct 15.

4.

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.

Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E, Shain A, Xu M, Lill J, Dixit VM, Bastian BC, Dey A.

Pigment Cell Melanoma Res. 2018 Aug 29. doi: 10.1111/pcmr.12735. [Epub ahead of print]

PMID:
30156010
5.

OTULIN limits cell death and inflammation by deubiquitinating LUBAC.

Heger K, Wickliffe KE, Ndoja A, Zhang J, Murthy A, Dugger DL, Maltzman A, de Sousa E Melo F, Hung J, Zeng Y, Verschueren E, Kirkpatrick DS, Vucic D, Lee WP, Roose-Girma M, Newman RJ, Warming S, Hsiao YC, Kőműves LG, Webster JD, Newton K, Dixit VM.

Nature. 2018 Jul;559(7712):120-124. doi: 10.1038/s41586-018-0256-2. Epub 2018 Jun 27.

PMID:
29950720
6.

Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.

Huang CS, Oberbeck N, Hsiao YC, Liu P, Johnson AR, Dixit VM, Hymowitz SG.

Structure. 2018 May 1;26(5):767-777.e5. doi: 10.1016/j.str.2018.04.002. Epub 2018 Apr 26.

PMID:
29706531
7.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

8.

A new lead to NLRP3 inhibition.

Lamkanfi M, Dixit VM.

J Exp Med. 2017 Nov 6;214(11):3147-3149. doi: 10.1084/jem.20171848. Epub 2017 Oct 23.

9.

Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.

Yau RG, Doerner K, Castellanos ER, Haakonsen DL, Werner A, Wang N, Yang XW, Martinez-Martin N, Matsumoto ML, Dixit VM, Rape M.

Cell. 2017 Nov 2;171(4):918-933.e20. doi: 10.1016/j.cell.2017.09.040. Epub 2017 Oct 12.

10.

In Retrospect: The inflammasome turns 15.

Lamkanfi M, Dixit VM.

Nature. 2017 Aug 30;548(7669):534-535. doi: 10.1038/548534a. No abstract available.

PMID:
28858314
11.

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.

Zhang Z, Newton K, Kummerfeld SK, Webster J, Kirkpatrick DS, Phu L, Eastham-Anderson J, Liu J, Lee WP, Wu J, Li H, Junttila MR, Dixit VM.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3903-3908. doi: 10.1073/pnas.1621177114. Epub 2017 Mar 28.

12.

RIPK1 inhibits ZBP1-driven necroptosis during development.

Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, Lill JR, Roose-Girma M, Warming S, Solon M, Ngu H, Webster JD, Dixit VM.

Nature. 2016 Dec 1;540(7631):129-133. doi: 10.1038/nature20559. Epub 2016 Nov 7.

PMID:
27819682
13.

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes.

Aglietti RA, Estevez A, Gupta A, Ramirez MG, Liu PS, Kayagaki N, Ciferri C, Dixit VM, Dueber EC.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7858-63. doi: 10.1073/pnas.1607769113. Epub 2016 Jun 23.

14.

Inflammasomes: mechanism of assembly, regulation and signalling.

Broz P, Dixit VM.

Nat Rev Immunol. 2016 Jul;16(7):407-20. doi: 10.1038/nri.2016.58. Epub 2016 Jun 13. Review.

PMID:
27291964
15.

NLRP3 recruitment by NLRC4 during Salmonella infection.

Qu Y, Misaghi S, Newton K, Maltzman A, Izrael-Tomasevic A, Arnott D, Dixit VM.

J Exp Med. 2016 May 30;213(6):877-85. doi: 10.1084/jem.20132234. Epub 2016 May 2.

16.

Drugging the undruggables: exploring the ubiquitin system for drug development.

Huang X, Dixit VM.

Cell Res. 2016 Apr;26(4):484-98. doi: 10.1038/cr.2016.31. Epub 2016 Mar 22. Review.

17.

The 7th Barossa Meeting--Cell Signalling in Cancer Biology and Therapy in Barossa Valley, Australia.

Grimbaldeston MA, Dixit VM, Samuel MS.

Cell Death Dis. 2016 Mar 3;7:e2129. doi: 10.1038/cddis.2016.39. No abstract available.

18.

Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.

Naik E, Dixit VM.

J Immunol. 2016 Apr 15;196(8):3438-51. doi: 10.4049/jimmunol.1403165. Epub 2016 Mar 2.

19.

Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies.

Zhai Q, He M, Song A, Deshayes K, Dixit VM, Carter PJ.

J Mol Biol. 2016 Feb 13;428(3):603-617. doi: 10.1016/j.jmb.2016.01.006. Epub 2016 Jan 14.

20.

Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman RJ, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother WJ, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee WP, Goodnow CC, Balazs M, Yu K, Kolumam G, Dixit VM.

Nature. 2016 Apr 21;532(7599):402. doi: 10.1038/nature16541. Epub 2016 Jan 13. No abstract available.

PMID:
26760210
21.

Ubiquitin in the activation and attenuation of innate antiviral immunity.

Heaton SM, Borg NA, Dixit VM.

J Exp Med. 2016 Jan 11;213(1):1-13. doi: 10.1084/jem.20151531. Epub 2015 Dec 28. Review.

22.

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.

Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman RJ, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother WJ, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee WP, Goodnow CC, Balazs M, Yu K, Kolumam G, Dixit VM.

Nature. 2015 Dec 17;528(7582):370-5. doi: 10.1038/nature16165. Epub 2015 Dec 9. Erratum in: Nature. 2016 Apr 21;532(7599):402.

PMID:
26649818
23.

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

Suriben R, Kaihara KA, Paolino M, Reichelt M, Kummerfeld SK, Modrusan Z, Dugger DL, Newton K, Sagolla M, Webster JD, Liu J, Hebrok M, Dixit VM.

Cell. 2015 Dec 3;163(6):1457-67. doi: 10.1016/j.cell.2015.10.076. Epub 2015 Nov 25.

24.

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.

Nature. 2015 Oct 29;526(7575):666-71. doi: 10.1038/nature15541. Epub 2015 Sep 16.

PMID:
26375259
25.

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.

Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick DS, Lill JR, Ouyang W, Dixit VM.

Nature. 2015 Feb 19;518(7539):417-21. doi: 10.1038/nature13979. Epub 2014 Dec 3.

PMID:
25470037
26.

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.

Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19. Review.

27.

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X.

Naik E, Webster JD, DeVoss J, Liu J, Suriben R, Dixit VM.

J Exp Med. 2014 Sep 22;211(10):1947-55. doi: 10.1084/jem.20140860. Epub 2014 Sep 8.

28.

Mechanisms and functions of inflammasomes.

Lamkanfi M, Dixit VM.

Cell. 2014 May 22;157(5):1013-22. doi: 10.1016/j.cell.2014.04.007. Review.

29.

Is SIRT2 required for necroptosis?

Newton K, Hildebrand JM, Shen Z, Rodriguez D, Alvarez-Diaz S, Petersen S, Shah S, Dugger DL, Huang C, Auwerx J, Vandenabeele P, Green DR, Ashkenazi A, Dixit VM, Kaiser WJ, Strasser A, Degterev A, Silke J.

Nature. 2014 Feb 27;506(7489):E4-6. doi: 10.1038/nature13024.

30.

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.

Newton K, Dugger DL, Wickliffe KE, Kapoor N, de Almagro MC, Vucic D, Komuves L, Ferrando RE, French DM, Webster J, Roose-Girma M, Warming S, Dixit VM.

Science. 2014 Mar 21;343(6177):1357-60. doi: 10.1126/science.1249361. Epub 2014 Feb 20.

PMID:
24557836
31.

An interview with Vishva M. Dixit.

Dixit VM.

Trends Pharmacol Sci. 2013 Nov;34(11):596-8. doi: 10.1016/j.tips.2013.09.005. Epub 2013 Oct 21. No abstract available.

PMID:
24157182
32.

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.

Misaghi S, Senger K, Sai T, Qu Y, Sun Y, Hamidzadeh K, Nguyen A, Jin Z, Zhou M, Yan D, Lin WY, Lin Z, Lorenzo MN, Sebrell A, Ding J, Xu M, Caplazi P, Austin CD, Balazs M, Roose-Girma M, DeForge L, Warming S, Lee WP, Dixit VM, Zarrin AA.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15770-5. doi: 10.1073/pnas.1221661110. Epub 2013 Sep 9.

33.

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

Kayagaki N, Wong MT, Stowe IB, Ramani SR, Gonzalez LC, Akashi-Takamura S, Miyake K, Zhang J, Lee WP, Muszyński A, Forsberg LS, Carlson RW, Dixit VM.

Science. 2013 Sep 13;341(6151):1246-9. doi: 10.1126/science.1240248. Epub 2013 Jul 25.

34.

Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.

Huang X, McGann JC, Liu BY, Hannoush RN, Lill JR, Pham V, Newton K, Kakunda M, Liu J, Yu C, Hymowitz SG, Hongo JA, Wynshaw-Boris A, Polakis P, Harland RM, Dixit VM.

Science. 2013 Mar 22;339(6126):1441-5. doi: 10.1126/science.1232253. Epub 2013 Jan 31.

35.
36.

Inflammasomes and their roles in health and disease.

Lamkanfi M, Dixit VM.

Annu Rev Cell Dev Biol. 2012;28:137-61. doi: 10.1146/annurev-cellbio-101011-155745. Epub 2012 Sep 10. Review.

PMID:
22974247
37.

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.

Broz P, Ruby T, Belhocine K, Bouley DM, Kayagaki N, Dixit VM, Monack DM.

Nature. 2012 Oct 11;490(7419):288-91. doi: 10.1038/nature11419. Epub 2012 Aug 15.

38.

Phosphorylation of NLRC4 is critical for inflammasome activation.

Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM.

Nature. 2012 Oct 25;490(7421):539-42. doi: 10.1038/nature11429. Epub 2012 Aug 12.

PMID:
22885697
39.

Loss of the tumor suppressor BAP1 causes myeloid transformation.

Dey A, Seshasayee D, Noubade R, French DM, Liu J, Chaurushiya MS, Kirkpatrick DS, Pham VC, Lill JR, Bakalarski CE, Wu J, Phu L, Katavolos P, LaFave LM, Abdel-Wahab O, Modrusan Z, Seshagiri S, Dong K, Lin Z, Balazs M, Suriben R, Newton K, Hymowitz S, Garcia-Manero G, Martin F, Levine RL, Dixit VM.

Science. 2012 Sep 21;337(6101):1541-6. Epub 2012 Aug 9.

40.

Regulation of NF-κB by deubiquitinases.

Harhaj EW, Dixit VM.

Immunol Rev. 2012 Mar;246(1):107-24. doi: 10.1111/j.1600-065X.2012.01100.x. Review.

41.

Using linkage-specific monoclonal antibodies to analyze cellular ubiquitylation.

Newton K, Matsumoto ML, Ferrando RE, Wickliffe KE, Rape M, Kelley RF, Dixit VM.

Methods Mol Biol. 2012;832:185-96. doi: 10.1007/978-1-61779-474-2_13.

PMID:
22350886
42.

Signaling in innate immunity and inflammation.

Newton K, Dixit VM.

Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3). pii: a006049. doi: 10.1101/cshperspect.a006049. Review.

43.

Phosphorylation-dependent activity of the deubiquitinase DUBA.

Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG.

Nat Struct Mol Biol. 2012 Jan 15;19(2):171-5. doi: 10.1038/nsmb.2206.

PMID:
22245969
44.

Engineering and structural characterization of a linear polyubiquitin-specific antibody.

Matsumoto ML, Dong KC, Yu C, Phu L, Gao X, Hannoush RN, Hymowitz SG, Kirkpatrick DS, Dixit VM, Kelley RF.

J Mol Biol. 2012 May 4;418(3-4):134-44. doi: 10.1016/j.jmb.2011.12.053. Epub 2011 Dec 29.

45.

Non-canonical inflammasome activation targets caspase-11.

Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM.

Nature. 2011 Oct 16;479(7371):117-21. doi: 10.1038/nature10558.

PMID:
22002608
46.

USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.

Williams SA, Maecker HL, French DM, Liu J, Gregg A, Silverstein LB, Cao TC, Carano RA, Dixit VM.

Cell. 2011 Sep 16;146(6):918-30. doi: 10.1016/j.cell.2011.07.040.

47.

A20 edits ubiquitin and autoimmune paradigms.

Martin F, Dixit VM.

Nat Genet. 2011 Aug 29;43(9):822-3. doi: 10.1038/ng.916. No abstract available.

PMID:
21874034
48.

Cross talk between ubiquitination and demethylation.

Huang X, Dixit VM.

Mol Cell Biol. 2011 Sep;31(18):3682-3. doi: 10.1128/MCB.06001-11. Epub 2011 Aug 1. No abstract available.

49.

Modulation of inflammasome pathways by bacterial and viral pathogens.

Lamkanfi M, Dixit VM.

J Immunol. 2011 Jul 15;187(2):597-602. doi: 10.4049/jimmunol.1100229. Review.

50.

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.

Vucic D, Dixit VM, Wertz IE.

Nat Rev Mol Cell Biol. 2011 Jun 23;12(7):439-52. doi: 10.1038/nrm3143. Review.

PMID:
21697901

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