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Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.

Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD.

Cell Metab. 2019 Dec 3;30(6):1024-1039.e6. doi: 10.1016/j.cmet.2019.10.006. Epub 2019 Nov 14.


Ketogenic diet activates protective γδ T cell responses against influenza virus infection.

Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A.

Sci Immunol. 2019 Nov 15;4(41). pii: eaav2026. doi: 10.1126/sciimmunol.aav2026.


Bone Marrow: An Immunometabolic Refuge during Energy Depletion.

Goldberg EL, Dixit VD.

Cell Metab. 2019 Oct 1;30(4):621-623. doi: 10.1016/j.cmet.2019.08.022.


Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.

Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI.

J Physiol. 2019 Aug;597(15):3885-3903. doi: 10.1113/JP277270. Epub 2019 Jul 4.


Gaining Weight: Insulin-Eating Islet Macrophages.

Spadaro O, Dixit VD.

Immunity. 2019 Jan 15;50(1):13-15. doi: 10.1016/j.immuni.2018.12.026.


Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD.

Cell Rep. 2018 Jul 31;24(5):1085-1092.e6. doi: 10.1016/j.celrep.2018.06.112.


Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.

Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9172-E9180. doi: 10.1073/pnas.1707797114. Epub 2017 Oct 10.


Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.

Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD.

Nature. 2017 Oct 5;550(7674):119-123. doi: 10.1038/nature24022. Epub 2017 Sep 27.


Energy Sparing Orexigenic Inflammation of Obesity.

Lee A, Dixit VD.

Cell Metab. 2017 Jul 5;26(1):10-12. doi: 10.1016/j.cmet.2017.06.013.


IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge.

Spadaro O, Camell CD, Bosurgi L, Nguyen KY, Youm YH, Rothlin CV, Dixit VD.

Cell Rep. 2017 Apr 11;19(2):225-234. doi: 10.1016/j.celrep.2017.03.046.


β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.

Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD.

Cell Rep. 2017 Feb 28;18(9):2077-2087. doi: 10.1016/j.celrep.2017.02.004.


Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation.

Goldberg EL, Dixit VD.

Mol Metab. 2017 Jan 3;6(2):219-225. doi: 10.1016/j.molmet.2016.12.008. eCollection 2017 Feb.


Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.

Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L.

Aging (Albany NY). 2016 Jul;8(7):1416-31. doi: 10.18632/aging.100994.


Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.

Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD.

Cell Rep. 2016 Feb 23;14(7):1571-1580. doi: 10.1016/j.celrep.2016.01.044. Epub 2016 Feb 11.


Regulation of Nlrp3 inflammasome by dietary metabolites.

Camell C, Goldberg E, Dixit VD.

Semin Immunol. 2015 Sep;27(5):334-42. Review.


Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.

Youm YH, Horvath TL, Mangelsdorf DJ, Kliewer SA, Dixit VD.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1026-31. doi: 10.1073/pnas.1514511113. Epub 2016 Jan 11.


A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents.

Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S.

Diabetes. 2016 Mar;65(3):610-8. doi: 10.2337/db15-1478. Epub 2015 Dec 30.


Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity.

Camell CD, Nguyen KY, Jurczak MJ, Christian BE, Shulman GI, Shadel GS, Dixit VD.

J Biol Chem. 2015 Dec 4;290(49):29402-13. doi: 10.1074/jbc.M115.680199. Epub 2015 Oct 5.


Editorial: "Crowning" eosinophils in adipose tissue: does location matter?

Goldberg EL, Dixit VD.

J Leukoc Biol. 2015 Oct;98(4):451-2. doi: 10.1189/jlb.3CE0415-178RR. No abstract available.


Drivers of age-related inflammation and strategies for healthspan extension.

Goldberg EL, Dixit VD.

Immunol Rev. 2015 May;265(1):63-74. doi: 10.1111/imr.12295. Review.


The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.

Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD.

Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.


Adipose tissue as an immunological organ.

Grant RW, Dixit VD.

Obesity (Silver Spring). 2015 Mar;23(3):512-8. doi: 10.1002/oby.21003. Epub 2015 Jan 22. Review.


Metabolically healthy and unhealthy obese--the 2013 Stock Conference report.

Samocha-Bonet D, Dixit VD, Kahn CR, Leibel RL, Lin X, Nieuwdorp M, Pietiläinen KH, Rabasa-Lhoret R, Roden M, Scherer PE, Klein S, Ravussin E.

Obes Rev. 2014 Sep;15(9):697-708. doi: 10.1111/obr.12199. Epub 2014 Jul 25. Review.


Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.

Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ.

Cell Metab. 2014 May 6;19(5):821-35. doi: 10.1016/j.cmet.2014.03.029.


Inactivation of C/ebp homologous protein-driven immune-metabolic interactions exacerbate obesity and adipose tissue leukocytosis.

Grant R, Nguyen KY, Ravussin A, Albarado D, Youm YH, Dixit VD.

J Biol Chem. 2014 May 16;289(20):14045-55. doi: 10.1074/jbc.M113.545921. Epub 2014 Mar 24.


Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging.

Youm YH, Grant RW, McCabe LR, Albarado DC, Nguyen KY, Ravussin A, Pistell P, Newman S, Carter R, Laque A, Münzberg H, Rosen CJ, Ingram DK, Salbaum JM, Dixit VD.

Cell Metab. 2013 Oct 1;18(4):519-32. doi: 10.1016/j.cmet.2013.09.010.


Adipose tissue macrophages are innate to the immunological awareness of adipose tissue.

Dixit VD.

Diabetes. 2013 Aug;62(8):2656-8. doi: 10.2337/db13-0608. No abstract available.


Quantification of adipose tissue leukocytosis in obesity.

Grant R, Youm YH, Ravussin A, Dixit VD.

Methods Mol Biol. 2013;1040:195-209. doi: 10.1007/978-1-62703-523-1_15.


Mechanisms of disease: inflammasome activation and the development of type 2 diabetes.

Grant RW, Dixit VD.

Front Immunol. 2013 Mar 8;4:50. doi: 10.3389/fimmu.2013.00050. eCollection 2013.


Nlrp3 inflammasome activation in type 2 diabetes: is it clinically relevant?

Dixit VD.

Diabetes. 2013 Jan;62(1):22-4. doi: 10.2337/db12-1115. No abstract available.


The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence.

Youm YH, Kanneganti TD, Vandanmagsar B, Zhu X, Ravussin A, Adijiang A, Owen JS, Thomas MJ, Francis J, Parks JS, Dixit VD.

Cell Rep. 2012 Jan 26;1(1):56-68. doi: 10.1016/j.celrep.2011.11.005. Epub 2012 Jan 26.


Immunological complications of obesity.

Kanneganti TD, Dixit VD.

Nat Immunol. 2012 Jul 19;13(8):707-12. doi: 10.1038/ni.2343.


Chronic caloric restriction partially protects against age-related alteration in serum metabolome.

De Guzman JM, Ku G, Fahey R, Youm YH, Kass I, Ingram DK, Dixit VD, Kheterpal I.

Age (Dordr). 2013 Aug;35(4):1091-104. doi: 10.1007/s11357-012-9430-x. Epub 2012 Jun 4.


Editorial: lipids: fueling the fire in tuberculosis?

Dixit VD.

J Leukoc Biol. 2012 Jun;91(6):843-4. doi: 10.1189/jlb.1211640. No abstract available.


Impact of immune-metabolic interactions on age-related thymic demise and T cell senescence.

Dixit VD.

Semin Immunol. 2012 Oct;24(5):321-30. doi: 10.1016/j.smim.2012.04.002. Epub 2012 Apr 28. Review.


Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW.

Johannsen NM, Swift DL, Johnson WD, Dixit VD, Earnest CP, Blair SN, Church TS.

PLoS One. 2012;7(2):e31319. doi: 10.1371/journal.pone.0031319. Epub 2012 Feb 17.


Identification of ghrelin receptor blocker, D-[Lys3] GHRP-6 as a CXCR4 receptor antagonist.

Patel K, Dixit VD, Lee JH, Kim JW, Schaffer EM, Nguyen D, Taub DD.

Int J Biol Sci. 2012;8(1):108-17. Epub 2011 Nov 26.


The GHS-R blocker D-[Lys3] GHRP-6 serves as CCR5 chemokine receptor antagonist.

Patel K, Dixit VD, Lee JH, Kim JW, Schaffer EM, Nguyen D, Taub DD.

Int J Med Sci. 2012;9(1):51-8. Epub 2011 Nov 18.


Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage.

Youm YH, Adijiang A, Vandanmagsar B, Burk D, Ravussin A, Dixit VD.

Endocrinology. 2011 Nov;152(11):4039-45. doi: 10.1210/en.2011-1326. Epub 2011 Aug 23.


Inflammasome activation in obesity-related inflammatory diseases and autoimmunity.

Lukens JR, Dixit VD, Kanneganti TD.

Discov Med. 2011 Jul;12(62):65-74. Review.


Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production.

Dixit VD, Yang H, Sayeed KS, Stote KS, Rumpler WV, Baer DJ, Longo DL, Mattson MP, Taub DD.

J Inflamm (Lond). 2011 Mar 7;8:6. doi: 10.1186/1476-9255-8-6.


Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging.

Ma X, Lin L, Qin G, Lu X, Fiorotto M, Dixit VD, Sun Y.

PLoS One. 2011 Jan 26;6(1):e16391. doi: 10.1371/journal.pone.0016391.


The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance.

Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, Dixit VD.

Nat Med. 2011 Feb;17(2):179-88. doi: 10.1038/nm.2279. Epub 2011 Jan 9.


Thymic fatness and approaches to enhance thymopoietic fitness in aging.

Dixit VD.

Curr Opin Immunol. 2010 Aug;22(4):521-8. doi: 10.1016/j.coi.2010.06.010. Review.


Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance.

Yang H, Youm YH, Vandanmagsar B, Ravussin A, Gimble JM, Greenway F, Stephens JM, Mynatt RL, Dixit VD.

J Immunol. 2010 Aug 1;185(3):1836-45. doi: 10.4049/jimmunol.1000021. Epub 2010 Jun 25.


Thiazolidinedione treatment and constitutive-PPARgamma activation induces ectopic adipogenesis and promotes age-related thymic involution.

Youm YH, Yang H, Amin R, Smith SR, Leff T, Dixit VD.

Aging Cell. 2010 Aug;9(4):478-89. doi: 10.1111/j.1474-9726.2010.00574.x. Epub 2010 Apr 1.


Obesity accelerates thymic aging.

Yang H, Youm YH, Vandanmagsar B, Rood J, Kumar KG, Butler AA, Dixit VD.

Blood. 2009 Oct 29;114(18):3803-12. doi: 10.1182/blood-2009-03-213595. Epub 2009 Aug 31.


Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution.

Yang H, Youm YH, Dixit VD.

J Immunol. 2009 Sep 1;183(5):3040-52. doi: 10.4049/jimmunol.0900562. Epub 2009 Jul 31.


Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.

Kumar KG, Sutton GM, Dong JZ, Roubert P, Plas P, Halem HA, Culler MD, Yang H, Dixit VD, Butler AA.

Peptides. 2009 Oct;30(10):1892-900. doi: 10.1016/j.peptides.2009.07.012. Epub 2009 Jul 29.


Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression: implications for age-associated increases in inflammation.

Dixit VD, Yang H, Cooper-Jenkins A, Giri BB, Patel K, Taub DD.

Blood. 2009 May 21;113(21):5202-5. doi: 10.1182/blood-2008-09-181255. Epub 2009 Mar 26.

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