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Items: 1 to 50 of 64

1.

Signatures of the Evolution of Parthenogenesis and Cryptobiosis in the Genomes of Panagrolaimid Nematodes.

Schiffer PH, Danchin EGJ, Burnell AM, Creevey CJ, Wong S, Dix I, O'Mahony G, Culleton BA, Rancurel C, Stier G, Martínez-Salazar EA, Marconi A, Trivedi U, Kroiher M, Thorne MAS, Schierenberg E, Wiehe T, Blaxter M.

iScience. 2019 Nov 22;21:587-602. doi: 10.1016/j.isci.2019.10.039. Epub 2019 Oct 24.

2.

Bioinspired co-crystals of Imatinib providing enhanced kinetic solubility.

Reggane M, Wiest J, Saedtler M, Harlacher C, Gutmann M, Zottnick SH, Piechon P, Dix I, Müller-Buschbaum K, Holzgrabe U, Meinel L, Galli B.

Eur J Pharm Biopharm. 2018 Jul;128:290-299. doi: 10.1016/j.ejpb.2018.05.012. Epub 2018 May 4.

PMID:
29733951
3.

Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.

Velcicky J, Bodendorf U, Rigollier P, Epple R, Beisner DR, Guerini D, Smith P, Liu B, Feifel R, Wipfli P, Aichholz R, Couttet P, Dix I, Widmer T, Wen B, Brandl T.

J Med Chem. 2018 Feb 8;61(3):865-880. doi: 10.1021/acs.jmedchem.7b01371. Epub 2018 Jan 23.

PMID:
29359565
4.

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

Nishiguchi GA, Rico A, Tanner H, Aversa RJ, Taft BR, Subramanian S, Setti L, Burger MT, Wan L, Tamez V, Smith A, Lou Y, Barsanti PA, Appleton BA, Mamo M, Tandeske L, Dix I, Tellew JE, Huang S, Mathews Griner LA, Cooke VG, Van Abbema A, Merritt H, Ma S, Gampa K, Feng F, Yuan J, Wang Y, Haling JR, Vaziri S, Hekmat-Nejad M, Jansen JM, Polyakov V, Zang R, Sethuraman V, Amiri P, Singh M, Lees E, Shao W, Stuart DD, Dillon MP, Ramurthy S.

J Med Chem. 2017 Jun 22;60(12):4869-4881. doi: 10.1021/acs.jmedchem.6b01862. Epub 2017 Jun 8.

PMID:
28557458
5.

Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit.

Kounde CS, Yeo HQ, Wang QY, Wan KF, Dong H, Karuna R, Dix I, Wagner T, Zou B, Simon O, Bonamy GMC, Yeung BKS, Yokokawa F.

Bioorg Med Chem Lett. 2017 Mar 15;27(6):1385-1389. doi: 10.1016/j.bmcl.2017.02.005. Epub 2017 Feb 4.

PMID:
28216045
6.

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.

Levell JR, Caferro T, Chenail G, Dix I, Dooley J, Firestone B, Fortin PD, Giraldes J, Gould T, Growney JD, Jones MD, Kulathila R, Lin F, Liu G, Mueller A, van der Plas S, Slocum K, Smith T, Terranova R, Touré BB, Tyagi V, Wagner T, Xie X, Xu M, Yang FS, Zhou LX, Pagliarini R, Cho YS.

ACS Med Chem Lett. 2016 Dec 16;8(2):151-156. doi: 10.1021/acsmedchemlett.6b00334. eCollection 2017 Feb 9.

7.

Construction of a 3D-shaped, natural product like fragment library by fragmentation and diversification of natural products.

Prescher H, Koch G, Schuhmann T, Ertl P, Bussenault A, Glick M, Dix I, Petersen F, Lizos DE.

Bioorg Med Chem. 2017 Feb 1;25(3):921-925. doi: 10.1016/j.bmc.2016.12.005. Epub 2016 Dec 8.

PMID:
28011199
8.

Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure.

Fouché M, Schäfer M, Berghausen J, Desrayaud S, Blatter M, Piéchon P, Dix I, Martin Garcia A, Roth HJ.

ChemMedChem. 2016 May 19;11(10):1048-59. doi: 10.1002/cmdc.201600082. Epub 2016 May 6.

PMID:
27154275
9.

The chemical behavior of terminally tert-butylated polyolefins.

Klein D, Hopf H, Jones PG, Dix I, Hänel R.

Beilstein J Org Chem. 2015 Jul 24;11:1246-58. doi: 10.3762/bjoc.11.139. eCollection 2015.

10.

Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.

Zou B, Chan WL, Ding M, Leong SY, Nilar S, Seah PG, Liu W, Karuna R, Blasco F, Yip A, Chao A, Susila A, Dong H, Wang QY, Xu HY, Chan K, Wan KF, Gu F, Diagana TT, Wagner T, Dix I, Shi PY, Smith PW.

ACS Med Chem Lett. 2015 Feb 2;6(3):344-8. doi: 10.1021/ml500521r. eCollection 2015 Mar 12.

11.

Anhydrobiosis and freezing-tolerance: adaptations that facilitate the establishment of Panagrolaimus nematodes in polar habitats.

McGill LM, Shannon AJ, Pisani D, Félix MA, Ramløv H, Dix I, Wharton DA, Burnell AM.

PLoS One. 2015 Mar 6;10(3):e0116084. doi: 10.1371/journal.pone.0116084. eCollection 2015.

12.

Preparation, structural properties and thermal isomerization of hex-3-ene-1,5-diyne bridged [2.2]paracyclophanes.

Dix I, Bondarenko L, Jones PG, Ernst L, Ibrom K, Grunenberg J, Boese R, Hopf H.

Chemistry. 2014 Dec 1;20(49):16360-76. doi: 10.1002/chem.201403122. Epub 2014 Oct 21.

PMID:
25336292
13.

Building complex carbon skeletons with ethynyl[2.2]paracyclophanes.

Dix I, Bondarenko L, Jones PG, Oeser T, Hopf H.

Beilstein J Org Chem. 2014 Aug 27;10:2013-20. doi: 10.3762/bjoc.10.209. eCollection 2014.

14.

Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents.

Yokokawa F, Wang G, Chan WL, Ang SH, Wong J, Ma I, Rao SP, Manjunatha U, Lakshminarayana SB, Herve M, Kounde C, Tan BH, Thayalan P, Ng SH, Nanjundappa M, Ravindran S, Gee P, Tan M, Wei L, Goh A, Chen PY, Lee KS, Zhong C, Wagner T, Dix I, Chatterjee AK, Pethe K, Kuhen K, Glynne R, Smith P, Bifani P, Jiricek J.

ACS Med Chem Lett. 2013 Apr 1;4(5):451-5. doi: 10.1021/ml400071a. eCollection 2013 May 9. Erratum in: ACS Med Chem Lett. 2014 Apr 10;5(4):451.

15.

The preparation of several 1,2,3,4,5-functionalized cyclopentane derivatives.

Kelch AS, Jones PG, Dix I, Hopf H.

Beilstein J Org Chem. 2013 Aug 19;9:1705-12. doi: 10.3762/bjoc.9.195. eCollection 2013.

16.

Bromine-bromine interactions in the packing of cis,trans,cis-1,2,3,4-tetrakis(bromomethyl)cyclobutane.

Kelch A, Dix I, Hopf H, Jones PG.

Acta Crystallogr C. 2013 Jun;69(Pt 6):627-9. doi: 10.1107/S0108270113010597. Epub 2013 May 2.

PMID:
23744383
17.

Towards virtual knowledge broker services for semantic integration of life science literature and data sources.

Harrow I, Filsell W, Woollard P, Dix I, Braxenthaler M, Gedye R, Hoole D, Kidd R, Wilson J, Rebholz-Schuhmann D.

Drug Discov Today. 2013 May;18(9-10):428-34. doi: 10.1016/j.drudis.2012.11.012. Epub 2012 Dec 12. Review.

18.

Toxicology ontology perspectives.

Hardy B, Apic G, Carthew P, Clark D, Cook D, Dix I, Escher S, Hastings J, Heard DJ, Jeliazkova N, Judson P, Matis-Mitchell S, Mitic D, Myatt G, Shah I, Spjuth O, Tcheremenskaia O, Toldo L, Watson D, White A, Yang C.

ALTEX. 2012;29(2):139-56. doi: 10.14573/altex.2012.2.139. Review.

19.

A toxicology ontology roadmap.

Hardy B, Apic G, Carthew P, Clark D, Cook D, Dix I, Escher S, Hastings J, Heard DJ, Jeliazkova N, Judson P, Matis-Mitchell S, Mitic D, Myatt G, Shah I, Spjuth O, Tcheremenskaia O, Toldo L, Watson D, White A, Yang C.

ALTEX. 2012;29(2):129-37. doi: 10.14573/altex.2012.2.129.

20.

Toward interoperable bioscience data.

Sansone SA, Rocca-Serra P, Field D, Maguire E, Taylor C, Hofmann O, Fang H, Neumann S, Tong W, Amaral-Zettler L, Begley K, Booth T, Bougueleret L, Burns G, Chapman B, Clark T, Coleman LA, Copeland J, Das S, de Daruvar A, de Matos P, Dix I, Edmunds S, Evelo CT, Forster MJ, Gaudet P, Gilbert J, Goble C, Griffin JL, Jacob D, Kleinjans J, Harland L, Haug K, Hermjakob H, Ho Sui SJ, Laederach A, Liang S, Marshall S, McGrath A, Merrill E, Reilly D, Roux M, Shamu CE, Shang CA, Steinbeck C, Trefethen A, Williams-Jones B, Wolstencroft K, Xenarios I, Hide W.

Nat Genet. 2012 Jan 27;44(2):121-6. doi: 10.1038/ng.1054.

21.

Empowering industrial research with shared biomedical vocabularies.

Harland L, Larminie C, Sansone SA, Popa S, Marshall MS, Braxenthaler M, Cantor M, Filsell W, Forster MJ, Huang E, Matern A, Musen M, Saric J, Slater T, Wilson J, Lynch N, Wise J, Dix I.

Drug Discov Today. 2011 Nov;16(21-22):940-7. doi: 10.1016/j.drudis.2011.09.013. Epub 2011 Sep 23. Review.

22.

Minimum information about a bioactive entity (MIABE).

Orchard S, Al-Lazikani B, Bryant S, Clark D, Calder E, Dix I, Engkvist O, Forster M, Gaulton A, Gilson M, Glen R, Grigorov M, Hammond-Kosack K, Harland L, Hopkins A, Larminie C, Lynch N, Mann RK, Murray-Rust P, Lo Piparo E, Southan C, Steinbeck C, Wishart D, Hermjakob H, Overington J, Thornton J.

Nat Rev Drug Discov. 2011 Aug 31;10(9):661-9. doi: 10.1038/nrd3503. Review.

PMID:
21878981
23.

Automatic extraction of angiogenesis bioprocess from text.

Wang X, McKendrick I, Barrett I, Dix I, French T, Tsujii J, Ananiadou S.

Bioinformatics. 2011 Oct 1;27(19):2730-7. doi: 10.1093/bioinformatics/btr460. Epub 2011 Aug 5.

24.

Preparation and NMR spectra of four isomeric diformyl[2.2]paracyclophanes (cyclophanes 66).

Dix I, Hopf H, Satyanarayana TB, Ernst L.

Beilstein J Org Chem. 2010 Sep 29;6:932-7. doi: 10.3762/bjoc.6.104.

25.

A general route to fully terminally tert-butylated linear polyenes.

Klein D, Kiliçkiran P, Mlynek C, Hopf H, Dix I, Jones PG.

Chemistry. 2010 Sep 10;16(34):10507-22. doi: 10.1002/chem.201000019.

PMID:
20665574
26.

Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda.

Van Hoorebeke A, Stout J, Kyndt J, De Groeve M, Dix I, Desmet T, Soetaert W, Van Beeumen J, Savvides SN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):346-51. doi: 10.1107/S1744309110002642. Epub 2010 Feb 27.

27.

Structural studies on the full-length LysR-type regulator TsaR from Comamonas testosteroni T-2 reveal a novel open conformation of the tetrameric LTTR fold.

Monferrer D, Tralau T, Kertesz MA, Dix I, Solà M, Usón I.

Mol Microbiol. 2010 Mar;75(5):1199-214. doi: 10.1111/j.1365-2958.2010.07043.x. Epub 2010 Jan 5.

28.

Towards structural studies of the old yellow enzyme homologue SYE4 from Shewanella oneidensis and its complexes at atomic resolution.

Elegheert J, van den Hemel D, Dix I, Stout J, Van Beeumen J, Brigé A, Savvides SN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):85-90. doi: 10.1107/S1744309109050386. Epub 2009 Dec 25.

29.

Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery.

Barnes MR, Harland L, Foord SM, Hall MD, Dix I, Thomas S, Williams-Jones BI, Brouwer CR.

Nat Rev Drug Discov. 2009 Sep;8(9):701-8. doi: 10.1038/nrd2944. Epub 2009 Jul 17. Review.

PMID:
19609266
30.

Sr(5)(VOF(5))(3)F(H(2)O)(3) refined from a non-merohedrally twinned crystal.

Le Bail A, Mercier AM, Dix I.

Acta Crystallogr Sect E Struct Rep Online. 2009 May 23;65(Pt 6):i46-i47. doi: 10.1107/S1600536809019126.

31.

Female presence is required for male sexual maturity in the nematode Steinernema longicaudum.

Ebssa L, Dix I, Griffin CT.

Curr Biol. 2008 Nov 11;18(21):R997-8. doi: 10.1016/j.cub.2008.09.032. No abstract available.

32.

Crystallographic characterization and identification of a minor isomer of C(84) fullerene.

Epple L, Amsharov K, Simeonov K, Dix I, Jansen M.

Chem Commun (Camb). 2008 Nov 21;(43):5610-2. doi: 10.1039/b811872h. Epub 2008 Sep 26.

PMID:
18997968
33.

Bulky N-substituted 1,3-benzazaphospholes: access via Pd-catalyzed C-N and C-P cross coupling, lithiation, and conversion to novel P=C-PtBu2 hybrid ligands.

Aluri BR, Kindermann MK, Jones PG, Dix I, Heinicke J.

Inorg Chem. 2008 Aug 4;47(15):6900-12. doi: 10.1021/ic800430f. Epub 2008 Jul 9.

PMID:
18610971
34.

Systemic RNAi mediated gene silencing in the anhydrobiotic nematode Panagrolaimus superbus.

Shannon AJ, Tyson T, Dix I, Boyd J, Burnell AM.

BMC Mol Biol. 2008 Jun 19;9:58. doi: 10.1186/1471-2199-9-58.

35.

MP2 and DFT calculations on circulenes and an attempt to prepare the second lowest benzolog, [4]circulene.

Christoph H, Grunenberg J, Hopf H, Dix I, Jones PG, Scholtissek M, Maier G.

Chemistry. 2008;14(18):5604-16. doi: 10.1002/chem.200701837.

PMID:
18478614
36.

The 'cyclophene' [2.2.2](1,2,4)cyclophan-9-ene.

Broschinski K, Kannan A, Jones PG, Dix I, Hopf H.

Acta Crystallogr C. 2007 Dec;63(Pt 12):o711-3. Epub 2007 Nov 14.

PMID:
18057619
37.

1,x-elimination reactions: extending the limits of a classical organic reaction.

Werner C, Hopf H, Dix I, Bubenitschek P, Jones PG.

Chemistry. 2007;13(34):9462-77.

PMID:
17963211
38.

A triazine-based three-directional rigid-rod tecton forms a novel 1D channel structure.

Ranganathan A, Heisen BC, Dix I, Meyer F.

Chem Commun (Camb). 2007 Sep 21;(35):3637-9. Epub 2007 Aug 7.

PMID:
17728878
39.

C-H...pi interactions in five ethynyl-substituted [2.2]paracyclophanes: further examples of the '7,11' packing pattern.

Jones PG, Dix I, Hopf H.

Acta Crystallogr C. 2007 Aug;63(Pt 8):o468-73. Epub 2007 Jul 14.

PMID:
17675698
40.

Intramolecular reactions in pseudo-geminally substituted [2.2]paracyclophanes.

Bondarenko L, Hentschel S, Greiving H, Grunenberg J, Hopf H, Dix I, Jones PG, Ernst L.

Chemistry. 2007;13(14):3950-63.

PMID:
17373005
41.
42.

The Ru(II)-supported heptatungstates [HXW7O28Ru(dmso)3]6-(X=P, As).

Bi LH, Dickman MH, Kortz U, Dix I.

Chem Commun (Camb). 2005 Aug 21;(31):3962-4. Epub 2005 Jul 6.

PMID:
16075086
43.

Synthesis, structure, and complexation properties of amide-substituted derivatives of norbornadiene and quadricyclane.

Winkler T, Dix I, Jones PG, Herges R.

Angew Chem Int Ed Engl. 2003 Aug 4;42(30):3541-4. No abstract available.

PMID:
12900976
44.

Hydrogen-bonded superstructures of a small host molecule and lanthanide aquo ions.

Ahmad R, Dix I, Hardie MJ.

Inorg Chem. 2003 Apr 7;42(7):2182-4.

PMID:
12665345
45.
46.

[2.2]paracyclophane/dehydrobenzoannulene hybrids: transannular delocalization in open-circuited conjugated macrocycles.

Boydston AJ, Bondarenko L, Dix I, Weakley TJ, Hopf H, Haley MM.

Angew Chem Int Ed Engl. 2001;40(16):2986-9. doi: 10.1002/1521-3773(20010817)40:16<2986::AID-ANIE2986>3.0.CO;2-I.

PMID:
12203624
47.

Syntheses and structures of isomeric [6.6]- and [8.8]cyclophanes with 1,4-dioxabut-2-yne and 1,6-dioxahexa-2,4-diyne bridges.

Srinivasan M, Sankararaman S, Hopf H, Dix I, Jones PG.

J Org Chem. 2001 Jun 15;66(12):4299-303.

PMID:
11397167
48.
49.

2,4-Bis([6-(2,2-dimethylpropyl)-3-ethyl-1,3-benzothiazol-2(3H)-ylidene]methyl)cyclobutenediylium-1,3-diolate.

Lawrentz U, Grahn W, Dix I, Jones PG.

Acta Crystallogr C. 2001 Jan;57(Pt 1):126-8.

PMID:
11173424
50.

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