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Items: 10


Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants.

Awasthi S, Hook LM, Swaminathan G, Cairns TM, Brooks B, Smith JS, Ditto NT, Gindy ME, Bett AJ, Espeseth AS, Cohen GH, Friedman HM.

Vaccine. 2019 Jun 27;37(29):3770-3778. doi: 10.1016/j.vaccine.2019.05.068. Epub 2019 May 29.


Surface Plasmon Resonance Reveals Direct Binding of Herpes Simplex Virus Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD.

Cairns TM, Ditto NT, Atanasiu D, Lou H, Brooks BD, Saw WT, Eisenberg RJ, Cohen GH.

J Virol. 2019 Jul 17;93(15). pii: e00289-19. doi: 10.1128/JVI.00289-19. Print 2019 Aug 1.


Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth.

Chukwuma VU, Kose N, Sather DN, Sapparapu G, Falk R, King H, Singh V, Lampley R, Malherbe DC, Ditto NT, Sullivan JT, Barnes T, Doranz BJ, Labranche CC, Montefiori DC, Kalams SA, Haigwood NL, Crowe JE Jr.

PLoS One. 2018 Dec 19;13(12):e0209437. doi: 10.1371/journal.pone.0209437. eCollection 2018.


Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs.

Hook LM, Cairns TM, Awasthi S, Brooks BD, Ditto NT, Eisenberg RJ, Cohen GH, Friedman HM.

PLoS Pathog. 2018 May 23;14(5):e1007095. doi: 10.1371/journal.ppat.1007095. eCollection 2018 May.


Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging.

Cairns TM, Ditto NT, Lou H, Brooks BD, Atanasiu D, Eisenberg RJ, Cohen GH.

PLoS Pathog. 2017 Jun 14;13(6):e1006430. doi: 10.1371/journal.ppat.1006430. eCollection 2017 Jun.


The emerging role of biosensor-based epitope binning and mapping in antibody-based drug discovery.

Ditto NT, Brooks BD.

Expert Opin Drug Discov. 2016 Oct;11(10):925-37. doi: 10.1080/17460441.2016.1229295. Epub 2016 Sep 8. Review.


Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.

Mangan PR, Su LJ, Jenny V, Tatum AL, Picarillo C, Skala S, Ditto N, Lin Z, Yang X, Cotter PZ, Shuster DJ, Song Y, Borowski V, Thomas RL, Heimrich EM, Devaux B, Das Gupta R, Carvajal I, McIntyre KW, Xie J, Zhao Q, Struthers M, Salter-Cid LM.

J Pharmacol Exp Ther. 2015 Aug;354(2):152-65. doi: 10.1124/jpet.115.224246. Epub 2015 May 26.


Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.

Wang C, Yamniuk A, Dai J, Chen S, Stetsko P, Ditto N, Zhang Y.

Pharm Res. 2015 Aug;32(8):2625-35. doi: 10.1007/s11095-015-1648-8. Epub 2015 Feb 12.


Application of a kosmotrope-based solubility assay to multiple protein therapeutic classes indicates broad use as a high-throughput screen for protein therapeutic aggregation propensity.

Yamniuk AP, Ditto N, Patel M, Dai J, Sejwal P, Stetsko P, Doyle ML.

J Pharm Sci. 2013 Aug;102(8):2424-39. doi: 10.1002/jps.23618. Epub 2013 May 27.


Enrichment and analysis of Alzheimer's Abeta1-42 peptide in human plasma and whole blood.

Ditto NT, Kline TR, Alfinito PD, Slemmon JR.

J Neurosci Methods. 2009 Sep 15;182(2):260-5. doi: 10.1016/j.jneumeth.2009.05.025. Epub 2009 Jun 9.


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