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Items: 1 to 50 of 98

1.

Unlocking the Spatial Control of Secondary Metabolism Uncovers Hidden Natural Product Diversity in Nostoc punctiforme.

Dehm D, Krumbholz J, Baunach M, Wiebach V, Hinrichs K, Guljamow A, Tabuchi T, Jenke-Kodama H, Süssmuth RD, Dittmann E.

ACS Chem Biol. 2019 Jun 21;14(6):1271-1279. doi: 10.1021/acschembio.9b00240. Epub 2019 May 24.

PMID:
31091070
2.

Unique Biosynthetic Pathway in Bloom-Forming Cyanobacterial Genus Microcystis Jointly Assembles Cytotoxic Aeruginoguanidines and Microguanidines.

Pancrace C, Ishida K, Briand E, Pichi DG, Weiz AR, Guljamow A, Scalvenzi T, Sassoon N, Hertweck C, Dittmann E, Gugger M.

ACS Chem Biol. 2019 Jan 18;14(1):67-75. doi: 10.1021/acschembio.8b00918. Epub 2018 Dec 28.

PMID:
30556994
3.

Microcystin interferes with defense against high oxidative stress in harmful cyanobacteria.

Schuurmans JM, Brinkmann BW, Makower AK, Dittmann E, Huisman J, Matthijs HCP.

Harmful Algae. 2018 Sep;78:47-55. doi: 10.1016/j.hal.2018.07.008. Epub 2018 Aug 10.

PMID:
30196924
4.

Mycosporine-like amino acids (MAAs)-producing Microcystis in Lake Erie: Development of a qPCR assay and insight into its ecology.

Hu C, Ludsin SA, Martin JF, Dittmann E, Lee J.

Harmful Algae. 2018 Jul;77:1-10. doi: 10.1016/j.hal.2018.05.010. Epub 2018 Jun 1.

PMID:
30005796
5.

Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria.

Hackenberg C, Hakanpää J, Cai F, Antonyuk S, Eigner C, Meissner S, Laitaoja M, Jänis J, Kerfeld CA, Dittmann E, Lamzin VS.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7141-7146. doi: 10.1073/pnas.1806668115. Epub 2018 Jun 18.

6.

Prerequisites of Isopeptide Bond Formation in Microcystin Biosynthesis.

Meyer S, Mainz A, Kehr JC, Süssmuth RD, Dittmann E.

Chembiochem. 2017 Dec 14;18(24):2376-2379. doi: 10.1002/cbic.201700389. Epub 2017 Oct 27.

PMID:
29024253
7.

Draft Genome Sequences of Two Uncultured Armatimonadetes Associated with a Microcystis sp. (Cyanobacteria) Isolate.

Woodhouse JN, Makower AK, Grossart HP, Dittmann E.

Genome Announc. 2017 Oct 5;5(40). pii: e00717-17. doi: 10.1128/genomeA.00717-17.

8.

High-Density Cultivation of Terrestrial Nostoc Strains Leads to Reprogramming of Secondary Metabolome.

Guljamow A, Kreische M, Ishida K, Liaimer A, Altermark B, Bähr L, Hertweck C, Ehwald R, Dittmann E.

Appl Environ Microbiol. 2017 Nov 16;83(23). pii: e01510-17. doi: 10.1128/AEM.01510-17. Print 2017 Dec 1.

9.

Phylogenomic Analysis of the Microviridin Biosynthetic Pathway Coupled with Targeted Chemo-Enzymatic Synthesis Yields Potent Protease Inhibitors.

Ahmed MN, Reyna-González E, Schmid B, Wiebach V, Süssmuth RD, Dittmann E, Fewer DP.

ACS Chem Biol. 2017 Jun 16;12(6):1538-1546. doi: 10.1021/acschembio.7b00124. Epub 2017 Apr 26.

PMID:
28406289
10.

The genetics, biosynthesis and regulation of toxic specialized metabolites of cyanobacteria.

Pearson LA, Dittmann E, Mazmouz R, Ongley SE, D'Agostino PM, Neilan BA.

Harmful Algae. 2016 Apr;54:98-111. doi: 10.1016/j.hal.2015.11.002. Review.

PMID:
28073484
11.
12.

Leader Peptide-Free In Vitro Reconstitution of Microviridin Biosynthesis Enables Design of Synthetic Protease-Targeted Libraries.

Reyna-González E, Schmid B, Petras D, Süssmuth RD, Dittmann E.

Angew Chem Int Ed Engl. 2016 Aug 1;55(32):9398-401. doi: 10.1002/anie.201604345. Epub 2016 Jun 23.

PMID:
27336908
13.

Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS.

Meyer S, Kehr JC, Mainz A, Dehm D, Petras D, Süssmuth RD, Dittmann E.

Cell Chem Biol. 2016 Apr 21;23(4):462-71. doi: 10.1016/j.chembiol.2016.03.011.

14.

Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria.

Dittmann E, Gugger M, Sivonen K, Fewer DP.

Trends Microbiol. 2015 Oct;23(10):642-652. doi: 10.1016/j.tim.2015.07.008. Review.

PMID:
26433696
15.

Protective tunicate endosymbiont with extreme genome reduction.

Kehr JC, Dittmann E.

Environ Microbiol. 2015 Oct;17(10):3430-2. doi: 10.1111/1462-2920.12941. Epub 2015 Jul 22. No abstract available.

PMID:
26201437
16.

Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme.

Liaimer A, Helfrich EJ, Hinrichs K, Guljamow A, Ishida K, Hertweck C, Dittmann E.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1862-7. doi: 10.1073/pnas.1419543112. Epub 2015 Jan 26.

17.

Biosynthesis and function of extracellular glycans in cyanobacteria.

Kehr JC, Dittmann E.

Life (Basel). 2015 Jan 12;5(1):164-80. doi: 10.3390/life5010164. Review.

18.

Transcriptomics-aided dissection of the intracellular and extracellular roles of microcystin in Microcystis aeruginosa PCC 7806.

Makower AK, Schuurmans JM, Groth D, Zilliges Y, Matthijs HC, Dittmann E.

Appl Environ Microbiol. 2015 Jan;81(2):544-54. doi: 10.1128/AEM.02601-14. Epub 2014 Nov 7.

19.

Functional assessment of mycosporine-like amino acids in Microcystis aeruginosa strain PCC 7806.

Hu C, Völler G, Süßmuth R, Dittmann E, Kehr JC.

Environ Microbiol. 2015 May;17(5):1548-59. doi: 10.1111/1462-2920.12577. Epub 2014 Aug 27.

PMID:
25059440
20.

Metabolomic analysis indicates a pivotal role of the hepatotoxin microcystin in high light adaptation of Microcystis.

Meissner S, Steinhauser D, Dittmann E.

Environ Microbiol. 2015 May;17(5):1497-509. doi: 10.1111/1462-2920.12565. Epub 2014 Aug 20.

PMID:
25041118
21.

Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions.

Weiz AR, Ishida K, Quitterer F, Meyer S, Kehr JC, Müller KM, Groll M, Hertweck C, Dittmann E.

Angew Chem Int Ed Engl. 2014 Apr 1;53(14):3735-8. doi: 10.1002/anie.201309721. Epub 2014 Mar 3.

PMID:
24591244
22.

Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family.

Gatte-Picchi D, Weiz A, Ishida K, Hertweck C, Dittmann E.

Appl Environ Microbiol. 2014 Feb;80(4):1380-7. doi: 10.1128/AEM.03502-13. Epub 2013 Dec 13.

23.

Casting a net: fibres produced by Microcystis sp. in field and laboratory populations.

Harel M, Weiss G, Daniel E, Wilenz A, Hadas O, Sukenik A, Sedmak B, Dittmann E, Braun S, Kaplan A.

Environ Microbiol Rep. 2012 Jun;4(3):342-9. doi: 10.1111/j.1758-2229.2012.00339.x. Epub 2012 Mar 29.

PMID:
23760798
24.

Insights into the physiology and ecology of the brackish-water-adapted Cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome analysis.

Voss B, Bolhuis H, Fewer DP, Kopf M, Möke F, Haas F, El-Shehawy R, Hayes P, Bergman B, Sivonen K, Dittmann E, Scanlan DJ, Hagemann M, Stal LJ, Hess WR.

PLoS One. 2013;8(3):e60224. doi: 10.1371/journal.pone.0060224. Epub 2013 Mar 28.

25.

Microcystin production revisited: conjugate formation makes a major contribution.

Meissner S, Fastner J, Dittmann E.

Environ Microbiol. 2013 Jun;15(6):1810-20. doi: 10.1111/1462-2920.12072. Epub 2013 Jan 25.

PMID:
23347128
26.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.

27.

Cyanobacteria as a source of natural products.

Welker M, Dittmann E, von Döhren H.

Methods Enzymol. 2012;517:23-46. doi: 10.1016/B978-0-12-404634-4.00002-4.

PMID:
23084932
28.

Cyanobacterial toxins: biosynthetic routes and evolutionary roots.

Dittmann E, Fewer DP, Neilan BA.

FEMS Microbiol Rev. 2013 Jan;37(1):23-43. doi: 10.1111/j.1574-6976.2012.12000.x. Epub 2012 Oct 10. Review.

29.

The languages spoken in the water body (or the biological role of cyanobacterial toxins).

Kaplan A, Harel M, Kaplan-Levy RN, Hadas O, Sukenik A, Dittmann E.

Front Microbiol. 2012 Apr 18;3:138. doi: 10.3389/fmicb.2012.00138. eCollection 2012.

30.

Environmental conditions that influence toxin biosynthesis in cyanobacteria.

Neilan BA, Pearson LA, Muenchhoff J, Moffitt MC, Dittmann E.

Environ Microbiol. 2013 May;15(5):1239-53. doi: 10.1111/j.1462-2920.2012.02729.x. Epub 2012 Mar 20. Review.

PMID:
22429476
31.

Unique properties of eukaryote-type actin and profilin horizontally transferred to cyanobacteria.

Guljamow A, Delissen F, Baumann O, Thünemann AF, Dittmann E.

PLoS One. 2012;7(1):e29926. doi: 10.1371/journal.pone.0029926. Epub 2012 Jan 10.

32.

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes.

Kehr JC, Gatte Picchi D, Dittmann E.

Beilstein J Org Chem. 2011;7:1622-35. doi: 10.3762/bjoc.7.191. Epub 2011 Dec 5.

33.

Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin.

Weiz AR, Ishida K, Makower K, Ziemert N, Hertweck C, Dittmann E.

Chem Biol. 2011 Nov 23;18(11):1413-21. doi: 10.1016/j.chembiol.2011.09.011.

34.

A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme.

Liaimer A, Jenke-Kodama H, Ishida K, Hinrichs K, Stangeland J, Hertweck C, Dittmann E.

Environ Microbiol Rep. 2011 Oct;3(5):550-8. doi: 10.1111/j.1758-2229.2011.00258.x. Epub 2011 May 9.

PMID:
23761334
35.

Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).

Férir G, Vermeire K, Huskens D, Balzarini J, Van Damme EJ, Kehr JC, Dittmann E, Swanson MD, Markovitz DM, Schols D.

Antiviral Res. 2011 Jun;90(3):200-4. doi: 10.1016/j.antiviral.2011.03.188. Epub 2011 Apr 8.

PMID:
21501631
36.

The cyanobacterial hepatotoxin microcystin binds to proteins and increases the fitness of microcystis under oxidative stress conditions.

Zilliges Y, Kehr JC, Meissner S, Ishida K, Mikkat S, Hagemann M, Kaplan A, Börner T, Dittmann E.

PLoS One. 2011 Mar 18;6(3):e17615. doi: 10.1371/journal.pone.0017615.

37.

Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile.

Huskens D, Férir G, Vermeire K, Kehr JC, Balzarini J, Dittmann E, Schols D.

J Biol Chem. 2010 Aug 6;285(32):24845-54. doi: 10.1074/jbc.M110.128546. Epub 2010 May 27.

38.

Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides.

Ziemert N, Ishida K, Weiz A, Hertweck C, Dittmann E.

Appl Environ Microbiol. 2010 Jun;76(11):3568-74. doi: 10.1128/AEM.02858-09. Epub 2010 Apr 2.

39.

Evolution of metabolic diversity: insights from microbial polyketide synthases.

Jenke-Kodama H, Dittmann E.

Phytochemistry. 2009 Oct-Nov;70(15-16):1858-66. doi: 10.1016/j.phytochem.2009.05.021. Epub 2009 Jul 18. Review.

PMID:
19619887
40.

Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges.

Jenke-Kodama H, Dittmann E.

Nat Prod Rep. 2009 Jul;26(7):874-83. doi: 10.1039/b810283j. Epub 2009 Apr 7. Review.

PMID:
19554239
41.

Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria.

Ishida K, Welker M, Christiansen G, Cadel-Six S, Bouchier C, Dittmann E, Hertweck C, Tandeau de Marsac N.

Appl Environ Microbiol. 2009 Apr;75(7):2017-26. doi: 10.1128/AEM.02258-08. Epub 2009 Feb 5.

42.

Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria.

Ziemert N, Ishida K, Liaimer A, Hertweck C, Dittmann E.

Angew Chem Int Ed Engl. 2008;47(40):7756-9. doi: 10.1002/anie.200802730. No abstract available.

PMID:
18683268
43.

Highly plastic genome of Microcystis aeruginosa PCC 7806, a ubiquitous toxic freshwater cyanobacterium.

Frangeul L, Quillardet P, Castets AM, Humbert JF, Matthijs HC, Cortez D, Tolonen A, Zhang CC, Gribaldo S, Kehr JC, Zilliges Y, Ziemert N, Becker S, Talla E, Latifi A, Billault A, Lepelletier A, Dittmann E, Bouchier C, de Marsac NT.

BMC Genomics. 2008 Jun 5;9:274. doi: 10.1186/1471-2164-9-274.

44.

An extracellular glycoprotein is implicated in cell-cell contacts in the toxic cyanobacterium Microcystis aeruginosa PCC 7806.

Zilliges Y, Kehr JC, Mikkat S, Bouchier C, de Marsac NT, Börner T, Dittmann E.

J Bacteriol. 2008 Apr;190(8):2871-9. doi: 10.1128/JB.01867-07. Epub 2008 Feb 15.

45.

Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa.

Ziemert N, Ishida K, Quillardet P, Bouchier C, Hertweck C, de Marsac NT, Dittmann E.

Appl Environ Microbiol. 2008 Mar;74(6):1791-7. doi: 10.1128/AEM.02392-07. Epub 2008 Feb 1.

46.

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection.

Nguyen T, Ishida K, Jenke-Kodama H, Dittmann E, Gurgui C, Hochmuth T, Taudien S, Platzer M, Hertweck C, Piel J.

Nat Biotechnol. 2008 Feb;26(2):225-33. doi: 10.1038/nbt1379. Epub 2008 Jan 27.

PMID:
18223641
47.

Evolutionary mechanisms underlying secondary metabolite diversity.

Jenke-Kodama H, Müller R, Dittmann E.

Prog Drug Res. 2008;65:119, 121-40. Review.

PMID:
18084914
48.

Horizontal gene transfer of two cytoskeletal elements from a eukaryote to a cyanobacterium.

Guljamow A, Jenke-Kodama H, Saumweber H, Quillardet P, Frangeul L, Castets AM, Bouchier C, Tandeau de Marsac N, Dittmann E.

Curr Biol. 2007 Sep 4;17(17):R757-9. No abstract available.

49.

Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective.

Traitcheva N, Jenke-Kodama H, He J, Dittmann E, Hertweck C.

Chembiochem. 2007 Oct 15;8(15):1841-9.

PMID:
17763486
50.

Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety.

Ishida K, Christiansen G, Yoshida WY, Kurmayer R, Welker M, Valls N, Bonjoch J, Hertweck C, Börner T, Hemscheidt T, Dittmann E.

Chem Biol. 2007 May;14(5):565-576. doi: 10.1016/j.chembiol.2007.04.006.

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