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Items: 28


N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway.

Qanungo S, Uys JD, Manevich Y, Distler AM, Shaner B, Hill EG, Mieyal JJ, Lemasters JJ, Townsend DM, Nieminen AL.

Biomed Pharmacother. 2014 Sep;68(7):855-64. doi: 10.1016/j.biopha.2014.08.007. Epub 2014 Aug 28.


Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.

Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA.

Antimicrob Agents Chemother. 2011 Jul;55(7):3465-75. doi: 10.1128/AAC.00089-11. Epub 2011 May 9.


Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.

Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, Bethel CR, Distler AM, Drawz SM, Pagadala SR, van den Akker F, Bonomo RA, Romero A, Buynak JD.

J Am Chem Soc. 2010 Sep 29;132(38):13320-31. doi: 10.1021/ja104092z.


Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.

Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.

Antimicrob Agents Chemother. 2010 Jul;54(7):2867-77. doi: 10.1128/AAC.00197-10. Epub 2010 Apr 26.


Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.

Papp-Wallace KM, Bethel CR, Distler AM, Kasuboski C, Taracila M, Bonomo RA.

Antimicrob Agents Chemother. 2010 Feb;54(2):890-7. doi: 10.1128/AAC.00693-09. Epub 2009 Dec 14.


Inhibition of the class C beta-lactamase from Acinetobacter spp.: insights into effective inhibitor design.

Drawz SM, Babic M, Bethel CR, Taracila M, Distler AM, Ori C, Caselli E, Prati F, Bonomo RA.

Biochemistry. 2010 Jan 19;49(2):329-40. doi: 10.1021/bi9015988.


Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme.

Schneider KD, Bethel CR, Distler AM, Hujer AM, Bonomo RA, Leonard DA.

Biochemistry. 2009 Jul 7;48(26):6136-45. doi: 10.1021/bi900448u.


Post-translational modifications of mitochondrial outer membrane proteins.

Distler AM, Kerner J, Lee K, Hoppel CL.

Methods Enzymol. 2009;457:97-115. doi: 10.1016/S0076-6879(09)05006-X.


The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.

Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA.

Biochemistry. 2009 Jun 2;48(21):4557-66. doi: 10.1021/bi9003292.


Mass spectrometric demonstration of the presence of liver carnitine palmitoyltransferase-I (CPT-I) in heart mitochondria of adult rats.

Distler AM, Kerner J, Hoppel CL.

Biochim Biophys Acta. 2009 Mar;1794(3):431-7. doi: 10.1016/j.bbapap.2008.11.009. Epub 2008 Dec 3.


Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells.

Shelton MD, Distler AM, Kern TS, Mieyal JJ.

J Biol Chem. 2009 Feb 20;284(8):4760-6. doi: 10.1074/jbc.M805464200. Epub 2008 Dec 12.


Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.

Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA.

J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27.


Proteomics of mitochondrial inner and outer membranes.

Distler AM, Kerner J, Hoppel CL.

Proteomics. 2008 Oct;8(19):4066-82. doi: 10.1002/pmic.200800102. Review.


Inhibition of OXA-1 beta-lactamase by penems.

Bethel CR, Distler AM, Ruszczycky MW, Carey MP, Carey PR, Hujer AM, Taracila M, Helfand MS, Thomson JM, Kalp M, Anderson VE, Leonard DA, Hujer KM, Abe T, Venkatesan AM, Mansour TS, Bonomo RA.

Antimicrob Agents Chemother. 2008 Sep;52(9):3135-43. doi: 10.1128/AAC.01677-07. Epub 2008 Jun 16.


Quinol type compound in cytochrome c preparations leads to non-enzymatic reduction of cytochrome c during the measurement of complex III activity.

Moghaddas S, Distler AM, Hoppel CL, Lesnefsky EJ.

Mitochondrion. 2008 Mar;8(2):155-63. doi: 10.1016/j.mito.2007.12.001. Epub 2007 Dec 23.


Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum).

Mader DR, Yike I, Distler AM, Dearborn DG.

J Am Vet Med Assoc. 2007 Sep 1;231(5):731-5.


Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry.

Distler AM, Kerner J, Hoppel CL.

Biochim Biophys Acta. 2007 May;1774(5):628-36. Epub 2007 Mar 28.


Mycotoxin adducts on human serum albumin: biomarkers of exposure to Stachybotrys chartarum.

Yike I, Distler AM, Ziady AG, Dearborn DG.

Environ Health Perspect. 2006 Aug;114(8):1221-6.


A targeted proteomic approach for the analysis of rat liver mitochondrial outer membrane proteins with extensive sequence coverage.

Distler AM, Kerner J, Peterman SM, Hoppel CL.

Anal Biochem. 2006 Sep 1;356(1):18-29. Epub 2006 May 3.


Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance.

Thomson JM, Distler AM, Prati F, Bonomo RA.

J Biol Chem. 2006 Sep 8;281(36):26734-44. Epub 2006 Jun 27.


Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme.

Kerner J, Distler AM, Minkler P, Parland W, Peterman SM, Hoppel CL.

J Biol Chem. 2004 Sep 24;279(39):41104-13. Epub 2004 Jul 9.


Mass spectrometric detection of protein, lipid and heme components of cytochrome c oxidase from R. sphaeroides and the stabilization of non-covalent complexes from the enzyme.

Distler AM, Allison J, Hiser C, Qin L, Hilmi Y, Ferguson-Miller S.

Eur J Mass Spectrom (Chichester). 2004;10(2):295-308.


Additives for the stabilization of double-stranded DNA in UV-MALDI MS.

Distler AM, Allison J.

J Am Soc Mass Spectrom. 2002 Sep;13(9):1129-37.


Improved MALDI-MS analysis of oligonucleotides through the use of fucose as a matrix additive.

Distler AM, Allison J.

Anal Chem. 2001 Oct 15;73(20):5000-3.


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