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The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction.

Förster S, Koziol U, Schäfer T, Duvoisin R, Cailliau K, Vanderstraete M, Dissous C, Brehm K.

PLoS Negl Trop Dis. 2019 Mar 8;13(3):e0006959. doi: 10.1371/journal.pntd.0006959. [Epub ahead of print]


Dual role of the Anopheles coluzzii Venus Kinase Receptor in both larval growth and immunity.

Gouignard N, Cherrier F, Brito-Fravallo E, Pain A, Zmarlak NM, Cailliau K, Genève C, Vernick KD, Dissous C, Mitri C.

Sci Rep. 2019 Mar 5;9(1):3615. doi: 10.1038/s41598-019-40407-x.


Kinases: Molecular Stage Directors for Schistosome Development and Differentiation.

Grevelding CG, Langner S, Dissous C.

Trends Parasitol. 2018 Mar;34(3):246-260. doi: 10.1016/ Epub 2017 Dec 21. Review.


The RIO protein kinase-encoding gene Sj-riok-2 is involved in key reproductive processes in Schistosoma japonicum.

Zhao L, He X, Grevelding CG, Ye Q, Li Y, Gasser RB, Dissous C, Mughal MN, Zhou YQ, Zhao JL, Hu M.

Parasit Vectors. 2017 Dec 12;10(1):604. doi: 10.1186/s13071-017-2524-7.


First characterization of SmOPG1, a novel protein involved in gonad-associated processes in Schistosoma mansoni.

Hahnel S, Parker-Manuel R, Dissous C, Cailliau K, Grevelding CG.

Mol Biochem Parasitol. 2017 Apr;213:22-25. doi: 10.1016/j.molbiopara.2017.01.007. Epub 2017 Jan 31.


Evidence for Integrin - Venus Kinase Receptor 1 Alliance in the Ovary of Schistosoma mansoni Females Controlling Cell Survival.

Gelmedin V, Morel M, Hahnel S, Cailliau K, Dissous C, Grevelding CG.

PLoS Pathog. 2017 Jan 23;13(1):e1006147. doi: 10.1371/journal.ppat.1006147. eCollection 2017 Jan.


SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways.

Morel M, Vanderstraete M, Cailliau K, Hahnel S, Grevelding CG, Dissous C.

PLoS One. 2016 Sep 16;11(9):e0163283. doi: 10.1371/journal.pone.0163283. eCollection 2016.


Correction: Venus Kinase Receptors Control Reproduction in the Platyhelminth Parasite Schistosoma mansoni.

Vanderstraete M, Gouignard N, Cailliau K, Morel M, Hahnel S, Leutner S, Beckmann S, Grevelding CG, Dissous C.

PLoS Pathog. 2016 Jul 25;12(7):e1005798. doi: 10.1371/journal.ppat.1005798. eCollection 2016 Jul.


Caspase Cleavages of the Lymphocyte-oriented Kinase Prevent Ezrin, Radixin, and Moesin Phosphorylation during Apoptosis.

Leroy C, Belkina NV, Long T, Deruy E, Dissous C, Shaw S, Tulasne D.

J Biol Chem. 2016 May 6;291(19):10148-61. doi: 10.1074/jbc.M116.721365. Epub 2016 Mar 4.


Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.

Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004356. doi: 10.1371/journal.pntd.0004356. eCollection 2016 Jan.


Venus Kinase Receptors at the Crossroads of Insulin Signaling: Their Role in Reproduction for Helminths and Insects.

Dissous C.

Front Endocrinol (Lausanne). 2015 Aug 3;6:118. doi: 10.3389/fendo.2015.00118. eCollection 2015. Review.


Re-positioning protein-kinase inhibitors against schistosomiasis.

Gelmedin V, Dissous C, Grevelding CG.

Future Med Chem. 2015;7(6):737-52. doi: 10.4155/fmc.15.31. Review.


Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis.

Morel M, Vanderstraete M, Cailliau K, Lescuyer A, Lancelot J, Dissous C.

Int J Parasitol Drugs Drug Resist. 2014 Oct 12;4(3):256-66. doi: 10.1016/j.ijpddr.2014.09.004. eCollection 2014 Dec.


Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy.

Morel M, Vanderstraete M, Hahnel S, Grevelding CG, Dissous C.

Front Genet. 2014 Jul 18;5:238. doi: 10.3389/fgene.2014.00238. eCollection 2014. Review.


Gonad RNA-specific qRT-PCR analyses identify genes with potential functions in schistosome reproduction such as SmFz1 and SmFGFRs.

Hahnel S, Quack T, Parker-Manuel SJ, Lu Z, Vanderstraete M, Morel M, Dissous C, Cailliau K, Grevelding CG.

Front Genet. 2014 Jun 10;5:170. doi: 10.3389/fgene.2014.00170. eCollection 2014.


Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects.

Buro C, Beckmann S, Oliveira KC, Dissous C, Cailliau K, Marhöfer RJ, Selzer PM, Verjovski-Almeida S, Grevelding CG.

PLoS Negl Trop Dis. 2014 Jun 12;8(6):e2923. doi: 10.1371/journal.pntd.0002923. eCollection 2014 Jun.


Targeting Echinococcus multilocularis stem cells by inhibition of the Polo-like kinase EmPlk1.

Schubert A, Koziol U, Cailliau K, Vanderstraete M, Dissous C, Brehm K.

PLoS Negl Trop Dis. 2014 Jun 5;8(6):e2870. doi: 10.1371/journal.pntd.0002870. eCollection 2014 Jun.


Venus kinase receptors control reproduction in the platyhelminth parasite Schistosoma mansoni.

Vanderstraete M, Gouignard N, Cailliau K, Morel M, Hahnel S, Leutner S, Beckmann S, Grevelding CG, Dissous C.

PLoS Pathog. 2014 May 29;10(5):e1004138. doi: 10.1371/journal.ppat.1004138. eCollection 2014 May. Erratum in: PLoS Pathog. 2016 Jul;12(7):e1005798.


Venus kinase receptors: prospects in signaling and biological functions of these invertebrate kinases.

Dissous C, Morel M, Vanderstraete M.

Front Endocrinol (Lausanne). 2014 May 13;5:72. doi: 10.3389/fendo.2014.00072. eCollection 2014. Review.


Mediation of T-helper 17 responses to schistosomes by dendritic cells but not basophils.

Sharma M, Lecerf M, Friboulet A, Kaveri SV, Dissous C, Bayry J.

J Infect Dis. 2014 Jun 15;209(12):2019-21. doi: 10.1093/infdis/jiu025. Epub 2014 Jan 12. No abstract available.


Transcriptome analyses of inhibitor-treated schistosome females provide evidence for cooperating Src-kinase and TGFβ receptor pathways controlling mitosis and eggshell formation.

Buro C, Oliveira KC, Lu Z, Leutner S, Beckmann S, Dissous C, Cailliau K, Verjovski-Almeida S, Grevelding CG.

PLoS Pathog. 2013;9(6):e1003448. doi: 10.1371/journal.ppat.1003448. Epub 2013 Jun 13.


The venus kinase receptor (VKR) family: structure and evolution.

Vanderstraete M, Gouignard N, Ahier A, Morel M, Vicogne J, Dissous C.

BMC Genomics. 2013 May 30;14:361. doi: 10.1186/1471-2164-14-361.


Dual targeting of insulin and venus kinase Receptors of Schistosoma mansoni for novel anti-schistosome therapy.

Vanderstraete M, Gouignard N, Cailliau K, Morel M, Lancelot J, Bodart JF, Dissous C.

PLoS Negl Trop Dis. 2013 May 16;7(5):e2226. doi: 10.1371/journal.pntd.0002226. Print 2013.


Discovery of platyhelminth-specific α/β-integrin families and evidence for their role in reproduction in Schistosoma mansoni.

Beckmann S, Quack T, Dissous C, Cailliau K, Lang G, Grevelding CG.

PLoS One. 2012;7(12):e52519. doi: 10.1371/journal.pone.0052519. Epub 2012 Dec 27.


SmSak, the second Polo-like kinase of the helminth parasite Schistosoma mansoni: conserved and unexpected roles in meiosis.

Long T, Vanderstraete M, Cailliau K, Morel M, Lescuyer A, Gouignard N, Grevelding CG, Browaeys E, Dissous C.

PLoS One. 2012;7(6):e40045. doi: 10.1371/journal.pone.0040045. Epub 2012 Jun 29.


Protein kinases as potential targets for novel anti-schistosomal strategies.

Beckmann S, Leutner S, Gouignard N, Dissous C, Grevelding CG.

Curr Pharm Des. 2012;18(24):3579-94. Review.


Characterization of the Src/Abl hybrid kinase SmTK6 of Schistosoma mansoni.

Beckmann S, Hahnel S, Cailliau K, Vanderstraete M, Browaeys E, Dissous C, Grevelding CG.

J Biol Chem. 2011 Dec 9;286(49):42325-36. doi: 10.1074/jbc.M110.210336. Epub 2011 Oct 19.


Schistosoma mansoni Polo-like kinases and their function in control of mitosis and parasite reproduction.

Dissous C, Grevelding CG, Long T.

An Acad Bras Cienc. 2011 Jun;83(2):627-35.


Schistosoma mansoni: structural and biochemical characterization of two distinct Venus Kinase Receptors.

Gouignard N, Vanderstraete M, Cailliau K, Lescuyer A, Browaeys E, Dissous C.

Exp Parasitol. 2012 Sep;132(1):32-9. doi: 10.1016/j.exppara.2011.05.007. Epub 2011 May 15.


Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?

Dissous C, Grevelding CG.

Trends Parasitol. 2011 Feb;27(2):59-66. doi: 10.1016/ Epub 2010 Oct 1.


Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni.

Baeza Garcia A, Pierce RJ, Gourbal B, Werkmeister E, Colinet D, Reichhart JM, Dissous C, Coustau C.

PLoS Pathog. 2010 Sep 23;6(9):e1001115. doi: 10.1371/journal.ppat.1001115.


Schistosoma mansoni Polo-like kinase 1: A mitotic kinase with key functions in parasite reproduction.

Long T, Cailliau K, Beckmann S, Browaeys E, Trolet J, Grevelding CG, Dissous C.

Int J Parasitol. 2010 Aug 1;40(9):1075-86. doi: 10.1016/j.ijpara.2010.03.002. Epub 2010 Mar 27.


The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis.

Beckmann S, Buro C, Dissous C, Hirzmann J, Grevelding CG.

PLoS Pathog. 2010 Feb 12;6(2):e1000769. doi: 10.1371/journal.ppat.1000769.


Schistosoma mansoni: signal transduction processes during the development of the reproductive organs.

Beckmann S, Quack T, Burmeister C, Buro C, Long T, Dissous C, Grevelding CG.

Parasitology. 2010 Mar;137(3):497-520. doi: 10.1017/S0031182010000053. Epub 2010 Feb 18. Review.


The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni.

Quack T, Knobloch J, Beckmann S, Vicogne J, Dissous C, Grevelding CG.

PLoS One. 2009 Sep 10;4(9):e6998. doi: 10.1371/journal.pone.0006998.


Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.

Dubois F, Caby S, Oger F, Cosseau C, Capron M, Grunau C, Dissous C, Pierce RJ.

Mol Biochem Parasitol. 2009 Nov;168(1):7-15. doi: 10.1016/j.molbiopara.2009.06.001. Epub 2009 Jun 16.


A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids.

Ahier A, Rondard P, Gouignard N, Khayath N, Huang S, Trolet J, Donoghue DJ, Gauthier M, Pin JP, Dissous C.

PLoS One. 2009 May 21;4(5):e5651. doi: 10.1371/journal.pone.0005651.


Characterization of the mannose 6-phosphate receptor (Mr 300 kDa) protein dependent pathway of lysosomal enzyme targeting in Biomphalaria glabrata mollusc cells.

Amancha PK, Dissous C, Nadimpalli SK.

Biochimie. 2009 Aug;91(8):982-8. doi: 10.1016/j.biochi.2009.05.001. Epub 2009 May 13.


Insulin receptors and glucose uptake in the human parasite Schistosoma mansoni.

Ahier A, Khayath N, Vicogne J, Dissous C.

Parasite. 2008 Dec;15(4):573-9.


[A new promising drug against schistosomiasis].

Dissous C, Ahier A, Long T.

Med Sci (Paris). 2009 Jan;25(1):24-6. doi: 10.1051/medsci/200925124. French. No abstract available.


Crystallization and X-ray analysis of the Schistosoma mansoni guanidino kinase.

Awama AM, Paracuellos P, Laurent S, Dissous C, Marcillat O, Gouet P.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):854-7. doi: 10.1107/S1744309108025979. Epub 2008 Aug 20.


Protein tyrosine kinases as new potential targets against human schistosomiasis.

Dissous C, Ahier A, Khayath N.

Bioessays. 2007 Dec;29(12):1281-8. Review.


Molecular cloning and characterisation of SmSLK, a novel Ste20-like kinase in Schistosoma mansoni.

Yan Y, Tulasne D, Browaeys E, Cailliau K, Khayath N, Pierce RJ, Trolet J, Fafeur V, Ben Younes A, Dissous C.

Int J Parasitol. 2007 Dec;37(14):1539-50. Epub 2007 Jun 21.


Molecular analysis of SmFes, a tyrosine kinase of Schistosoma mansoni orthologous to the members of the Fes/Fps/Fer family.

Ludolf F, Bahia D, Andrade LF, Cousin A, Capron M, Dissous C, Pierce RJ, Oliveira G.

Biochem Biophys Res Commun. 2007 Aug 17;360(1):163-72. Epub 2007 Jun 14.


Schistosoma mansoni: expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration.

Bahia D, Mortara RA, Kusel JR, Andrade LF, Ludolf F, Kuser PR, Avelar L, Trolet J, Dissous C, Pierce RJ, Oliveira G.

Exp Parasitol. 2007 Jul;116(3):225-32. Epub 2007 Jan 25.


Diversification of the insulin receptor family in the helminth parasite Schistosoma mansoni.

Khayath N, Vicogne J, Ahier A, BenYounes A, Konrad C, Trolet J, Viscogliosi E, Brehm K, Dissous C.

FEBS J. 2007 Feb;274(3):659-76. Epub 2006 Dec 20.


Host glucose metabolism mediates T4 and IL-7 action on Schistosoma mansoni development.

Saule P, Vicogne J, Delacre M, Macia L, Tailleux A, Dissous C, Auriault C, Wolowczuk I.

J Parasitol. 2005 Aug;91(4):737-44.


Snail control strategies for reduction of schistosomiasis transmission.

Lardans V, Dissous C.

Parasitol Today. 1998 Oct;14(10):413-7.


A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite.

Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH.

J Biol Chem. 2006 Dec 22;281(51):39316-29. Epub 2006 Oct 6.


SmPKC1, a new protein kinase C identified in the platyhelminth parasite Schistosoma mansoni.

Bahia D, Avelar L, Mortara RA, Khayath N, Yan Y, Noël C, Capron M, Dissous C, Pierce RJ, Oliveira G.

Biochem Biophys Res Commun. 2006 Jul 7;345(3):1138-48. Epub 2006 May 12.


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