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Items: 1 to 50 of 131

1.

Methods to identify and optimize small molecules interacting with RNA (SMIRNAs).

Ursu A, Vézina-Dawod S, Disney MD.

Drug Discov Today. 2019 Jul 26. pii: S1359-6446(19)30208-9. doi: 10.1016/j.drudis.2019.06.019. [Epub ahead of print] Review.

PMID:
31356880
2.

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology.

Chen JL, Moss WN, Spencer A, Zhang P, Childs-Disney JL, Disney MD.

PLoS One. 2019 Jul 10;14(7):e0219210. doi: 10.1371/journal.pone.0219210. eCollection 2019.

3.

Identifying and validating small molecules interacting with RNA (SMIRNAs).

Disney MD, Velagapudi SP, Li Y, Costales MG, Childs-Disney JL.

Methods Enzymol. 2019;623:45-66. doi: 10.1016/bs.mie.2019.04.027. Epub 2019 May 15.

PMID:
31239057
4.

RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression.

O'Leary CA, Andrews RJ, Tompkins VS, Chen JL, Childs-Disney JL, Disney MD, Moss WN.

PLoS One. 2019 Jun 17;14(6):e0213758. doi: 10.1371/journal.pone.0213758. eCollection 2019.

5.

Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA.

Costales MG, Suresh B, Vishnu K, Disney MD.

Cell Chem Biol. 2019 Aug 15;26(8):1180-1186.e5. doi: 10.1016/j.chembiol.2019.04.008. Epub 2019 May 23.

PMID:
31130520
6.

Adding Broccoli to the Biosensor Menu.

Costales MG, Disney MD.

Cell Chem Biol. 2019 Apr 18;26(4):463-465. doi: 10.1016/j.chembiol.2019.04.004.

PMID:
31002799
7.

A cross-linking approach to map small molecule-RNA binding sites in cells.

Velagapudi SP, Li Y, Disney MD.

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1532-1536. doi: 10.1016/j.bmcl.2019.04.001. Epub 2019 Apr 2.

PMID:
30987892
8.

Small molecule targeting of RNA structures in neurological disorders.

Angelbello AJ, Chen JL, Disney MD.

Ann N Y Acad Sci. 2019 Apr 9. doi: 10.1111/nyas.14051. [Epub ahead of print] Review.

PMID:
30964958
9.

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model.

Angelbello AJ, Rzuczek SG, Mckee KK, Chen JL, Olafson H, Cameron MD, Moss WN, Wang ET, Disney MD.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7799-7804. doi: 10.1073/pnas.1901484116. Epub 2019 Mar 29.

10.

Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine.

Disney MD.

J Am Chem Soc. 2019 May 1;141(17):6776-6790. doi: 10.1021/jacs.8b13419. Epub 2019 Apr 19.

PMID:
30896935
11.

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy.

Chew J, Cook C, Gendron TF, Jansen-West K, Del Rosso G, Daughrity LM, Castanedes-Casey M, Kurti A, Stankowski JN, Disney MD, Rothstein JD, Dickson DW, Fryer JD, Zhang YJ, Petrucelli L.

Mol Neurodegener. 2019 Feb 15;14(1):9. doi: 10.1186/s13024-019-0310-z.

12.

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin.

Costales MG, Hoch DG, Abegg D, Childs-Disney JL, Velagapudi SP, Adibekian A, Disney MD.

J Am Chem Soc. 2019 Feb 20;141(7):2960-2974. doi: 10.1021/jacs.8b10558. Epub 2019 Feb 6.

PMID:
30726072
13.

A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence.

Childs-Disney JL, Tran T, Vummidi BR, Velagapudi SP, Haniff HS, Matsumoto Y, Crynen G, Southern MR, Biswas A, Wang ZF, Tellinghuisen TL, Disney MD.

Chem. 2018 Oct 11;4(10):2384-2404. doi: 10.1016/j.chempr.2018.08.003. Epub 2018 Sep 13.

PMID:
30719503
14.

Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism.

Wales DJ, Disney MD, Yildirim I.

J Phys Chem B. 2019 Jan 10;123(1):57-65. doi: 10.1021/acs.jpcb.8b09139. Epub 2019 Jan 2.

PMID:
30517788
15.

The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.

Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD.

Cell Chem Biol. 2019 Feb 21;26(2):179-190.e12. doi: 10.1016/j.chembiol.2018.10.018. Epub 2018 Nov 29.

PMID:
30503283
16.

Introduction to the Symposium In Print for Laura Kiessling.

Disney MD.

Bioorg Med Chem. 2018 Oct 15;26(19):iii. doi: 10.1016/j.bmc.2018.10.021. No abstract available.

PMID:
30420097
17.

Drugging the RNA World.

Disney MD, Dwyer BG, Childs-Disney JL.

Cold Spring Harb Perspect Biol. 2018 Nov 1;10(11). pii: a034769. doi: 10.1101/cshperspect.a034769. Review.

PMID:
30385607
18.

Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype.

Li Y, Disney MD.

ACS Chem Biol. 2018 Nov 16;13(11):3065-3071. doi: 10.1021/acschembio.8b00827. Epub 2018 Oct 30.

PMID:
30375843
19.

Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.

Velagapudi SP, Costales MG, Vummidi BR, Nakai Y, Angelbello AJ, Tran T, Haniff HS, Matsumoto Y, Wang ZF, Chatterjee AK, Childs-Disney JL, Disney MD.

Cell Chem Biol. 2018 Sep 20;25(9):1086-1094.e7. doi: 10.1016/j.chembiol.2018.05.015. Epub 2018 Jun 28.

PMID:
30251629
20.

Introduction.

Disney MD, Janda KD.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2661-2662. doi: 10.1016/j.bmcl.2018.07.013. Epub 2018 Jul 10. No abstract available.

PMID:
30029841
21.

Selective Small Molecule Recognition of RNA Base Pairs.

Haniff HS, Graves A, Disney MD.

ACS Comb Sci. 2018 Aug 13;20(8):482-491. doi: 10.1021/acscombsci.8b00049. Epub 2018 Jul 31.

22.

Small Molecule Targeted Recruitment of a Nuclease to RNA.

Costales MG, Matsumoto Y, Velagapudi SP, Disney MD.

J Am Chem Soc. 2018 Jun 6;140(22):6741-6744. doi: 10.1021/jacs.8b01233. Epub 2018 May 24.

23.

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.

Angelbello AJ, Chen JL, Childs-Disney JL, Zhang P, Wang ZF, Disney MD.

Chem Rev. 2018 Feb 28;118(4):1599-1663. doi: 10.1021/acs.chemrev.7b00504. Epub 2018 Jan 11. Review.

24.

Bleomycin Can Cleave an Oncogenic Noncoding RNA.

Angelbello AJ, Disney MD.

Chembiochem. 2018 Jan 4;19(1):43-47. doi: 10.1002/cbic.201700581. Epub 2017 Nov 22.

25.

Small molecule alteration of RNA sequence in cells and animals.

Guan L, Luo Y, Ja WW, Disney MD.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2794-2796. doi: 10.1016/j.bmcl.2017.10.034. Epub 2017 Oct 18.

PMID:
29079470
26.

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.

Chen JL, VanEtten DM, Fountain MA, Yildirim I, Disney MD.

Biochemistry. 2017 Jul 11;56(27):3463-3474. doi: 10.1021/acs.biochem.7b00252. Epub 2017 Jun 29.

27.

Inhibiting Translation One Protein at a Time.

Disney MD.

Trends Biochem Sci. 2017 Jun;42(6):412-413. doi: 10.1016/j.tibs.2017.04.008. Epub 2017 May 15.

PMID:
28522328
28.

Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA.

Velagapudi SP, Luo Y, Tran T, Haniff HS, Nakai Y, Fallahi M, Martinez GJ, Childs-Disney JL, Disney MD.

ACS Cent Sci. 2017 Mar 22;3(3):205-216. doi: 10.1021/acscentsci.7b00009. Epub 2017 Mar 6.

29.

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.

Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, Tabassian LJ, Lee CW, Yue M, Tong J, Song Y, Castanedes-Casey M, Rousseau L, Phillips V, Dickson DW, Rademakers R, Fryer JD, Rush BK, Pedraza O, Caputo AM, Desaro P, Palmucci C, Robertson A, Heckman MG, Diehl NN, Wiggs E, Tierney M, Braun L, Farren J, Lacomis D, Ladha S, Fournier CN, McCluskey LF, Elman LB, Toledo JB, McBride JD, Tiloca C, Morelli C, Poletti B, Solca F, Prelle A, Wuu J, Jockel-Balsarotti J, Rigo F, Ambrose C, Datta A, Yang W, Raitcheva D, Antognetti G, McCampbell A, Van Swieten JC, Miller BL, Boxer AL, Brown RH, Bowser R, Miller TM, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Traynor BJ, Disney MD, Benatar M, Silani V, Glass JD, Floeter MK, Rothstein JD, Boylan KB, Petrucelli L.

Sci Transl Med. 2017 Mar 29;9(383). pii: eaai7866. doi: 10.1126/scitranslmed.aai7866.

30.

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

Costales MG, Haga CL, Velagapudi SP, Childs-Disney JL, Phinney DG, Disney MD.

J Am Chem Soc. 2017 Mar 8;139(9):3446-3455. doi: 10.1021/jacs.6b11273. Epub 2017 Feb 27.

31.

Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence.

Disney MD, Angelbello AJ.

Acc Chem Res. 2016 Dec 20;49(12):2698-2704. Epub 2016 Nov 22.

32.

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

Rzuczek SG, Colgan LA, Nakai Y, Cameron MD, Furling D, Yasuda R, Disney MD.

Nat Chem Biol. 2017 Feb;13(2):188-193. doi: 10.1038/nchembio.2251. Epub 2016 Dec 12.

33.

Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods.

Haga CL, Velagapudi SP, Childs-Disney JL, Strivelli J, Disney MD, Phinney DG.

Methods Mol Biol. 2017;1517:179-198.

PMID:
27924483
34.

Development of pharmacophore models for small molecules targeting RNA: Application to the RNA repeat expansion in myotonic dystrophy type 1.

Angelbello AJ, González ÀL, Rzuczek SG, Disney MD.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5792-5796. doi: 10.1016/j.bmcl.2016.10.037. Epub 2016 Oct 13.

35.

Controlled dehydration improves the diffraction quality of two RNA crystals.

Park H, Tran T, Lee JH, Park H, Disney MD.

BMC Struct Biol. 2016 Nov 3;16(1):19.

36.

Corrigendum: A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor.

Rzuczek SG, Park H, Disney MD.

Angew Chem Int Ed Engl. 2016 Aug 16;55(34):9817. doi: 10.1002/anie.201605756. No abstract available.

PMID:
27503420
37.

Chemistry and Chemical Biology of Therapeutically Important Compounds.

Disney MD.

Bioorg Med Chem. 2016 Sep 1;24(17):3875. doi: 10.1016/j.bmc.2016.06.049. Epub 2016 Jun 27. No abstract available.

PMID:
27460698
38.

Small Molecule Recognition and Tools to Study Modulation of r(CGG)(exp) in Fragile X-Associated Tremor Ataxia Syndrome.

Yang WY, He F, Strack RL, Oh SY, Frazer M, Jaffrey SR, Todd PK, Disney MD.

ACS Chem Biol. 2016 Sep 16;11(9):2456-65. doi: 10.1021/acschembio.6b00147. Epub 2016 Jul 11.

39.

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10.

Yang WY, Gao R, Southern M, Sarkar PS, Disney MD.

Nat Commun. 2016 Jun 1;7:11647. doi: 10.1038/ncomms11647.

40.

Design of a small molecule against an oncogenic noncoding RNA.

Velagapudi SP, Cameron MD, Haga CL, Rosenberg LH, Lafitte M, Duckett DR, Phinney DG, Disney MD.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):5898-903. doi: 10.1073/pnas.1523975113. Epub 2016 May 11.

41.

Comparison of small molecules and oligonucleotides that target a toxic, non-coding RNA.

Costales MG, Rzuczek SG, Disney MD.

Bioorg Med Chem Lett. 2016 Jun 1;26(11):2605-9. doi: 10.1016/j.bmcl.2016.04.025. Epub 2016 Apr 11.

PMID:
27117425
42.

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs.

Disney MD, Winkelsas AM, Velagapudi SP, Southern M, Fallahi M, Childs-Disney JL.

ACS Chem Biol. 2016 Jun 17;11(6):1720-8. doi: 10.1021/acschembio.6b00001. Epub 2016 Apr 20.

43.

Analysis of secondary structural elements in human microRNA hairpin precursors.

Liu B, Childs-Disney JL, Znosko BM, Wang D, Fallahi M, Gallo SM, Disney MD.

BMC Bioinformatics. 2016 Mar 1;17:112. doi: 10.1186/s12859-016-0960-6.

44.

Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma.

Childs-Disney JL, Disney MD.

ACS Chem Biol. 2016 Feb 19;11(2):375-80. doi: 10.1021/acschembio.5b00615. Epub 2015 Dec 7.

45.

Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.

Childs-Disney JL, Disney MD.

Annu Rev Pharmacol Toxicol. 2016;56:123-40. doi: 10.1146/annurev-pharmtox-010715-103910. Epub 2015 Oct 22. Review.

46.

Computational investigation of RNA CUG repeats responsible for myotonic dystrophy 1.

Yildirim I, Chakraborty D, Disney MD, Wales DJ, Schatz GC.

J Chem Theory Comput. 2015 Oct 13;11(10):4943-58. doi: 10.1021/acs.jctc.5b00728.

47.

Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy.

Rzuczek SG, Southern MR, Disney MD.

ACS Chem Biol. 2015 Dec 18;10(12):2706-15. doi: 10.1021/acschembio.5b00430. Epub 2015 Sep 28.

48.

Preface.

Garbaccio RM, Johnson DS, Hong J, Disney MD.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4714. doi: 10.1016/j.bmcl.2015.08.083. Epub 2015 Sep 1. No abstract available.

PMID:
26358161
49.

Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling.

Haga CL, Velagapudi SP, Strivelli JR, Yang WY, Disney MD, Phinney DG.

ACS Chem Biol. 2015 Oct 16;10(10):2267-76. doi: 10.1021/acschembio.5b00265. Epub 2015 Jul 30.

50.

RNA Structures as Mediators of Neurological Diseases and as Drug Targets.

Bernat V, Disney MD.

Neuron. 2015 Jul 1;87(1):28-46. doi: 10.1016/j.neuron.2015.06.012. Review.

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