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Macrophages eat more after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα.

Hayes BH, Tsai RK, Dooling LJ, Kadu S, Lee JY, Pantano D, Rodriguez PL, Subramanian S, Shin JW, Discher DE.

J Cell Sci. 2020 Jan 21. pii: jcs.237800. doi: 10.1242/jcs.237800. [Epub ahead of print]


Mesenchymal stem cell perspective: cell biology to clinical progress.

Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI.

NPJ Regen Med. 2019 Dec 2;4:22. doi: 10.1038/s41536-019-0083-6. eCollection 2019. Review.


Forced Unfolding of Proteins Directs Biochemical Cascades.

Saini K, Discher DE.

Biochemistry. 2019 Dec 10;58(49):4893-4902. doi: 10.1021/acs.biochem.9b00839. Epub 2019 Nov 25.


Nuclear mechanosensing.

Xia Y, Pfeifer CR, Cho S, Discher DE, Irianto J.

Emerg Top Life Sci. 2018 Dec;2(5):713-725. doi: 10.1042/ETLS20180051. Epub 2018 Dec 21.


Nuclear Mechanics and Cancer Cell Migration.

Pfeifer CR, Irianto J, Discher DE.

Adv Exp Med Biol. 2019;1146:117-130. doi: 10.1007/978-3-030-17593-1_8.


The macrophage checkpoint CD47 : SIRPα for recognition of 'self' cells: from clinical trials of blocking antibodies to mechanobiological fundamentals.

Andrechak JC, Dooling LJ, Discher DE.

Philos Trans R Soc Lond B Biol Sci. 2019 Aug 19;374(1779):20180217. doi: 10.1098/rstb.2018.0217. Epub 2019 Jul 1.


Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: a brief review.

Pfeifer CR, Vashisth M, Xia Y, Discher DE.

Essays Biochem. 2019 Oct 31;63(5):569-577. doi: 10.1042/EBC20190007.


Pulling the Roof Down on Anchored Nuclei.

Pfeifer CR, Discher DE.

Dev Cell. 2019 Jul 22;50(2):130-131. doi: 10.1016/j.devcel.2019.07.003.


From DNA damage to epithelial integrity: new roles for cell forces.

Discher DE.

Mol Biol Cell. 2019 Jul 22;30(16):1879-1881. doi: 10.1091/mbc.E19-06-0338. No abstract available.


Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle.

Xia Y, Pfeifer CR, Zhu K, Irianto J, Liu D, Pannell K, Chen EJ, Dooling LJ, Tobin MP, Wang M, Ivanovska IL, Smith LR, Greenberg RA, Discher DE.

J Cell Biol. 2019 Aug 5;218(8):2545-2563. doi: 10.1083/jcb.201811100. Epub 2019 Jun 25.


Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for 'use it or lose it'.

Saini K, Cho S, Dooling LJ, Discher DE.

Matrix Biol. 2019 Jun 12. pii: S0945-053X(19)30047-2. doi: 10.1016/j.matbio.2019.06.001. [Epub ahead of print] Review.


Constricted migration modulates stem cell differentiation.

Smith LR, Irianto J, Xia Y, Pfeifer CR, Discher DE.

Mol Biol Cell. 2019 Jul 22;30(16):1985-1999. doi: 10.1091/mbc.E19-02-0090. Epub 2019 Jun 12.


Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.

Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE.

Dev Cell. 2019 Jun 17;49(6):920-935.e5. doi: 10.1016/j.devcel.2019.04.020. Epub 2019 May 16.


Rationally engineered advances in cancer research.

Engler AJ, Discher DE.

APL Bioeng. 2018 Sep 26;2(3):031601. doi: 10.1063/1.5056176. eCollection 2018 Sep.


Inhibiting Tumor Fibrosis and Actomyosin through GPCR activation.

Dooling LJ, Discher DE.

Trends Cancer. 2019 Apr;5(4):197-199. doi: 10.1016/j.trecan.2019.02.005. Epub 2019 Feb 23.


Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure.

Xia Y, Cho S, Vashisth M, Ivanovska IL, Dingal PCDP, Discher DE.

Methods. 2019 Mar 15;157:3-14. doi: 10.1016/j.ymeth.2018.12.009. Epub 2018 Dec 26.


Erratum: Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients [Phys. Rev. Lett. 118, 078103 (2017)].

Novikova EA, Raab M, Discher DE, Storm C.

Phys Rev Lett. 2018 Oct 12;121(15):159901. doi: 10.1103/PhysRevLett.121.159901.


Biomembrane Adhesion to Substrates Topographically Patterned with Nanopits.

Agudo-Canalejo J, Discher DE.

Biophys J. 2018 Oct 2;115(7):1292-1306. doi: 10.1016/j.bpj.2018.08.006. Epub 2018 Aug 16.


Nuclear rupture at sites of high curvature compromises retention of DNA repair factors.

Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE.

J Cell Biol. 2018 Nov 5;217(11):3796-3808. doi: 10.1083/jcb.201711161. Epub 2018 Aug 31.


Membrane fluctuations and acidosis regulate cooperative binding of 'marker of self' protein CD47 with the macrophage checkpoint receptor SIRPα.

Steinkühler J, Różycki B, Alvey C, Lipowsky R, Weikl TR, Dimova R, Discher DE.

J Cell Sci. 2018 Jul 16;132(4). pii: jcs216770. doi: 10.1242/jcs.216770.


Glassy worm-like micelles in solvent and shear mediated shape transitions.

Chakraborty K, Vijayan K, Brown AEX, Discher DE, Loverde SM.

Soft Matter. 2018 May 23;14(20):4194-4203. doi: 10.1039/c8sm00080h.


Constricted migration increases DNA damage and independently represses cell cycle.

Pfeifer CR, Xia Y, Zhu K, Liu D, Irianto J, García VMM, Millán LMS, Niese B, Harding S, Deviri D, Greenberg RA, Discher DE.

Mol Biol Cell. 2018 Aug 8;29(16):1948-1962. doi: 10.1091/mbc.E18-02-0079. Epub 2018 May 9.


Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells.

Cho S, Abbas A, Irianto J, Ivanovska IL, Xia Y, Tewari M, Discher DE.

Nucleus. 2018 Jan 1;9(1):230-245. doi: 10.1080/19491034.2018.1460185.


Filomicelles Deliver a Chemo-Differentiation Combination of Paclitaxel and Retinoic Acid That Durably Represses Carcinomas in Liver to Prolong Survival.

Nair PR, Alvey C, Jin X, Irianto J, Ivanovska I, Discher DE.

Bioconjug Chem. 2018 Apr 18;29(4):914-927. doi: 10.1021/acs.bioconjchem.7b00816. Epub 2018 Mar 1.


Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics.

Smith LR, Cho S, Discher DE.

Physiology (Bethesda). 2018 Jan 1;33(1):16-25. doi: 10.1152/physiol.00026.2017. Review.


Genome variation across cancers scales with tissue stiffness - an invasion-mutation mechanism and implications for immune cell infiltration.

Pfeifer CR, Alvey CM, Irianto J, Discher DE.

Curr Opin Syst Biol. 2017 Apr;2:103-114. doi: 10.1016/j.coisb.2017.04.005. Epub 2017 Apr 27.


Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes.

Buxboim A, Irianto J, Swift J, Athirasala A, Shin JW, Rehfeldt F, Discher DE.

Mol Biol Cell. 2017 Nov 7;28(23):3333-3348. doi: 10.1091/mbc.E17-06-0393. Epub 2017 Sep 20.


Rupture Dynamics and Chromatin Herniation in Deformed Nuclei.

Deviri D, Discher DE, Safran SA.

Biophys J. 2017 Sep 5;113(5):1060-1071. doi: 10.1016/j.bpj.2017.07.014.


Optimal Contractile Forces for a Mesenchymal Engine.

Discher DE, Dooling LJ.

Dev Cell. 2017 Aug 21;42(4):313-315. doi: 10.1016/j.devcel.2017.08.005.


Mitotic progression following DNA damage enables pattern recognition within micronuclei.

Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA.

Nature. 2017 Aug 24;548(7668):466-470. doi: 10.1038/nature23470. Epub 2017 Jul 31.


SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors.

Alvey CM, Spinler KR, Irianto J, Pfeifer CR, Hayes B, Xia Y, Cho S, Dingal PCPD, Hsu J, Smith L, Tewari M, Discher DE.

Curr Biol. 2017 Jul 24;27(14):2065-2077.e6. doi: 10.1016/j.cub.2017.06.005. Epub 2017 Jun 29.


Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration.

Bennett RR, Pfeifer CR, Irianto J, Xia Y, Discher DE, Liu AJ.

Biophys J. 2017 Jun 6;112(11):2271-2279. doi: 10.1016/j.bpj.2017.04.037.


Mechanosensing of matrix by stem cells: From matrix heterogeneity, contractility, and the nucleus in pore-migration to cardiogenesis and muscle stem cells in vivo.

Smith L, Cho S, Discher DE.

Semin Cell Dev Biol. 2017 Nov;71:84-98. doi: 10.1016/j.semcdb.2017.05.025. Epub 2017 Jun 3. Review.


Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation.

Ivanovska IL, Swift J, Spinler K, Dingal D, Cho S, Discher DE.

Mol Biol Cell. 2017 Jul 7;28(14):2010-2022. doi: 10.1091/mbc.E17-01-0010. Epub 2017 May 31.


Spray stability of self-assembled filaments for delivery.

Mahmud A, Harada T, Rajagopal K, Christian DA, Nair P, Murphy R, Discher DE.

J Control Release. 2017 Oct 10;263:162-171. doi: 10.1016/j.jconrel.2017.05.026. Epub 2017 May 24.


Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer.

Discher DE, Smith L, Cho S, Colasurdo M, García AJ, Safran S.

Annu Rev Biophys. 2017 May 22;46:295-315. doi: 10.1146/annurev-biophys-062215-011206. Review.


Engineering macrophages to eat cancer: from "marker of self" CD47 and phagocytosis to differentiation.

Alvey C, Discher DE.

J Leukoc Biol. 2017 Jul;102(1):31-40. doi: 10.1189/jlb.4RI1216-516R. Epub 2017 May 18. Review.


Mechanotransduction in cancer.

Chin L, Xia Y, Discher DE, Janmey PA.

Curr Opin Chem Eng. 2016 Feb;11:77-84. doi: 10.1016/j.coche.2016.01.011. Epub 2016 Feb 16.


As a Nucleus Enters a Small Pore, Chromatin Stretches and Maintains Integrity, Even with DNA Breaks.

Irianto J, Xia Y, Pfeifer CR, Greenberg RA, Discher DE.

Biophys J. 2017 Feb 7;112(3):446-449. doi: 10.1016/j.bpj.2016.09.047. Epub 2016 Oct 27.


Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients.

Novikova EA, Raab M, Discher DE, Storm C.

Phys Rev Lett. 2017 Feb 17;118(7):078103. doi: 10.1103/PhysRevLett.118.078103. Epub 2017 Feb 16. Erratum in: Phys Rev Lett. 2018 Oct 12;121(15):159901.


"Marker of Self" CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors.

Sosale NG, Ivanovska II, Tsai RK, Swift J, Hsu JW, Alvey CM, Zoltick PW, Discher DE.

Mol Ther Methods Clin Dev. 2016 Dec 7;3:16080. doi: 10.1038/mtm.2016.80. eCollection 2016.


Mechanosensing by the nucleus: From pathways to scaling relationships.

Cho S, Irianto J, Discher DE.

J Cell Biol. 2017 Feb;216(2):305-315. doi: 10.1083/jcb.201610042. Epub 2017 Jan 2. Review.


DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration.

Irianto J, Xia Y, Pfeifer CR, Athirasala A, Ji J, Alvey C, Tewari M, Bennett RR, Harding SM, Liu AJ, Greenberg RA, Discher DE.

Curr Biol. 2017 Jan 23;27(2):210-223. doi: 10.1016/j.cub.2016.11.049. Epub 2016 Dec 15.


Matrix rigidity regulates microtubule network polarization in migration.

Raab M, Discher DE.

Cytoskeleton (Hoboken). 2017 Mar;74(3):114-124. doi: 10.1002/cm.21349. Epub 2017 Jan 31.


Nuclear constriction segregates mobile nuclear proteins away from chromatin.

Irianto J, Pfeifer CR, Bennett RR, Xia Y, Ivanovska IL, Liu AJ, Greenberg RA, Discher DE.

Mol Biol Cell. 2016 Dec 15;27(25):4011-4020. Epub 2016 Oct 26.


Nuclear lamins in cancer.

Irianto J, Pfeifer CR, Ivanovska IL, Swift J, Discher DE.

Cell Mol Bioeng. 2016 Jun;9(2):258-267. Epub 2016 Apr 18.


Leishmania major Infection-Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease.

Weinkopff T, Konradt C, Christian DA, Discher DE, Hunter CA, Scott P.

J Immunol. 2016 Sep 1;197(5):1823-31. doi: 10.4049/jimmunol.1600717. Epub 2016 Jul 29.


Mechanical signaling coordinates the embryonic heartbeat.

Chiou KK, Rocks JW, Chen CY, Cho S, Merkus KE, Rajaratnam A, Robison P, Tewari M, Vogel K, Majkut SF, Prosser BL, Discher DE, Liu AJ.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):8939-44. doi: 10.1073/pnas.1520428113. Epub 2016 Jul 25.


SnapShot: Mechanosensing Matrix.

Irianto J, Pfeifer CR, Xia Y, Discher DE.

Cell. 2016 Jun 16;165(7):1820-1820.e1. doi: 10.1016/j.cell.2016.06.002.


Filomicelles from aromatic diblock copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared with aliphatic copolymers.

Nair PR, Karthick SA, Spinler KR, Vakili MR, Lavasanifar A, Discher DE.

Nanomedicine (Lond). 2016 Jun;11(12):1551-69. doi: 10.2217/nnm-2016-0007. Epub 2016 May 13.

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