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Items: 46


A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.

Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D.

Nat Commun. 2019 Jan 18;10(1):329. doi: 10.1038/s41467-018-08276-6.


Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2.

Ueta CB, Campos JC, Albuquerque RPE, Lima VM, Disatnik MH, Sanchez AB, Chen CH, de Medeiros MHG, Yang W, Mochly-Rosen D, Ferreira JCB.

Cardiovasc Res. 2018 Jun 1;114(7):1006-1015. doi: 10.1093/cvr/cvy070.


Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites.

Nene A, Chen CH, Disatnik MH, Cruz L, Mochly-Rosen D.

J Biomed Sci. 2017 Jan 5;24(1):3. doi: 10.1186/s12929-016-0312-x.


Potential biomarkers to follow the progression and treatment response of Huntington's disease.

Disatnik MH, Joshi AU, Saw NL, Shamloo M, Leavitt BR, Qi X, Mochly-Rosen D.

J Exp Med. 2016 Nov 14;213(12):2655-2669. Epub 2016 Nov 7.


Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo.

Qvit N, Disatnik MH, Sho E, Mochly-Rosen D.

J Am Chem Soc. 2016 Jun 22;138(24):7626-35. doi: 10.1021/jacs.6b02724. Epub 2016 Jun 8.


Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease.

Hwang S, Disatnik MH, Mochly-Rosen D.

EMBO Mol Med. 2015 Oct;7(10):1307-26. doi: 10.15252/emmm.201505256.


Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.

Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D.

Circ Res. 2015 May 22;116(11):1783-99. doi: 10.1161/CIRCRESAHA.116.305432. Review.


New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases.

Disatnik MH, Hwang S, Ferreira JC, Mochly-Rosen D.

J Mol Med (Berl). 2015 Mar;93(3):279-87. doi: 10.1007/s00109-015-1256-4. Epub 2015 Feb 5. Review.


Protein folding creates structure-based, noncontiguous consensus phosphorylation motifs recognized by kinases.

Duarte ML, Pena DA, Nunes Ferraz FA, Berti DA, Paschoal Sobreira TJ, Costa-Junior HM, Abdel Baqui MM, Disatnik MH, Xavier-Neto J, Lopes de Oliveira PS, Schechtman D.

Sci Signal. 2014 Nov 4;7(350):ra105. doi: 10.1126/scisignal.2005412.


The challenge in translating basic research discoveries to treatment of Huntington disease.

Mochly-Rosen D, Disatnik MH, Qi X.

Rare Dis. 2014 Mar 31;2:e28637. doi: 10.4161/rdis.28637. eCollection 2014.


Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.

Gomes KM, Campos JC, Bechara LR, Queliconi B, Lima VM, Disatnik MH, Magno P, Chen CH, Brum PC, Kowaltowski AJ, Mochly-Rosen D, Ferreira JC.

Cardiovasc Res. 2014 Sep 1;103(4):498-508. doi: 10.1093/cvr/cvu125. Epub 2014 May 9.


Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X.

J Clin Invest. 2013 Dec;123(12):5371-88. doi: 10.1172/JCI70911. Epub 2013 Nov 15.


Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.

Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D.

J Am Heart Assoc. 2013 Oct 8;2(5):e000461. doi: 10.1161/JAHA.113.000461.


Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.

Ferreira JC, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D.

J Mol Cell Cardiol. 2011 Dec;51(6):980-7. doi: 10.1016/j.yjmcc.2011.08.025. Epub 2011 Sep 2.


Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.

Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D.

Mol Biol Cell. 2011 Jan 15;22(2):256-65. doi: 10.1091/mbc.E10-06-0551. Epub 2010 Nov 30.


Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.

Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D.

Cardiovasc Res. 2010 Oct 1;88(1):83-92. doi: 10.1093/cvr/cvq154. Epub 2010 Jun 16.


Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

Budas GR, Disatnik MH, Mochly-Rosen D.

Trends Cardiovasc Med. 2009 Jul;19(5):158-64. doi: 10.1016/j.tcm.2009.09.003. Review.


Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.

Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D.

J Mol Cell Cardiol. 2010 Apr;48(4):757-64. doi: 10.1016/j.yjmcc.2009.10.030. Epub 2009 Nov 11.


Ethanol for cardiac ischemia: the role of protein kinase c.

Churchill EN, Disatnik MH, Budas GR, Mochly-Rosen D.

Ther Adv Cardiovasc Dis. 2008 Dec;2(6):469-83. doi: 10.1177/1753944708094735. Review.


Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.

Churchill EN, Disatnik MH, Mochly-Rosen D.

J Mol Cell Cardiol. 2009 Feb;46(2):278-84. doi: 10.1016/j.yjmcc.2008.09.713. Epub 2008 Oct 17.


Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.

Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D.

Science. 2008 Sep 12;321(5895):1493-5. doi: 10.1126/science.1158554.


Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.

Boutet SC, Disatnik MH, Chan LS, Iori K, Rando TA.

Cell. 2007 Jul 27;130(2):349-62.


The bi-directional translocation of MARCKS between membrane and cytosol regulates integrin-mediated muscle cell spreading.

Disatnik MH, Boutet SC, Pacio W, Chan AY, Ross LB, Lee CH, Rando TA.

J Cell Sci. 2004 Sep 1;117(Pt 19):4469-79. Epub 2004 Aug 17.


Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway.

Disatnik MH, Boutet SC, Lee CH, Mochly-Rosen D, Rando TA.

J Cell Sci. 2002 May 15;115(Pt 10):2151-63.


The susceptibility of muscle cells to oxidative stress is independent of nitric oxide synthase expression.

Zhuang W, Eby JC, Cheong M, Mohapatra PK, Bredt DS, Disatnik MH, Rando TA.

Muscle Nerve. 2001 Apr;24(4):502-11.


Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides.

Rando TA, Disatnik MH, Zhou LZ.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5363-8.


Dystrophin mutations predict cellular susceptibility to oxidative stress.

Disatnik MH, Chamberlain JS, Rando TA.

Muscle Nerve. 2000 May;23(5):784-92.


Evidence of oxidative stress in mdx mouse muscle: studies of the pre-necrotic state.

Disatnik MH, Dhawan J, Yu Y, Beal MF, Whirl MM, Franco AA, Rando TA.

J Neurol Sci. 1998 Nov 26;161(1):77-84.


Dystrophic muscle in mice chimeric for expression of alpha5 integrin.

Taverna D, Disatnik MH, Rayburn H, Bronson RT, Yang J, Rando TA, Hynes RO.

J Cell Biol. 1998 Nov 2;143(3):849-59.


Muscle cells from mdx mice have an increased susceptibility to oxidative stress.

Rando TA, Disatnik MH, Yu Y, Franco A.

Neuromuscul Disord. 1998 Feb;8(1):14-21.


Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells.

Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA.

J Invest Dermatol. 1996 Aug;107(2):248-52.


The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.

Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF.

Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7824-8.


Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction.

Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D.

Biochem Soc Trans. 1995 Aug;23(3):596-600. Review. No abstract available.


Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells.

Disatnik MH, Winnier AR, Mochly-Rosen D, Arteaga CL.

Cell Growth Differ. 1994 Aug;5(8):873-80.


Developmental expression of protein kinase C subspecies in rat brain-pituitary axis.

Garcia-Navarro S, Marantz Y, Eyal R, Kalina M, Disatnik MH, Mochly-Rosen D, Ben-Menahem D, Reiss N, Naor Z.

Mol Cell Endocrinol. 1994 Jul;103(1-2):133-8.


Localization of protein kinase C isozymes in cardiac myocytes.

Disatnik MH, Buraggi G, Mochly-Rosen D.

Exp Cell Res. 1994 Feb;210(2):287-97.


Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.

Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D.

Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):559-63.


Regulation of beta-adrenoceptors by thyroid hormone and amiodarone in rat myocardiac cells in culture.

Disatnik MH, Shainberg A.

Biochem Pharmacol. 1991 Mar 15-Apr 1;41(6-7):1039-44.


Characterization of beta-adrenoceptors on rat skeletal muscle cells grown in vitro.

Disatnik MH, Sampson SR, Shainberg A.

Biochem Pharmacol. 1990 Sep 1;40(5):1043-8.


Murine macrophage heparanase: inhibition and comparison with metastatic tumor cells.

Savion N, Disatnik MH, Nevo Z.

J Cell Physiol. 1987 Jan;130(1):77-84.


Evidence for a functional role of acetylcholinesterase in cultured chick myotubes.

Sampson SR, Babila T, Disatnik MH, Shainberg A, Yoles E.

Brain Res. 1983 Dec 19;289(1-2):338-41.


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