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Items: 1 to 50 of 132

1.

Impact of natural products on the cholesterol transporter ABCA1.

Wang D, Hiebl V, Xu T, Ladurner A, Atanasov AG, Heiss EH, Dirsch VM.

J Ethnopharmacol. 2019 Dec 2:112444. doi: 10.1016/j.jep.2019.112444. [Epub ahead of print] Review.

PMID:
31805338
2.

Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease.

Linder T, Liu R, Atanasov AG, Li Y, Geyrhofer S, Schwaiger S, Stuppner H, Schnürch M, Dirsch VM, Mihovilovic MD.

Chem Sci. 2019 May 14;10(22):5815-5820. doi: 10.1039/c9sc00446g. eCollection 2019 Jun 14.

3.

Tylophorine reduces protein biosynthesis and rapidly decreases cyclin D1, inhibiting vascular smooth muscle cell proliferation in vitro and in organ culture.

Joa H, Blažević T, Grojer C, Zeller I, Heiss EH, Atanasov AG, Feldler I, Gruzdaitis P, Czaloun C, Proksch P, Messner B, Bernhard D, Dirsch VM.

Phytomedicine. 2019 Jul;60:152938. doi: 10.1016/j.phymed.2019.152938. Epub 2019 Apr 23.

PMID:
31078367
4.

Stereoselective Synthesis of the Isomers of Notoincisol A: Assigment of the Absolute Configuration of this Natural Product and Biological Evaluation.

Rycek L, Ticli V, Pyszkowski J, Latkolik S, Liu X, Atanasov AG, Steinacher T, Bauer R, Schuster D, Dirsch VM, Schnürch M, Ernst M, Mihovilovic MD.

J Nat Prod. 2018 Nov 26;81(11):2419-2428. doi: 10.1021/acs.jnatprod.8b00439. Epub 2018 Oct 26.

5.

Evaluation of Apricot, Bilberry, and Elderberry Pomace Constituents and Their Potential To Enhance the Endothelial Nitric Oxide Synthase (eNOS) Activity.

Waldbauer K, Seiringer G, Sykora C, Dirsch VM, Zehl M, Kopp B.

ACS Omega. 2018 Sep 30;3(9):10545-10553. doi: 10.1021/acsomega.8b00638. Epub 2018 Sep 5.

6.

Magnolol dimer-derived fragments as PPARγ-selective probes.

Dreier D, Resetar M, Temml V, Rycek L, Kratena N, Schnürch M, Schuster D, Dirsch VM, Mihovilovic MD.

Org Biomol Chem. 2018 Oct 3;16(38):7019-7028. doi: 10.1039/c8ob01745j.

7.

Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux.

Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG.

Sci Rep. 2018 Jul 23;8(1):11061. doi: 10.1038/s41598-018-29281-1.

8.

In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1.

Kirchweger B, Kratz JM, Ladurner A, Grienke U, Langer T, Dirsch VM, Rollinger JM.

Front Chem. 2018 Jul 2;6:242. doi: 10.3389/fchem.2018.00242. eCollection 2018.

9.

6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

Wang D, Hiebl V, Ladurner A, Latkolik SL, Bucar F, Heiß EH, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2018 May 26:e1800011. doi: 10.1002/mnfr.201800011. [Epub ahead of print]

10.

Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR.

Hiebl V, Ladurner A, Latkolik S, Dirsch VM.

Biotechnol Adv. 2018 Nov 1;36(6):1657-1698. doi: 10.1016/j.biotechadv.2018.03.003. Epub 2018 Mar 13. Review.

11.

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor.

Liu R, Heiss EH, Waltenberger B, Blažević T, Schachner D, Jiang B, Krystof V, Liu W, Schwaiger S, Peña-Rodríguez LM, Breuss JM, Stuppner H, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2018 Apr;62(7):e1700860. doi: 10.1002/mnfr.201700860. Epub 2018 Mar 30.

PMID:
29405576
12.

Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level.

Malainer C, Schachner D, Sangiovanni E, Atanasov AG, Schwaiger S, Stuppner H, Heiss EH, Dirsch VM.

J Nat Prod. 2017 Dec 22;80(12):3186-3193. doi: 10.1021/acs.jnatprod.7b00503. Epub 2017 Nov 17.

13.

Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro.

Holzner S, Brenner S, Atanasov AG, Senfter D, Stadler S, Nguyen CH, Fristiohady A, Milovanovic D, Huttary N, Krieger S, Bago-Horvath Z, de Wever O, Tentes I, Özmen A, Jäger W, Dolznig H, Dirsch VM, Mader RM, Krenn L, Krupitza G.

Food Chem Toxicol. 2018 Jan;111:114-124. doi: 10.1016/j.fct.2017.11.015. Epub 2017 Nov 10.

PMID:
29129665
14.

Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation.

Dreier D, Latkolik S, Rycek L, Schnürch M, Dymáková A, Atanasov AG, Ladurner A, Heiss EH, Stuppner H, Schuster D, Mihovilovic MD, Dirsch VM.

Sci Rep. 2017 Oct 20;7(1):13002. doi: 10.1038/s41598-017-12628-5.

15.

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability.

Wang L, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Bauer R, Dirsch VM, Atanasov AG.

Front Pharmacol. 2017 Sep 1;8:596. doi: 10.3389/fphar.2017.00596. eCollection 2017.

16.

Bupleurum chinense Roots: a Bioactivity-Guided Approach toward Saponin-Type NF-κB Inhibitors.

Liu X, Latkolik S, Atanasov AG, Kunert O, Pferschy-Wenzig EM, Heiss EH, Malainer C, Schinkovitz A, Kollroser M, Dirsch VM, Bauer R.

Planta Med. 2017 Oct;83(14-15):1242-1250. doi: 10.1055/s-0043-118226. Epub 2017 Sep 8.

17.

Assessment of anti-inflammatory properties of extracts from Honeysuckle (Lonicera sp. L., Caprifoliaceae) by ATR-FTIR spectroscopy.

Nikzad-Langerodi R, Ortmann S, Pferschy-Wenzig EM, Bochkov V, Zhao YM, Miao JH, Saukel J, Ladurner A, Heiss EH, Dirsch VM, Bauer R, Atanasov AG.

Talanta. 2017 Dec 1;175:264-272. doi: 10.1016/j.talanta.2017.07.045. Epub 2017 Jul 18.

PMID:
28841989
18.

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5.

Ladurner A, Zehl M, Grienke U, Hofstadler C, Faur N, Pereira FC, Berry D, Dirsch VM, Rollinger JM.

Front Pharmacol. 2017 Jul 17;8:468. doi: 10.3389/fphar.2017.00468. eCollection 2017.

19.

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages.

Wang L, Wesemann S, Krenn L, Ladurner A, Heiss EH, Dirsch VM, Atanasov AG.

Front Pharmacol. 2017 Jun 13;8:375. doi: 10.3389/fphar.2017.00375. eCollection 2017.

20.

Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo.

Liu R, Heiss EH, Schachner D, Jiang B, Liu W, Breuss JM, Dirsch VM, Atanasov AG.

J Nat Prod. 2017 Jul 28;80(7):2146-2150. doi: 10.1021/acs.jnatprod.7b00268. Epub 2017 Jun 19.

21.

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.

Wang D, Tosevska A, Heiß EH, Ladurner A, Mölzer C, Wallner M, Bulmer A, Wagner KH, Dirsch VM, Atanasov AG.

J Am Heart Assoc. 2017 Apr 28;6(5). pii: e005520. doi: 10.1161/JAHA.117.005520.

22.

Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model.

Nguyen CH, Huttary N, Atanasov AG, Chatuphonprasert W, Brenner S, Fristiohady A, Hong J, Stadler S, Holzner S, Milovanovic D, Dirsch VM, Kopp B, Saiko P, Krenn L, Jäger W, Krupitza G.

Int J Oncol. 2017 May;50(5):1879-1888. doi: 10.3892/ijo.2017.3956. Epub 2017 Apr 7.

PMID:
28393180
23.

AHR/CYP1A1 interplay triggers lymphatic barrier breaching in breast cancer spheroids by inducing 12(S)-HETE synthesis.

Nguyen CH, Brenner S, Huttary N, Atanasov AG, Dirsch VM, Chatuphonprasert W, Holzner S, Stadler S, Riha J, Krieger S, de Martin R, Bago-Horvath Z, Krupitza G, Jäger W.

Hum Mol Genet. 2016 Nov 15;25(22):5006-5016. doi: 10.1093/hmg/ddw329.

PMID:
28171546
24.

Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages.

Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201500960. Epub 2016 Dec 23.

25.

12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply.

Nguyen CH, Brenner S, Huttary N, Li Y, Atanasov AG, Dirsch VM, Holzner S, Stadler S, Riha J, Krieger S, Milovanovic D, Fristiohardy A, Simonitsch-Klupp I, Dolznig H, Saiko P, Szekeres T, Giessrigl B, Jäger W, Krupitza G.

Cancer Lett. 2016 Sep 28;380(1):174-83. doi: 10.1016/j.canlet.2016.06.022. Epub 2016 Jul 4.

PMID:
27390016
26.

Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages.

Wang L, Ladurner A, Latkolik S, Schwaiger S, Linder T, Hošek J, Palme V, Schilcher N, Polanský O, Heiss EH, Stangl H, Mihovilovic MD, Stuppner H, Dirsch VM, Atanasov AG.

J Nat Prod. 2016 Jun 24;79(6):1651-7. doi: 10.1021/acs.jnatprod.6b00227. Epub 2016 May 24.

27.

Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3'-monoxime.

Heiss EH, Schachner D, Donati M, Grojer CS, Dirsch VM.

Vascul Pharmacol. 2016 Aug;83:47-56. doi: 10.1016/j.vph.2016.05.002. Epub 2016 May 14.

28.

Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project.

Waltenberger B, Atanasov AG, Heiss EH, Bernhard D, Rollinger JM, Breuss JM, Schuster D, Bauer R, Kopp B, Franz C, Bochkov V, Mihovilovic MD, Dirsch VM, Stuppner H.

Monatsh Chem. 2016;147:479-491. Epub 2016 Feb 25. Review.

29.

Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation.

Heiss EH, Liu R, Waltenberger B, Khan S, Schachner D, Kollmann P, Zimmermann K, Cabaravdic M, Uhrin P, Stuppner H, Breuss JM, Atanasov AG, Dirsch VM.

Sci Rep. 2016 Feb 9;6:20771. doi: 10.1038/srep20771.

30.

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.

Wang L, Rotter S, Ladurner A, Heiss EH, Oberlies NH, Dirsch VM, Atanasov AG.

Molecules. 2015 Dec 31;21(1):E55. doi: 10.3390/molecules21010055.

31.

Triterpenoic Acids from Apple Pomace Enhance the Activity of the Endothelial Nitric Oxide Synthase (eNOS).

Waldbauer K, Seiringer G, Nguyen DL, Winkler J, Blaschke M, McKinnon R, Urban E, Ladurner A, Dirsch VM, Zehl M, Kopp B.

J Agric Food Chem. 2016 Jan 13;64(1):185-94. doi: 10.1021/acs.jafc.5b05061. Epub 2015 Dec 30.

PMID:
26682617
32.

Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation.

Waltenberger B, Liu R, Atanasov AG, Schwaiger S, Heiss EH, Dirsch VM, Stuppner H.

Molecules. 2015 Nov 13;20(11):20381-90. doi: 10.3390/molecules201119703.

33.

Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases.

Blažević T, Heiss EH, Atanasov AG, Breuss JM, Dirsch VM, Uhrin P.

Evid Based Complement Alternat Med. 2015;2015:654098. doi: 10.1155/2015/654098. Epub 2015 Sep 17. Review.

34.

Quantitation of phenylpropanoids and iridoids in insulin-sensitising extracts of Leonurus sibiricus L. (Lamiaceae).

Pitschmann A, Zehl M, Heiss E, Purevsuren S, Urban E, Dirsch VM, Glasl S.

Phytochem Anal. 2016 Jan-Feb;27(1):23-31. doi: 10.1002/pca.2583. Epub 2015 Sep 2.

PMID:
26333151
35.

Discovery and resupply of pharmacologically active plant-derived natural products: A review.

Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H.

Biotechnol Adv. 2015 Dec;33(8):1582-1614. doi: 10.1016/j.biotechadv.2015.08.001. Epub 2015 Aug 15. Review.

36.

The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation.

Unger C, Kiss I, Vasas A, Lajter I, Kramer N, Atanasov AG, Nguyen CH, Chatuphonprasert W, Brenner S, Krieger S, McKinnon R, Peschel A, Kain R, Saiko P, Szekeres T, Kenner L, Hassler MR, Diaz R, Frisch R, Dirsch VM, Jäger W, de Martin R, Bochkov VN, Passreiter CM, Peter-Vörösmarty B, Mader RM, Grusch M, Dolznig H, Kopp B, Zupko I, Hohmann J, Krupitza G.

Phytomedicine. 2015 Aug 15;22(9):862-74. doi: 10.1016/j.phymed.2015.06.003. Epub 2015 Jun 26.

PMID:
26220634
37.

Piperine Congeners as Inhibitors of Vascular Smooth Muscle Cell Proliferation.

Mair CE, Liu R, Atanasov AG, Wimmer L, Nemetz-Fiedler D, Sider N, Heiss EH, Mihovilovic MD, Dirsch VM, Rollinger JM.

Planta Med. 2015 Aug;81(12-13):1065-74. doi: 10.1055/s-0035-1546165. Epub 2015 Jul 1.

PMID:
26132851
38.

A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro.

Blaschke M, McKinnon R, Nguyen CH, Holzner S, Zehl M, Atanasov AG, Schelch K, Krieger S, Diaz R, Frisch R, Feistel B, Jäger W, Ecker GF, Dirsch VM, Grusch M, Zupko I, Urban E, Kopp B, Krupitza G.

Mutat Res. 2015 Jul;777:79-90. doi: 10.1016/j.mrfmmm.2015.04.011. Epub 2015 May 5.

PMID:
25989051
39.

Activated AMPK boosts the Nrf2/HO-1 signaling axis--A role for the unfolded protein response.

Zimmermann K, Baldinger J, Mayerhofer B, Atanasov AG, Dirsch VM, Heiss EH.

Free Radic Biol Med. 2015 Nov;88(Pt B):417-426. doi: 10.1016/j.freeradbiomed.2015.03.030. Epub 2015 Apr 3.

40.

Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation.

Liu R, Heiss EH, Guo D, Dirsch VM, Atanasov AG.

F1000Res. 2015 Jan 27;4:26. doi: 10.12688/f1000research.6007.1. eCollection 2015.

41.

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation.

Liu R, Heiss EH, Sider N, Schinkovitz A, Gröblacher B, Guo D, Bucar F, Bauer R, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2015 May;59(5):843-52. doi: 10.1002/mnfr.201400791. Epub 2015 Mar 16.

42.

Glycolytic switch in response to betulinic acid in non-cancer cells.

Heiss EH, Kramer MP, Atanasov AG, Beres H, Schachner D, Dirsch VM.

PLoS One. 2014 Dec 22;9(12):e115683. doi: 10.1371/journal.pone.0115683. eCollection 2014.

43.

Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: assessing the activity of flavonoids from the stem bark of Oroxylum indicum.

Tran TV, Malainer C, Schwaiger S, Hung T, Atanasov AG, Heiss EH, Dirsch VM, Stuppner H.

J Ethnopharmacol. 2015 Jan 15;159:36-42. doi: 10.1016/j.jep.2014.10.012. Epub 2014 Oct 31.

44.

Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation.

Kiss I, Unger C, Huu CN, Atanasov AG, Kramer N, Chatruphonprasert W, Brenner S, McKinnon R, Peschel A, Vasas A, Lajter I, Kain R, Saiko P, Szekeres T, Kenner L, Hassler MR, Diaz R, Frisch R, Dirsch VM, Jäger W, de Martin R, Bochkov VN, Passreiter CM, Peter-Vörösmarty B, Mader RM, Grusch M, Dolznig H, Kopp B, Zupko I, Hohmann J, Krupitza G.

Cancer Lett. 2015 Jan 28;356(2 Pt B):994-1006. doi: 10.1016/j.canlet.2014.11.019. Epub 2014 Nov 15.

PMID:
25444930
45.

Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity.

Bollmann F, Art J, Henke J, Schrick K, Besche V, Bros M, Li H, Siuda D, Handler N, Bauer F, Erker T, Behnke F, Mönch B, Härdle L, Hoffmann M, Chen CY, Förstermann U, Dirsch VM, Werz O, Kleinert H, Pautz A.

Nucleic Acids Res. 2014 Nov 10;42(20):12555-69. doi: 10.1093/nar/gku1033. Epub 2014 Oct 28.

46.

Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects.

Liu X, Kunert O, Blunder M, Fakhrudin N, Noha SM, Malainer C, Schinkovitz A, Heiss EH, Atanasov AG, Kollroser M, Schuster D, Dirsch VM, Bauer R.

J Nat Prod. 2014 Nov 26;77(11):2513-21. doi: 10.1021/np500605v. Epub 2014 Oct 21.

47.

Impact of trans-resveratrol-sulfates and -glucuronides on endothelial nitric oxide synthase activity, nitric oxide release and intracellular reactive oxygen species.

Ladurner A, Schachner D, Schueller K, Pignitter M, Heiss EH, Somoza V, Dirsch VM.

Molecules. 2014 Oct 17;19(10):16724-36. doi: 10.3390/molecules191016724.

48.

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.

Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X, Malainer C, Blazevic T, Schwaiger S, Rollinger JM, Heiss EH, Schuster D, Kopp B, Bauer R, Stuppner H, Dirsch VM, Atanasov AG.

Biochem Pharmacol. 2014 Nov 1;92(1):73-89. doi: 10.1016/j.bcp.2014.07.018. Epub 2014 Jul 30. Review.

49.

Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma.

Pferschy-Wenzig EM, Atanasov AG, Malainer C, Noha SM, Kunert O, Schuster D, Heiss EH, Oberlies NH, Wagner H, Bauer R, Dirsch VM.

J Nat Prod. 2014 Apr 25;77(4):842-7. doi: 10.1021/np400943b. Epub 2014 Mar 5.

50.

Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro.

Pitschmann A, Zehl M, Atanasov AG, Dirsch VM, Heiss E, Glasl S.

J Ethnopharmacol. 2014 Mar 28;152(3):599-602. doi: 10.1016/j.jep.2014.02.017. Epub 2014 Feb 15.

PMID:
24548753

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