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Items: 1 to 50 of 345

1.

Preregistration of exploratory research: Learning from the golden age of discovery.

Dirnagl U.

PLoS Biol. 2020 Mar 26;18(3):e3000690. doi: 10.1371/journal.pbio.3000690. eCollection 2020 Mar.

PMID:
32214315
2.

Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative.

Strech D, Weissgerber T, Dirnagl U; QUEST Group.

PLoS Biol. 2020 Feb 11;18(2):e3000576. doi: 10.1371/journal.pbio.3000576. eCollection 2020 Feb.

3.

SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesis.

Malik AR, Lips J, Gorniak-Walas M, Broekaart DWM, Asaro A, Kuffner MTC, Hoffmann CJ, Kikhia M, Dopatka M, Boehm-Sturm P, Mueller S, Dirnagl U, Aronica E, Harms C, Willnow TE.

Glia. 2020 Jan 3. doi: 10.1002/glia.23778. [Epub ahead of print]

PMID:
31898841
4.

Checklists for Authors Improve the Reporting of Basic Science Research.

Minnerup J, Dirnagl U, Schäbitz WR.

Stroke. 2020 Jan;51(1):6-7. doi: 10.1161/STROKEAHA.119.027626. Epub 2019 Nov 13. No abstract available.

PMID:
31718506
5.

Resolving the Tension Between Exploration and Confirmation in Preclinical Biomedical Research.

Dirnagl U.

Handb Exp Pharmacol. 2020;257:71-79. doi: 10.1007/164_2019_278.

PMID:
31696348
6.

An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models.

Foddis M, Winek K, Bentele K, Mueller S, Blumenau S, Reichhart N N, Crespo-Garcia S, Harnett D, Ivanov A, Meisel A, Joussen A, Strauss O, Beule D, Dirnagl U, Sassi C.

J Cereb Blood Flow Metab. 2020 Feb;40(2):276-287. doi: 10.1177/0271678X19827251. Epub 2019 Feb 7.

PMID:
31549895
7.

The p value wars (again).

Dirnagl U.

Eur J Nucl Med Mol Imaging. 2019 Nov;46(12):2421-2423. doi: 10.1007/s00259-019-04467-5. No abstract available.

PMID:
31375858
8.

Human gestational N-methyl-d-aspartate receptor autoantibodies impair neonatal murine brain function.

Jurek B, Chayka M, Kreye J, Lang K, Kraus L, Fidzinski P, Kornau HC, Dao LM, Wenke NK, Long M, Rivalan M, Winter Y, Leubner J, Herken J, Mayer S, Mueller S, Boehm-Sturm P, Dirnagl U, Schmitz D, Kölch M, Prüss H.

Ann Neurol. 2019 Nov;86(5):656-670. doi: 10.1002/ana.25552. Epub 2019 Sep 18.

PMID:
31325344
9.

Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete.

Wieschowski S, Riedel N, Wollmann K, Kahrass H, Müller-Ohlraun S, Schürmann C, Kelley S, Kszuk U, Siegerink B, Dirnagl U, Meerpohl J, Strech D.

J Clin Epidemiol. 2019 Nov;115:37-45. doi: 10.1016/j.jclinepi.2019.06.002. Epub 2019 Jun 10.

PMID:
31195110
10.

Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis.

Watzlawick R, Antonic A, Sena ES, Kopp MA, Rind J, Dirnagl U, Macleod M, Howells DW, Schwab JM.

Neurology. 2019 Jul 2;93(1):e40-e51. doi: 10.1212/WNL.0000000000007718. Epub 2019 Jun 7.

11.

Tracking the timely dissemination of clinical studies. Characteristics and impact of 10 tracking variables.

Strech D, Sievers S, Märschenz S, Riedel N, Wieschowski S, Meerpohl J, Langhof H, Müller-Ohlraun S, Dirnagl U.

F1000Res. 2018 Nov 29;7:1863. doi: 10.12688/f1000research.17022.1. eCollection 2018.

12.

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition.

Mei J, Banneke S, Lips J, Kuffner MTC, Hoffmann CJ, Dirnagl U, Endres M, Harms C, Emmrich JV.

ALTEX. 2019;36(4):555-571. doi: 10.14573/altex.1812231. Epub 2019 Apr 18.

13.

Exact replication: Foundation of science or game of chance?

Piper SK, Grittner U, Rex A, Riedel N, Fischer F, Nadon R, Siegerink B, Dirnagl U.

PLoS Biol. 2019 Apr 9;17(4):e3000188. doi: 10.1371/journal.pbio.3000188. eCollection 2019 Apr.

14.

Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.

Jochner MCE, An J, Lättig-Tünnemann G, Kirchner M, Dagane A, Dittmar G, Dirnagl U, Eickholt BJ, Harms C.

Sci Rep. 2019 Feb 28;9(1):3183. doi: 10.1038/s41598-019-39438-1.

15.

Rethinking research reproducibility.

Dirnagl U.

EMBO J. 2019 Jan 15;38(2). pii: e101117. doi: 10.15252/embj.2018101117. Epub 2018 Dec 5. No abstract available.

16.

Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse.

Oyama N, Winek K, Bäcker-Koduah P, Zhang T, Dames C, Werich M, Kershaw O, Meisel C, Meisel A, Dirnagl U.

Front Neurol. 2018 Nov 19;9:937. doi: 10.3389/fneur.2018.00937. eCollection 2018.

17.

Longitudinal 19F magnetic resonance imaging of brain oxygenation in a mouse model of vascular cognitive impairment using a cryogenic radiofrequency coil.

Khalil AA, Mueller S, Foddis M, Mosch L, Lips J, Przesdzing I, Temme S, Flögel U, Dirnagl U, Boehm-Sturm P.

MAGMA. 2019 Feb;32(1):105-114. doi: 10.1007/s10334-018-0712-x. Epub 2018 Nov 12.

PMID:
30421249
18.

Quality management for academic laboratories: burden or boon? Professional quality management could be very beneficial for academic research but needs to overcome specific caveats.

Dirnagl U, Kurreck C, Castaños-Vélez E, Bernard R.

EMBO Rep. 2018 Nov;19(11). pii: e47143. doi: 10.15252/embr.201847143. Epub 2018 Oct 19. No abstract available.

19.

Presentation abstracts.

Rice L, Sung J, Keane K, Peterson E, Sosnoff J, Farkas G, Swartz A, Strath S, Gorgey A, Berg A, Gater D, Dyson-Hudson T, Malanga G, Cherian C, Michalec M, Kirshblum S, Miller C, Garlanger K, Kortes S, Schnorenberg A, Slavens B, Lee K, Potter-Baker K, Frost F, Plow E, Solinsky R, Wilson C, Henry CA, Lombard A, Maher M, Weir J, Saeed S, Cirnigliaro C, Specht A, Garbarini E, Augustine J, Forrest G, Bauman W, Wecht J, Maher M, Weir J, Lombard A, Saeed S, Kirshblum S, Bauman W, Wecht J, Hearn J, Razvi IS, Wilson C, Henry CA, Sikka S, Callender L, Bennett M, Robertson K, Driver S, Kline-Quiroz C, Donovan J, Botticello A, Arnold D, Latham N, Houlihan B, Bickmore T, Trinh H, Shamekhi A, Ellis T, LaVela SL, Burkhart E, Kale I, Bombardier C, Snoxell E, Knezevic S, Hong E, Asselin P, Cirnigliaro C, Kornfeld S, Gorman P, Forrest G, Bauman W, Spungen A, Farkas G, Berg A, Castillo C, Gater D, Cleveland C, Gabet J, Harrington A, Arenth P, Farkas G, Gorgey A, Dolbow D, Berg A, Gater D, Luther S, Finch D, Bouayad L, Cirnigliaro C, Donovan J, Forrest G, Gater D, Kopp M, Watzlawick R, Martus P, Failli V, Finkenstaedt F, Chen Y, DeVivo M, Dirnagl U, Schwab J MD, LiMonta J, Saeed S, Santiago T, Maher M, Wu YK, Harel N, Monden K, Trost Z, Nguyen N, Morse L, Boals A, Wenzel L, Silveira S, Hughes R, Nosek M, LeDoux T, Taylor H, Diaz L, Robinson-Whelen S, Garshick E, Betz K, Krause J, Cao Y, Li C, Hon B, Kirshblum S, Khong CM, Dirlikov B, Shem K, Charlifue S, Song S, Burns S.

J Spinal Cord Med. 2018 Sep;41(5):599-622. doi: 10.1080/10790268.2018.1498262. No abstract available.

20.

Stage 1 Registered Report: Effect of deficient phagocytosis on neuronal survival and neurological outcome after temporary middle cerebral artery occlusion (tMCAo).

Emmrich JV, Neher JJ, Boehm-Sturm P, Endres M, Dirnagl U, Harms C.

Version 3. F1000Res. 2017 Oct 12 [revised 2018 Jan 1];6:1827. doi: 10.12688/f1000research.12537.3. eCollection 2017.

21.

The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials.

Yarborough M, Bredenoord A, D'Abramo F, Joyce NC, Kimmelman J, Ogbogu U, Sena E, Strech D, Dirnagl U.

PLoS Biol. 2018 Jun 6;16(6):e2006343. doi: 10.1371/journal.pbio.2006343. eCollection 2018 Jun.

22.

Health tips for research groups.

Norris D, Dirnagl U, Zigmond MJ, Thompson-Peer K, Chow TT.

Nature. 2018 May;557(7705):302-304. doi: 10.1038/d41586-018-05146-5. No abstract available.

PMID:
29769687
23.

Correction: Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO).

Crespo-Garcia S, Reichhart N, Skosyrski S, Foddis M, Wu J, Figura A, Herrspiegel C, Füchtemeier M, Sassi C, Dirnagl U, Joussen AM, Strauss O.

PLoS One. 2018 Apr 23;13(4):e0196538. doi: 10.1371/journal.pone.0196538. eCollection 2018.

24.

Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO).

Crespo-Garcia S, Reichhart N, Skosyrski S, Foddis M, Wu J, Figura A, Herrspiegel C, Füchtemeier M, Sassi C, Dirnagl U, Joussen AM, Strauss O.

PLoS One. 2018 Mar 16;13(3):e0193961. doi: 10.1371/journal.pone.0193961. eCollection 2018. Erratum in: PLoS One. 2018 Apr 23;13(4):e0196538.

25.

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.

Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J; ARUK Consortium, Blumenau S, Thielke M, Josties C, Freyer D, Dietrich A, Hammer M, Baier M, Dirnagl U, Morgan K, Powell JF, Kauwe JS, Cruchaga C, Goate AM, Singleton AB, Guerreiro R, Hodges A, Hardy J.

Neurobiol Aging. 2018 Jun;66:179.e17-179.e29. doi: 10.1016/j.neurobiolaging.2018.01.015. Epub 2018 Feb 2.

26.

Preclinical research: Meet patients to sharpen up research.

Yarborough M, Dirnagl U.

Nature. 2017 Nov 16;551(7680):300. doi: 10.1038/d41586-017-06024-2. No abstract available.

PMID:
29144480
27.

Preclinical research: Meet patients to sharpen up research.

Yarborough M, Dirnagl U.

Nature. 2017 Nov;551(7680):300. doi: 10.1038/d41586-017-06024-2. No abstract available.

PMID:
32080556
28.

Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex.

Prüss H, Tedeschi A, Thiriot A, Lynch L, Loughhead SM, Stutte S, Mazo IB, Kopp MA, Brommer B, Blex C, Geurtz LC, Liebscher T, Niedeggen A, Dirnagl U, Bradke F, Volz MS, DeVivo MJ, Chen Y, von Andrian UH, Schwab JM.

Nat Neurosci. 2017 Nov;20(11):1549-1559. doi: 10.1038/nn.4643. Epub 2017 Sep 18.

PMID:
28920935
29.

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models.

Koch S, Mueller S, Foddis M, Bienert T, von Elverfeldt D, Knab F, Farr TD, Bernard R, Dopatka M, Rex A, Dirnagl U, Harms C, Boehm-Sturm P.

J Cereb Blood Flow Metab. 2019 Feb;39(2):313-323. doi: 10.1177/0271678X17726635. Epub 2017 Aug 22.

30.

Dr Smart talks to Prof Pries and Prof Dirnagl on animal experimentation in biomedical research.

Smart N, Pries AR, Dirnagl U.

Cardiovasc Res. 2017 May 1;113(6):e12-e15. doi: 10.1093/cvr/cvx056. No abstract available.

PMID:
28453737
31.

Increasing efficiency of preclinical research by group sequential designs.

Neumann K, Grittner U, Piper SK, Rex A, Florez-Vargas O, Karystianis G, Schneider A, Wellwood I, Siegerink B, Ioannidis JP, Kimmelman J, Dirnagl U.

PLoS Biol. 2017 Mar 10;15(3):e2001307. doi: 10.1371/journal.pbio.2001307. eCollection 2017 Mar.

32.

Long-term functional outcome in patients with acquired infections after acute spinal cord injury.

Kopp MA, Watzlawick R, Martus P, Failli V, Finkenstaedt FW, Chen Y, DeVivo MJ, Dirnagl U, Schwab JM.

Neurology. 2017 Feb 28;88(9):892-900. doi: 10.1212/WNL.0000000000003652. Epub 2017 Jan 27.

33.

Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment.

Dam K, Füchtemeier M, Farr TD, Boehm-Sturm P, Foddis M, Dirnagl U, Malysheva O, Caudill MA, Jadavji NM.

Behav Brain Res. 2017 Mar 15;321:201-208. doi: 10.1016/j.bbr.2016.12.041. Epub 2017 Jan 11.

PMID:
28087280
34.

Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment.

Boehm-Sturm P, Füchtemeier M, Foddis M, Mueller S, Trueman RC, Zille M, Rinnenthal JL, Kypraios T, Shaw L, Dirnagl U, Farr TD.

Stroke. 2017 Feb;48(2):468-475. doi: 10.1161/STROKEAHA.116.014394. Epub 2017 Jan 9.

35.

A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine.

Dirnagl U, Przesdzing I, Kurreck C, Major S.

PLoS Biol. 2016 Dec 1;14(12):e2000705. doi: 10.1371/journal.pbio.2000705. eCollection 2016 Dec.

36.

The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke.

Winek K, Dirnagl U, Meisel A.

Neurotherapeutics. 2016 Oct;13(4):762-774. doi: 10.1007/s13311-016-0475-x. Review.

37.

Natural Killer (NK) Cell Functionality after human Spinal Cord Injury (SCI): protocol of a prospective, longitudinal study.

Laginha I, Kopp MA, Druschel C, Schaser KD, Brommer B, Hellmann RC, Watzlawick R, Ossami-Saidi RR, Prüss H, Failli V, Meisel C, Liebscher T, Prilipp E, Niedeggen A, Ekkernkamp A, Grittner U, Piper SK, Dirnagl U, Killig M, Romagnani C, Schwab JM.

BMC Neurol. 2016 Sep 13;16:170. doi: 10.1186/s12883-016-0681-5.

38.

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.

Kreye J, Wenke NK, Chayka M, Leubner J, Murugan R, Maier N, Jurek B, Ly LT, Brandl D, Rost BR, Stumpf A, Schulz P, Radbruch H, Hauser AE, Pache F, Meisel A, Harms L, Paul F, Dirnagl U, Garner C, Schmitz D, Wardemann H, Prüss H.

Brain. 2016 Oct;139(Pt 10):2641-2652. Epub 2016 Aug 20.

PMID:
27543972
39.

Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice.

Donath S, An J, Lee SL, Gertz K, Datwyler AL, Harms U, Müller S, Farr TD, Füchtemeier M, Lättig-Tünnemann G, Lips J, Foddis M, Mosch L, Bernard R, Grittner U, Balkaya M, Kronenberg G, Dirnagl U, Endres M, Harms C.

J Neurosci. 2016 Aug 3;36(31):8132-48. doi: 10.1523/JNEUROSCI.4428-15.2016.

40.

SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol.

Kopp MA, Liebscher T, Watzlawick R, Martus P, Laufer S, Blex C, Schindler R, Jungehulsing GJ, Knüppel S, Kreutzträger M, Ekkernkamp A, Dirnagl U, Strittmatter SM, Niedeggen A, Schwab JM.

BMJ Open. 2016 Jul 26;6(7):e010651. doi: 10.1136/bmjopen-2015-010651.

41.

Thomas Willis Lecture: Is Translational Stroke Research Broken, and if So, How Can We Fix It?

Dirnagl U.

Stroke. 2016 Aug;47(8):2148-53. doi: 10.1161/STROKEAHA.116.013244. Epub 2016 Jun 28.

PMID:
27354221
42.

Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis.

Watzlawick R, Rind J, Sena ES, Brommer B, Zhang T, Kopp MA, Dirnagl U, Macleod MR, Howells DW, Schwab JM.

PLoS Biol. 2016 May 31;14(5):e1002468. doi: 10.1371/journal.pbio.1002468. eCollection 2016 May.

43.

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation.

Chamorro Á, Dirnagl U, Urra X, Planas AM.

Lancet Neurol. 2016 Jul;15(8):869-881. doi: 10.1016/S1474-4422(16)00114-9. Epub 2016 May 11. Review.

PMID:
27180033
44.

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke.

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U.

Stroke. 2016 May;47(5):1354-63. doi: 10.1161/STROKEAHA.115.011800. Epub 2016 Apr 7.

45.

Gut microbiota impact on stroke outcome: Fad or fact?

Winek K, Meisel A, Dirnagl U.

J Cereb Blood Flow Metab. 2016 May;36(5):891-8. doi: 10.1177/0271678X16636890. Epub 2016 Mar 4. Review.

46.

Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue.

Jadavji NM, Wieske F, Dirnagl U, Winter C.

Mol Genet Metab Rep. 2015 Feb 20;3:1-4. doi: 10.1016/j.ymgmr.2015.02.001. eCollection 2015 Jun.

47.

Methylprednisolone blocks interleukin 1 beta induced calcitonin gene related peptide release in trigeminal ganglia cells.

Neeb L, Hellen P, Hoffmann J, Dirnagl U, Reuter U.

J Headache Pain. 2016;17:19. doi: 10.1186/s10194-016-0609-x. Epub 2016 Mar 1.

48.

A pocket guide to electronic laboratory notebooks in the academic life sciences.

Dirnagl U, Przesdzing I.

F1000Res. 2016 Jan 4;5:2. doi: 10.12688/f1000research.7628.1. eCollection 2016.

49.

A new home for the Journal of Cerebral Blood Flow and Metabolism.

Dirnagl U, Lauritzen M.

J Cereb Blood Flow Metab. 2016 Feb;36(2):277. doi: 10.1177/0271678X15621576. No abstract available.

50.

Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study).

Scherbakov N, Ebner N, Sandek A, Meisel A, Haeusler KG, von Haehling S, Anker SD, Dirnagl U, Joebges M, Doehner W.

BMC Neurol. 2016 Jan 22;16:10. doi: 10.1186/s12883-016-0531-5.

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