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Items: 1 to 50 of 330

1.

Rethinking research reproducibility.

Dirnagl U.

EMBO J. 2018 Dec 5. pii: e101117. doi: 10.15252/embj.2018101117. [Epub ahead of print] No abstract available.

PMID:
30518534
2.

Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse.

Oyama N, Winek K, Bäcker-Koduah P, Zhang T, Dames C, Werich M, Kershaw O, Meisel C, Meisel A, Dirnagl U.

Front Neurol. 2018 Nov 19;9:937. doi: 10.3389/fneur.2018.00937. eCollection 2018.

3.

Longitudinal 19F magnetic resonance imaging of brain oxygenation in a mouse model of vascular cognitive impairment using a cryogenic radiofrequency coil.

Khalil AA, Mueller S, Foddis M, Mosch L, Lips J, Przesdzing I, Temme S, Flögel U, Dirnagl U, Boehm-Sturm P.

MAGMA. 2018 Nov 12. doi: 10.1007/s10334-018-0712-x. [Epub ahead of print]

PMID:
30421249
4.

Quality management for academic laboratories: burden or boon? Professional quality management could be very beneficial for academic research but needs to overcome specific caveats.

Dirnagl U, Kurreck C, Castaños-Vélez E, Bernard R.

EMBO Rep. 2018 Nov;19(11). pii: e47143. doi: 10.15252/embr.201847143. Epub 2018 Oct 19. No abstract available.

PMID:
30341068
5.

Presentation abstracts.

Rice L, Sung J, Keane K, Peterson E, Sosnoff J, Farkas G, Swartz A, Strath S, Gorgey A, Berg A, Gater D, Dyson-Hudson T, Malanga G, Cherian C, Michalec M, Kirshblum S, Miller C, Garlanger K, Kortes S, Schnorenberg A, Slavens B, Lee K, Potter-Baker K, Frost F, Plow E, Solinsky R, Wilson C, Henry CA, Lombard A, Maher M, Weir J, Saeed S, Cirnigliaro C, Specht A, Garbarini E, Augustine J, Forrest G, Bauman W, Wecht J, Maher M, Weir J, Lombard A, Saeed S, Kirshblum S, Bauman W, Wecht J, Hearn J, Razvi IS, Wilson C, Henry CA, Sikka S, Callender L, Bennett M, Robertson K, Driver S, Kline-Quiroz C, Donovan J, Botticello A, Arnold D, Latham N, Houlihan B, Bickmore T, Trinh H, Shamekhi A, Ellis T, LaVela SL, Burkhart E, Kale I, Bombardier C, Snoxell E, Knezevic S, Hong E, Asselin P, Cirnigliaro C, Kornfeld S, Gorman P, Forrest G, Bauman W, Spungen A, Farkas G, Berg A, Castillo C, Gater D, Cleveland C, Gabet J, Harrington A, Arenth P, Farkas G, Gorgey A, Dolbow D, Berg A, Gater D, Luther S, Finch D, Bouayad L, Cirnigliaro C, Donovan J, Forrest G, Gater D, Kopp M, Watzlawick R, Martus P, Failli V, Finkenstaedt F, Chen Y, DeVivo M, Dirnagl U, Schwab J MD, LiMonta J, Saeed S, Santiago T, Maher M, Wu YK, Harel N, Monden K, Trost Z, Nguyen N, Morse L, Boals A, Wenzel L, Silveira S, Hughes R, Nosek M, LeDoux T, Taylor H, Diaz L, Robinson-Whelen S, Garshick E, Betz K, Krause J, Cao Y, Li C, Hon B, Kirshblum S, Khong CM, Dirlikov B, Shem K, Charlifue S, Song S, Burns S.

J Spinal Cord Med. 2018 Sep;41(5):599-622. doi: 10.1080/10790268.2018.1498262. No abstract available.

PMID:
30132748
6.

Stage 1 Registered Report: Effect of deficient phagocytosis on neuronal survival and neurological outcome after temporary middle cerebral artery occlusion (tMCAo).

Emmrich JV, Neher JJ, Boehm-Sturm P, Endres M, Dirnagl U, Harms C.

Version 3. F1000Res. 2017 Oct 12 [revised 2018 Jan 1];6:1827. doi: 10.12688/f1000research.12537.3. eCollection 2017.

7.

The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials.

Yarborough M, Bredenoord A, D'Abramo F, Joyce NC, Kimmelman J, Ogbogu U, Sena E, Strech D, Dirnagl U.

PLoS Biol. 2018 Jun 6;16(6):e2006343. doi: 10.1371/journal.pbio.2006343. eCollection 2018 Jun.

8.

Health tips for research groups.

Norris D, Dirnagl U, Zigmond MJ, Thompson-Peer K, Chow TT.

Nature. 2018 May;557(7705):302-304. doi: 10.1038/d41586-018-05146-5. No abstract available.

PMID:
29769687
9.

Correction: Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO).

Crespo-Garcia S, Reichhart N, Skosyrski S, Foddis M, Wu J, Figura A, Herrspiegel C, Füchtemeier M, Sassi C, Dirnagl U, Joussen AM, Strauss O.

PLoS One. 2018 Apr 23;13(4):e0196538. doi: 10.1371/journal.pone.0196538. eCollection 2018.

10.

Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO).

Crespo-Garcia S, Reichhart N, Skosyrski S, Foddis M, Wu J, Figura A, Herrspiegel C, Füchtemeier M, Sassi C, Dirnagl U, Joussen AM, Strauss O.

PLoS One. 2018 Mar 16;13(3):e0193961. doi: 10.1371/journal.pone.0193961. eCollection 2018. Erratum in: PLoS One. 2018 Apr 23;13(4):e0196538.

11.

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.

Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J; ARUK Consortium, Blumenau S, Thielke M, Josties C, Freyer D, Dietrich A, Hammer M, Baier M, Dirnagl U, Morgan K, Powell JF, Kauwe JS, Cruchaga C, Goate AM, Singleton AB, Guerreiro R, Hodges A, Hardy J.

Neurobiol Aging. 2018 Jun;66:179.e17-179.e29. doi: 10.1016/j.neurobiolaging.2018.01.015. Epub 2018 Feb 2.

12.

Preclinical research: Meet patients to sharpen up research.

Yarborough M, Dirnagl U.

Nature. 2017 Nov 16;551(7680):300. doi: 10.1038/d41586-017-06024-2. No abstract available.

PMID:
29144480
13.

Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex.

Prüss H, Tedeschi A, Thiriot A, Lynch L, Loughhead SM, Stutte S, Mazo IB, Kopp MA, Brommer B, Blex C, Geurtz LC, Liebscher T, Niedeggen A, Dirnagl U, Bradke F, Volz MS, DeVivo MJ, Chen Y, von Andrian UH, Schwab JM.

Nat Neurosci. 2017 Nov;20(11):1549-1559. doi: 10.1038/nn.4643. Epub 2017 Sep 18.

PMID:
28920935
14.

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models.

Koch S, Mueller S, Foddis M, Bienert T, von Elverfeldt D, Knab F, Farr TD, Bernard R, Dopatka M, Rex A, Dirnagl U, Harms C, Boehm-Sturm P.

J Cereb Blood Flow Metab. 2017 Jan 1:271678X17726635. doi: 10.1177/0271678X17726635. [Epub ahead of print]

PMID:
28829217
15.

Dr Smart talks to Prof Pries and Prof Dirnagl on animal experimentation in biomedical research.

Smart N, Pries AR, Dirnagl U.

Cardiovasc Res. 2017 May 1;113(6):e12-e15. doi: 10.1093/cvr/cvx056. No abstract available.

PMID:
28453737
16.

Increasing efficiency of preclinical research by group sequential designs.

Neumann K, Grittner U, Piper SK, Rex A, Florez-Vargas O, Karystianis G, Schneider A, Wellwood I, Siegerink B, Ioannidis JP, Kimmelman J, Dirnagl U.

PLoS Biol. 2017 Mar 10;15(3):e2001307. doi: 10.1371/journal.pbio.2001307. eCollection 2017 Mar.

17.

Long-term functional outcome in patients with acquired infections after acute spinal cord injury.

Kopp MA, Watzlawick R, Martus P, Failli V, Finkenstaedt FW, Chen Y, DeVivo MJ, Dirnagl U, Schwab JM.

Neurology. 2017 Feb 28;88(9):892-900. doi: 10.1212/WNL.0000000000003652. Epub 2017 Jan 27.

18.

Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment.

Dam K, Füchtemeier M, Farr TD, Boehm-Sturm P, Foddis M, Dirnagl U, Malysheva O, Caudill MA, Jadavji NM.

Behav Brain Res. 2017 Mar 15;321:201-208. doi: 10.1016/j.bbr.2016.12.041. Epub 2017 Jan 11.

PMID:
28087280
19.

Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment.

Boehm-Sturm P, Füchtemeier M, Foddis M, Mueller S, Trueman RC, Zille M, Rinnenthal JL, Kypraios T, Shaw L, Dirnagl U, Farr TD.

Stroke. 2017 Feb;48(2):468-475. doi: 10.1161/STROKEAHA.116.014394. Epub 2017 Jan 9.

20.

A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine.

Dirnagl U, Przesdzing I, Kurreck C, Major S.

PLoS Biol. 2016 Dec 1;14(12):e2000705. doi: 10.1371/journal.pbio.2000705. eCollection 2016 Dec.

21.

The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke.

Winek K, Dirnagl U, Meisel A.

Neurotherapeutics. 2016 Oct;13(4):762-774. doi: 10.1007/s13311-016-0475-x. Review.

22.

Natural Killer (NK) Cell Functionality after human Spinal Cord Injury (SCI): protocol of a prospective, longitudinal study.

Laginha I, Kopp MA, Druschel C, Schaser KD, Brommer B, Hellmann RC, Watzlawick R, Ossami-Saidi RR, Prüss H, Failli V, Meisel C, Liebscher T, Prilipp E, Niedeggen A, Ekkernkamp A, Grittner U, Piper SK, Dirnagl U, Killig M, Romagnani C, Schwab JM.

BMC Neurol. 2016 Sep 13;16:170. doi: 10.1186/s12883-016-0681-5.

23.

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.

Kreye J, Wenke NK, Chayka M, Leubner J, Murugan R, Maier N, Jurek B, Ly LT, Brandl D, Rost BR, Stumpf A, Schulz P, Radbruch H, Hauser AE, Pache F, Meisel A, Harms L, Paul F, Dirnagl U, Garner C, Schmitz D, Wardemann H, Prüss H.

Brain. 2016 Oct;139(Pt 10):2641-2652. Epub 2016 Aug 20.

PMID:
27543972
24.

Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice.

Donath S, An J, Lee SL, Gertz K, Datwyler AL, Harms U, Müller S, Farr TD, Füchtemeier M, Lättig-Tünnemann G, Lips J, Foddis M, Mosch L, Bernard R, Grittner U, Balkaya M, Kronenberg G, Dirnagl U, Endres M, Harms C.

J Neurosci. 2016 Aug 3;36(31):8132-48. doi: 10.1523/JNEUROSCI.4428-15.2016.

25.

SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol.

Kopp MA, Liebscher T, Watzlawick R, Martus P, Laufer S, Blex C, Schindler R, Jungehulsing GJ, Knüppel S, Kreutzträger M, Ekkernkamp A, Dirnagl U, Strittmatter SM, Niedeggen A, Schwab JM.

BMJ Open. 2016 Jul 26;6(7):e010651. doi: 10.1136/bmjopen-2015-010651.

26.

Thomas Willis Lecture: Is Translational Stroke Research Broken, and if So, How Can We Fix It?

Dirnagl U.

Stroke. 2016 Aug;47(8):2148-53. doi: 10.1161/STROKEAHA.116.013244. Epub 2016 Jun 28.

PMID:
27354221
27.

Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis.

Watzlawick R, Rind J, Sena ES, Brommer B, Zhang T, Kopp MA, Dirnagl U, Macleod MR, Howells DW, Schwab JM.

PLoS Biol. 2016 May 31;14(5):e1002468. doi: 10.1371/journal.pbio.1002468. eCollection 2016 May.

28.

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation.

Chamorro Á, Dirnagl U, Urra X, Planas AM.

Lancet Neurol. 2016 Jul;15(8):869-881. doi: 10.1016/S1474-4422(16)00114-9. Epub 2016 May 11. Review.

PMID:
27180033
29.

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke.

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U.

Stroke. 2016 May;47(5):1354-63. doi: 10.1161/STROKEAHA.115.011800. Epub 2016 Apr 7.

30.

Gut microbiota impact on stroke outcome: Fad or fact?

Winek K, Meisel A, Dirnagl U.

J Cereb Blood Flow Metab. 2016 May;36(5):891-8. doi: 10.1177/0271678X16636890. Epub 2016 Mar 4. Review.

31.

Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue.

Jadavji NM, Wieske F, Dirnagl U, Winter C.

Mol Genet Metab Rep. 2015 Feb 20;3:1-4. doi: 10.1016/j.ymgmr.2015.02.001. eCollection 2015 Jun.

32.

Methylprednisolone blocks interleukin 1 beta induced calcitonin gene related peptide release in trigeminal ganglia cells.

Neeb L, Hellen P, Hoffmann J, Dirnagl U, Reuter U.

J Headache Pain. 2016;17:19. doi: 10.1186/s10194-016-0609-x. Epub 2016 Mar 1.

33.

A pocket guide to electronic laboratory notebooks in the academic life sciences.

Dirnagl U, Przesdzing I.

F1000Res. 2016 Jan 4;5:2. doi: 10.12688/f1000research.7628.1. eCollection 2016.

34.

A new home for the Journal of Cerebral Blood Flow and Metabolism.

Dirnagl U, Lauritzen M.

J Cereb Blood Flow Metab. 2016 Feb;36(2):277. doi: 10.1177/0271678X15621576. No abstract available.

35.

Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study).

Scherbakov N, Ebner N, Sandek A, Meisel A, Haeusler KG, von Haehling S, Anker SD, Dirnagl U, Joebges M, Doehner W.

BMC Neurol. 2016 Jan 22;16:10. doi: 10.1186/s12883-016-0531-5.

36.

Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level.

Brommer B, Engel O, Kopp MA, Watzlawick R, Müller S, Prüss H, Chen Y, DeVivo MJ, Finkenstaedt FW, Dirnagl U, Liebscher T, Meisel A, Schwab JM.

Brain. 2016 Mar;139(Pt 3):692-707. doi: 10.1093/brain/awv375. Epub 2016 Jan 10.

37.

Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke.

Holman C, Piper SK, Grittner U, Diamantaras AA, Kimmelman J, Siegerink B, Dirnagl U.

PLoS Biol. 2016 Jan 4;14(1):e1002331. doi: 10.1371/journal.pbio.1002331. eCollection 2016 Jan.

38.

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.

Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A.

Stroke. 2015 Nov;46(11):3232-40. doi: 10.1161/STROKEAHA.115.008989. Epub 2015 Oct 8.

PMID:
26451017
39.

Infarct Volume Prediction by Early Magnetic Resonance Imaging in a Murine Stroke Model Depends on Ischemia Duration and Time of Imaging.

Leithner C, Füchtemeier M, Jorks D, Mueller S, Dirnagl U, Royl G.

Stroke. 2015 Nov;46(11):3249-59. doi: 10.1161/STROKEAHA.114.007832. Epub 2015 Oct 8.

PMID:
26451016
40.

Robust research: Institutions must do their part for reproducibility.

Begley CG, Buchan AM, Dirnagl U.

Nature. 2015 Sep 3;525(7567):25-7. doi: 10.1038/525025a. No abstract available.

PMID:
26333454
41.

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A.

Sci Transl Med. 2015 Aug 5;7(299):299ra121. doi: 10.1126/scitranslmed.aaa9853.

PMID:
26246166
42.

The Journal of Cerebral Blood Flow and Metabolism clinical, inaugural issue.

Lauritzen M, Dirnagl U.

J Cereb Blood Flow Metab. 2016 Jan;36(1):3. No abstract available.

43.

Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.

Römer C, Engel O, Winek K, Hochmeister S, Zhang T, Royl G, Klehmet J, Dirnagl U, Meisel C, Meisel A.

J Neurosci. 2015 May 20;35(20):7777-94. doi: 10.1523/JNEUROSCI.1532-14.2015.

44.

Neurovascular coupling during cortical spreading depolarization and -depression.

Østergaard L, Dreier JP, Hadjikhani N, Jespersen SN, Dirnagl U, Dalkara T.

Stroke. 2015 May;46(5):1392-401. doi: 10.1161/STROKEAHA.114.008077. Epub 2015 Apr 16. Review. No abstract available.

PMID:
25882051
45.

Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.

Hoffmann CJ, Harms U, Rex A, Szulzewsky F, Wolf SA, Grittner U, Lättig-Tünnemann G, Sendtner M, Kettenmann H, Dirnagl U, Endres M, Harms C.

Circulation. 2015 May 19;131(20):1772-82. doi: 10.1161/CIRCULATIONAHA.114.013003. Epub 2015 Mar 20.

PMID:
25794850
46.

Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment.

Jadavji NM, Farr TD, Lips J, Khalil AA, Boehm-Sturm P, Foddis M, Harms C, Füchtemeier M, Dirnagl U.

Behav Brain Res. 2015 Apr 15;283:215-26. doi: 10.1016/j.bbr.2015.01.040. Epub 2015 Feb 2.

PMID:
25655513
47.

High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types.

Doss S, Wandinger KP, Hyman BT, Panzer JA, Synofzik M, Dickerson B, Mollenhauer B, Scherzer CR, Ivinson AJ, Finke C, Schöls L, Müller Vom Hagen J, Trenkwalder C, Jahn H, Höltje M, Biswal BB, Harms L, Ruprecht K, Buchert R, Höglinger GU, Oertel WH, Unger MM, Körtvélyessy P, Bittner D, Priller J, Spruth EJ, Paul F, Meisel A, Lynch DR, Dirnagl U, Endres M, Teegen B, Probst C, Komorowski L, Stöcker W, Dalmau J, Prüss H.

Ann Clin Transl Neurol. 2014 Oct;1(10):822-32. doi: 10.1002/acn3.120. Epub 2014 Oct 18.

48.

Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment.

Füchtemeier M, Brinckmann MP, Foddis M, Kunz A, Po C, Curato C, Dirnagl U, Farr TD.

J Cereb Blood Flow Metab. 2015 Mar;35(3):476-84. doi: 10.1038/jcbfm.2014.221. Epub 2014 Dec 10.

49.

Changing the mindset in life sciences toward translation: a consensus.

Duda GN, Grainger DW, Frisk ML, Bruckner-Tuderman L, Carr A, Dirnagl U, Einhäupl KM, Gottschalk S, Gruskin E, Huber C, June CH, Mooney DJ, Rietschel ET, Schütte G, Seeger W, Stevens MM, Urban R, Veldman A, Wess G, Volk HD.

Sci Transl Med. 2014 Nov 26;6(264):264cm12. doi: 10.1126/scitranslmed.aaa0599.

PMID:
25429054
50.

Catabolic signaling and muscle wasting after acute ischemic stroke in mice: indication for a stroke-specific sarcopenia.

Springer J, Schust S, Peske K, Tschirner A, Rex A, Engel O, Scherbakov N, Meisel A, von Haehling S, Boschmann M, Anker SD, Dirnagl U, Doehner W.

Stroke. 2014 Dec;45(12):3675-83. doi: 10.1161/STROKEAHA.114.006258. Epub 2014 Oct 28.

PMID:
25352483

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