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Items: 28


Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging.

Quijada P, Misra A, Velasquez LS, Burke RM, Lighthouse JK, Mickelsen DM, Dirkx RA Jr, Small EM.

J Mol Cell Cardiol. 2019 Apr;129:92-104. doi: 10.1016/j.yjmcc.2019.01.015. Epub 2019 Feb 13.


Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts.

Lighthouse JK, Burke RM, Velasquez LS, Dirkx RA Jr, Aiezza A 2nd, Moravec CS, Alexis JD, Rosenberg A, Small EM.

JCI Insight. 2019 Jan 10;4(1). pii: 92098. doi: 10.1172/jci.insight.92098. [Epub ahead of print]


Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.

Trembley MA, Quijada P, Agullo-Pascual E, Tylock KM, Colpan M, Dirkx RA Jr, Myers JR, Mickelsen DM, de Mesy Bentley K, Rothenberg E, Moravec CS, Alexis JD, Gregorio CC, Dirksen RT, Delmar M, Small EM.

Circulation. 2018 Oct 23;138(17):1864-1878. doi: 10.1161/CIRCULATIONAHA.117.031788.


Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure.

Burke RM, Lighthouse JK, Quijada P, Dirkx RA Jr, Rosenberg A, Moravec CS, Alexis JD, Small EM.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3436-E3445. doi: 10.1073/pnas.1717423115. Epub 2018 Mar 26.


Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.

Guo B, Lyu Q, Slivano OJ, Dirkx R, Christie CK, Czyzyk J, Hezel AF, Gharavi AG, Small EM, Miano JM.

J Am Soc Nephrol. 2018 Feb;29(2):416-422. doi: 10.1681/ASN.2017050473. Epub 2017 Nov 7.


Adaptive lipid packing and bioactivity in membrane domains.

Sezgin E, Gutmann T, Buhl T, Dirkx R, Grzybek M, Coskun Ü, Solimena M, Simons K, Levental I, Schwille P.

PLoS One. 2015 Apr 23;10(4):e0123930. doi: 10.1371/journal.pone.0123930. eCollection 2015.


Stability of proICA512/IA-2 and its targeting to insulin secretory granules require β4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum.

Torkko JM, Primo ME, Dirkx R, Friedrich A, Viehrig A, Vergari E, Borgonovo B, Sönmez A, Wegbrod C, Lachnit M, Münster C, Sica MP, Ermácora MR, Solimena M.

Mol Cell Biol. 2015 Mar;35(6):914-27. doi: 10.1128/MCB.00994-14. Epub 2015 Jan 5.


Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation.

Peeters A, Shinde AB, Dirkx R, Smet J, De Bock K, Espeel M, Vanhorebeek I, Vanlander A, Van Coster R, Carmeliet P, Fransen M, Van Veldhoven PP, Baes M.

Biochim Biophys Acta. 2015 Feb;1853(2):285-98. doi: 10.1016/j.bbamcr.2014.11.017. Epub 2014 Nov 20.


Age-dependent labeling and imaging of insulin secretory granules.

Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Müller A, Liu Y, Andree C, Mulligan B, Münster C, Kurth T, Bickle M, Speier S, Anastassiadis K, Solimena M.

Diabetes. 2013 Nov;62(11):3687-96. doi: 10.2337/db12-1819. Epub 2013 Aug 8.


Cholesterol-enriched membrane rafts and insulin secretion.

Dirkx R Jr, Solimena M.

J Diabetes Investig. 2012 Aug 20;3(4):339-46. doi: 10.1111/j.2040-1124.2012.00200.x. Review.


Human stiff-person syndrome IgG induces anxious behavior in rats.

Geis C, Weishaupt A, Grünewald B, Wultsch T, Reif A, Gerlach M, Dirkx R, Solimena M, Perani D, Heckmann M, Toyka KV, Folli F, Sommer C.

PLoS One. 2011 Feb 8;6(2):e16775. doi: 10.1371/journal.pone.0016775.


Automated suppression of sample-related artifacts in Fluorescence Correlation Spectroscopy.

Ries J, Bayer M, Csúcs G, Dirkx R, Solimena M, Ewers H, Schwille P.

Opt Express. 2010 May 24;18(11):11073-82. doi: 10.1364/OE.18.011073.


Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.

Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P.

Nat Genet. 2008 Feb;40(2):170-80. doi: 10.1038/ng.2007.62. Epub 2008 Jan 6.


Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts.

Dirkx R, Meyhi E, Asselberghs S, Reddy J, Baes M, Van Veldhoven PP.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):718-23. Epub 2007 Apr 9.


Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities.

Dirkx R, Vanhorebeek I, Martens K, Schad A, Grabenbauer M, Fahimi D, Declercq P, Van Veldhoven PP, Baes M.

Hepatology. 2005 Apr;41(4):868-78.


betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system.

Berghs S, Aggujaro D, Dirkx R Jr, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M.

J Cell Biol. 2000 Nov 27;151(5):985-1002.


The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells.

Ort T, Maksimova E, Dirkx R, Kachinsky AM, Berghs S, Froehner SC, Solimena M.

Eur J Cell Biol. 2000 Sep;79(9):621-30.


Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules.

Hermel JM, Dirkx R Jr, Solimena M.

Eur J Neurosci. 1999 Aug;11(8):2609-20.


ICA 512, a receptor tyrosine phosphatase-like protein, is concentrated in neurosecretory granule membranes.

Dirkx R Jr, Hermel JM, Rabin DU, Solimena M.

Adv Pharmacol. 1998;42:243-6. No abstract available.


STEP: a family of brain-enriched PTPs. Alternative splicing produces transmembrane, cytosolic and truncated isoforms.

Bult A, Zhao F, Dirkx R Jr, Raghunathan A, Solimena M, Lombroso PJ.

Eur J Cell Biol. 1997 Apr;72(4):337-44.


STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum.

Bult A, Zhao F, Dirkx R Jr, Sharma E, Lukacsi E, Solimena M, Naegele JR, Lombroso PJ.

J Neurosci. 1996 Dec 15;16(24):7821-31.


ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules.

Solimena M, Dirkx R Jr, Hermel JM, Pleasic-Williams S, Shapiro JA, Caron L, Rabin DU.

EMBO J. 1996 May 1;15(9):2102-14.


A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region.

Solimena M, Dirkx R Jr, Radzynski M, Mundigl O, De Camilli P.

J Cell Biol. 1994 Jul;126(2):331-41.


Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome.

Butler MH, Solimena M, Dirkx R Jr, Hayday A, De Camilli P.

J Exp Med. 1993 Dec 1;178(6):2097-106.


Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region.

Solimena M, Aggujaro D, Muntzel C, Dirkx R, Butler M, De Camilli P, Hayday A.

Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3073-7.

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