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Items: 1 to 50 of 128

1.

Cardiac metabolic effects of KNa1.2 channel deletion and evidence for its mitochondrial localization.

Smith CO, Wang YT, Nadtochiy SM, Miller JH, Jonas EA, Dirksen RT, Nehrke K, Brookes PS.

FASEB J. 2018 Jun 4:fj201800139R. doi: 10.1096/fj.201800139R. [Epub ahead of print]

PMID:
29863912
2.

Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.

Trembley MA, Quijada P, Agullo-Pascual E, Tylock KM, Colpan M, Dirkx RA Jr, Myers JR, Mickelsen DM, de Mesy Bentley K, Rothenberg E, Moravec CS, Alexis JD, Gregorio CC, Dirksen RT, Delmar M, Small EM.

Circulation. 2018 May 1. pii: CIRCULATIONAHA.117.031788. doi: 10.1161/CIRCULATIONAHA.117.031788. [Epub ahead of print]

PMID:
29716942
3.

Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications.

Auerbach DS, Biton Y, Polonsky B, McNitt S, Gross RA, Dirksen RT, Moss AJ.

Transl Res. 2018 Jan;191:81-92.e7. doi: 10.1016/j.trsl.2017.10.002. Epub 2017 Oct 20.

PMID:
29121487
4.

Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle.

Boncompagni S, Michelucci A, Pietrangelo L, Dirksen RT, Protasi F.

Sci Rep. 2017 Oct 27;7(1):14286. doi: 10.1038/s41598-017-14134-0.

5.

Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.

Chen W, Koop A, Liu Y, Guo W, Wei J, Wang R, MacLennan DH, Dirksen RT, Chen SRW.

Biochem J. 2017 Aug 7;474(16):2749-2761. doi: 10.1042/BCJ20170282.

6.

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration.

Liu W, Klose A, Forman S, Paris ND, Wei-LaPierre L, Cortés-Lopéz M, Tan A, Flaherty M, Miura P, Dirksen RT, Chakkalakal JV.

Elife. 2017 Jun 6;6. pii: e26464. doi: 10.7554/eLife.26464.

7.

CD73 Controls Extracellular Adenosine Generation in the Trigeminal Nociceptive Nerves.

Liu X, Ma L, Zhang S, Ren Y, Dirksen RT.

J Dent Res. 2017 Jun;96(6):671-677. doi: 10.1177/0022034517692953. Epub 2017 Feb 16.

8.

Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3.

Linsley JW, Hsu IU, Groom L, Yarotskyy V, Lavorato M, Horstick EJ, Linsley D, Wang W, Franzini-Armstrong C, Dirksen RT, Kuwada JY.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E228-E236. doi: 10.1073/pnas.1619238114. Epub 2016 Dec 21.

9.

Trojan triplets: RNA-based pathomechanisms for muscle dysfunction in Huntington's disease.

Skov M, Dirksen RT.

J Gen Physiol. 2017 Jan;149(1):49-53. doi: 10.1085/jgp.201611728. Epub 2016 Dec 9. No abstract available.

10.

Genetic biomarkers for the risk of seizures in long QT syndrome.

Auerbach DS, McNitt S, Gross RA, Zareba W, Dirksen RT, Moss AJ.

Neurology. 2016 Oct 18;87(16):1660-1668. Epub 2016 Jul 27. Erratum in: Neurology. 2018 Jun 12;90(24):1127.

11.

Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway.

Ma L, Trinh T, Ren Y, Dirksen RT, Liu X.

PLoS One. 2016 Oct 5;11(10):e0164028. doi: 10.1371/journal.pone.0164028. eCollection 2016.

12.

Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content but not through acute store-operated Ca2+ entry.

Carrell EM, Coppola AR, McBride HJ, Dirksen RT.

FASEB J. 2016 Dec;30(12):4109-4119. Epub 2016 Sep 1.

13.

Dmpk gene deletion or antisense knockdown does not compromise cardiac or skeletal muscle function in mice.

Carrell ST, Carrell EM, Auerbach D, Pandey SK, Bennett CF, Dirksen RT, Thornton CA.

Hum Mol Genet. 2016 Oct 1;25(19):4328-4338. doi: 10.1093/hmg/ddw266. Epub 2016 Aug 13.

14.

Age-dependent uncoupling of mitochondria from Ca2⁺ release units in skeletal muscle.

Pietrangelo L, D'Incecco A, Ainbinder A, Michelucci A, Kern H, Dirksen RT, Boncompagni S, Protasi F.

Oncotarget. 2015 Nov 3;6(34):35358-71. doi: 10.18632/oncotarget.6139.

15.

Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions.

Liu W, Wei-LaPierre L, Klose A, Dirksen RT, Chakkalakal JV.

Elife. 2015 Aug 27;4. doi: 10.7554/eLife.09221.

16.

Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism.

Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL.

J Biol Chem. 2015 Sep 25;290(39):23751-65. doi: 10.1074/jbc.M115.643544. Epub 2015 Aug 5.

17.

Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit.

Rebbeck RT, Willemse H, Groom L, Casarotto MG, Board PG, Beard NA, Dirksen RT, Dulhunty AF.

Skelet Muscle. 2015 Jul 22;5:23. doi: 10.1186/s13395-015-0049-3. eCollection 2015.

18.

Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death.

Michelucci A, Paolini C, Canato M, Wei-Lapierre L, Pietrangelo L, De Marco A, Reggiani C, Dirksen RT, Protasi F.

Anesthesiology. 2015 Sep;123(3):603-17. doi: 10.1097/ALN.0000000000000748.

19.

External Dentin Stimulation Induces ATP Release in Human Teeth.

Liu X, Wang C, Fujita T, Malmstrom HS, Nedergaard M, Ren YF, Dirksen RT.

J Dent Res. 2015 Sep;94(9):1259-66. doi: 10.1177/0022034515592858. Epub 2015 Jun 30.

20.

Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice.

Paolini C, Quarta M, Wei-LaPierre L, Michelucci A, Nori A, Reggiani C, Dirksen RT, Protasi F.

Skelet Muscle. 2015 Apr 18;5:10. doi: 10.1186/s13395-015-0035-9. eCollection 2015.

21.

Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.

Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL.

Skelet Muscle. 2015 Jan 29;5:4. doi: 10.1186/s13395-014-0027-1. eCollection 2015.

22.

New method for determining total calcium content in tissue applied to skeletal muscle with and without calsequestrin.

Lamboley CR, Kake Guena SA, Touré F, Hébert C, Yaddaden L, Nadeau S, Bouchard P, Wei-LaPierre L, Lainé J, Rousseau EC, Frenette J, Protasi F, Dirksen RT, Pape PC.

J Gen Physiol. 2015 Feb;145(2):127-53. doi: 10.1085/jgp.201411250.

23.

RGK proteins: fashioning muscle with “Rad” new brakes.

Yarotskyy V, Dirksen RT.

Channels (Austin). 2014;8(4):286-7. No abstract available.

24.

Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle.

Ainbinder A, Boncompagni S, Protasi F, Dirksen RT.

Cell Calcium. 2015 Jan;57(1):14-24. doi: 10.1016/j.ceca.2014.11.002. Epub 2014 Nov 15.

25.

Monovalent cationic channel activity in the inner membrane of nuclei from skeletal muscle fibers.

Yarotskyy V, Dirksen RT.

Biophys J. 2014 Nov 4;107(9):2027-36. doi: 10.1016/j.bpj.2014.09.030.

26.

Cheng et al. reply.

Cheng H, Wang W, Wang X, Sheu SS, Dirksen RT, Dong MQ.

Nature. 2014 Oct 23;514(7523):E14-5. doi: 10.1038/nature13859. No abstract available.

PMID:
25341791
27.

Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference.

Riazi S, Kraeva N, Muldoon SM, Dowling J, Ho C, Petre MA, Parness J, Dirksen RT, Rosenberg H.

Can J Anaesth. 2014 Nov;61(11):1040-9. doi: 10.1007/s12630-014-0227-5. Epub 2014 Sep 5.

28.

Triadopathies: an emerging class of skeletal muscle diseases.

Dowling JJ, Lawlor MW, Dirksen RT.

Neurotherapeutics. 2014 Oct;11(4):773-85. doi: 10.1007/s13311-014-0300-3. Review.

29.

Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.

Wagner LE 2nd, Groom LA, Dirksen RT, Yule DI.

Cell Calcium. 2014 Aug;56(2):96-107. doi: 10.1016/j.ceca.2014.05.004. Epub 2014 Jun 6.

30.

Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter.

O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS.

Antioxid Redox Signal. 2014 Aug 20;21(6):863-79. doi: 10.1089/ars.2013.5394. Epub 2014 Jun 25.

31.

Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy.

Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-LaPierre L, Sargent MA, Dirksen RT, Molkentin JD.

Hum Mol Genet. 2014 Jul 15;23(14):3706-15. doi: 10.1093/hmg/ddu079. Epub 2014 Feb 20.

32.

Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue.

Wei-Lapierre L, Carrell EM, Boncompagni S, Protasi F, Dirksen RT.

Nat Commun. 2013;4:2805. doi: 10.1038/ncomms3805.

33.

Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes.

Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC.

Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H154-9. doi: 10.1152/ajpheart.00749.2013. Epub 2013 Nov 1.

34.

Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death.

Yarotskyy V, Protasi F, Dirksen RT.

PLoS One. 2013 Oct 15;8(10):e77633. doi: 10.1371/journal.pone.0077633. eCollection 2013.

35.

Murine Fig4 is dispensable for muscle development but required for muscle function.

Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ.

Skelet Muscle. 2013 Sep 1;3(1):21. doi: 10.1186/2044-5040-3-21.

36.

Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity.

Wei-LaPierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W.

J Biol Chem. 2013 Apr 12;288(15):10567-77. doi: 10.1074/jbc.M113.455709. Epub 2013 Mar 1.

37.

Ca2+ release in muscle fibers expressing R4892W and G4896V type 1 ryanodine receptor disease mutants.

Lefebvre R, Legrand C, Groom L, Dirksen RT, Jacquemond V.

PLoS One. 2013;8(1):e54042. doi: 10.1371/journal.pone.0054042. Epub 2013 Jan 7.

38.

Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease.

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S.

Neuromuscul Disord. 2013 Feb;23(2):120-32. doi: 10.1016/j.nmd.2012.08.007. Epub 2012 Nov 24.

39.

Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy.

Loy RE, Lueck JD, Mostajo-Radji MA, Carrell EM, Dirksen RT.

PLoS One. 2012;7(11):e49757. doi: 10.1371/journal.pone.0049757. Epub 2012 Nov 12.

40.

Temperature and RyR1 regulate the activation rate of store-operated Ca²+ entry current in myotubes.

Yarotskyy V, Dirksen RT.

Biophys J. 2012 Jul 18;103(2):202-11. doi: 10.1016/j.bpj.2012.06.001. Epub 2012 Jul 17.

41.

Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial superoxide flashes: from discovery to new controversies.

Wei L, Dirksen RT.

J Gen Physiol. 2012 Jun;139(6):425-34. doi: 10.1085/jgp.201210790. No abstract available.

42.

Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage.

Sheu SS, Dirksen RT, Pugh EN Jr.

J Gen Physiol. 2012 Jun;139(6):391-3. doi: 10.1085/jgp.201210819. No abstract available.

43.

AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.

Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL.

Nat Med. 2012 Jan 8;18(2):244-51. doi: 10.1038/nm.2598.

44.

Expression of ecto-ATPase NTPDase2 in human dental pulp.

Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sévigny J, Malmström HS, Dirksen RT, Ren YF.

J Dent Res. 2012 Mar;91(3):261-7. doi: 10.1177/0022034511431582. Epub 2011 Dec 14.

45.

Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel.

Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA.

Hum Mol Genet. 2012 Mar 15;21(6):1312-24. doi: 10.1093/hmg/ddr568. Epub 2011 Dec 2.

46.

The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine.

Sheu SS, Dirksen RT, Pugh EN Jr.

J Gen Physiol. 2011 Dec;138(6):563-7. doi: 10.1085/jgp.201110739. No abstract available.

47.

Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CMB, Jin ZG.

Circ Res. 2012 Jan 6;110(1):59-70. doi: 10.1161/CIRCRESAHA.111.254672. Epub 2011 Nov 10.

48.

Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres.

Lefebvre R, Legrand C, González-Rodríguez E, Groom L, Dirksen RT, Jacquemond V.

J Physiol. 2011 Nov 15;589(Pt 22):5361-82. doi: 10.1113/jphysiol.2011.216408. Epub 2011 Oct 3.

49.

Response to "A critical evaluation of cpYFP as a probe for superoxide".

Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS.

Free Radic Biol Med. 2011 Nov 15;51(10):1937-40. doi: 10.1016/j.freeradbiomed.2011.08.024. Epub 2011 Aug 30. No abstract available.

PMID:
21925593
50.

Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families.

Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT.

Anesthesiology. 2011 Nov;115(5):938-45. doi: 10.1097/ALN.0b013e3182320068.

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