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Items: 1 to 50 of 241

1.

Effects of Conformational Changes in Peptide-CRM197 Conjugate Vaccines.

Jaffe J, Wucherer K, Sperry J, Zou Q, Chang Q, Massa MA, Bhattacharya K, Kumar S, Caparon M, Stead D, Wright P, Dirksen A, Francis MB.

Bioconjug Chem. 2019 Jan 16;30(1):47-53. doi: 10.1021/acs.bioconjchem.8b00661. Epub 2018 Dec 12.

PMID:
30475601
2.

Interstitial lung abnormalities are associated with increased mortality in smokers.

Hoyer N, Wille MMW, Thomsen LH, Wilcke T, Dirksen A, Pedersen JH, Saghir Z, Ashraf H, Shaker SB.

Respir Med. 2018 Mar;136:77-82. doi: 10.1016/j.rmed.2018.02.001. Epub 2018 Feb 3.

3.

European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency.

Miravitlles M, Dirksen A, Ferrarotti I, Koblizek V, Lange P, Mahadeva R, McElvaney NG, Parr D, Piitulainen E, Roche N, Stolk J, Thabut G, Turner A, Vogelmeier C, Stockley RA.

Eur Respir J. 2017 Nov 30;50(5). pii: 1700610. doi: 10.1183/13993003.00610-2017. Print 2017 Nov. Review.

4.

Malignancy risk estimation of pulmonary nodules in screening CTs: Comparison between a computer model and human observers.

van Riel SJ, Ciompi F, Winkler Wille MM, Dirksen A, Lam S, Scholten ET, Rossi SE, Sverzellati N, Naqibullah M, Wittenberg R, Hovinga-de Boer MC, Snoeren M, Peters-Bax L, Mets O, Brink M, Prokop M, Schaefer-Prokop C, van Ginneken B.

PLoS One. 2017 Nov 9;12(11):e0185032. doi: 10.1371/journal.pone.0185032. eCollection 2017.

5.

Process development of a FGF21 protein-antibody conjugate.

Dirksen A, Davis KA, Collins JT, Bhattacharya K, Finneman JI, Pepin EL, Ryczek JS, Brown PW, Wellborn WB, Mangalathillam R, Evans BP, Pozzo MJ, Finn RF.

Biopolymers. 2017 Sep 26. doi: 10.1002/bip.23042. [Epub ahead of print]

PMID:
28948603
6.

Computed Tomography-based Subclassification of Chronic Obstructive Pulmonary Disease.

Dirksen A, Wille MM.

Ann Am Thorac Soc. 2016 Apr;13 Suppl 2:S114-7. doi: 10.1513/AnnalsATS.201503-178KV.

PMID:
27115944
7.

A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences.

Thorgeirsson TE, Steinberg S, Reginsson GW, Bjornsdottir G, Rafnar T, Jonsdottir I, Helgadottir A, Gretarsdottir S, Helgadottir H, Jonsson S, Matthiasson SE, Gislason T, Tyrfingsson T, Gudbjartsson T, Isaksson HJ, Hardardottir H, Sigvaldason A, Kiemeney LA, Haugen A, Zienolddiny S, Wolf HJ, Franklin WA, Panadero A, Mayordomo JI, Hall IP, Rönmark E, Lundbäck B, Dirksen A, Ashraf H, Pedersen JH, Masson G, Sulem P, Thorsteinsdottir U, Gudbjartsson DF, Stefansson K.

Mol Psychiatry. 2016 May;21(5):594-600. doi: 10.1038/mp.2016.13. Epub 2016 Mar 8.

8.

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

Volgraf M, Sellers BD, Jiang Y, Wu G, Ly CQ, Villemure E, Pastor RM, Yuen PW, Lu A, Luo X, Liu M, Zhang S, Sun L, Fu Y, Lupardus PJ, Wallweber HJ, Liederer BM, Deshmukh G, Plise E, Tay S, Reynen P, Herrington J, Gustafson A, Liu Y, Dirksen A, Dietz MG, Liu Y, Wang TM, Hanson JE, Hackos D, Scearce-Levie K, Schwarz JB.

J Med Chem. 2016 Mar 24;59(6):2760-79. doi: 10.1021/acs.jmedchem.5b02010. Epub 2016 Mar 8.

PMID:
26919761
9.

Results of the Randomized Danish Lung Cancer Screening Trial with Focus on High-Risk Profiling.

Wille MM, Dirksen A, Ashraf H, Saghir Z, Bach KS, Brodersen J, Clementsen PF, Hansen H, Larsen KR, Mortensen J, Rasmussen JF, Seersholm N, Skov BG, Thomsen LH, Tønnesen P, Pedersen JH.

Am J Respir Crit Care Med. 2016 Mar 1;193(5):542-51. doi: 10.1164/rccm.201505-1040OC.

PMID:
26485620
10.

Correlation Between Emphysema and Lung Function in Healthy Smokers and Smokers With COPD.

Thomsen LH, Shaker SB, Dirksen A, Pedersen JH, Tal-Singer R, Bakke P, Vestbo J.

Chronic Obstr Pulm Dis. 2015 May 19;2(3):204-213. doi: 10.15326/jcopdf.2.3.2014.0154.

11.

Visual assessment of early emphysema and interstitial abnormalities on CT is useful in lung cancer risk analysis.

Wille MM, Thomsen LH, Petersen J, de Bruijne M, Dirksen A, Pedersen JH, Shaker SB.

Eur Radiol. 2016 Feb;26(2):487-94. doi: 10.1007/s00330-015-3826-9. Epub 2015 May 9.

PMID:
25956938
12.

Coronary artery calcification detected in lung cancer screening predicts cardiovascular death.

Rasmussen T, Køber L, Abdulla J, Pedersen JH, Wille MM, Dirksen A, Kofoed KF.

Scand Cardiovasc J. 2015 Jun;49(3):159-67. doi: 10.3109/14017431.2015.1039572. Epub 2015 Apr 29.

PMID:
25919145
13.

Predictive Accuracy of the PanCan Lung Cancer Risk Prediction Model -External Validation based on CT from the Danish Lung Cancer Screening Trial.

Winkler Wille MM, van Riel SJ, Saghir Z, Dirksen A, Pedersen JH, Jacobs C, Thomsen LH, Scholten ET, Skovgaard LT, van Ginneken B.

Eur Radiol. 2015 Oct;25(10):3093-9. doi: 10.1007/s00330-015-3689-0. Epub 2015 Mar 13.

PMID:
25764091
14.

Geodesic Atlas-Based Labeling of Anatomical Trees: Application and Evaluation on Airways Extracted From CT.

Feragen A, Petersen J, Owen M, Pechin Lo, Hohwu Thomsen L, Wille MM, Dirksen A, de Bruijne M.

IEEE Trans Med Imaging. 2015 Jun;34(6):1212-26. doi: 10.1109/TMI.2014.2380991. Epub 2014 Dec 18.

PMID:
25532169
15.

[Lung cancer screening with low-dose CT - Danish and international results].

Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, Døssing M, Hansen H, Kofoed KF, Larsen KR, Mortensen J, Rasmussen JF, Thomsen LH, Wille MM, Seersholm N, Skov BG, Thorsen H, Tønnesen P, Pedersen JH.

Ugeskr Laeger. 2014 Oct 13;176(42). pii: V05140283. Review. Danish.

PMID:
25316371
16.

[Lung cancer screening with low dose CT requires careful consideration].

Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, Døssing M, Hansen H, Kofoed KF, Larsen KR, Mortensen J, Rasmussen JF, Thomsen LH, Wille MM, Seersholm N, Skov BG, Thorsen H, Tønnesen P, Pedersen JH.

Ugeskr Laeger. 2014 Oct 13;176(42). pii: V06140341. Review. Danish.

PMID:
25316363
17.

Emphysema progression is visually detectable in low-dose CT in continuous but not in former smokers.

Wille MM, Thomsen LH, Dirksen A, Petersen J, Pedersen JH, Shaker SB.

Eur Radiol. 2014 Nov;24(11):2692-9. doi: 10.1007/s00330-014-3294-7. Epub 2014 Jul 20.

PMID:
25038853
18.

Effect of inspiration on airway dimensions measured in maximal inspiration CT images of subjects without airflow limitation.

Petersen J, Wille MM, Rakêt LL, Feragen A, Pedersen JH, Nielsen M, Dirksen A, de Bruijne M.

Eur Radiol. 2014 Sep;24(9):2319-25. doi: 10.1007/s00330-014-3261-3. Epub 2014 Jun 6.

PMID:
24903230
19.

Parallel synthesis and screening of peptide conjugates.

Dirksen A, Madsen M, Dello Iacono G, Matin MJ, Bacica M, Stanković N, Callans S, Bhat A.

Bioconjug Chem. 2014 Jun 18;25(6):1052-60. doi: 10.1021/bc500129w. Epub 2014 May 13.

PMID:
24824568
20.

Screening for lung cancer with low-dose computed tomography.

Brodersen J, Dirksen A, Pedersen JH.

Ann Intern Med. 2014 Feb 4;160(3):212. doi: 10.7326/L14-5003-2. No abstract available.

PMID:
24658700
21.

Optimal surface segmentation using flow lines to quantify airway abnormalities in chronic obstructive pulmonary disease.

Petersen J, Nielsen M, Lo P, Nordenmark LH, Pedersen JH, Wille MM, Dirksen A, de Bruijne M.

Med Image Anal. 2014 Apr;18(3):531-41. doi: 10.1016/j.media.2014.02.004. Epub 2014 Feb 17.

PMID:
24603047
22.

Quantitative airway analysis in longitudinal studies using groupwise registration and 4D optimal surfaces.

Petersen J, Modat M, Cardoso MJ, Dirksen A, Ourselin S, de Bruijne M.

Med Image Comput Comput Assist Interv. 2013;16(Pt 2):287-94.

PMID:
24579152
23.

Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme.

Ashraf H, Saghir Z, Dirksen A, Pedersen JH, Thomsen LH, Døssing M, Tønnesen P.

Thorax. 2014 Jun;69(6):574-9. doi: 10.1136/thoraxjnl-2013-203849. Epub 2014 Jan 17.

PMID:
24443174
24.

The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study.

Coxson HO, Dirksen A, Edwards LD, Yates JC, Agusti A, Bakke P, Calverley PM, Celli B, Crim C, Duvoix A, Fauerbach PN, Lomas DA, Macnee W, Mayer RJ, Miller BE, Müller NL, Rennard SI, Silverman EK, Tal-Singer R, Wouters EF, Vestbo J; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators.

Lancet Respir Med. 2013 Apr;1(2):129-36. doi: 10.1016/S2213-2600(13)70006-7. Epub 2013 Feb 1.

PMID:
24429093
25.

The search for distinct and clinically useful phenotypes in chronic obstructive pulmonary disease.

Dirksen A, MacNee W.

Am J Respir Crit Care Med. 2013 Nov 1;188(9):1045-6. doi: 10.1164/rccm.201309-1649ED. No abstract available.

PMID:
24180437
26.

The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs.

Muchekehu R, Liu D, Horn M, Campbell L, Del Rosario J, Bacica M, Moskowitz H, Osothprarop T, Dirksen A, Doppalapudi V, Kaspar A, Pirie-Shepherd SR, Coronella J.

Transl Oncol. 2013 Oct 1;6(5):562-72. eCollection 2013.

27.

Analysis of FEV1 decline in relatively healthy heavy smokers: implications of expressing changes in FEV1 in relative terms.

Thomsen LH, Dirksen A, Shaker SB, Skovgaard LT, Dahlbäck M, Pedersen JH.

COPD. 2014 Feb;11(1):96-104. doi: 10.3109/15412555.2013.830096. Epub 2013 Oct 10.

PMID:
24111638
28.

Synthesis and application of cNGR-containing imaging agents for detection of angiogenesis.

Dijkgraaf I, Van de Vijver P, Dirksen A, Hackeng TM.

Bioorg Med Chem. 2013 Jun 15;21(12):3555-64. doi: 10.1016/j.bmc.2013.04.002. Epub 2013 Apr 13. Review.

PMID:
23643902
29.

Development and progression of coronary artery calcification in long-term smokers: adverse effects of continued smoking.

Rasmussen T, Frestad D, Køber L, Pedersen JH, Thomsen LH, Dirksen A, Kofoed KF.

J Am Coll Cardiol. 2013 Jul 16;62(3):255-257. doi: 10.1016/j.jacc.2013.04.013. Epub 2013 Apr 30. No abstract available.

30.

Relationship between chronic obstructive pulmonary disease and subclinical coronary artery disease in long-term smokers.

Rasmussen T, Køber L, Pedersen JH, Dirksen A, Thomsen LH, Stender S, Brodersen J, Groen J, Ashraf H, Kofoed KF.

Eur Heart J Cardiovasc Imaging. 2013 Dec;14(12):1159-66. doi: 10.1093/ehjci/jet057. Epub 2013 May 2.

PMID:
23639550
31.

Alpha-1 antitrypsin deficiency: the European experience.

Stockley RA, Dirksen A, Stolk J.

COPD. 2013 Mar;10 Suppl 1:50-3. doi: 10.3109/15412555.2013.765838. Review.

PMID:
23527820
32.

Mortality by level of emphysema and airway wall thickness.

Johannessen A, Skorge TD, Bottai M, Grydeland TB, Nilsen RM, Coxson H, Dirksen A, Omenaas E, Gulsvik A, Bakke P.

Am J Respir Crit Care Med. 2013 Mar 15;187(6):602-8. doi: 10.1164/rccm.201209-1722OC. Epub 2013 Jan 17.

PMID:
23328525
33.

A hierarchical scheme for geodesic anatomical labeling of airway trees.

Feragen A, Petersen J, Owen M, Lo P, Thomsen LH, Wille MM, Dirksen A, de Bruijne M.

Med Image Comput Comput Assist Interv. 2012;15(Pt 3):147-55.

PMID:
23286125
34.

Geometric tree kernels: classification of COPD from airway tree geometry.

Feragen A, Petersen J, Grimm D, Dirksen A, Pedersen JH, Borgwardt K, de Bruijne M.

Inf Process Med Imaging. 2013;23:171-83.

PMID:
24683967
35.

Tree-space statistics and approximations for large-scale analysis of anatomical trees.

Feragen A, Owen M, Petersen J, Wille MM, Thomsen LH, Dirksen A, de Bruijne M.

Inf Process Med Imaging. 2013;23:74-85.

PMID:
24683959
36.

Lung cancer screening and video-assisted thoracic surgery.

Petersen RH, Hansen HJ, Dirksen A, Pedersen JH.

J Thorac Oncol. 2012 Jun;7(6):1026-31. doi: 10.1097/JTO.0b013e31824fe942.

37.

Development of viral nanoparticles for efficient intracellular delivery.

Wu Z, Chen K, Yildiz I, Dirksen A, Fischer R, Dawson PE, Steinmetz NF.

Nanoscale. 2012 Jun 7;4(11):3567-76. doi: 10.1039/c2nr30366c. Epub 2012 Apr 16.

38.

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation.

COPDGene CT Workshop Group, Barr RG, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, MacNee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD Jr, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, van Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG.

COPD. 2012 Apr;9(2):151-9. doi: 10.3109/15412555.2012.654923. Epub 2012 Mar 19.

39.

Factors influencing the decline in lung density in a Danish lung cancer screening cohort.

Shaker SB, Dirksen A, Lo P, Skovgaard LT, de Bruijne M, Pedersen JH.

Eur Respir J. 2012 Nov;40(5):1142-8. doi: 10.1183/09031936.00207911. Epub 2012 Mar 9.

40.

Mass preserving image registration for lung CT.

Gorbunova V, Sporring J, Lo P, Loeve M, Tiddens HA, Nielsen M, Dirksen A, de Bruijne M.

Med Image Anal. 2012 May;16(4):786-95. doi: 10.1016/j.media.2011.11.001. Epub 2012 Jan 14.

PMID:
22336692
41.

CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT.

Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, Døssing M, Hansen H, Kofoed KF, Larsen KR, Mortensen J, Rasmussen JF, Seersholm N, Skov BG, Thorsen H, Tønnesen P, Pedersen JH.

Thorax. 2012 Apr;67(4):296-301. doi: 10.1136/thoraxjnl-2011-200736. Epub 2012 Jan 27.

PMID:
22286927
42.

Dissimilarity-based classification of anatomical tree structures.

Sørensen L, Lo P, Dirksen A, Petersen J, de Bruijne M.

Inf Process Med Imaging. 2011;22:475-85.

PMID:
21761679
43.

Optimal graph based segmentation using flow lines with application to airway wall segmentation.

Petersen J, Nielsen M, Lo P, Saghir Z, Dirksen A, de Bruijne M.

Inf Process Med Imaging. 2011;22:49-60.

PMID:
21761645
44.

Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD.

Rutten EP, Grydeland TB, Pillai SG, Wagers S, Dirksen A, Coxson HO, Gulsvik A, Wouters EF, Bakke PS.

Pulm Med. 2011;2011:419328. doi: 10.1155/2011/419328. Epub 2011 Jan 16.

45.

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo.

Carter RI, Mumford RA, Treonze KM, Finke PE, Davies P, Si Q, Humes JL, Dirksen A, Piitulainen E, Ahmad A, Stockley RA.

Thorax. 2011 Aug;66(8):686-91. doi: 10.1136/thx.2010.154690. Epub 2011 May 26.

PMID:
21617168
46.

Multivalent display of proteins on viral nanoparticles using molecular recognition and chemical ligation strategies.

Venter PA, Dirksen A, Thomas D, Manchester M, Dawson PE, Schneemann A.

Biomacromolecules. 2011 Jun 13;12(6):2293-301. doi: 10.1021/bm200369e. Epub 2011 May 13.

47.

Eureka?

Stoel BC, Dirksen A, Stockley RA, Parr D, Piitulainen E, Shaker SB, Russi EW, Bakker ME, Reiber JH, Stolk J.

Radiology. 2011 May;259(2):610-1; author reply 611-2. doi: 10.1148/radiol.11102262. No abstract available.

PMID:
21502395
48.

MicroRNA miR-125b induces senescence in human melanoma cells.

Glud M, Manfé V, Biskup E, Holst L, Dirksen AM, Hastrup N, Nielsen FC, Drzewiecki KT, Gniadecki R.

Melanoma Res. 2011 Jun;21(3):253-6. doi: 10.1097/CMR.0b013e328345333b.

PMID:
21460750
49.

Non-allergic cutaneous reactions in airborne chemical sensitivity--a population based study.

Berg ND, Linneberg A, Thyssen JP, Dirksen A, Elberling J.

Int J Hyg Environ Health. 2011 Jun;214(3):239-45. doi: 10.1016/j.ijheh.2011.01.003. Epub 2011 Feb 16.

PMID:
21324740
50.

Participation bias in a randomised trial of screening for lung cancer.

Hestbech MS, Siersma V, Dirksen A, Pedersen JH, Brodersen J.

Lung Cancer. 2011 Sep;73(3):325-31. doi: 10.1016/j.lungcan.2010.12.018. Epub 2011 Feb 15.

PMID:
21324544

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