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Items: 1 to 50 of 157

1.

Responses to the Selective Bruton's Tyrosine Kinase (BTK) Inhibitor Tirabrutinib (ONO/GS-4059) in Diffuse Large B-cell Lymphoma Cell Lines.

Kozaki R, Vogler M, Walter HS, Jayne S, Dinsdale D, Siebert R, Dyer MJS, Yoshizawa T.

Cancers (Basel). 2018 Apr 23;10(4). pii: E127. doi: 10.3390/cancers10040127.

2.

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.

Robinson SW, Bourgognon JM, Spiers JG, Breda C, Campesan S, Butcher A, Mallucci GR, Dinsdale D, Morone N, Mistry R, Smith TM, Guerra-Martin M, Challiss RAJ, Giorgini F, Steinert JR.

PLoS Biol. 2018 Apr 9;16(4):e2003611. doi: 10.1371/journal.pbio.2003611. eCollection 2018 Apr.

3.

Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).

Chernova T, Murphy FA, Galavotti S, Sun XM, Powley IR, Grosso S, Schinwald A, Zacarias-Cabeza J, Dudek KM, Dinsdale D, Le Quesne J, Bennett J, Nakas A, Greaves P, Poland CA, Donaldson K, Bushell M, Willis AE, MacFarlane M.

Curr Biol. 2017 Nov 6;27(21):3302-3314.e6. doi: 10.1016/j.cub.2017.09.007.

4.

A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS.

Amodeo V, A D, Betts J, Bartesaghi S, Zhang Y, Richard-Londt A, Ellis M, Roshani R, Vouri M, Galavotti S, Oberndorfer S, Leite AP, Mackay A, Lampada A, Stratford EW, Li N, Dinsdale D, Grimwade D, Jones C, Nicotera P, Michod D, Brandner S, Salomoni P.

Cell Rep. 2017 Jul 11;20(2):411-426. doi: 10.1016/j.celrep.2017.06.047.

5.

Metabolic reprogramming during neuronal differentiation.

Agostini M, Romeo F, Inoue S, Niklison-Chirou MV, Elia AJ, Dinsdale D, Morone N, Knight RA, Mak TW, Melino G.

Cell Death Differ. 2016 Sep 1;23(9):1502-14. doi: 10.1038/cdd.2016.36. Epub 2016 Apr 8.

6.

Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease.

Chernova T, Sun XM, Powley IR, Galavotti S, Grosso S, Murphy FA, Miles GJ, Cresswell L, Antonov AV, Bennett J, Nakas A, Dinsdale D, Cain K, Bushell M, Willis AE, MacFarlane M.

Cell Death Differ. 2016 Jul;23(7):1152-64. doi: 10.1038/cdd.2015.165. Epub 2016 Feb 19.

7.

p63 supports aerobic respiration through hexokinase II.

Viticchiè G, Agostini M, Lena AM, Mancini M, Zhou H, Zolla L, Dinsdale D, Saintigny G, Melino G, Candi E.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11577-82. doi: 10.1073/pnas.1508871112. Epub 2015 Aug 31.

8.

Structure and magnetic properties of an unusual homoleptic iron(III) thiocyanate dimer.

Dinsdale DR, Lough AJ, Lemaire MT.

Dalton Trans. 2015 Jun 28;44(24):11077-82. doi: 10.1039/c5dt00743g. Epub 2015 May 21.

PMID:
25996241
9.

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.

Peretti D, Bastide A, Radford H, Verity N, Molloy C, Martin MG, Moreno JA, Steinert JR, Smith T, Dinsdale D, Willis AE, Mallucci GR.

Nature. 2015 Feb 12;518(7538):236-9. doi: 10.1038/nature14142. Epub 2015 Jan 14.

10.

A coculture model of the lung–blood barrier: the role of activated phagocytic cells.

Luyts K, Napierska D, Dinsdale D, Klein SG, Serchi T, Hoet PH.

Toxicol In Vitro. 2015 Feb;29(1):234-41.

PMID:
25448809
11.

Prion protein facilitates synaptic vesicle release by enhancing release probability.

Robinson SW, Nugent ML, Dinsdale D, Steinert JR.

Hum Mol Genet. 2014 Sep 1;23(17):4581-96. doi: 10.1093/hmg/ddu171. Epub 2014 Apr 9.

12.

TAp73 is required for spermatogenesis and the maintenance of male fertility.

Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1843-8. doi: 10.1073/pnas.1323416111. Epub 2014 Jan 21.

13.

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease.

Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, Willis AE, Mallucci GR, Loh SH, Martins LM.

Nat Cell Biol. 2014 Feb;16(2):157-66. doi: 10.1038/ncb2901. Epub 2014 Jan 19.

14.

TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor.

Niklison-Chirou MV, Steinert JR, Agostini M, Knight RA, Dinsdale D, Cattaneo A, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18952-7. doi: 10.1073/pnas.1221172110. Epub 2013 Nov 4.

15.

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants.

de Castro IP, Costa AC, Celardo I, Tufi R, Dinsdale D, Loh SH, Martins LM.

Cell Death Dis. 2013 Oct 24;4:e873. doi: 10.1038/cddis.2013.394.

16.

Evaluation and critical assessment of putative MCL-1 inhibitors.

Varadarajan S, Vogler M, Butterworth M, Dinsdale D, Walensky LD, Cohen GM.

Cell Death Differ. 2013 Nov;20(11):1475-84. doi: 10.1038/cdd.2013.79. Epub 2013 Jul 5.

17.

ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.

Vogler M, Dinsdale D, Dyer MJ, Cohen GM.

Br J Haematol. 2013 Oct;163(1):139-42. doi: 10.1111/bjh.12457. Epub 2013 Jul 4. No abstract available.

PMID:
23826785
18.

Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.

Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM.

Neoplasia. 2013 May;15(5):568-78.

19.

Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes.

Tucci P, Porta G, Agostini M, Dinsdale D, Iavicoli I, Cain K, Finazzi-Agró A, Melino G, Willis A.

Cell Death Dis. 2013 Mar 21;4:e549. doi: 10.1038/cddis.2013.76.

20.

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM.

PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15.

21.

miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.

Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G.

J Cell Biol. 2012 Oct 15;199(2):347-63. doi: 10.1083/jcb.201203134.

22.

TAp73 depletion accelerates aging through metabolic dysregulation.

Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2009-14. doi: 10.1101/gad.197640.112.

23.

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM.

Cell Death Differ. 2012 Dec;19(12):1896-907. doi: 10.1038/cdd.2012.108. Epub 2012 Sep 7.

24.

Sustained translational repression by eIF2α-P mediates prion neurodegeneration.

Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR.

Nature. 2012 May 6;485(7399):507-11. doi: 10.1038/nature11058. Erratum in: Nature.2014 Jul 17;511(7509):370.

25.

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells.

Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C, Salomoni P.

Oncogene. 2013 Feb 7;32(6):699-712. doi: 10.1038/onc.2012.111. Epub 2012 Apr 23.

PMID:
22525272
26.

Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL.

Robinson GL, Dinsdale D, Macfarlane M, Cain K.

Oncogene. 2012 Nov 29;31(48):4996-5006. doi: 10.1038/onc.2012.13. Epub 2012 Feb 6.

PMID:
22310286
27.

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

Pimenta de Castro I, Costa AC, Lam D, Tufi R, Fedele V, Moisoi N, Dinsdale D, Deas E, Loh SH, Martins LM.

Cell Death Differ. 2012 Aug;19(8):1308-16. doi: 10.1038/cdd.2012.5. Epub 2012 Feb 3.

28.

Oxidative stress induced by pure and iron-doped amorphous silica nanoparticles in subtoxic conditions.

Napierska D, Rabolli V, Thomassen LC, Dinsdale D, Princen C, Gonzalez L, Poels KL, Kirsch-Volders M, Lison D, Martens JA, Hoet PH.

Chem Res Toxicol. 2012 Apr 16;25(4):828-37. doi: 10.1021/tx200361v. Epub 2012 Mar 13.

PMID:
22263782
29.

Investigation of the cytotoxicity of nanozeolites A and Y.

Thomassen LC, Napierska D, Dinsdale D, Lievens N, Jammaer J, Lison D, Kirschhock CE, Hoet PH, Martens JA.

Nanotoxicology. 2012 Aug;6(5):472-85. doi: 10.3109/17435390.2011.587901. Epub 2011 Sep 27.

PMID:
21950480
30.

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM.

Blood. 2011 Jun 30;117(26):7145-54. doi: 10.1182/blood-2011-03-344812. Epub 2011 May 11.

31.

Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse.

Haustein MD, Read DJ, Steinert JR, Pilati N, Dinsdale D, Forsythe ID.

J Physiol. 2010 Dec 1;588(Pt 23):4683-93. doi: 10.1113/jphysiol.2010.199778. Epub 2010 Oct 11.

32.

Lung exposure to nanoparticles modulates an asthmatic response in a mouse model.

Hussain S, Vanoirbeek JA, Luyts K, De Vooght V, Verbeken E, Thomassen LC, Martens JA, Dinsdale D, Boland S, Marano F, Nemery B, Hoet PH.

Eur Respir J. 2011 Feb;37(2):299-309. doi: 10.1183/09031936.00168509. Epub 2010 Jun 7.

33.

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Baou M, Kohlhaas SL, Butterworth M, Vogler M, Dinsdale D, Walewska R, Majid A, Eldering E, Dyer MJ, Cohen GM.

Haematologica. 2010 Sep;95(9):1510-8. doi: 10.3324/haematol.2010.022368. Epub 2010 Apr 7.

34.

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. doi: 10.1038/ni.1843. Epub 2010 Feb 7.

35.

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.

Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P.

Hum Mol Genet. 2010 May 1;19(9):1669-77. doi: 10.1093/hmg/ddq043. Epub 2010 Feb 1.

36.

Alteration of the nuclear pore complex in Ca(2+)-mediated cell death.

Bano D, Dinsdale D, Cabrera-Socorro A, Maida S, Lambacher N, McColl B, Ferrando-May E, Hengartner MO, Nicotera P.

Cell Death Differ. 2010 Jan;17(1):119-33. doi: 10.1038/cdd.2009.112.

37.

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux.

Rossi M, Munarriz ER, Bartesaghi S, Milanese M, Dinsdale D, Guerra-Martin MA, Bampton ET, Glynn P, Bonanno G, Knight RA, Nicotera P, Melino G.

J Cell Sci. 2009 Sep 15;122(Pt 18):3330-9. doi: 10.1242/jcs.048181. Epub 2009 Aug 25.

38.

Different forms of cell death induced by putative BCL2 inhibitors.

Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJ, Cohen GM.

Cell Death Differ. 2009 Jul;16(7):1030-9. doi: 10.1038/cdd.2009.48. Epub 2009 Apr 24.

39.

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.

Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, Galavotti S, Young KW, Selmi T, Yacobi R, Van Etten RA, Donato N, Hunter A, Dinsdale D, Tirrò E, Vigneri P, Nicotera P, Dyer MJ, Holyoake T, Salomoni P, Calabretta B.

J Clin Invest. 2009 May;119(5):1109-23. doi: 10.1172/JCI35660. Epub 2009 Apr 13. Erratum in: J Clin Invest. 2013 Aug 1;123(8):3634.

40.

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.

Vogler M, Dinsdale D, Dyer MJ, Cohen GM.

Cell Death Differ. 2009 Mar;16(3):360-7. doi: 10.1038/cdd.2008.137. Epub 2008 Sep 19. Review.

41.

P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis.

Sayan AE, Sayan BS, Gogvadze V, Dinsdale D, Nyman U, Hansen TM, Zhivotovsky B, Cohen GM, Knight RA, Melino G.

Oncogene. 2008 Jul 17;27(31):4363-72. doi: 10.1038/onc.2008.64. Epub 2008 Mar 24.

PMID:
18362891
42.

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.

Vogler M, Dinsdale D, Sun XM, Young KW, Butterworth M, Nicotera P, Dyer MJ, Cohen GM.

Cell Death Differ. 2008 May;15(5):820-30. doi: 10.1038/cdd.2008.25. Epub 2008 Feb 29.

43.

Enhanced peripheral thrombogenicity after lung inflammation is mediated by platelet-leukocyte activation: role of P-selectin.

Nemmar A, Hoet PH, Vandervoort P, Dinsdale D, Nemery B, Hoylaerts MF.

J Thromb Haemost. 2007 Jun;5(6):1217-26.

44.

TAp63 and DeltaNp63 in cancer and epidermal development.

Candi E, Dinsdale D, Rufini A, Salomoni P, Knight RA, Mueller M, Krammer PH, Melino G.

Cell Cycle. 2007 Feb 1;6(3):274-85. Epub 2007 Feb 3. Review.

PMID:
17264681
45.

A cytoplasmic PML mutant inhibits p53 function.

Bellodi C, Kindle K, Bernassola F, Cossarizza A, Dinsdale D, Melino G, Heery D, Salomoni P.

Cell Cycle. 2006 Nov;5(22):2688-92. Epub 2006 Nov 15.

PMID:
17172828
46.

FLASH is an essential component of Cajal bodies.

Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14802-7. Epub 2006 Sep 26.

47.

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice.

Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli LG, Catani MV, Ramadan S, Knight RA, Melino G.

Cell Death Differ. 2006 Jun;13(6):1037-47.

48.

Cytoplasmic function of mutant promyelocytic leukemia (PML) and PML-retinoic acid receptor-alpha.

Bellodi C, Kindle K, Bernassola F, Dinsdale D, Cossarizza A, Melino G, Heery D, Salomoni P.

J Biol Chem. 2006 May 19;281(20):14465-73. Epub 2006 Mar 15.

49.

Motor neurone disease presenting as postoperative respiratory failure.

Walker HC, Dinsdale D, Abernethy DA.

Anaesth Intensive Care. 2006 Feb;34(1):93-6.

50.

Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro.

Dimova S, Hoet PH, Dinsdale D, Nemery B.

Int J Biochem Cell Biol. 2005 Aug;37(8):1727-37. Epub 2005 Apr 26.

PMID:
15878691

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