Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 90

1.

17β-estradiol regulates the RNA-binding protein Nova1, which then regulates the alternative splicing of estrogen receptor β in the aging female rat brain.

Shults CL, Dingwall CB, Kim CK, Pinceti E, Rao YS, Pak TR.

Neurobiol Aging. 2018 Jan;61:13-22. doi: 10.1016/j.neurobiolaging.2017.09.005. Epub 2017 Sep 14.

2.

Muscle-derived matrix metalloproteinase regulates stem cell proliferation in planarians.

Dingwall CB, King RS.

Dev Dyn. 2016 Sep;245(9):963-70. doi: 10.1002/dvdy.24428. Epub 2016 Jul 28.

3.

Visibility and Voice: Aboriginal People Experience Culturally Safe and Unsafe Health Care.

Hole RD, Evans M, Berg LD, Bottorff JL, Dingwall C, Alexis C, Nyberg J, Smith ML.

Qual Health Res. 2015 Dec;25(12):1662-74. doi: 10.1177/1049732314566325. Epub 2015 Jan 12.

PMID:
25583958
4.

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.

Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T.

J Biol Chem. 2012 Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15.

5.

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.

Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW.

J Biol Chem. 2011 Nov 25;286(47):40443-51. doi: 10.1074/jbc.M111.280495. Epub 2011 Sep 28.

6.

Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.

Gray EH, De Vos KJ, Dingwall C, Perkinton MS, Miller CC.

J Alzheimers Dis. 2010;21(4):1101-5. doi: 10.3233/JAD-2010-100717.

7.

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4639-44. doi: 10.1016/j.bmcl.2010.05.111. Epub 2010 Jun 8.

PMID:
20579874
8.

Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP.

Hughes M, Snetkov V, Rose RS, Trousil S, Mermoud JE, Dingwall C.

J Neurochem. 2010 Aug;114(3):832-42. doi: 10.1111/j.1471-4159.2010.06811.x. Epub 2010 May 13.

9.

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

Charrier N, Clarke B, Demont E, Dingwall C, Dunsdon R, Hawkins J, Hubbard J, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3669-73. doi: 10.1016/j.bmcl.2009.03.150. Epub 2009 Apr 5.

PMID:
19477642
10.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

Charrier N, Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hubbard J, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3664-8. doi: 10.1016/j.bmcl.2009.03.165. Epub 2009 Apr 17.

PMID:
19428244
11.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

Charrier N, Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hubbard J, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3674-8. doi: 10.1016/j.bmcl.2009.03.149. Epub 2009 Apr 5.

PMID:
19406640
12.

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Charrier N, Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, East P, Hawkins J, Howes C, Hussain I, Jeffrey P, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G.

J Med Chem. 2008 Jun 12;51(11):3313-7. doi: 10.1021/jm800138h. Epub 2008 May 6.

PMID:
18457381
13.

Chronic hydrocephalus-induced hypoxia: increased expression of VEGFR-2+ and blood vessel density in hippocampus.

Dombrowski SM, Deshpande A, Dingwall C, Leichliter A, Leibson Z, Luciano MG.

Neuroscience. 2008 Mar 18;152(2):346-59. doi: 10.1016/j.neuroscience.2007.11.049. Epub 2007 Dec 14.

14.

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

Beswick P, Charrier N, Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Gleave R, Hawkins J, Hussain I, Johnson CN, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Skidmore J, Soleil V, Smith KJ, Stanway S, Stemp G, Stuart A, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1022-6. doi: 10.1016/j.bmcl.2007.12.020. Epub 2007 Dec 15.

PMID:
18171615
15.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1011-6. doi: 10.1016/j.bmcl.2007.12.017. Epub 2007 Dec 15.

PMID:
18171614
16.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1017-21. doi: 10.1016/j.bmcl.2007.12.019. Epub 2007 Dec 15.

PMID:
18166458
18.

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.

Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.

J Neurochem. 2007 Feb;100(3):802-9.

19.

Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease.

Koistinen H, Prinjha R, Soden P, Harper A, Banner SJ, Pradat PF, Loeffler JP, Dingwall C.

Muscle Nerve. 2006 Oct;34(4):444-50.

PMID:
16856153
20.

gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.

Doglio LE, Kanwar R, Jackson GR, Perez M, Avila J, Dingwall C, Dotti CG, Fortini ME, Feiguin F.

Neuron. 2006 May 4;50(3):359-75. Retraction in: Dotti CG, Feiguin F, Fortini ME. Neuron. 2007 Feb 1;53(3):463.

21.

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

Angeletti B, Waldron KJ, Freeman KB, Bawagan H, Hussain I, Miller CC, Lau KF, Tennant ME, Dennison C, Robinson NJ, Dingwall C.

J Biol Chem. 2005 May 6;280(18):17930-7. Epub 2005 Feb 18.

22.

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction.

Thilakawardhana S, Everett DM, Murdock PR, Dingwall C, Owen JS.

Neurobiol Aging. 2005 Jun;26(6):813-23.

PMID:
15718039
23.

Neuronal membrane cholesterol loss enhances amyloid peptide generation.

Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, De Strooper B, Dotti CG.

J Cell Biol. 2004 Dec 6;167(5):953-60.

24.

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS, Anderton BH, Cooper JD, Dingwall C, Leigh PN, Shaw CE, Miller CC.

Mol Cell Neurosci. 2004 Jun;26(2):354-64.

PMID:
15207859
25.

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.

Harrison SM, Harper AJ, Hawkins J, Duddy G, Grau E, Pugh PL, Winter PH, Shilliam CS, Hughes ZA, Dawson LA, Gonzalez MI, Upton N, Pangalos MN, Dingwall C.

Mol Cell Neurosci. 2003 Nov;24(3):646-55.

PMID:
14664815
26.

Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains.

Ledesma MD, Abad-Rodriguez J, Galvan C, Biondi E, Navarro P, Delacourte A, Dingwall C, Dotti CG.

EMBO Rep. 2003 Dec;4(12):1190-6. Epub 2003 Nov 14.

27.

Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis.

Korfali N, Ruchaud S, Loegering D, Bernard D, Dingwall C, Kaufmann SH, Earnshaw WC.

J Biol Chem. 2004 Jan 9;279(2):1030-9. Epub 2003 Oct 28.

28.

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein.

Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11735-40. Epub 2003 Sep 22.

29.

Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

Hussain I, Hawkins J, Shikotra A, Riddell DR, Faller A, Dingwall C.

J Biol Chem. 2003 Sep 19;278(38):36264-8. Epub 2003 Jul 11.

30.

Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons.

Vinson M, Rausch O, Maycox PR, Prinjha RK, Chapman D, Morrow R, Harper AJ, Dingwall C, Walsh FS, Burbidge SA, Riddell DR.

Mol Cell Neurosci. 2003 Mar;22(3):344-52.

PMID:
12691736
31.

Mutation of charged residues in the TR3 death domain does not perturb interaction with TRADD.

Tunbridge E, Dingwall C, Edge C, Konduri M, DeMarini DJ, Livi GP, Maycox PR.

Protein Eng. 2002 Oct;15(10):811-5.

PMID:
12468715
32.

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

Lau KF, Howlett DR, Kesavapany S, Standen CL, Dingwall C, McLoughlin DM, Miller CC.

Mol Cell Neurosci. 2002 May;20(1):13-20.

PMID:
12056836
33.

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.

Ruchaud S, Korfali N, Villa P, Kottke TJ, Dingwall C, Kaufmann SH, Earnshaw WC.

EMBO J. 2002 Apr 15;21(8):1967-77.

34.

Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease.

Dingwall C.

J Clin Invest. 2001 Nov;108(9):1243-6. Review. No abstract available.

35.

The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly.

Dutta S, Akey IV, Dingwall C, Hartman KL, Laue T, Nolte RT, Head JF, Akey CW.

Mol Cell. 2001 Oct;8(4):841-53.

36.

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.

Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C, Downward J.

J Biol Chem. 2002 Jan 4;277(1):439-44. Epub 2001 Oct 15.

37.

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts.

Riddell DR, Christie G, Hussain I, Dingwall C.

Curr Biol. 2001 Aug 21;11(16):1288-93.

38.

Prodomain processing of Asp1 (BACE2) is autocatalytic.

Hussain I, Christie G, Schneider K, Moore S, Dingwall C.

J Biol Chem. 2001 Jun 29;276(26):23322-8. Epub 2001 Apr 20.

39.

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

Charlwood J, Dingwall C, Matico R, Hussain I, Johanson K, Moore S, Powell DJ, Skehel JM, Ratcliffe S, Clarke B, Trill J, Sweitzer S, Camilleri P.

J Biol Chem. 2001 May 18;276(20):16739-48. Epub 2001 Jan 30.

40.

Genetic transformation of HeLa cells by Agrobacterium.

Kunik T, Tzfira T, Kapulnik Y, Gafni Y, Dingwall C, Citovsky V.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1871-6. Epub 2001 Jan 30.

41.

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.

Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, Ratcliffe SJ, Tattersall D, Testa TT, Southan C, Ryan DM, Simmons DL, Walsh FS, Dingwall C, Christie G.

Mol Cell Neurosci. 2000 Nov;16(5):609-19.

PMID:
11083922
42.

In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase.

Howlett DR, Simmons DL, Dingwall C, Christie G.

Trends Neurosci. 2000 Nov;23(11):565-70. Review.

PMID:
11074266
43.

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL.

Eur J Biochem. 2000 Sep;267(18):5699-710.

44.

Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1.

Kumar KP, McBride KM, Weaver BK, Dingwall C, Reich NC.

Mol Cell Biol. 2000 Jun;20(11):4159-68.

45.

A genetic system for detection of protein nuclear import and export.

Rhee Y, Gurel F, Gafni Y, Dingwall C, Citovsky V.

Nat Biotechnol. 2000 Apr;18(4):433-7.

PMID:
10748526
46.

Identification of a novel aspartic protease (Asp 2) as beta-secretase.

Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G.

Mol Cell Neurosci. 1999 Dec;14(6):419-27.

PMID:
10656250
47.

Nuclear import: a tale of two sites.

Dingwall C, Laskey RA.

Curr Biol. 1998 Dec 17-31;8(25):R922-4.

48.

In vitro systems for the reconstitution of snRNP and protein nuclear import.

Dingwall C, Palacios I.

Methods Cell Biol. 1998;53:517-43. Review.

PMID:
9348523
50.

Transportin nuclear proteins.

Dingwall C.

Nature. 1996 Nov 21;384(6606):210-1. No abstract available.

PMID:
8918867

Supplemental Content

Loading ...
Support Center