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Chronic poly-drug administration damages adult mouse brain neural stem cells.

McGrath EL, Schlagal CR, Cortez I, Dunn TJ, Gao J, Fox RG, Stutz SJ, Kuo YF, Hommel JD, Dineley KT, Cunningham KA, Kaphalia BS, Wu P.

Brain Res. 2019 Nov 15;1723:146425. doi: 10.1016/j.brainres.2019.146425. Epub 2019 Aug 29.


Elevated Neuroglobin Lessens Neuroinflammation and Alleviates Neurobehavioral Deficits Induced by Acute Inhalation of Combustion Smoke in the Mouse.

Gorgun MF, Zhuo M, Dineley KT, Englander EW.

Neurochem Res. 2019 Sep;44(9):2170-2181. doi: 10.1007/s11064-019-02856-8. Epub 2019 Aug 16.


Divergent Mechanisms for PPARγ Agonism in Ameliorating Aging-Related Versus Cranial Irradiation-Induced Context Discrimination Deficits.

Cortez I, Denner L, Dineley KT.

Front Aging Neurosci. 2019 Mar 14;11:38. doi: 10.3389/fnagi.2019.00038. eCollection 2019.


A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder.

Dimet AL, Cisneros IE, Fox RG, Stutz SJ, Anastasio NC, Cunningham KA, Dineley KT.

J Vis Exp. 2018 Jun 18;(136). doi: 10.3791/55864.


Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions.

Lee JH, Jahrling JB, Denner L, Dineley KT.

J Alzheimers Dis. 2018;64(s1):S427-S453. doi: 10.3233/JAD-179923. Review.


Corrigendum to "Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease" [Neurobiol. Aging 58 (2017) 1-13].

Velazquez R, Tran A, Ishimwe E, Denner L, Dave N, Oddo S, Dineley KT.

Neurobiol Aging. 2018 May;65:235-238. doi: 10.1016/j.neurobiolaging.2018.02.010. No abstract available.


Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes.

Cisneros IE, Erdenizmenli M, Cunningham KA, Paessler S, Dineley KT.

Neuropharmacology. 2018 Jun;135:431-443. doi: 10.1016/j.neuropharm.2018.03.019. Epub 2018 Mar 23.


Acute inhalation of combustion smoke triggers neuroinflammation and persistent anxiety-like behavior in the mouse.

Gorgun MF, Zhuo M, Cortez I, Dineley KT, Englander EW.

Inhal Toxicol. 2017 Oct - Dec;29(12-14):598-610. doi: 10.1080/08958378.2018.1432728. Epub 2018 Feb 6.


Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption.

McGrath EL, Gao J, Kuo YF, Dunn TJ, Ray MJ, Dineley KT, Cunningham KA, Kaphalia BS, Wu P.

Stem Cell Reports. 2017 Dec 12;9(6):1916-1930. doi: 10.1016/j.stemcr.2017.10.007. Epub 2017 Nov 9.


Corrigendum to "Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease" [Neurobiol. Aging 58 (2017) 1-13].

Velazquez R, Tran A, Ishimwe E, Denner L, Dave N, Oddo S, Dineley KT.

Neurobiol Aging. 2017 Oct;58:241. doi: 10.1016/j.neurobiolaging.2017.08.011. No abstract available.


Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease.

Velazquez R, Tran A, Ishimwe E, Denner L, Dave N, Oddo S, Dineley KT.

Neurobiol Aging. 2017 Oct;58:1-13. doi: 10.1016/j.neurobiolaging.2017.06.003. Epub 2017 Jun 17. Erratum in: Neurobiol Aging. 2017 Oct;58:241. Neurobiol Aging. 2018 May;65:235-238.


PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease.

Hsu WJ, Wildburger NC, Haidacher SJ, Nenov MN, Folorunso O, Singh AK, Chesson BC, Franklin WF, Cortez I, Sadygov RG, Dineley KT, Rudra JS, Taglialatela G, Lichti CF, Denner L, Laezza F.

Exp Neurol. 2017 Sep;295:1-17. doi: 10.1016/j.expneurol.2017.05.005. Epub 2017 May 15.


PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double-blind randomized controlled pilot trial.

Schmitz JM, Green CE, Hasan KM, Vincent J, Suchting R, Weaver MF, Moeller FG, Narayana PA, Cunningham KA, Dineley KT, Lane SD.

Addiction. 2017 Oct;112(10):1861-1868. doi: 10.1111/add.13868. Epub 2017 Jul 3.


Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness.

Papouin T, Dunphy JM, Tolman M, Dineley KT, Haydon PG.

Neuron. 2017 May 17;94(4):840-854.e7. doi: 10.1016/j.neuron.2017.04.021. Epub 2017 May 4.


Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection.

Ronca SE, Smith J, Koma T, Miller MM, Yun N, Dineley KT, Paessler S.

Front Microbiol. 2017 Feb 7;8:188. doi: 10.3389/fmicb.2017.00188. eCollection 2017.


PPARγ agonism attenuates cocaine cue reactivity.

Miller WR, Fox RG, Stutz SJ, Lane SD, Denner L, Cunningham KA, Dineley KT.

Addict Biol. 2018 Jan;23(1):55-68. doi: 10.1111/adb.12471. Epub 2016 Nov 11.


Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning.

Cortez I, Bulavin DV, Wu P, McGrath EL, Cunningham KA, Wakamiya M, Papaconstantinou J, Dineley KT.

Behav Brain Res. 2017 Mar 30;322(Pt B):212-222. doi: 10.1016/j.bbr.2016.10.023. Epub 2016 Oct 17.


Behavioural and neurological symptoms accompanied by cellular neuroinflammation in IL-10-deficient mice infected with Plasmodium chabaudi.

Wilson KD, Stutz SJ, Ochoa LF, Valbuena GA, Cravens PD, Dineley KT, Vargas G, Stephens R.

Malar J. 2016 Aug 24;15(1):428. doi: 10.1186/s12936-016-1477-1.


Neurological Sequelae Resulting from Encephalitic Alphavirus Infection.

Ronca SE, Dineley KT, Paessler S.

Front Microbiol. 2016 Jun 20;7:959. doi: 10.3389/fmicb.2016.00959. eCollection 2016. Review.


Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection.

Yun NE, Ronca S, Tamura A, Koma T, Seregin AV, Dineley KT, Miller M, Cook R, Shimizu N, Walker AG, Smith JN, Fair JN, Wauquier N, Bockarie B, Khan SH, Makishima T, Paessler S.

J Virol. 2015 Dec 30;90(6):2920-7. doi: 10.1128/JVI.02948-15.


Nicotinic ACh receptors as therapeutic targets in CNS disorders.

Dineley KT, Pandya AA, Yakel JL.

Trends Pharmacol Sci. 2015 Feb;36(2):96-108. doi: 10.1016/ Epub 2015 Jan 29. Review.


Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.

Nenov MN, Tempia F, Denner L, Dineley KT, Laezza F.

J Neurophysiol. 2015 Mar 15;113(6):1712-26. doi: 10.1152/jn.00419.2014. Epub 2014 Dec 24.


Islet amyloid polypeptide (IAPP): a second amyloid in Alzheimer's disease.

Fawver JN, Ghiwot Y, Koola C, Carrera W, Rodriguez-Rivera J, Hernandez C, Dineley KT, Kong Y, Li J, Jhamandas J, Perry G, Murray IV.

Curr Alzheimer Res. 2014;11(10):928-40.


Insulin resistance in Alzheimer's disease.

Dineley KT, Jahrling JB, Denner L.

Neurobiol Dis. 2014 Dec;72 Pt A:92-103. doi: 10.1016/j.nbd.2014.09.001. Epub 2014 Sep 16. Review.


Research tool: Validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches.

Hernandez CM, Cortez I, Gu Z, Colón-Sáez JO, Lamb PW, Wakamiya M, Yakel JL, Dineley KT.

J Physiol. 2014 Aug 1;592(15):3201-14. doi: 10.1113/jphysiol.2014.272054. Epub 2014 May 30.


Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R.

J Neurosci. 2014 Mar 19;34(12):4260-72. doi: 10.1523/JNEUROSCI.3192-13.2014.


PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement.

Jahrling JB, Hernandez CM, Denner L, Dineley KT.

J Neurosci. 2014 Mar 12;34(11):4054-63. doi: 10.1523/JNEUROSCI.4024-13.2014.


Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice.

Nenov MN, Laezza F, Haidacher SJ, Zhao Y, Sadygov RG, Starkey JM, Spratt H, Luxon BA, Dineley KT, Denner L.

J Neurosci. 2014 Jan 15;34(3):1028-36. doi: 10.1523/JNEUROSCI.3413-13.2014.


α7 Nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model.

Pirttimaki TM, Codadu NK, Awni A, Pratik P, Nagel DA, Hill EJ, Dineley KT, Parri HR.

PLoS One. 2013 Nov 28;8(11):e81828. doi: 10.1371/journal.pone.0081828. eCollection 2013.


Ruthenium red colorimetric and birefringent staining of amyloid-β aggregates in vitro and in Tg2576 mice.

Cook NP, Archer CM, Fawver JN, Schall HE, Rodriguez-Rivera J, Dineley KT, Martí AA, Murray IV.

ACS Chem Neurosci. 2013 Mar 20;4(3):379-84. doi: 10.1021/cn300219n. Epub 2013 Jan 11.


Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.

Yan J, Mei FC, Cheng H, Lao DH, Hu Y, Wei J, Patrikeev I, Hao D, Stutz SJ, Dineley KT, Motamedi M, Hommel JD, Cunningham KA, Chen J, Cheng X.

Mol Cell Biol. 2013 Mar;33(5):918-26. doi: 10.1128/MCB.01227-12. Epub 2012 Dec 21.


Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways.

Denner LA, Rodriguez-Rivera J, Haidacher SJ, Jahrling JB, Carmical JR, Hernandez CM, Zhao Y, Sadygov RG, Starkey JM, Spratt H, Luxon BA, Wood TG, Dineley KT.

J Neurosci. 2012 Nov 21;32(47):16725-35a. doi: 10.1523/JNEUROSCI.2153-12.2012.


α7 nicotinic acetylcholine receptors in Alzheimer's disease: neuroprotective, neurotrophic or both?

Hernandez CM, Dineley KT.

Curr Drug Targets. 2012 May;13(5):613-22. Review.


α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.

Martin ZS, Neugebauer V, Dineley KT, Kayed R, Zhang W, Reese LC, Taglialatela G.

J Neurochem. 2012 Feb;120(3):440-52. doi: 10.1111/j.1471-4159.2011.07576.x. Epub 2011 Nov 28.


Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease.

Parri HR, Hernandez CM, Dineley KT.

Biochem Pharmacol. 2011 Oct 15;82(8):931-42. doi: 10.1016/j.bcp.2011.06.039. Epub 2011 Jul 7. Review.


Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status.

Rodriguez-Rivera J, Denner L, Dineley KT.

Behav Brain Res. 2011 Jan 1;216(1):255-61. doi: 10.1016/j.bbr.2010.08.002. Epub 2010 Aug 13.


Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice.

Dineley KT, Kayed R, Neugebauer V, Fu Y, Zhang W, Reese LC, Taglialatela G.

J Neurosci Res. 2010 Oct;88(13):2923-32. doi: 10.1002/jnr.22445.


Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition.

Taglialatela G, Hogan D, Zhang WR, Dineley KT.

Behav Brain Res. 2009 Jun 8;200(1):95-9. doi: 10.1016/j.bbr.2008.12.034. Epub 2009 Jan 8.


Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.

Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G.

Aging Cell. 2008 Dec;7(6):824-35. doi: 10.1111/j.1474-9726.2008.00434.x. Epub 2008 Sep 8.


Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.

Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, Richardson JC, Yan SD, Hanger DP, Allan SM, Sutherland C.

J Neurochem. 2007 Nov;103(3):1132-44. Epub 2007 Aug 7.


Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice.

Dineley KT, Hogan D, Zhang WR, Taglialatela G.

Neurobiol Learn Mem. 2007 Sep;88(2):217-24. Epub 2007 May 22.


Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo.

Hotte M, Thuault S, Dineley KT, Hemmings HC Jr, Nairn AC, Jay TM.

Synapse. 2007 Jan;61(1):24-8.


D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex.

Hotte M, Thuault S, Lachaise F, Dineley KT, Hemmings HC, Nairn AC, Jay TM.

Behav Brain Res. 2006 Jul 15;171(1):127-33. Epub 2006 May 9.


Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo.

Galvan CD, Wenzel JH, Dineley KT, Lam TT, Schwartzkroin PA, Sweatt JD, Swann JW.

Eur J Neurosci. 2003 Oct;18(7):1861-72.


beta -Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes.

Dineley KT, Bell KA, Bui D, Sweatt JD.

J Biol Chem. 2002 Jul 12;277(28):25056-61. Epub 2002 Apr 30.

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