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Items: 1 to 50 of 179

1.

Neutrophil Defects and Diagnosis Disorders of Neutrophil Function: An Overview.

Dinauer MC.

Methods Mol Biol. 2020;2087:11-29. doi: 10.1007/978-1-0716-0154-9_2.

PMID:
31728980
2.

Insights into the NOX NADPH Oxidases Using Heterologous Whole Cell Assays.

Dinauer MC.

Methods Mol Biol. 2019;1982:139-151. doi: 10.1007/978-1-4939-9424-3_9.

PMID:
31172471
3.

Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption.

Jang JS, Kang IS, Cha YN, Lee ZH, Dinauer MC, Kim YJ, Kim C.

BMB Rep. 2019 May 10. pii: 4489. [Epub ahead of print]

4.

Inflammatory consequences of inherited disorders affecting neutrophil function.

Dinauer MC.

Blood. 2019 May 16;133(20):2130-2139. doi: 10.1182/blood-2018-11-844563. Epub 2019 Mar 21. Review.

PMID:
30898864
5.

Inherited p40phox deficiency differs from classic chronic granulomatous disease.

van de Geer A, Nieto-Patlán A, Kuhns DB, Tool AT, Arias AA, Bouaziz M, de Boer M, Franco JL, Gazendam RP, van Hamme JL, van Houdt M, van Leeuwen K, Verkuijlen PJ, van den Berg TK, Alzate JF, Arango-Franco CA, Batura V, Bernasconi AR, Boardman B, Booth C, Burns SO, Cabarcas F, Bensussan NC, Charbit-Henrion F, Corveleyn A, Deswarte C, Azcoiti ME, Foell D, Gallin JI, Garcés C, Guedes M, Hinze CH, Holland SM, Hughes SM, Ibañez P, Malech HL, Meyts I, Moncada-Velez M, Moriya K, Neves E, Oleastro M, Perez L, Rattina V, Oleaga-Quintas C, Warner N, Muise AM, López JS, Trindade E, Vasconcelos J, Vermeire S, Wittkowski H, Worth A, Abel L, Dinauer MC, Arkwright PD, Roos D, Casanova JL, Kuijpers TW, Bustamante J.

J Clin Invest. 2018 Aug 31;128(9):3957-3975. doi: 10.1172/JCI97116. Epub 2018 Aug 6.

6.

Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.

Arai Y, Choi U, Corsino CI, Koontz SM, Tajima M, Sweeney CL, Black MA, Feldman SA, Dinauer MC, Malech HL.

Mol Ther. 2018 May 2;26(5):1181-1197. doi: 10.1016/j.ymthe.2018.03.003. Epub 2018 Mar 10.

7.

NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages.

Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC.

Blood. 2018 May 24;131(21):2367-2378. doi: 10.1182/blood-2017-09-809004. Epub 2018 Apr 4.

8.

LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Viehmann Milam A, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW.

J Biol Chem. 2018 Apr 20;293(16):6022-6038. doi: 10.1074/jbc.RA117.001246. Epub 2018 Mar 1.

9.

Somatic mutations and clonal hematopoiesis in congenital neutropenia.

Xia J, Miller CA, Baty J, Ramesh A, Jotte MRM, Fulton RS, Vogel TP, Cooper MA, Walkovich KJ, Makaryan V, Bolyard AA, Dinauer MC, Wilson DB, Vlachos A, Myers KC, Rothbaum RJ, Bertuch AA, Dale DC, Shimamura A, Boxer LA, Link DC.

Blood. 2018 Jan 25;131(4):408-416. doi: 10.1182/blood-2017-08-801985. Epub 2017 Nov 1.

10.

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 Jun 6;19(10):2174-2176. doi: 10.1016/j.celrep.2017.05.075. No abstract available.

11.

Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.

Jacob CO, Yu N, Yoo DG, Perez-Zapata LJ, Barbu EA, Kaplan MJ, Purmalek M, Pingel JT, Idol RA, Dinauer MC.

Arthritis Rheumatol. 2017 Aug;69(8):1647-1660. doi: 10.1002/art.40141. Epub 2017 Jul 5.

12.

Laurence Alan Boxer, M.D. (1940-2017).

Dinauer MC.

J Leukoc Biol. 2017 May;101(5):1075. doi: 10.1189/jlb.1LT0217-060. No abstract available.

PMID:
28468985
13.

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 May 2;19(5):1008-1021. doi: 10.1016/j.celrep.2017.04.019. Erratum in: Cell Rep. 2017 Jun 6;19(10 ):2174-2176.

14.

Primary immune deficiencies with defects in neutrophil function.

Dinauer MC.

Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):43-50. Review.

15.

PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo.

Bagaitkar J, Barbu EA, Perez-Zapata LJ, Austin A, Huang G, Pallat S, Dinauer MC.

J Leukoc Biol. 2017 Feb;101(2):449-457. doi: 10.1189/jlb.3AB0316-139R. Epub 2016 Aug 19.

PMID:
27543673
16.

Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.

Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW.

Cell Host Microbe. 2016 Jan 13;19(1):102-13. doi: 10.1016/j.chom.2015.12.011.

17.

NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis.

Bagaitkar J, Pech NK, Ivanov S, Austin A, Zeng MY, Pallat S, Huang G, Randolph GJ, Dinauer MC.

Blood. 2015 Dec 17;126(25):2724-33. doi: 10.1182/blood-2015-05-644773. Epub 2015 Oct 6.

18.

Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts.

McLetchie S, Volpp BD, Dinauer MC, Blum JS.

Immunology. 2015 Dec;146(4):595-606. doi: 10.1111/imm.12530. Epub 2015 Sep 29.

19.

Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67phox.

Roos D, van Buul JD, Tool AT, Matute JD, Marchal CM, Hayee B, Köker MY, de Boer M, van Leeuwen K, Segal AW, Pick E, Dinauer MC.

J Clin Cell Immunol. 2014 Jun 30;5(3). pii: 1000231.

20.

Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia.

Gomez JC, Yamada M, Martin JR, Dang H, Brickey WJ, Bergmeier W, Dinauer MC, Doerschuk CM.

Am J Respir Cell Mol Biol. 2015 Mar;52(3):349-64. doi: 10.1165/rcmb.2013-0316OC.

21.

Disorders of neutrophil function: an overview.

Dinauer MC.

Methods Mol Biol. 2014;1124:501-15. doi: 10.1007/978-1-62703-845-4_30. Review.

PMID:
24504971
22.

Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic.

Chaturvedi KS, Hung CS, Giblin DE, Urushidani S, Austin AM, Dinauer MC, Henderson JP.

ACS Chem Biol. 2014 Feb 21;9(2):551-61. doi: 10.1021/cb400658k. Epub 2013 Dec 11.

23.

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.

Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS.

EMBO J. 2013 Dec 11;32(24):3130-44. doi: 10.1038/emboj.2013.233. Epub 2013 Nov 1.

24.

Primary Immune Deficiency Treatment Consortium (PIDTC) report.

Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker JC; workshop participants.

J Allergy Clin Immunol. 2014 Feb;133(2):335-47. doi: 10.1016/j.jaci.2013.07.052. Epub 2013 Oct 15.

25.

Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis.

Nunes P, Demaurex N, Dinauer MC.

Traffic. 2013 Nov;14(11):1118-31. doi: 10.1111/tra.12115. Epub 2013 Sep 16. Review.

26.

From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease.

Stein S, Scholz S, Schwäble J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Müller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG Jr, Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kühlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M.

Hum Gene Ther Clin Dev. 2013 Jun;24(2):86-98. doi: 10.1089/humc.2013.019.

27.

An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD.

Zeng MY, Pham D, Bagaitkar J, Liu J, Otero K, Shan M, Wynn TA, Brombacher F, Brutkiewicz RR, Kaplan MH, Dinauer MC.

Blood. 2013 Apr 25;121(17):3473-83. doi: 10.1182/blood-2012-10-461913. Epub 2013 Feb 20.

28.

Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40(phox) in humans but not in mice.

Bagaitkar J, Matute JD, Austin A, Arias AA, Dinauer MC.

Blood. 2012 Oct 18;120(16):3385-7. doi: 10.1182/blood-2012-07-445619. No abstract available.

PMID:
23086626
29.

Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.

Crotzer VL, Matute JD, Arias AA, Zhao H, Quilliam LA, Dinauer MC, Blum JS.

J Immunol. 2012 Oct 15;189(8):3800-4. doi: 10.4049/jimmunol.1103080. Epub 2012 Sep 14.

30.

Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558.

Casbon AJ, Long ME, Dunn KW, Allen LA, Dinauer MC.

J Leukoc Biol. 2012 Oct;92(4):869-82. doi: 10.1189/jlb.0512244. Epub 2012 Jul 20.

31.

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.

Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP Jr, Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, Gaffney PM, Moser KL, Klein-Gitelman M, Wagner-Weiner L, Langefeld CD, Armstrong DL, Zidovetzki R.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):E59-67. doi: 10.1073/pnas.1113251108. Epub 2011 Dec 27.

32.

Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.

Mahankali M, Peng HJ, Henkels KM, Dinauer MC, Gomez-Cambronero J.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19617-22. doi: 10.1073/pnas.1114692108. Epub 2011 Nov 21.

33.

The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis.

Peng HJ, Henkels KM, Mahankali M, Marchal C, Bubulya P, Dinauer MC, Gomez-Cambronero J.

Mol Cell Biol. 2011 Jun;31(11):2227-40. doi: 10.1128/MCB.01348-10. Epub 2011 Mar 28.

34.

Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.

Peng HJ, Henkels KM, Mahankali M, Dinauer MC, Gomez-Cambronero J.

J Biol Chem. 2011 May 6;286(18):16308-20. doi: 10.1074/jbc.M110.206672. Epub 2011 Mar 4.

35.

Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease.

Bustamante J, Arias AA, Vogt G, Picard C, Galicia LB, Prando C, Grant AV, Marchal CC, Hubeau M, Chapgier A, de Beaucoudrey L, Puel A, Feinberg J, Valinetz E, Jannière L, Besse C, Boland A, Brisseau JM, Blanche S, Lortholary O, Fieschi C, Emile JF, Boisson-Dupuis S, Al-Muhsen S, Woda B, Newburger PE, Condino-Neto A, Dinauer MC, Abel L, Casanova JL.

Nat Immunol. 2011 Mar;12(3):213-21. doi: 10.1038/ni.1992. Epub 2011 Jan 30.

36.

Interferon-γ production by neutrophils during bacterial pneumonia in mice.

Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM.

Am J Respir Crit Care Med. 2011 May 15;183(10):1391-401. doi: 10.1164/rccm.201004-0592OC. Epub 2010 Dec 17.

37.

Gene therapy of chronic granulomatous disease: the engraftment dilemma.

Grez M, Reichenbach J, Schwäble J, Seger R, Dinauer MC, Thrasher AJ.

Mol Ther. 2011 Jan;19(1):28-35. doi: 10.1038/mt.2010.232. Epub 2010 Nov 2. Review.

38.

p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.

Li XJ, Marchal CC, Stull ND, Stahelin RV, Dinauer MC.

J Biol Chem. 2010 Nov 5;285(45):35169-79. doi: 10.1074/jbc.M110.164475. Epub 2010 Sep 5.

39.

Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice.

Xue X, Pech NK, Shelley WC, Srour EF, Yoder MC, Dinauer MC.

Blood. 2010 Dec 9;116(24):5419-22. doi: 10.1182/blood-2010-07-295949. Epub 2010 Sep 2.

40.

Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner.

Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL.

J Immunol. 2010 Oct 1;185(7):4030-41. doi: 10.4049/jimmunol.1001778. Epub 2010 Aug 30.

41.

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.

Lasater EA, Li F, Bessler WK, Estes ML, Vemula S, Hingtgen CM, Dinauer MC, Kapur R, Conway SJ, Ingram DA Jr.

J Clin Invest. 2010 Mar;120(3):859-70. doi: 10.1172/JCI41443. Epub 2010 Feb 15.

42.

Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells.

Nie B, Cheng N, Dinauer MC, Ye RD.

Cell Signal. 2010 May;22(5):770-82. doi: 10.1016/j.cellsig.2010.01.001. Epub 2010 Jan 13.

43.

Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.

Lewis EM, Sergeant S, Ledford B, Stull N, Dinauer MC, McPhail LC.

J Biol Chem. 2010 Jan 29;285(5):2959-67. doi: 10.1074/jbc.M109.030643. Epub 2009 Nov 30.

44.

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity.

Matute JD, Arias AA, Wright NA, Wrobel I, Waterhouse CC, Li XJ, Marchal CC, Stull ND, Lewis DB, Steele M, Kellner JD, Yu W, Meroueh SO, Nauseef WM, Dinauer MC.

Blood. 2009 Oct 8;114(15):3309-15. doi: 10.1182/blood-2009-07-231498. Epub 2009 Aug 19.

45.

Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation.

Sadat MA, Dirscherl S, Sastry L, Dantzer J, Pech N, Griffin S, Hawkins T, Zhao Y, Barese CN, Cross S, Orazi A, An C, Goebel WS, Yoder MC, Li X, Grez M, Cornetta K, Mooney SD, Dinauer MC.

Gene Ther. 2009 Dec;16(12):1452-64. doi: 10.1038/gt.2009.96.

46.

Activation of antibacterial autophagy by NADPH oxidases.

Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, Glogauer M, Grinstein S, Brumell JH.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6226-31. doi: 10.1073/pnas.0811045106. Epub 2009 Apr 1.

47.

Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes.

Casbon AJ, Allen LA, Dunn KW, Dinauer MC.

J Immunol. 2009 Feb 15;182(4):2325-39. doi: 10.4049/jimmunol.0803476.

48.

Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth.

Distasi MR, Case J, Ziegler MA, Dinauer MC, Yoder MC, Haneline LS, Dalsing MC, Miller SJ, Labarrere CA, Murphy MP, Ingram DA, Unthank JL.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H877-86. doi: 10.1152/ajpheart.00772.2008. Epub 2009 Jan 16.

49.

A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis.

Li XJ, Tian W, Stull ND, Grinstein S, Atkinson S, Dinauer MC.

Mol Biol Cell. 2009 Mar;20(5):1520-32. doi: 10.1091/mbc.E08-06-0620. Epub 2009 Jan 7.

50.

Mutational analysis reveals distinct features of the Nox4-p22 phox complex.

von Löhneysen K, Noack D, Jesaitis AJ, Dinauer MC, Knaus UG.

J Biol Chem. 2008 Dec 12;283(50):35273-82. doi: 10.1074/jbc.M804200200. Epub 2008 Oct 10.

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