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Items: 1 to 50 of 1002

1.

Interleukin-37 Treatment of Mice with Metabolic Syndrome Improves Insulin Sensitivity and Reduces Pro-inflammatory Cytokine Production in Adipose Tissue.

Ballak DB, Li S, Cavalli G, Stahl JL, Tengesdal IW, van Diepen JA, Kluck V, Swartzwelter B, Azam T, Tack CJ, Stienstra R, Mandrup-Poulsen T, Seals DR, Dinarello CA.

J Biol Chem. 2018 Jul 13. pii: jbc.RA118.003698. doi: 10.1074/jbc.RA118.003698. [Epub ahead of print]

2.

Indeed, IL-18 is more than an inducer of IFN-γ.

Dinarello CA, Kaplanski G.

J Leukoc Biol. 2018 May 7. doi: 10.1002/JLB.CE0118-025RR. [Epub ahead of print] No abstract available.

PMID:
29733453
3.

Interleukin-32 upregulates the expression of ABCA1 and ABCG1 resulting in reduced intracellular lipid concentrations in primary human hepatocytes.

Damen MSMA, Dos Santos JC, Hermsen R, Adam van der Vliet J, Netea MG, Riksen NP, Dinarello CA, Joosten LAB, Heinhuis B.

Atherosclerosis. 2018 Apr;271:193-202. doi: 10.1016/j.atherosclerosis.2018.02.027. Epub 2018 Mar 2.

4.

Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice.

Gomes RS, Silva MVT, Dos Santos JC, van Linge C, Reis JM, Teixeira MM, Pinto SA, Dorta ML, Bai X, Chan ED, Dinarello CA, Oliveira MAP, Joosten LAB, Ribeiro-Dias F.

Infect Immun. 2018 Apr 23;86(5). pii: e00796-17. doi: 10.1128/IAI.00796-17. Print 2018 May.

PMID:
29483288
5.

Role of glutathione metabolism in host defense against Borrelia burgdorferi infection.

Kerstholt M, Vrijmoeth H, Lachmandas E, Oosting M, Lupse M, Flonta M, Dinarello CA, Netea MG, Joosten LAB.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2320-E2328. doi: 10.1073/pnas.1720833115. Epub 2018 Feb 14.

PMID:
29444855
6.

α1-Antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease.

Magenau JM, Goldstein SC, Peltier D, Soiffer RJ, Braun T, Pawarode A, Riwes MM, Kennel M, Antin JH, Cutler CS, Ho VT, Alyea EP 3rd, Parkin BL, Yanik GA, Choi SW, Lewis EC, Dinarello CA, Koreth J, Reddy P.

Blood. 2018 Mar 22;131(12):1372-1379. doi: 10.1182/blood-2017-11-815746. Epub 2018 Feb 2.

PMID:
29437593
7.

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.

Jeong MY, Lin YH, Wennersten SA, Demos-Davies KM, Cavasin MA, Mahaffey JH, Monzani V, Saripalli C, Mascagni P, Reece TB, Ambardekar AV, Granzier HL, Dinarello CA, McKinsey TA.

Sci Transl Med. 2018 Feb 7;10(427). pii: eaao0144. doi: 10.1126/scitranslmed.aao0144.

8.

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29.

9.

Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation.

Nold-Petry CA, Nold MF, Levy O, Kliger Y, Oren A, Borukhov I, Becker C, Wirtz S, Sandhu MK, Neurath M, Dinarello CA.

Front Immunol. 2017 Dec 11;8:1531. doi: 10.3389/fimmu.2017.01531. eCollection 2017.

10.

Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity.

Dinarello CA.

Immunol Rev. 2018 Jan;281(1):5-7. doi: 10.1111/imr.12624. No abstract available.

PMID:
29248001
11.

Overview of the IL-1 family in innate inflammation and acquired immunity.

Dinarello CA.

Immunol Rev. 2018 Jan;281(1):8-27. doi: 10.1111/imr.12621. Review.

12.

Suppression of inflammation and acquired immunity by IL-37.

Cavalli G, Dinarello CA.

Immunol Rev. 2018 Jan;281(1):179-190. doi: 10.1111/imr.12605. Review.

PMID:
29247987
13.

Biology of IL-38 and its role in disease.

van de Veerdonk FL, de Graaf DM, Joosten LA, Dinarello CA.

Immunol Rev. 2018 Jan;281(1):191-196. doi: 10.1111/imr.12612. Review.

PMID:
29247986
14.

Ethanol-mediated suppression of IL-37 licenses alcoholic liver disease.

Grabherr F, Grander C, Adolph TE, Wieser V, Mayr L, Enrich B, Macheiner S, Sangineto M, Reiter A, Viveiros A, Zoller H, Bufler P, Moschen AR, Dinarello CA, Tilg H.

Liver Int. 2018 Jun;38(6):1095-1101. doi: 10.1111/liv.13642. Epub 2017 Dec 16.

PMID:
29193575
15.

MABp1 Targeting IL-1α for Moderate to Severe Hidradenitis Suppurativa Not Eligible for Adalimumab: A Randomized Study.

Kanni T, Argyropoulou M, Spyridopoulos T, Pistiki A, Stecher M, Dinarello CA, Simard J, Giamarellos-Bourboulis EJ.

J Invest Dermatol. 2018 Apr;138(4):795-801. doi: 10.1016/j.jid.2017.10.030. Epub 2017 Nov 10.

16.

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.

Cavalli G, Koenders M, Kalabokis V, Kim J, Choon Tan A, Garlanda C, Mantovani A, Dagna L, Joosten LAB, Dinarello CA.

Rheumatology (Oxford). 2017 Dec 1;56(12):2256. doi: 10.1093/rheumatology/kex348. No abstract available.

PMID:
28968825
17.

The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice.

Hoeke G, Khedoe PPSJ, van Diepen JA, Pike-Overzet K, van de Ven B, Vazirpanah N, Mol I, Hiemstra PS, Staal FJT, Stienstra R, Netea MG, Dinarello CA, Rensen PCN, Berbée JFP.

Int J Mol Sci. 2017 Aug 9;18(8). pii: E1672. doi: 10.3390/ijms18081672.

18.

Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT.

Choi SW, Braun T, Henig I, Gatza E, Magenau J, Parkin B, Pawarode A, Riwes M, Yanik G, Dinarello CA, Reddy P.

Blood. 2017 Oct 12;130(15):1760-1767. doi: 10.1182/blood-2017-06-790469. Epub 2017 Aug 7.

19.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

20.

Interleukin-32 in chronic inflammatory conditions is associated with a higher risk of cardiovascular diseases.

Damen MSMA, Popa CD, Netea MG, Dinarello CA, Joosten LAB.

Atherosclerosis. 2017 Sep;264:83-91. doi: 10.1016/j.atherosclerosis.2017.07.005. Epub 2017 Jul 6. Review.

21.

IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis.

Gomes RS, Silva MVT, Dos Santos JC, de Lima Silva LL, Batista AC, Machado JR, Teixeira MM, Dorta ML, de Oliveira MAP, Dinarello CA, Joosten LAB, Ribeiro-Dias F.

Parasit Vectors. 2017 Jul 14;10(1):336. doi: 10.1186/s13071-017-2268-4.

22.

IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia.

Schauer AE, Klassert TE, von Lachner C, Riebold D, Schneeweiß A, Stock M, Müller MM, Hammerschmidt S, Bufler P, Seifert U, Dietert K, Dinarello CA, Nold MF, Gruber AD, Nold-Petry CA, Slevogt H.

J Innate Immun. 2017;9(4):403-418. doi: 10.1159/000469661. Epub 2017 Jun 10.

PMID:
28601872
23.

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O'Neill LA, Eltzschig HK, Masters SL, McNamee EN.

J Exp Med. 2017 Jun 5;214(6):1737-1752. doi: 10.1084/jem.20160462. Epub 2017 May 9.

24.

Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway.

Crişan TO, Cleophas MCP, Novakovic B, Erler K, van de Veerdonk FL, Stunnenberg HG, Netea MG, Dinarello CA, Joosten LAB.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5485-5490. doi: 10.1073/pnas.1620910114. Epub 2017 May 8.

25.

IL-18 binding protein reverses the life-threatening hyperinflammation of a baby with the NLRC4 mutation.

Novick D, Dinarello CA.

J Allergy Clin Immunol. 2017 Jul;140(1):316. doi: 10.1016/j.jaci.2017.02.037. Epub 2017 Apr 28. No abstract available.

PMID:
28457594
26.

IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells.

Zhan Q, Zeng Q, Song R, Zhai Y, Xu D, Fullerton DA, Dinarello CA, Meng X.

Mol Med. 2017 Mar 27;23. doi: 10.2119/molmed.2017.00022. [Epub ahead of print]

27.

Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes.

Needell JC, Dinarello CA, Ir D, Robertson CE, Ryan SM, Kroehl ME, Frank DN, Zipris D.

PLoS One. 2017 Mar 16;12(3):e0173968. doi: 10.1371/journal.pone.0173968. eCollection 2017.

28.

Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial.

Roerink ME, Bredie SJH, Heijnen M, Dinarello CA, Knoop H, Van der Meer JWM.

Ann Intern Med. 2017 Apr 18;166(8):557-564. doi: 10.7326/M16-2391. Epub 2017 Mar 7.

PMID:
28265678
29.

NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.

Zhai Z, Liu W, Kaur M, Luo Y, Domenico J, Samson JM, Shellman YG, Norris DA, Dinarello CA, Spritz RA, Fujita M.

Oncogene. 2017 Jul 6;36(27):3820-3830. doi: 10.1038/onc.2017.26. Epub 2017 Mar 6.

30.

Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species.

Dos Santos JC, Heinhuis B, Gomes RS, Damen MS, Real F, Mortara RA, Keating ST, Dinarello CA, Joosten LA, Ribeiro-Dias F.

PLoS Negl Trop Dis. 2017 Feb 27;11(2):e0005413. doi: 10.1371/journal.pntd.0005413. eCollection 2017 Feb.

31.

Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice.

Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng X.

Cytokine. 2017 Jul;95:55-63. doi: 10.1016/j.cyto.2017.02.008. Epub 2017 Feb 24.

32.

Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.

Maicas N, van der Vlag J, Bublitz J, Florquin S, Bakker-van Bebber M, Dinarello CA, Verweij V, Masereeuw R, Joosten LA, Hilbrands LB.

PLoS One. 2017 Feb 24;12(2):e0168981. doi: 10.1371/journal.pone.0168981. eCollection 2017.

33.

Interleukin-1 Receptor Blockade Rescues Myocarditis-Associated End-Stage Heart Failure.

Cavalli G, Foppoli M, Cabrini L, Dinarello CA, Tresoldi M, Dagna L.

Front Immunol. 2017 Feb 9;8:131. doi: 10.3389/fimmu.2017.00131. eCollection 2017.

34.

Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects.

Davegårdh C, Broholm C, Perfilyev A, Henriksen T, García-Calzón S, Peijs L, Hansen NS, Volkov P, Kjøbsted R, Wojtaszewski JF, Pedersen M, Pedersen BK, Ballak DB, Dinarello CA, Heinhuis B, Joosten LA, Nilsson E, Vaag A, Scheele C, Ling C.

BMC Med. 2017 Feb 22;15(1):39. doi: 10.1186/s12916-017-0792-x.

35.

Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.

Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2313-2318. doi: 10.1073/pnas.1619011114. Epub 2017 Feb 13.

36.

Alarmins: Feel the Stress.

Rider P, Voronov E, Dinarello CA, Apte RN, Cohen I.

J Immunol. 2017 Feb 15;198(4):1395-1402. doi: 10.4049/jimmunol.1601342. Review.

37.

Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice.

Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC Jr, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1631-1636. doi: 10.1073/pnas.1619667114. Epub 2017 Jan 30.

38.

IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis.

Damen MS, Agca R, Holewijn S, de Graaf J, Dos Santos JC, van Riel PL, Fransen J, Coenen MJ, Nurmohamed MT, Netea MG, Dinarello CA, Joosten LA, Heinhuis B, Popa CD.

Sci Rep. 2017 Jan 30;7:41629. doi: 10.1038/srep41629.

39.

Interleukin-1 as a mediator of fatigue in disease: a narrative review.

Roerink ME, van der Schaaf ME, Dinarello CA, Knoop H, van der Meer JW.

J Neuroinflammation. 2017 Jan 21;14(1):16. doi: 10.1186/s12974-017-0796-7. Review.

40.

Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection.

Davis CJ, Zielinski MR, Dunbrasky D, Taishi P, Dinarello CA, Krueger JM.

Neurobiol Sleep Circadian Rhythms. 2017 Jun;3:1-9. doi: 10.1016/j.nbscr.2016.11.005. Epub 2016 Dec 2.

41.

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

Arts RJ, Novakovic B, Ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng SC, Wang SY, Habibi E, Gonçalves LG, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk FL, Williams DL, van der Meer JW, Logie C, O'Neill LA, Dinarello CA, Riksen NP, van Crevel R, Clish C, Notebaart RA, Joosten LA, Stunnenberg HG, Xavier RJ, Netea MG.

Cell Metab. 2016 Dec 13;24(6):807-819. doi: 10.1016/j.cmet.2016.10.008. Epub 2016 Nov 17.

42.

Host and Environmental Factors Influencing Individual Human Cytokine Responses.

Ter Horst R, Jaeger M, Smeekens SP, Oosting M, Swertz MA, Li Y, Kumar V, Diavatopoulos DA, Jansen AFM, Lemmers H, Toenhake-Dijkstra H, van Herwaarden AE, Janssen M, van der Molen RG, Joosten I, Sweep FCGJ, Smit JW, Netea-Maier RT, Koenders MMJF, Xavier RJ, van der Meer JWM, Dinarello CA, Pavelka N, Wijmenga C, Notebaart RA, Joosten LAB, Netea MG.

Cell. 2016 Nov 3;167(4):1111-1124.e13. doi: 10.1016/j.cell.2016.10.018.

43.

IL-1 Inhibition and Vascular Function in CKD.

Nowak KL, Chonchol M, Ikizler TA, Farmer-Bailey H, Salas N, Chaudhry R, Wang W, Smits G, Tengesdal I, Dinarello CA, Hung AM.

J Am Soc Nephrol. 2017 Mar;28(3):971-980. doi: 10.1681/ASN.2016040453. Epub 2016 Sep 19.

44.

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.

Cavalli G, Koenders M, Kalabokis V, Kim J, Tan AC, Garlanda C, Mantovani A, Dagna L, Joosten LA, Dinarello CA.

Rheumatology (Oxford). 2016 Dec;55(12):2220-2229. Epub 2016 Aug 26. Erratum in: Rheumatology (Oxford). 2017 Dec 1;56(12 ):2256.

45.

Understanding human immune function using the resources from the Human Functional Genomics Project.

Netea MG, Joosten LA, Li Y, Kumar V, Oosting M, Smeekens S, Jaeger M, Ter Horst R, Schirmer M, Vlamakis H, Notebaart R, Pavelka N, Aguirre-Gamboa RR, Swertz MA, Tunjungputri RN, van de Heijden W, Franzosa EA, Ng A, Graham D, Lassen K, Schraa K, Netea-Maier R, Smit J, de Mast Q, van de Veerdonk F, Kullberg BJ, Tack C, van de Munckhof I, Rutten J, van der Graaf J, Franke L, Hofker M, Jonkers I, Platteel M, Maatman A, Fu J, Zhernakova A, van der Meer JW, Dinarello CA, van der Ven A, Huttenhouwer C, Koenen H, Joosten I, Xavier RJ, Wijmenga C.

Nat Med. 2016 Aug 4;22(8):831-3. doi: 10.1038/nm.4140. No abstract available.

PMID:
27490433
46.

α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide-induced IL-1β in human blood neutrophils.

Aggarwal N, Korenbaum E, Mahadeva R, Immenschuh S, Grau V, Dinarello CA, Welte T, Janciauskiene S.

Mol Med. 2016 Jul 13;22. doi: 10.2119/molmed.2016.00119. [Epub ahead of print]

47.

Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.

Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA.

Mol Med. 2016 May 24;22. doi: 10.2119/molmed.2016.00033.

48.

Response of Steroid-Refractory Acute GVHD to α1-Antitrypsin.

Marcondes AM, Hockenbery D, Lesnikova M, Dinarello CA, Woolfrey A, Gernsheimer T, Loghman-Adham M, Gelmont D, Storer B, Hansen JA, Deeg HJ.

Biol Blood Marrow Transplant. 2016 Sep;22(9):1596-1601. doi: 10.1016/j.bbmt.2016.05.011. Epub 2016 May 17.

49.

Toll-like receptors and chronic inflammation in rheumatic diseases: new developments.

Joosten LA, Abdollahi-Roodsaz S, Dinarello CA, O'Neill L, Netea MG.

Nat Rev Rheumatol. 2016 Jun;12(6):344-57. doi: 10.1038/nrrheum.2016.61. Epub 2016 May 12. Review.

PMID:
27170508
50.

Suppression of innate inflammation and immunity by interleukin-37.

Dinarello CA, Nold-Petry C, Nold M, Fujita M, Li S, Kim S, Bufler P.

Eur J Immunol. 2016 May;46(5):1067-81. doi: 10.1002/eji.201545828. Review.

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