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Elaboration of consensus clinical endpoints to evaluate antimicrobial treatment efficacy in future HABP/VABP clinical trials.

Weiss E, Zahar JR, Alder J, Asehnoune K, Bassetti M, Bonten MJM, Chastre J, De Waele J, Dimopoulos G, Eggimann P, Engelhardt M, Ewig S, Kollef M, Lipman J, Luna C, Martin-Loeches I, Pagani L, Palmer LB, Papazian L, Poulakou G, Prokocimer P, Rello J, Rex JH, Shorr AF, Talbot GH, Thamlikitkul V, Torres A, Wunderink RG, Timsit JF.

Clin Infect Dis. 2019 Feb 4. doi: 10.1093/cid/ciz093. [Epub ahead of print]


Intravenous fosfomycin for the treatment of multidrug-resistant pathogens: what is the evidence on dosing regimens?

Dimopoulos G, Koulenti D, Parker SL, Roberts JA, Arvaniti K, Poulakou G.

Expert Rev Anti Infect Ther. 2019 Jan 22:1-10. doi: 10.1080/14787210.2019.1573669. [Epub ahead of print]


New treatments of multidrug-resistant Gram-negative ventilator-associated pneumonia.

Poulakou G, Lagou S, Karageorgopoulos DE, Dimopoulos G.

Ann Transl Med. 2018 Nov;6(21):423. doi: 10.21037/atm.2018.10.29. Review.


ERS syllabus for postgraduate training in respiratory infections: a guide for comprehensive training.

Aliberti S, Farr A, Tabin N, Blasi F, Torres A, Woodhead M, Migliori GB, Sotgiu G, Dimopoulos G, Chalmers JD, Ringshausen FC, Loebinger MR, Read R, Rohde G.

Breathe (Sheff). 2018 Dec;14(4):269-275. doi: 10.1183/20734735.026218.


Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project.

Bassetti M, Scudeller L, Giacobbe DR, Lamoth F, Righi E, Zuccaro V, Grecchi C, Rebuffi C, Akova M, Alastruey-Izquierdo A, Arikan-Akdagli S, Azoulay E, Blot SI, Cornely OA, Lass-Flörl C, Koehler P, Cuenca-Estrella M, de Lange DW, De Rosa FG, De Waele JJ, Dimopoulos G, Garnacho-Montero J, Hoenigl M, Kanj SS, Maertens J, Martin-Loeches I, Muñoz P, Kullberg BJ, Agvald-Ohman C, Poulakou G, Rello J, Sanguinetti M, Taccone FS, Timsit JF, Torres A, Vazquez JA, Calandra T; from the Study Group for Infections in Critically Ill Patients (ESGCIP) and the Fungal Infection Study Group (EFISG) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID); European Society of Intensive Care Medicine (ESICM); European Confederation of Medical Mycology (ECMM); Mycoses Study Group Education and Research Consortium (MSGERC).

Mycoses. 2018 Nov 13. doi: 10.1111/myc.12869. [Epub ahead of print]


MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis.

Möhnle P, Hirschberger S, Hinske LC, Briegel J, Hübner M, Weis S, Dimopoulos G, Bauer M, Giamarellos-Bourboulis EJ, Kreth S.

Mol Med. 2018 Oct 17;24(1):54. doi: 10.1186/s10020-018-0056-z.


The impact of microRNAs in Breast Cancer Angiogenesis and Progression.

Kontomanolis EN, Fasoulakis Z, Papamanolis V, Koliantzaki S, Dimopoulos G, Kambas NJ.

Microrna. 2018 Oct 17. doi: 10.2174/2211536607666181017122921. [Epub ahead of print]


A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission.

Schleicher TR, Yang J, Freudzon M, Rembisz A, Craft S, Hamilton M, Graham M, Mlambo G, Tripathi AK, Li Y, Cresswell P, Sinnis P, Dimopoulos G, Fikrig E.

Nat Commun. 2018 Jul 25;9(1):2908. doi: 10.1038/s41467-018-05374-3.


Propofol associated Brugada - like coved type electrogardiogram in a trauma patient with a fatal outcome.

Paramythiotou E, Ntai K, Dimopoulos G, Armaganidis A.

Acta Cardiol. 2018 Jul 13:1-5. doi: 10.1080/00015385.2018.1481817. [Epub ahead of print] No abstract available.


Assessing predictive accuracy for outcomes of ventilator-associated events in an international cohort: the EUVAE study.

Ramírez-Estrada S, Lagunes L, Peña-López Y, Vahedian-Azimi A, Nseir S, Arvaniti K, Bastug A, Totorika I, Oztoprak N, Bouadma L, Koulenti D, Rello J; the EU-VAE Study Investigators Group.

Intensive Care Med. 2018 Jul 12. doi: 10.1007/s00134-018-5269-7. [Epub ahead of print]


Application of BioFire FilmArray Blood Culture Identification panel for rapid identification of the causative agents of ventilator-associated pneumonia.

Pulido MR, Moreno-Martínez P, González-Galán V, Fernández Cuenca F, Pascual Á, Garnacho-Montero J, Antonelli M, Dimopoulos G, Lepe JA, McConnell MJ, Cisneros JM; MagicBullet Working Group.

Clin Microbiol Infect. 2018 Nov;24(11):1213.e1-1213.e4. doi: 10.1016/j.cmi.2018.06.001. Epub 2018 Jun 12.


QT prolongation and cardiac toxicity of new tuberculosis drugs in Europe: a Tuberculosis Network European Trialsgroup (TBnet) study.

Guglielmetti L, Tiberi S, Burman M, Kunst H, Wejse C, Togonidze T, Bothamley G, Lange C; TBnet; of the TBnet QTc survey.

Eur Respir J. 2018 Aug 16;52(2). pii: 1800537. doi: 10.1183/13993003.00537-2018. Print 2018 Aug. No abstract available.


Hydrogen cyanide produced by the soil bacterium Chromobacterium sp. Panama contributes to mortality in Anopheles gambiae mosquito larvae.

Short SM, van Tol S, MacLeod HJ, Dimopoulos G.

Sci Rep. 2018 May 29;8(1):8358. doi: 10.1038/s41598-018-26680-2.


Diverse Host and Restriction Factors Regulate Mosquito-Pathogen Interactions.

Simões ML, Caragata EP, Dimopoulos G.

Trends Parasitol. 2018 Jul;34(7):603-616. doi: 10.1016/ Epub 2018 May 21. Review.


Regulation of midgut cell proliferation impacts Aedes aegypti susceptibility to dengue virus.

Taracena ML, Bottino-Rojas V, Talyuli OAC, Walter-Nuno AB, Oliveira JHM, Angleró-Rodriguez YI, Wells MB, Dimopoulos G, Oliveira PL, Paiva-Silva GO.

PLoS Negl Trop Dis. 2018 May 21;12(5):e0006498. doi: 10.1371/journal.pntd.0006498. eCollection 2018 May.


Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein.

Saraiva RG, Fang J, Kang S, Angleró-Rodríguez YI, Dong Y, Dimopoulos G.

PLoS Negl Trop Dis. 2018 Apr 25;12(4):e0006443. doi: 10.1371/journal.pntd.0006443. eCollection 2018 Apr.


Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin.

Saraiva RG, Huitt-Roehl CR, Tripathi A, Cheng YQ, Bosch J, Townsend CA, Dimopoulos G.

Sci Rep. 2018 Apr 18;8(1):6176. doi: 10.1038/s41598-018-24296-0.


Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice.

Dragovic SM, Agunbiade TA, Freudzon M, Yang J, Hastings AK, Schleicher TR, Zhou X, Craft S, Chuang YM, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, Ploss A, Dimopoulos G, Fikrig E.

Cell Host Microbe. 2018 Apr 11;23(4):523-535.e5. doi: 10.1016/j.chom.2018.03.008.


The mosquito adulticidal Chromobacterium sp. Panama causes transgenerational impacts on fitness parameters and elicits xenobiotic gene responses.

Short SM, van Tol S, Smith B, Dong Y, Dimopoulos G.

Parasit Vectors. 2018 Apr 5;11(1):229. doi: 10.1186/s13071-018-2822-8.


Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.

Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA.

Clin Microbiol Infect. 2018 May;24 Suppl 1:e1-e38. doi: 10.1016/j.cmi.2018.01.002. Epub 2018 Mar 12.


CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection.

Dong Y, Simões ML, Marois E, Dimopoulos G.

PLoS Pathog. 2018 Mar 8;14(3):e1006898. doi: 10.1371/journal.ppat.1006898. eCollection 2018 Mar.


Immune response-related genes associated to blocking midgut dengue virus infection in Aedes aegypti strains that differ in susceptibility.

Caicedo PA, Serrato IM, Sim S, Dimopoulos G, Coatsworth H, Lowenberger C, Ocampo CB.

Insect Sci. 2018 Feb 1. doi: 10.1111/1744-7917.12573. [Epub ahead of print]


New rapid one-step PCR diagnostic assay for Plasmodium falciparum infective mosquitoes.

Kefi M, Mavridis K, Simões ML, Dimopoulos G, Siden-Kiamos I, Vontas J.

Sci Rep. 2018 Jan 23;8(1):1462. doi: 10.1038/s41598-018-19780-6.


Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance.

De Waele JJ, Akova M, Antonelli M, Canton R, Carlet J, De Backer D, Dimopoulos G, Garnacho-Montero J, Kesecioglu J, Lipman J, Mer M, Paiva JA, Poljak M, Roberts JA, Rodriguez Bano J, Timsit JF, Zahar JR, Bassetti M.

Intensive Care Med. 2018 Feb;44(2):189-196. doi: 10.1007/s00134-017-5036-1. Epub 2017 Dec 29.


Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification.

Retsas T, Huse K, Lazaridis LD, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G.

Int J Infect Dis. 2018 Feb;67:102-106. doi: 10.1016/j.ijid.2017.12.008. Epub 2017 Dec 21.


Elderly versus nonelderly patients with invasive aspergillosis in the ICU: a comparison and risk factor analysis for mortality from the AspICU cohort.

Matthaiou DK, Dimopoulos G, Taccone FS, Bulpa P, Van den Abeele AM, Misset B, Meersseman W, Spapen H, Cardoso T, Charles PE, Vogelaers D, Blot S; AspICU Study Investigators**.

Med Mycol. 2018 Aug 1;56(6):668-678. doi: 10.1093/mmy/myx117.


An Aedes aegypti-associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity.

Angleró-Rodríguez YI, Talyuli OA, Blumberg BJ, Kang S, Demby C, Shields A, Carlson J, Jupatanakul N, Dimopoulos G.

Elife. 2017 Dec 5;6. pii: e28844. doi: 10.7554/eLife.28844.


Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project.

De Pascale G, Ranzani OT, Nseir S, Chastre J, Welte T, Antonelli M, Navalesi P, Garofalo E, Bruni A, Coelho LM, Skoczynski S, Longhini F, Taccone FS, Grimaldi D, Salzer HJF, Lange C, Froes F, Artigas A, Díaz E, Vallés J, Rodríguez A, Panigada M, Comellini V, Fasano L, Soave PM, Spinazzola G, Luyt CE, Alvarez-Lerma F, Marin J, Masclans JR, Chiumello D, Pezzi A, Schultz M, Mohamed H, Van Der Eerden M, Hoek RAS, Gommers DAMPJ, Pasquale MD, Civljak R, Kutleša M, Bassetti M, Dimopoulos G, Nava S, Rios F, Zampieri FG, Povoa P, Bos LD, Aliberti S, Torres A, Martín-Loeches I.

ERJ Open Res. 2017 Nov 17;3(4). pii: 00092-2017. doi: 10.1183/23120541.00092-2017. eCollection 2017 Oct.


Aedes aegypti Molecular Responses to Zika Virus: Modulation of Infection by the Toll and Jak/Stat Immune Pathways and Virus Host Factors.

Angleró-Rodríguez YI, MacLeod HJ, Kang S, Carlson JS, Jupatanakul N, Dimopoulos G.

Front Microbiol. 2017 Oct 23;8:2050. doi: 10.3389/fmicb.2017.02050. eCollection 2017.


Immune Regulation of Plasmodium Is Anopheles Species Specific and Infection Intensity Dependent.

Simões ML, Mlambo G, Tripathi A, Dong Y, Dimopoulos G.

MBio. 2017 Oct 17;8(5). pii: e01631-17. doi: 10.1128/mBio.01631-17.


Changes in the microbiota cause genetically modified Anopheles to spread in a population.

Pike A, Dong Y, Dizaji NB, Gacita A, Mongodin EF, Dimopoulos G.

Science. 2017 Sep 29;357(6358):1396-1399. doi: 10.1126/science.aak9691. Epub 2017 Sep 28.


Which algorithm diagnoses invasive pulmonary aspergillosis best in ICU patients with COPD?

Bulpa P, Bihin B, Dimopoulos G, Taccone FS, Van den Abeele AM, Misset B, Meersseman W, Spapen H, Cardoso T, Charles PE, Rello J, Vogelaers D, Blot S; AspICU study investigators.

Eur Respir J. 2017 Sep 27;50(3). pii: 1700532. doi: 10.1183/13993003.00532-2017. Print 2017 Sep. No abstract available.


Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis.

Kyriazopoulou E, Leventogiannis K, Norrby-Teglund A, Dimopoulos G, Pantazi A, Orfanos SE, Rovina N, Tsangaris I, Gkavogianni T, Botsa E, Chassiou E, Kotanidou A, Kontouli C, Chaloulis P, Velissaris D, Savva A, Cullberg JS, Akinosoglou K, Gogos C, Armaganidis A, Giamarellos-Bourboulis EJ; Hellenic Sepsis Study Group.

BMC Med. 2017 Sep 18;15(1):172. doi: 10.1186/s12916-017-0930-5.


Management of KPC-producing Klebsiella pneumoniae infections.

Bassetti M, Giacobbe DR, Giamarellou H, Viscoli C, Daikos GL, Dimopoulos G, De Rosa FG, Giamarellos-Bourboulis EJ, Rossolini GM, Righi E, Karaiskos I, Tumbarello M, Nicolau DP, Viale PL, Poulakou G; Critically Ill Patients Study Group of the European Society of Clinical Microbiology and Infectious Disease (ESCMID); Hellenic Society of Chemotherapy (HSC) and Società Italiana di Terapia Antinfettiva (SITA).

Clin Microbiol Infect. 2018 Feb;24(2):133-144. doi: 10.1016/j.cmi.2017.08.030. Epub 2017 Sep 9. Review.


Amino acid metabolic signaling influences Aedes aegypti midgut microbiome variability.

Short SM, Mongodin EF, MacLeod HJ, Talyuli OAC, Dimopoulos G.

PLoS Negl Trop Dis. 2017 Jul 28;11(7):e0005677. doi: 10.1371/journal.pntd.0005677. eCollection 2017 Jul.


Association of microRNAs with Argonaute proteins in the malaria mosquito Anopheles gambiae after blood ingestion.

Fu X, Dimopoulos G, Zhu J.

Sci Rep. 2017 Jul 26;7(1):6493. doi: 10.1038/s41598-017-07013-1.


Inhaled Antimicrobials for Ventilator-Associated Pneumonia: Practical Aspects.

Poulakou G, Matthaiou DK, Nicolau DP, Siakallis G, Dimopoulos G.

Drugs. 2017 Sep;77(13):1399-1412. doi: 10.1007/s40265-017-0787-0. Review.


Drivers and impact of antifungal therapy in critically ill patients with Aspergillus-positive respiratory tract cultures.

Paiva JA, Mergulhão P, Gomes A, Taccone FS, Van den Abeele AM, Bulpa P, Misset B, Meersseman W, Dimopoulos G, Rello J, Vogelaers D, Blot S.

Int J Antimicrob Agents. 2017 Oct;50(4):529-535. doi: 10.1016/j.ijantimicag.2017.05.017. Epub 2017 Jun 29.


Scedosporium apiospermum complex in cystic fibrosis; should we treat?

Noni M, Katelari A, Kapi A, Stathi A, Dimopoulos G, Doudounakis SE.

Mycoses. 2017 Sep;60(9):594-599. doi: 10.1111/myc.12634. Epub 2017 May 15.


Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study.

Karampela I, Kandri E, Antonakos G, Vogiatzakis E, Christodoulatos GS, Nikolaidou A, Dimopoulos G, Armaganidis A, Dalamaga M.

J Crit Care. 2017 Oct;41:78-85. doi: 10.1016/j.jcrc.2017.05.004. Epub 2017 May 6.


Endomyocardial and pericardial aspergillosis in critically ill patients.

Dimopoulos G, Frantzeskaki F, Kosmopoulos M, Taccone FS, Van den Abeele AM, Bulpa P, Forêt F, Vogelaers D, Blot S; AspICU investigators.

Mycoses. 2017 Sep;60(9):576-580. doi: 10.1111/myc.12630. Epub 2017 May 12.


Elderly versus non-elderly patients with intra-abdominal candidiasis in the ICU.

Dimopoulos G, Matthaiou DK, Righi E, Merelli M, Bassetti M.

Minerva Anestesiol. 2017 Nov;83(11):1126-1136. doi: 10.23736/S0375-9393.17.11528-2. Epub 2017 May 11.


"Salvage treatment" for infections by extensively- and pan-drug-resistant pathogens is common and often sub-optimal.

Poulakou G, Matthaiou DK, Bassetti M, Erdem H, Dimopoulos G, Curcio DJ, Carlet J, Lipman J, Timsit JF, Giamarellou H, Arfaras-Melainis A, Rello J; ESGCIP Investigators.

Intensive Care Med. 2017 Aug;43(8):1164-1166. doi: 10.1007/s00134-017-4796-y. Epub 2017 Apr 13. No abstract available.


Molecular analysis of Culex quinquefasciatus larvae responses to Lysinibacillus sphaericus Bin toxin.

Tangsongcharoen C, Jupatanakul N, Promdonkoy B, Dimopoulos G, Boonserm P.

PLoS One. 2017 Apr 13;12(4):e0175473. doi: 10.1371/journal.pone.0175473. eCollection 2017.


Clinical characteristics and predictors of mortality in cirrhotic patients with candidemia and intra-abdominal candidiasis: a multicenter study.

Bassetti M, Peghin M, Carnelutti A, Righi E, Merelli M, Ansaldi F, Trucchi C, Alicino C, Sartor A, Toniutto P, Wauters J, Laleman W, Tascini C, Menichetti F, Luzzati R, Brugnaro P, Mesini A, Raviolo S, De Rosa FG, Lagunes L, Rello J, Dimopoulos G, Colombo AL, Nucci M, Vena A, Bouza E, Muñoz P, Tumbarello M, Losito R, Martin-Loeches I, Viscoli C.

Intensive Care Med. 2017 Apr;43(4):509-518. doi: 10.1007/s00134-017-4717-0. Epub 2017 Mar 7.


Intensive care medicine research agenda on invasive fungal infection in critically ill patients.

Bassetti M, Garnacho-Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, Chakrabarti A, Kett D, Leon C, Ostrosky-Zeichner L, Sanguinetti M, Timsit JF, Richardson MD, Shorr A, Cornely OA.

Intensive Care Med. 2017 Sep;43(9):1225-1238. doi: 10.1007/s00134-017-4731-2. Epub 2017 Mar 2. Review.


The intensive care medicine research agenda on multidrug-resistant bacteria, antibiotics, and stewardship.

Kollef MH, Bassetti M, Francois B, Burnham J, Dimopoulos G, Garnacho-Montero J, Lipman J, Luyt CE, Nicolau DP, Postma MJ, Torres A, Welte T, Wunderink RG.

Intensive Care Med. 2017 Sep;43(9):1187-1197. doi: 10.1007/s00134-017-4682-7. Epub 2017 Feb 4. Review.


Invasive fungal tracheobronchitis in mechanically ventilated critically ill patients: underlying conditions, diagnosis, and outcomes.

Lin CY, Liu WL, Chang CC, Chang HT, Hu HC, Kao KC, Chen NH, Chen YJ, Yang CT, Huang CC, Dimopoulos G.

Ann Intensive Care. 2017 Dec;7(1):9. doi: 10.1186/s13613-016-0230-9. Epub 2017 Jan 6.


Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus.

Jupatanakul N, Sim S, Angleró-Rodríguez YI, Souza-Neto J, Das S, Poti KE, Rossi SL, Bergren N, Vasilakis N, Dimopoulos G.

PLoS Negl Trop Dis. 2017 Jan 12;11(1):e0005187. doi: 10.1371/journal.pntd.0005187. eCollection 2017 Jan.

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