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Items: 35


Multi-omics Biomarker Pipeline Reveals Elevated Levels of Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of Prostate Cancer Patients.

Drabovich AP, Saraon P, Drabovich M, Karakosta TD, Dimitromanolakis A, Hyndman ME, Jarvi K, Diamandis EP.

Mol Cell Proteomics. 2019 Sep;18(9):1807-1823. doi: 10.1074/mcp.RA119.001612. Epub 2019 Jun 27.


Fast and Accurate Shared Segment Detection and Relatedness Estimation in Un-phased Genetic Data via TRUFFLE.

Dimitromanolakis A, Paterson AD, Sun L.

Am J Hum Genet. 2019 Jul 3;105(1):78-88. doi: 10.1016/j.ajhg.2019.05.007. Epub 2019 Jun 6.


sim1000G: a user-friendly genetic variant simulator in R for unrelated individuals and family-based designs.

Dimitromanolakis A, Xu J, Krol A, Briollais L.

BMC Bioinformatics. 2019 Jan 15;20(1):26. doi: 10.1186/s12859-019-2611-1.


Identifying Cryptic Relationships.

Sun L, Dimitromanolakis A, Chen WM.

Methods Mol Biol. 2017;1666:45-60. doi: 10.1007/978-1-4939-7274-6_4.


Stable Isotope Labeling with Amino Acids (SILAC)-Based Proteomics of Primary Human Kidney Cells Reveals a Novel Link between Male Sex Hormones and Impaired Energy Metabolism in Diabetic Kidney Disease.

Clotet S, Soler MJ, Riera M, Pascual J, Fang F, Zhou J, Batruch I, Vasiliou SK, Dimitromanolakis A, Barrios C, Diamandis EP, Scholey JW, Konvalinka A.

Mol Cell Proteomics. 2017 Mar;16(3):368-385. doi: 10.1074/mcp.M116.061903. Epub 2017 Jan 4.


Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoring.

Konvalinka A, Batruch I, Tokar T, Dimitromanolakis A, Reid S, Song X, Pei Y, Drabovich AP, Diamandis EP, Jurisica I, Scholey JW.

Clin Proteomics. 2016 Aug 5;13:16. doi: 10.1186/s12014-016-9117-x. eCollection 2016.


Resampling to Address the Winner's Curse in Genetic Association Analysis of Time to Event.

Poirier JG, Faye LL, Dimitromanolakis A, Paterson AD, Sun L, Bull SB.

Genet Epidemiol. 2015 Nov;39(7):518-28. doi: 10.1002/gepi.21920. Epub 2015 Sep 28.


Serum LAMC2 enhances the prognostic value of a multi-parametric panel in non-small cell lung cancer.

Korbakis D, Dimitromanolakis A, Prassas I, Davis GJ, Barber E, Reckamp KL, Blasutig I, Diamandis EP.

Br J Cancer. 2015 Jul 28;113(3):484-91. doi: 10.1038/bjc.2015.171. Epub 2015 Jul 16.


Novel Biological Substrates of Human Kallikrein 7 Identified through Degradomics.

Yu Y, Prassas I, Dimitromanolakis A, Diamandis EP.

J Biol Chem. 2015 Jul 17;290(29):17762-75. doi: 10.1074/jbc.M115.643551. Epub 2015 Jun 1.


The relationship between sperm viability and DNA fragmentation rates.

Samplaski MK, Dimitromanolakis A, Lo KC, Grober ED, Mullen B, Garbens A, Jarvi KA.

Reprod Biol Endocrinol. 2015 May 14;13:42. doi: 10.1186/s12958-015-0035-y.


PREST-plus identifies pedigree errors and cryptic relatedness in the GAW18 sample using genome-wide SNP data.

Sun L, Dimitromanolakis A.

BMC Proc. 2014 Jun 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S23. doi: 10.1186/1753-6561-8-S1-S23. eCollection 2014.


Validation of biomarkers that complement CA19.9 in detecting early pancreatic cancer.

Chan A, Prassas I, Dimitromanolakis A, Brand RE, Serra S, Diamandis EP, Blasutig IM.

Clin Cancer Res. 2014 Nov 15;20(22):5787-95. doi: 10.1158/1078-0432.CCR-14-0289. Epub 2014 Sep 19.


Mining for single nucleotide variants (SNVs) at the kallikrein locus with predicted functional consequences.

Sukumar N, Scott E, Dimitromanolakis A, Misiak A, Prassas I, Diamandis EP, Konvalinka A.

Biol Chem. 2014 Sep;395(9):1037-50. doi: 10.1515/hsz-2014-0136.


Integrating meta-analysis of microarray data and targeted proteomics for biomarker identification: application in breast cancer.

Pavlou MP, Dimitromanolakis A, Martinez-Morillo E, Smid M, Foekens JA, Diamandis EP.

J Proteome Res. 2014 Jun 6;13(6):2897-909. doi: 10.1021/pr500352e. Epub 2014 May 14.


In-depth proteomic delineation of the colorectal cancer exoproteome: Mechanistic insight and identification of potential biomarkers.

Karagiannis GS, Pavlou MP, Saraon P, Musrap N, Xie A, Batruch I, Prassas I, Dimitromanolakis A, Petraki C, Diamandis EP.

J Proteomics. 2014 May 30;103:121-36. doi: 10.1016/j.jprot.2014.03.018. Epub 2014 Mar 27.


Phenotypic differences in mosaic Klinefelter patients as compared with non-mosaic Klinefelter patients.

Samplaski MK, Lo KC, Grober ED, Millar A, Dimitromanolakis A, Jarvi KA.

Fertil Steril. 2014 Apr;101(4):950-5. doi: 10.1016/j.fertnstert.2013.12.051. Epub 2014 Feb 4.


Differential diagnosis of azoospermia with proteomic biomarkers ECM1 and TEX101 quantified in seminal plasma.

Drabovich AP, Dimitromanolakis A, Saraon P, Soosaipillai A, Batruch I, Mullen B, Jarvi K, Diamandis EP.

Sci Transl Med. 2013 Nov 20;5(212):212ra160. doi: 10.1126/scitranslmed.3006260.


False biomarker discovery due to reactivity of a commercial ELISA for CUZD1 with cancer antigen CA125.

Prassas I, Brinc D, Farkona S, Leung F, Dimitromanolakis A, Chrystoja CC, Brand R, Kulasingam V, Blasutig IM, Diamandis EP.

Clin Chem. 2014 Feb;60(2):381-8. doi: 10.1373/clinchem.2013.215236. Epub 2013 Oct 4.


Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9.

Makawita S, Dimitromanolakis A, Soosaipillai A, Soleas I, Chan A, Gallinger S, Haun RS, Blasutig IM, Diamandis EP.

BMC Cancer. 2013 Sep 3;13:404. doi: 10.1186/1471-2407-13-404.


Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC).

Konvalinka A, Zhou J, Dimitromanolakis A, Drabovich AP, Fang F, Gurley S, Coffman T, John R, Zhang SL, Diamandis EP, Scholey JW.

J Biol Chem. 2013 Aug 23;288(34):24834-47. doi: 10.1074/jbc.M113.485326. Epub 2013 Jul 11.


Laminin, gamma 2 (LAMC2): a promising new putative pancreatic cancer biomarker identified by proteomic analysis of pancreatic adenocarcinoma tissues.

Kosanam H, Prassas I, Chrystoja CC, Soleas I, Chan A, Dimitromanolakis A, Blasutig IM, Rückert F, Gruetzmann R, Pilarsky C, Maekawa M, Brand R, Diamandis EP.

Mol Cell Proteomics. 2013 Oct;12(10):2820-32. doi: 10.1074/mcp.M112.023507. Epub 2013 Jun 24.


Enrichment map profiling of the cancer invasion front suggests regulation of colorectal cancer progression by the bone morphogenetic protein antagonist, gremlin-1.

Karagiannis GS, Berk A, Dimitromanolakis A, Diamandis EP.

Mol Oncol. 2013 Aug;7(4):826-39. doi: 10.1016/j.molonc.2013.04.002. Epub 2013 Apr 18.


Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer's disease and age-matched control brains.

Begcevic I, Kosanam H, Martínez-Morillo E, Dimitromanolakis A, Diamandis P, Kuzmanov U, Hazrati LN, Diamandis EP.

Clin Proteomics. 2013 May 1;10(1):5. doi: 10.1186/1559-0275-10-5.


Folate-receptor 1 (FOLR1) protein is elevated in the serum of ovarian cancer patients.

Leung F, Dimitromanolakis A, Kobayashi H, Diamandis EP, Kulasingam V.

Clin Biochem. 2013 Oct;46(15):1462-8. doi: 10.1016/j.clinbiochem.2013.03.010. Epub 2013 Mar 23.


Quantitative proteomic analysis of amniocytes reveals potentially dysregulated molecular networks in Down syndrome.

Cho CK, Drabovich AP, Karagiannis GS, Martínez-Morillo E, Dason S, Dimitromanolakis A, Diamandis EP.

Clin Proteomics. 2013 Feb 8;10(1):2. doi: 10.1186/1559-0275-10-2.


Coupling proteomics and transcriptomics in the quest of subtype-specific proteins in breast cancer.

Pavlou MP, Dimitromanolakis A, Diamandis EP.

Proteomics. 2013 Apr;13(7):1083-95. doi: 10.1002/pmic.201200526. Epub 2013 Feb 25.


Glycoproteomic identification of potential glycoprotein biomarkers in ovarian cancer proximal fluids.

Kuzmanov U, Musrap N, Kosanam H, Smith CR, Batruch I, Dimitromanolakis A, Diamandis EP.

Clin Chem Lab Med. 2013 Jul;51(7):1467-76. doi: 10.1515/cclm-2012-0642.


Quantitative analysis of energy metabolic pathways in MCF-7 breast cancer cells by selected reaction monitoring assay.

Drabovich AP, Pavlou MP, Dimitromanolakis A, Diamandis EP.

Mol Cell Proteomics. 2012 Aug;11(8):422-34. doi: 10.1074/mcp.M111.015214. Epub 2012 Apr 25.


Proteomic signatures of the desmoplastic invasion front reveal collagen type XII as a marker of myofibroblastic differentiation during colorectal cancer metastasis.

Karagiannis GS, Petraki C, Prassas I, Saraon P, Musrap N, Dimitromanolakis A, Diamandis EP.

Oncotarget. 2012 Mar;3(3):267-85.


Identifying cryptic relationships.

Sun L, Dimitromanolakis A.

Methods Mol Biol. 2012;850:47-57. doi: 10.1007/978-1-61779-555-8_4.


A genome-wide linkage study of mammographic density, a risk factor for breast cancer.

Greenwood CM, Paterson AD, Linton L, Andrulis IL, Apicella C, Dimitromanolakis A, Kriukov V, Martin LJ, Salleh A, Samiltchuk E, Parekh RV, Southey MC, John EM, Hopper JL, Boyd NF, Rommens JM.

Breast Cancer Res. 2011;13(6):R132. doi: 10.1186/bcr3078. Epub 2011 Dec 21.


Digitoxin-induced cytotoxicity in cancer cells is mediated through distinct kinase and interferon signaling networks.

Prassas I, Karagiannis GS, Batruch I, Dimitromanolakis A, Datti A, Diamandis EP.

Mol Cancer Ther. 2011 Nov;10(11):2083-93. doi: 10.1158/1535-7163.MCT-11-0421. Epub 2011 Aug 22.


Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.

Antoni G, Oudot-Mellakh T, Dimitromanolakis A, Germain M, Cohen W, Wells P, Lathrop M, Gagnon F, Morange PE, Tregouet DA.

BMC Med Genet. 2011 Aug 2;12:102. doi: 10.1186/1471-2350-12-102.


A flexible genome-wide bootstrap method that accounts for ranking and threshold-selection bias in GWAS interpretation and replication study design.

Faye LL, Sun L, Dimitromanolakis A, Bull SB.

Stat Med. 2011 Jul 10;30(15):1898-912. doi: 10.1002/sim.4228. Epub 2011 May 3.


BR-squared: a practical solution to the winner's curse in genome-wide scans.

Sun L, Dimitromanolakis A, Faye LL, Paterson AD, Waggott D; DCCT/EDIC Research Group, Bull SB.

Hum Genet. 2011 May;129(5):545-52. doi: 10.1007/s00439-011-0948-2. Epub 2011 Jan 19.

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