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Items: 25

1.

Intrinsic and Extrinsic Determinants of T Cell Metabolism in Health and Disease.

Munford H, Dimeloe S.

Front Mol Biosci. 2019 Oct 25;6:118. doi: 10.3389/fmolb.2019.00118. eCollection 2019. Review.

2.

Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+ T cells.

Dimeloe S, Gubser P, Loeliger J, Frick C, Develioglu L, Fischer M, Marquardsen F, Bantug GR, Thommen D, Lecoultre Y, Zippelius A, Langenkamp A, Hess C.

Sci Signal. 2019 Sep 17;12(599). pii: eaav3334. doi: 10.1126/scisignal.aav3334.

PMID:
31530731
3.

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.

Burgener AV, Bantug GR, Meyer BJ, Higgins R, Ghosh A, Bignucolo O, Ma EH, Loeliger J, Unterstab G, Geigges M, Steiner R, Enamorado M, Ivanek R, Hunziker D, Schmidt A, Müller-Durovic B, Grählert J, Epple R, Dimeloe S, Lötscher J, Sauder U, Ebnöther M, Burger B, Heijnen I, Martínez-Cano S, Cantoni N, Brücker R, Kahlert CR, Sancho D, Jones RG, Navarini A, Recher M, Hess C.

Nat Immunol. 2019 Oct;20(10):1311-1321. doi: 10.1038/s41590-019-0482-2. Epub 2019 Sep 16.

PMID:
31527833
4.

JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms.

Rao TN, Hansen N, Hilfiker J, Rai S, Majewska JM, Leković D, Gezer D, Andina N, Galli S, Cassel T, Geier F, Delezie J, Nienhold R, Hao-Shen H, Beisel C, Di Palma S, Dimeloe S, Trebicka J, Wolf D, Gassmann M, Fan TW, Lane AN, Handschin C, Dirnhofer S, Kröger N, Hess C, Radimerski T, Koschmieder S, Čokić VP, Skoda RC.

Blood. 2019 Nov 21;134(21):1832-1846. doi: 10.1182/blood.2019000162.

5.

Translating immunometabolism: towards curing human diseases by targeting metabolic processes underpinning the immune response.

Dimeloe S, Mauro C.

Clin Exp Immunol. 2019 Aug;197(2):141-142. doi: 10.1111/cei.13347. No abstract available.

PMID:
31327170
6.

Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10.

Dimeloe S, Rice LV, Chen H, Cheadle C, Raynes J, Pfeffer P, Lavender P, Richards DF, Nyon MP, McDonnell JM, Kemper C, Gooptu B, Hawrylowicz CM.

J Steroid Biochem Mol Biol. 2019 May;189:1-9. doi: 10.1016/j.jsbmb.2019.01.014. Epub 2019 Jan 25.

7.

Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis.

Fischer M, Bantug GR, Dimeloe S, Gubser PM, Burgener AV, Grählert J, Balmer ML, Develioglu L, Steiner R, Unterstab G, Sauder U, Hoenger G, Hess C.

Eur J Immunol. 2018 Oct;48(10):1632-1643. doi: 10.1002/eji.201747443. Epub 2018 Aug 7.

8.

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.

Thommen DS, Koelzer VH, Herzig P, Roller A, Trefny M, Dimeloe S, Kiialainen A, Hanhart J, Schill C, Hess C, Savic Prince S, Wiese M, Lardinois D, Ho PC, Klein C, Karanikas V, Mertz KD, Schumacher TN, Zippelius A.

Nat Med. 2018 Jul;24(7):994-1004. doi: 10.1038/s41591-018-0057-z. Epub 2018 Jun 11.

9.

Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells.

Bantug GR, Fischer M, Grählert J, Balmer ML, Unterstab G, Develioglu L, Steiner R, Zhang L, Costa ASH, Gubser PM, Burgener AV, Sauder U, Löliger J, Belle R, Dimeloe S, Lötscher J, Jauch A, Recher M, Hönger G, Hall MN, Romero P, Frezza C, Hess C.

Immunity. 2018 Mar 20;48(3):542-555.e6. doi: 10.1016/j.immuni.2018.02.012. Epub 2018 Mar 6.

10.

T-cell metabolism governing activation, proliferation and differentiation; a modular view.

Dimeloe S, Burgener AV, Grählert J, Hess C.

Immunology. 2017 Jan;150(1):35-44. doi: 10.1111/imm.12655. Epub 2016 Aug 23. Review.

11.

Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function.

Balmer ML, Ma EH, Bantug GR, Grählert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio P, Krzyzaniak MA, King CG, Burgener AV, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C.

Immunity. 2016 Jun 21;44(6):1312-24. doi: 10.1016/j.immuni.2016.03.016. Epub 2016 May 17.

12.

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy.

Pisarsky L, Bill R, Fagiani E, Dimeloe S, Goosen RW, Hagmann J, Hess C, Christofori G.

Cell Rep. 2016 May 10;15(6):1161-74. doi: 10.1016/j.celrep.2016.04.028. Epub 2016 Apr 28.

13.

The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions.

Dimeloe S, Mehling M, Frick C, Loeliger J, Bantug GR, Sauder U, Fischer M, Belle R, Develioglu L, Tay S, Langenkamp A, Hess C.

J Immunol. 2016 Jan 1;196(1):106-14. doi: 10.4049/jimmunol.1501766. Epub 2015 Nov 30.

14.

Tissue Distribution Dynamics of Human NK Cells Inferred from Peripheral Blood Depletion Kinetics after Sphingosine-1-Phosphate Receptor Blockade.

Mehling M, Burgener AV, Brinkmann V, Bantug GR, Dimeloe S, Hoenger G, Kappos L, Hess C.

Scand J Immunol. 2015 Nov;82(5):460-6. doi: 10.1111/sji.12347.

15.

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.

Kolev M, Dimeloe S, Le Friec G, Navarini A, Arbore G, Povoleri GA, Fischer M, Belle R, Loeliger J, Develioglu L, Bantug GR, Watson J, Couzi L, Afzali B, Lavender P, Hess C, Kemper C.

Immunity. 2015 Jun 16;42(6):1033-47. doi: 10.1016/j.immuni.2015.05.024.

16.

Inter-individual differences in HLA expression can impact the CDC crossmatch.

Hönger G, Krähenbühl N, Dimeloe S, Stern M, Schaub S, Hess C.

Tissue Antigens. 2015 Apr;85(4):260-6. doi: 10.1111/tan.12537.

PMID:
25786570
17.

Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis.

Dimeloe S, Frick C, Fischer M, Gubser PM, Razik L, Bantug GR, Ravon M, Langenkamp A, Hess C.

Eur J Immunol. 2014 Dec;44(12):3614-20. doi: 10.1002/eji.201444879. Epub 2014 Oct 27.

18.

Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma.

Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E, Bush A, Saglani S, Hawrylowicz CM.

Thorax. 2014 Jun;69(6):508-15. doi: 10.1136/thoraxjnl-2013-203421. Epub 2013 Dec 17.

PMID:
24347461
19.

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch.

Gubser PM, Bantug GR, Razik L, Fischer M, Dimeloe S, Hoenger G, Durovic B, Jauch A, Hess C.

Nat Immunol. 2013 Oct;14(10):1064-72. doi: 10.1038/ni.2687. Epub 2013 Aug 18.

PMID:
23955661
20.

The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells.

Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A, Saglani S, Bush A, O'Garra A, Brown Z, Hawrylowicz CM.

Eur J Immunol. 2012 Oct;42(10):2697-708. doi: 10.1002/eji.201242370. Epub 2012 Aug 20.

21.

T cells producing the anti-inflammatory cytokine IL-10 regulate allergen-specific Th2 responses in human airways.

Faith A, Singh N, Farooque S, Dimeloe S, Richards DF, Lu H, Roberts D, Chevretton E, Lee TH, Corrigan CJ, Hawrylowicz CM.

Allergy. 2012 Aug;67(8):1007-13. doi: 10.1111/j.1398-9995.2012.02852.x. Epub 2012 Jun 4.

PMID:
22671764
22.

Vitamin D binding protein and asthma severity in children.

Gupta A, Dimeloe S, Richards DF, Bush A, Saglani S, Hawrylowicz CM.

J Allergy Clin Immunol. 2012 Jun;129(6):1669-71. doi: 10.1016/j.jaci.2012.02.017. Epub 2012 Mar 28. No abstract available.

PMID:
22460073
23.

1α,25-dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells.

Dimeloe S, Richards DF, Urry ZL, Gupta A, Stratigou V, Farooque S, Saglani S, Bush A, Hawrylowicz CM.

Thorax. 2012 Jul;67(7):574-81. doi: 10.1136/thoraxjnl-2011-200651. Epub 2012 Feb 14.

24.

A direct role for vitamin D-binding protein in the pathogenesis of COPD?

Dimeloe S, Hawrylowicz C.

Thorax. 2011 Mar;66(3):189-90. doi: 10.1136/thx.2010.154005. Epub 2011 Jan 13. No abstract available.

PMID:
21233481
25.

Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D.

Dimeloe S, Nanzer A, Ryanna K, Hawrylowicz C.

J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):86-95. doi: 10.1016/j.jsbmb.2010.02.029. Epub 2010 Mar 19. Review.

PMID:
20227496

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