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Items: 39


ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1.

Ingram JP, Thapa RJ, Fisher A, Tummers B, Zhang T, Yin C, Rodriguez DA, Guo H, Lane R, Williams R, Slifker MJ, Basagoudanavar SH, Rall GF, Dillon CP, Green DR, Kaiser WJ, Balachandran S.

J Immunol. 2019 Sep 1;203(5):1348-1355. doi: 10.4049/jimmunol.1900216. Epub 2019 Jul 29.


Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.

Gomes B, Driessens G, Bartlett D, Cai D, Cauwenberghs S, Crosignani S, Dalvie D, Denies S, Dillon CP, Fantin VR, Guo J, Letellier MC, Li W, Maegley K, Marillier R, Miller N, Pirson R, Rabolli V, Ray C, Streiner N, Torti VR, Tsaparikos K, Van den Eynde BJ, Wythes M, Yao LC, Zheng X, Tumang J, Kraus M.

Mol Cancer Ther. 2018 Dec;17(12):2530-2542. doi: 10.1158/1535-7163.MCT-17-1104. Epub 2018 Sep 19.


RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense.

Peterson LW, Philip NH, DeLaney A, Wynosky-Dolfi MA, Asklof K, Gray F, Choa R, Bjanes E, Buza EL, Hu B, Dillon CP, Green DR, Berger SB, Gough PJ, Bertin J, Brodsky IE.

J Exp Med. 2017 Nov 6;214(11):3171-3182. doi: 10.1084/jem.20170347. Epub 2017 Aug 30.


The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage.

Baran K, Yang M, Dillon CP, Samson LL, Green DR.

Cell Death Differ. 2017 Nov;24(11):1925-1936. doi: 10.1038/cdd.2017.116. Epub 2017 Jul 28.


Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis.

Peterson LW, Philip NH, Dillon CP, Bertin J, Gough PJ, Green DR, Brodsky IE.

J Immunol. 2016 Nov 15;197(10):4110-4117. Epub 2016 Oct 12.


Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.

Dillon CP, Green DR.

Adv Exp Med Biol. 2016;930:1-23. doi: 10.1007/978-3-319-39406-0_1. Review.


The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.

Alvarez-Diaz S, Dillon CP, Lalaoui N, Tanzer MC, Rodriguez DA, Lin A, Lebois M, Hakem R, Josefsson EC, O'Reilly LA, Silke J, Alexander WS, Green DR, Strasser A.

Immunity. 2016 Sep 20;45(3):513-526. doi: 10.1016/j.immuni.2016.07.016. Epub 2016 Aug 11.


RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S.

Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16.


Developmental checkpoints guarded by regulated necrosis.

Dillon CP, Tummers B, Baran K, Green DR.

Cell Mol Life Sci. 2016 Jun;73(11-12):2125-36. doi: 10.1007/s00018-016-2188-z. Epub 2016 Apr 7. Review.


Programmed necrosis in inflammation: Toward identification of the effector molecules.

Wallach D, Kang TB, Dillon CP, Green DR.

Science. 2016 Apr 1;352(6281):aaf2154. doi: 10.1126/science.aaf2154. Review.


Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function.

Milasta S, Dillon CP, Sturm OE, Verbist KC, Brewer TL, Quarato G, Brown SA, Frase S, Janke LJ, Perry SS, Thomas PG, Green DR.

Immunity. 2016 Jan 19;44(1):88-102. doi: 10.1016/j.immuni.2015.12.002. Epub 2016 Jan 12.


StIKKing it to a death kinase: IKKs prevent TNF-α-induced cell death by phosphorylating RIPK1.

Dillon CP, Balachandran S.

Cytokine. 2016 Feb;78:47-50. doi: 10.1016/j.cyto.2015.10.014. Epub 2015 Nov 28.


IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells.

Wan CK, Li P, Spolski R, Oh J, Andraski AB, Du N, Yu ZX, Dillon CP, Green DR, Leonard WJ.

Nat Commun. 2015 Aug 13;6:7988. doi: 10.1038/ncomms8988.


Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis.

Rodriguez DA, Weinlich R, Brown S, Guy C, Fitzgerald P, Dillon CP, Oberst A, Quarato G, Low J, Cripps JG, Chen T, Green DR.

Cell Death Differ. 2016 Jan;23(1):76-88. doi: 10.1038/cdd.2015.70. Epub 2015 May 29.


Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.

Haverkamp JM, Smith AM, Weinlich R, Dillon CP, Qualls JE, Neale G, Koss B, Kim Y, Bronte V, Herold MJ, Green DR, Opferman JT, Murray PJ.

Immunity. 2014 Dec 18;41(6):947-59. doi: 10.1016/j.immuni.2014.10.020. Epub 2014 Dec 11.


Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.

Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA.

J Immunol. 2014 Sep 1;193(5):2519-2530. doi: 10.4049/jimmunol.1400276. Epub 2014 Jul 25.


RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.

Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR.

Cell. 2014 May 22;157(5):1189-202. doi: 10.1016/j.cell.2014.04.018. Epub 2014 May 8.


Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling.

Philip NH, Dillon CP, Snyder AG, Fitzgerald P, Wynosky-Dolfi MA, Zwack EE, Hu B, Fitzgerald L, Mauldin EA, Copenhaver AM, Shin S, Wei L, Parker M, Zhang J, Oberst A, Green DR, Brodsky IE.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7385-90. doi: 10.1073/pnas.1403252111. Epub 2014 May 5.


Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.

Shenderov K, Riteau N, Yip R, Mayer-Barber KD, Oland S, Hieny S, Fitzgerald P, Oberst A, Dillon CP, Green DR, Cerundolo V, Sher A.

J Immunol. 2014 Mar 1;192(5):2029-2033. doi: 10.4049/jimmunol.1302549. Epub 2014 Jan 31.


FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

Gurung P, Anand PK, Malireddi RK, Vande Walle L, Van Opdenbosch N, Dillon CP, Weinlich R, Green DR, Lamkanfi M, Kanneganti TD.

J Immunol. 2014 Feb 15;192(4):1835-46. doi: 10.4049/jimmunol.1302839. Epub 2014 Jan 22.


Protective roles for caspase-8 and cFLIP in adult homeostasis.

Weinlich R, Oberst A, Dillon CP, Janke LJ, Milasta S, Lukens JR, Rodriguez DA, Gurung P, Savage C, Kanneganti TD, Green DR.

Cell Rep. 2013 Oct 31;5(2):340-8. doi: 10.1016/j.celrep.2013.08.045. Epub 2013 Oct 3.


Survival function of the FADD-CASPASE-8-cFLIP(L) complex.

Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR.

Cell Rep. 2012 May 31;1(5):401-7.


The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.

Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, McCormick LL, Fitzgerald P, Chi H, Munger J, Green DR.

Immunity. 2011 Dec 23;35(6):871-82. doi: 10.1016/j.immuni.2011.09.021.


A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR.

Mol Cell. 2011 Nov 18;44(4):517-31. doi: 10.1016/j.molcel.2011.10.001. Epub 2011 Oct 27.


RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.

Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS.

Mol Cell. 2011 Oct 7;44(1):9-16. doi: 10.1016/j.molcel.2011.09.003. Review.


Ripped to death.

Weinlich R, Dillon CP, Green DR.

Trends Cell Biol. 2011 Nov;21(11):630-7. doi: 10.1016/j.tcb.2011.09.002. Epub 2011 Oct 4. Review.


Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells.

Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17396-401. doi: 10.1073/pnas.1113421108. Epub 2011 Oct 3.


Non-apoptotic role of BID in inflammation and innate immunity.

Yeretssian G, Correa RG, Doiron K, Fitzgerald P, Dillon CP, Green DR, Reed JC, Saleh M.

Nature. 2011 Jun 2;474(7349):96-9. doi: 10.1038/nature09982. Epub 2011 May 8.


Autophagy is a cell survival program for female germ cells in the murine ovary.

Gawriluk TR, Hale AN, Flaws JA, Dillon CP, Green DR, Rucker EB 3rd.

Reproduction. 2011 Jun;141(6):759-65. doi: 10.1530/REP-10-0489. Epub 2011 Apr 4.


Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.

Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.

Nature. 2011 Mar 17;471(7338):363-7. doi: 10.1038/nature09852. Epub 2011 Mar 2.


Characterization of cytoplasmic caspase-2 activation by induced proximity.

Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR.

Mol Cell. 2009 Sep 24;35(6):830-40. doi: 10.1016/j.molcel.2009.07.023.


Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

Chipuk JE, Fisher JC, Dillon CP, Kriwacki RW, Kuwana T, Green DR.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20327-32. doi: 10.1073/pnas.0808036105. Epub 2008 Dec 12.


Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.

Sanjuan MA, Dillon CP, Tait SW, Moshiach S, Dorsey F, Connell S, Komatsu M, Tanaka K, Cleveland JL, Withoff S, Green DR.

Nature. 2007 Dec 20;450(7173):1253-7.


Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes.

Dillon CP, Sandy P, Nencioni A, Kissler S, Rubinson DA, Van Parijs L.

Annu Rev Physiol. 2005;67:147-73. Review.


Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.

Nencioni A, Hua F, Dillon CP, Yokoo R, Scheiermann C, Cardone MH, Barbieri E, Rocco I, Garuti A, Wesselborg S, Belka C, Brossart P, Patrone F, Ballestrero A.

Blood. 2005 Apr 15;105(8):3255-62. Epub 2004 Dec 21.


Cre-lox-regulated conditional RNA interference from transgenes.

Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T.

Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10380-5. Epub 2004 Jul 6.


A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference.

Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, Gertler FB, Scott ML, Van Parijs L.

Nat Genet. 2003 Mar;33(3):401-6. Epub 2003 Feb 18. Erratum in: Nat Genet. 2003 Jun;34(2):231. Nat Genet. 2007 Jun;39(6):803. Zhang, Mingdi [added].


Small interfering RNA-mediated gene silencing in T lymphocytes.

McManus MT, Haines BB, Dillon CP, Whitehurst CE, van Parijs L, Chen J, Sharp PA.

J Immunol. 2002 Nov 15;169(10):5754-60.


The influence of physiologically active compounds and their inactive homologs on phase boundary potentials.


J Am Pharm Assoc Am Pharm Assoc. 1946 Aug;35:250-2. No abstract available.


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