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Items: 23

1.

EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer.

Viswanadhapalli S, Luo Y, Sareddy GR, Santhamma B, Zhou M, Li M, Ma S, Sonavane R, Pratap UP, Altwegg KA, Li X, Chang A, Chávez-Riveros A, Dileep KV, Zhang KYJ, Pan X, Murali R, Bajda M, Raj GV, Brenner AJ, Manthati V, Rao MK, Tekmal RR, Nair HB, Nickisch KJ, Vadlamudi RK.

Mol Cancer Ther. 2019 Aug;18(8):1341-1354. doi: 10.1158/1535-7163.MCT-18-1258. Epub 2019 May 29.

PMID:
31142661
2.

Indole fragments for the design of lead molecules against pancreatitis.

Dileep KV, Ashok S, Remya C, Dharmendra KY, Pérez-Sánchez H, Sadasivan C.

J Biomol Struct Dyn. 2019 Jan 11:1-5. doi: 10.1080/07391102.2019.1567389. [Epub ahead of print]

PMID:
30633717
3.

Crystal structure of phospholipase A2 in complex with 1-naphthaleneacetic acid.

Dileep KV, Remya C, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C.

IUBMB Life. 2018 Oct;70(10):995-1001. doi: 10.1002/iub.1924. Epub 2018 Aug 18.

PMID:
30120882
4.

Binding of acarbose, an anti-diabetic drug to lysozyme: a combined structural and thermodynamic study.

Dileep KV, Nithiyanandan K, Remya C.

J Biomol Struct Dyn. 2018 Oct;36(13):3354-3361. doi: 10.1080/07391102.2017.1388283. Epub 2017 Oct 20. No abstract available.

PMID:
28984494
5.

A comprehensive approach to ascertain the binding mode of curcumin with DNA.

Haris P, Mary V, Aparna P, Dileep KV, Sudarsanakumar C.

Spectrochim Acta A Mol Biomol Spectrosc. 2017 Mar 15;175:155-163. doi: 10.1016/j.saa.2016.11.049. Epub 2016 Dec 5.

PMID:
28033562
6.

Effects of Combination of Estradiol with Selective Progesterone Receptor Modulators (SPRMs) on Human Breast Cancer Cells In Vitro and In Vivo.

Nair HB, Santhamma B, Krishnegowda NK, Dileep KV, Nickisch KJ.

PLoS One. 2016 Mar 24;11(3):e0151182. doi: 10.1371/journal.pone.0151182. eCollection 2016.

7.

Rational design and interaction studies of combilexins towards duplex DNA.

Dileep KV, Vijeesh V, Remya C.

Mol Biosyst. 2016 Mar;12(3):860-7. doi: 10.1039/c5mb00808e. Epub 2016 Jan 13.

PMID:
26757743
8.

Comparative studies on the inhibitory activities of selected benzoic acid derivatives against secretory phospholipase A2, a key enzyme involved in the inflammatory pathway.

Dileep KV, Remya C, Cerezo J, Fassihi A, Pérez-Sánchez H, Sadasivan C.

Mol Biosyst. 2015 Jul;11(7):1973-9. doi: 10.1039/c5mb00073d.

PMID:
25927625
9.

Flavanone glycosides as acetylcholinesterase inhibitors: computational and experimental evidence.

Remya C, Dileep KV, Tintu I, Variyar EJ, Sadasivan C.

Indian J Pharm Sci. 2014 Nov-Dec;76(6):567-70.

10.

TRAIL-based tumor sensitizing galactoxyloglucan, a novel entity for targeting apoptotic machinery.

Aravind SR, Joseph MM, George SK, Dileep KV, Varghese S, Rose-James A, Balaram P, Sadasivan C, Sreelekha TT.

Int J Biochem Cell Biol. 2015 Feb;59:153-66. doi: 10.1016/j.biocel.2014.11.019. Epub 2014 Dec 23.

PMID:
25541375
11.

Derivatives form better lipoxygenase inhibitors than piperine: in vitro and in silico study.

Tomy MJ, Sharanya CS, Dileep KV, Prasanth S, Sabu A, Sadasivan C, Haridas M.

Chem Biol Drug Des. 2015 Jun;85(6):715-21. doi: 10.1111/cbdd.12455. Epub 2014 Nov 17.

PMID:
25327968
12.

Cuminaldehyde as a lipoxygenase inhibitor: in vitro and in silico validation.

Tomy MJ, Dileep KV, Prasanth S, Preethidan DS, Sabu A, Sadasivan C, Haridas M.

Appl Biochem Biotechnol. 2014 Sep;174(1):388-97. doi: 10.1007/s12010-014-1066-0. Epub 2014 Jul 31.

PMID:
25080377
13.

A lectin from Spatholobus parviflorus inhibits Aspergillus flavus α-amylase: enzyme kinetics and thermodynamic studies.

Tintu I, Abhilash J, Dileep KV, Augustine A, Haridas M, Sadasivan C.

Chem Biol Drug Des. 2014 Jul;84(1):116-22. doi: 10.1111/cbdd.12291. Epub 2014 Mar 13.

PMID:
24460654
14.

Interactions of selected indole derivatives with COX-2 and their in silico structure modifications towards the development of novel NSAIDs.

Dileep KV, Remya C, Tintu I, Sadasivan C.

J Biomol Struct Dyn. 2014;32(11):1855-63. doi: 10.1080/07391102.2013.839960. Epub 2013 Sep 20.

PMID:
24053423
15.

Metal ions in sugar binding, sugar specificity and structural stability of Spatholobus parviflorus seed lectin.

Abhilash J, Dileep KV, Palanimuthu M, Geethanandan K, Sadasivan C, Haridas M.

J Mol Model. 2013 Aug;19(8):3271-8. doi: 10.1007/s00894-013-1854-4. Epub 2013 May 8.

PMID:
23652482
16.

Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma.

Bhaskaran S, Dileep KV, Deepa SS, Sadasivan C, Klausner M, Krishnegowda NK, Tekmal RR, VandeBerg JL, Nair HB.

Mol Cancer Ther. 2013 Apr;12(4):361-72. doi: 10.1158/1535-7163.MCT-12-0965. Epub 2013 Mar 29.

17.

Interactions of selected indole derivatives with phospholipase A₂: in silico and in vitro analysis.

Dileep KV, Remya C, Tintu I, Haridas M, Sadasivan C.

J Mol Model. 2013 Apr;19(4):1811-7. doi: 10.1007/s00894-012-1741-4. Epub 2013 Jan 13.

PMID:
23315198
18.

In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile.

Remya C, Dileep KV, Tintu I, Variyar EJ, Sadasivan C.

J Mol Model. 2013 Mar;19(3):1179-94. doi: 10.1007/s00894-012-1656-0. Epub 2012 Nov 16.

PMID:
23229229
19.

An isoquinoline alkaloid, berberine, can inhibit fungal alpha amylase: enzyme kinetic and molecular modeling studies.

Tintu I, Dileep KV, Augustine A, Sadasivan C.

Chem Biol Drug Des. 2012 Oct;80(4):554-60. doi: 10.1111/j.1747-0285.2012.01426.x. Epub 2012 Jul 23.

PMID:
22690956
20.

Anti-inflammatory property of n-hexadecanoic acid: structural evidence and kinetic assessment.

Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasivan C, Haridas M.

Chem Biol Drug Des. 2012 Sep;80(3):434-9. doi: 10.1111/j.1747-0285.2012.01418.x. Epub 2012 Jun 27.

PMID:
22642495
21.

Binding to PLA2 may contribute to the anti-inflammatory activity of catechol.

Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C.

Chem Biol Drug Des. 2012 Jan;79(1):143-7. doi: 10.1111/j.1747-0285.2011.01258.x. Epub 2011 Nov 16.

PMID:
21995306
22.

Molecular docking studies of curcumin analogs with phospholipase A2.

Dileep KV, Tintu I, Sadasivan C.

Interdiscip Sci. 2011 Sep;3(3):189-97. doi: 10.1007/s12539-011-0090-9. Epub 2011 Sep 29.

PMID:
21956741
23.

Inhibition of beta-lactamase by 1,4-naphthalenedione from the plant Holoptelea integrifolia.

Vinod NV, Shijina R, Dileep KV, Sadasivan C.

Appl Biochem Biotechnol. 2010 Mar;160(6):1752-9. doi: 10.1007/s12010-009-8656-2. Epub 2009 May 9.

PMID:
19424669

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