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Items: 1 to 50 of 279

1.

Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation.

Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I.

Nature. 2019 Aug;572(7769):382-386. doi: 10.1038/s41586-019-1440-8. Epub 2019 Jul 22.

PMID:
31330532
2.

CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.

Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I.

Nat Microbiol. 2019 Jul 8. doi: 10.1038/s41564-019-0484-8. [Epub ahead of print]

PMID:
31285585
3.

Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.

Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S.

J Mol Biol. 2019 Aug 9;431(17):3146-3156. doi: 10.1016/j.jmb.2019.06.012. Epub 2019 Jun 24.

PMID:
31247202
4.

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy.

Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G.

Nat Commun. 2019 May 30;10(1):2370. doi: 10.1038/s41467-019-10345-3.

5.

NIPSNAP Beacons in Mitophagy.

Mukherjee R, Dikic I.

Dev Cell. 2019 May 20;49(4):503-505. doi: 10.1016/j.devcel.2019.05.008.

PMID:
31112696
6.

RNA binding to p62 impacts selective autophagy.

Misra M, Dikic I.

Cell Res. 2019 Jul;29(7):512-513. doi: 10.1038/s41422-019-0167-2. No abstract available.

PMID:
31000784
7.

An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.

Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV.

Autophagy. 2019 Apr 16:1-15. doi: 10.1080/15548627.2019.1606637. [Epub ahead of print]

PMID:
30990354
8.

Deubiquitinase USP10 regulates Notch signaling in the endothelium.

Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M.

Science. 2019 Apr 12;364(6436):188-193. doi: 10.1126/science.aat0778.

PMID:
30975888
9.

Autophagy without conjugation.

Tiku V, Dikic I.

Nat Struct Mol Biol. 2019 Apr;26(4):249-250. doi: 10.1038/s41594-019-0207-0. No abstract available.

PMID:
30911186
10.

Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D.

Cancers (Basel). 2019 Mar 12;11(3). pii: E350. doi: 10.3390/cancers11030350.

11.

Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome.

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M.

Elife. 2019 Mar 6;8. pii: e42549. doi: 10.7554/eLife.42549.

12.

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L.

Kidney Int. 2019 Mar;95(3):540-562. doi: 10.1016/j.kint.2018.10.037. Epub 2019 Jan 31.

PMID:
30712922
13.

Visualizing ubiquitination in mammalian cells.

van Wijk SJ, Fulda S, Dikic I, Heilemann M.

EMBO Rep. 2019 Feb;20(2). pii: e46520. doi: 10.15252/embr.201846520. Epub 2019 Jan 21. Review.

PMID:
30665942
14.

Quantitative Phosphoproteomics of Selective Autophagy Receptors.

Juretschke T, Beli P, Dikic I.

Methods Mol Biol. 2019;1880:691-701. doi: 10.1007/978-1-4939-8873-0_46.

PMID:
30610732
15.

A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex.

Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C.

EMBO J. 2019 Jan 15;38(2). pii: e99847. doi: 10.15252/embj.201899847. Epub 2018 Dec 17.

16.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.

EMBO Rep. 2018 Dec;19(12). pii: e47268. doi: 10.15252/embr.201847268. No abstract available.

17.

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.

Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH.

Blood. 2019 Jan 10;133(2):168-179. doi: 10.1182/blood-2018-02-833475. Epub 2018 Nov 29. Erratum in: Blood. 2019 Jul 4;134(1):94.

PMID:
30498063
18.

Open questions: why should we care about ER-phagy and ER remodelling?

Dikic I.

BMC Biol. 2018 Nov 1;16(1):131. doi: 10.1186/s12915-018-0603-7.

19.

Dimerization quality control via ubiquitylation.

Herhaus L, Dikic I.

Science. 2018 Oct 12;362(6411):151-152. doi: 10.1126/science.aav1391. No abstract available.

PMID:
30309930
20.

Elusive mitochondrial connection to inflammation uncovered.

Stolz A, Dikic I.

Nature. 2018 Sep;561(7722):185-186. doi: 10.1038/d41586-018-05988-z. No abstract available.

PMID:
30194366
21.

ER-phagy at a glance.

Grumati P, Dikic I, Stolz A.

J Cell Sci. 2018 Sep 3;131(17). pii: jcs217364. doi: 10.1242/jcs.217364. Review.

22.

Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination.

Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I.

Nature. 2018 May;557(7707):734-738. doi: 10.1038/s41586-018-0145-8. Epub 2018 May 23.

23.

Publisher Correction: Hitchhiking on selective autophagy.

Münch C, Dikic I.

Nat Cell Biol. 2018 Aug;20(8):990. doi: 10.1038/s41556-018-0051-1.

PMID:
29674679
24.

Mechanism and medical implications of mammalian autophagy.

Dikic I, Elazar Z.

Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364. doi: 10.1038/s41580-018-0003-4. Review.

PMID:
29618831
25.

Ubiquitin-induced phase separation of p62/SQSTM1.

Herhaus L, Dikic I.

Cell Res. 2018 Apr;28(4):389-390. doi: 10.1038/s41422-018-0030-x. No abstract available.

26.

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells.

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D.

Neoplasia. 2018 Mar;20(3):263-279. doi: 10.1016/j.neo.2018.01.001. Epub 2018 Feb 22.

27.

Hitchhiking on selective autophagy.

Münch C, Dikic I.

Nat Cell Biol. 2018 Feb;20(2):122-124. doi: 10.1038/s41556-018-0036-0. No abstract available. Erratum in: Nat Cell Biol. 2018 Apr 19;:.

PMID:
29371706
28.

Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains.

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V.

Structure. 2018 Feb 6;26(2):249-258.e4. doi: 10.1016/j.str.2017.12.011. Epub 2018 Jan 18.

29.

Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response.

Ramadan K, Dikic I.

Front Genet. 2017 Nov 27;8:188. doi: 10.3389/fgene.2017.00188. eCollection 2017. No abstract available.

30.

A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins.

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1659-1662. doi: 10.1002/anie.201710527. Epub 2018 Jan 8.

PMID:
29215186
31.

Heterotypic Ubiquitin Chains: Seeing is Believing.

Stolz A, Dikic I.

Trends Cell Biol. 2018 Jan;28(1):1-3. doi: 10.1016/j.tcb.2017.11.005. Epub 2017 Nov 27.

PMID:
29191367
32.

Ubiquitin signaling and autophagy.

Grumati P, Dikic I.

J Biol Chem. 2018 Apr 13;293(15):5404-5413. doi: 10.1074/jbc.TM117.000117. Epub 2017 Nov 29. Review.

33.

Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring.

Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13042-13047. doi: 10.1073/pnas.1621196114. Epub 2017 Nov 20.

34.

Regulation of Salmonella-host cell interactions via the ubiquitin system.

Herhaus L, Dikic I.

Int J Med Microbiol. 2018 Jan;308(1):176-184. doi: 10.1016/j.ijmm.2017.11.003. Epub 2017 Nov 6. Review.

PMID:
29126744
35.

Manatee invariants reveal functional pathways in signaling networks.

Amstein L, Ackermann J, Scheidel J, Fulda S, Dikic I, Koch I.

BMC Syst Biol. 2017 Jul 28;11(1):72. doi: 10.1186/s12918-017-0448-7.

36.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.

EMBO Rep. 2017 Aug;18(8):1382-1396. doi: 10.15252/embr.201643587. Epub 2017 Jun 27. Erratum in: EMBO Rep. 2018 Dec;19(12):.

37.

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy.

Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I.

Elife. 2017 Jun 15;6. pii: e25555. doi: 10.7554/eLife.25555.

38.

Molecular definitions of autophagy and related processes.

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G.

EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review.

39.

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.

Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM.

Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027.

40.

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I.

Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66.

PMID:
28481361
41.

Proteasomal and Autophagic Degradation Systems.

Dikic I.

Annu Rev Biochem. 2017 Jun 20;86:193-224. doi: 10.1146/annurev-biochem-061516-044908. Epub 2017 May 1. Review.

PMID:
28460188
42.

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins.

Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I.

Sci Rep. 2017 Apr 25;7(1):1131. doi: 10.1038/s41598-017-01258-6.

43.

Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy.

Šprung M, Dikic I, Novak I.

Methods Mol Biol. 2018;1759:105-110. doi: 10.1007/7651_2017_14.

PMID:
28324488
44.

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.

Cell Res. 2017 May;27(5):657-674. doi: 10.1038/cr.2017.40. Epub 2017 Mar 21.

45.

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.

Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C.

Elife. 2017 Feb 14;6. pii: e23063. doi: 10.7554/eLife.23063.

46.

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I.

Nat Commun. 2017 Jan 13;8:14004. doi: 10.1038/ncomms14004.

47.

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.

Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR.

J Exp Med. 2017 Feb;214(2):423-437. doi: 10.1084/jem.20161867. Epub 2017 Jan 12.

48.

Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.

Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I.

EMBO J. 2017 Feb 15;36(4):549-564. doi: 10.15252/embj.201695063. Epub 2016 Dec 27.

49.

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.

Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I.

Cell. 2016 Dec 1;167(6):1636-1649.e13. doi: 10.1016/j.cell.2016.11.019.

50.

Autophagy Captures the Nobel Prize.

Tooze SA, Dikic I.

Cell. 2016 Dec 1;167(6):1433-1435. doi: 10.1016/j.cell.2016.11.023.

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