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Items: 1 to 50 of 270

1.

Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D.

Cancers (Basel). 2019 Mar 12;11(3). pii: E350. doi: 10.3390/cancers11030350.

2.

Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome.

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M.

Elife. 2019 Mar 6;8. pii: e42549. doi: 10.7554/eLife.42549.

3.

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L.

Kidney Int. 2019 Mar;95(3):540-562. doi: 10.1016/j.kint.2018.10.037. Epub 2019 Jan 31.

PMID:
30712922
4.

Visualizing ubiquitination in mammalian cells.

van Wijk SJ, Fulda S, Dikic I, Heilemann M.

EMBO Rep. 2019 Feb;20(2). pii: e46520. doi: 10.15252/embr.201846520. Epub 2019 Jan 21. Review.

PMID:
30665942
5.

Quantitative Phosphoproteomics of Selective Autophagy Receptors.

Juretschke T, Beli P, Dikic I.

Methods Mol Biol. 2019;1880:691-701. doi: 10.1007/978-1-4939-8873-0_46.

PMID:
30610732
6.

A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex.

Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C.

EMBO J. 2019 Jan 15;38(2). pii: e99847. doi: 10.15252/embj.201899847. Epub 2018 Dec 17.

7.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.

EMBO Rep. 2018 Dec;19(12). pii: e47268. doi: 10.15252/embr.201847268. No abstract available.

8.

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.

Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH.

Blood. 2019 Jan 10;133(2):168-179. doi: 10.1182/blood-2018-02-833475. Epub 2018 Nov 29.

PMID:
30498063
9.

Open questions: why should we care about ER-phagy and ER remodelling?

Dikic I.

BMC Biol. 2018 Nov 1;16(1):131. doi: 10.1186/s12915-018-0603-7.

10.

Dimerization quality control via ubiquitylation.

Herhaus L, Dikic I.

Science. 2018 Oct 12;362(6411):151-152. doi: 10.1126/science.aav1391. No abstract available.

PMID:
30309930
11.

Elusive mitochondrial connection to inflammation uncovered.

Stolz A, Dikic I.

Nature. 2018 Sep;561(7722):185-186. doi: 10.1038/d41586-018-05988-z. No abstract available.

PMID:
30194366
12.

ER-phagy at a glance.

Grumati P, Dikic I, Stolz A.

J Cell Sci. 2018 Sep 3;131(17). pii: jcs217364. doi: 10.1242/jcs.217364. Review.

13.

Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination.

Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I.

Nature. 2018 May;557(7707):734-738. doi: 10.1038/s41586-018-0145-8. Epub 2018 May 23.

14.

Publisher Correction: Hitchhiking on selective autophagy.

Münch C, Dikic I.

Nat Cell Biol. 2018 Aug;20(8):990. doi: 10.1038/s41556-018-0051-1.

PMID:
29674679
15.

Mechanism and medical implications of mammalian autophagy.

Dikic I, Elazar Z.

Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364. doi: 10.1038/s41580-018-0003-4. Review.

PMID:
29618831
16.

Ubiquitin-induced phase separation of p62/SQSTM1.

Herhaus L, Dikic I.

Cell Res. 2018 Apr;28(4):389-390. doi: 10.1038/s41422-018-0030-x. No abstract available.

PMID:
29572488
17.

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells.

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D.

Neoplasia. 2018 Mar;20(3):263-279. doi: 10.1016/j.neo.2018.01.001. Epub 2018 Feb 22.

18.

Hitchhiking on selective autophagy.

Münch C, Dikic I.

Nat Cell Biol. 2018 Feb;20(2):122-124. doi: 10.1038/s41556-018-0036-0. No abstract available. Erratum in: Nat Cell Biol. 2018 Apr 19;:.

PMID:
29371706
19.

Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains.

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V.

Structure. 2018 Feb 6;26(2):249-258.e4. doi: 10.1016/j.str.2017.12.011. Epub 2018 Jan 18.

20.

Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response.

Ramadan K, Dikic I.

Front Genet. 2017 Nov 27;8:188. doi: 10.3389/fgene.2017.00188. eCollection 2017. No abstract available.

21.

A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins.

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1659-1662. doi: 10.1002/anie.201710527. Epub 2018 Jan 8.

PMID:
29215186
22.

Heterotypic Ubiquitin Chains: Seeing is Believing.

Stolz A, Dikic I.

Trends Cell Biol. 2018 Jan;28(1):1-3. doi: 10.1016/j.tcb.2017.11.005. Epub 2017 Nov 27.

PMID:
29191367
23.

Ubiquitin signaling and autophagy.

Grumati P, Dikic I.

J Biol Chem. 2018 Apr 13;293(15):5404-5413. doi: 10.1074/jbc.TM117.000117. Epub 2017 Nov 29. Review.

PMID:
29187595
24.

Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring.

Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13042-13047. doi: 10.1073/pnas.1621196114. Epub 2017 Nov 20.

25.

Regulation of Salmonella-host cell interactions via the ubiquitin system.

Herhaus L, Dikic I.

Int J Med Microbiol. 2017 Nov 6. pii: S1438-4221(17)30280-1. doi: 10.1016/j.ijmm.2017.11.003. [Epub ahead of print] Review.

PMID:
29126744
26.

Manatee invariants reveal functional pathways in signaling networks.

Amstein L, Ackermann J, Scheidel J, Fulda S, Dikic I, Koch I.

BMC Syst Biol. 2017 Jul 28;11(1):72. doi: 10.1186/s12918-017-0448-7.

27.

Structural and functional analysis of the GABARAP interaction motif (GIM).

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG.

EMBO Rep. 2017 Aug;18(8):1382-1396. doi: 10.15252/embr.201643587. Epub 2017 Jun 27. Erratum in: EMBO Rep. 2018 Dec;19(12):.

28.

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy.

Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I.

Elife. 2017 Jun 15;6. pii: e25555. doi: 10.7554/eLife.25555.

29.

Molecular definitions of autophagy and related processes.

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G.

EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review.

30.

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.

Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM.

Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027.

31.

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I.

Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66.

PMID:
28481361
32.

Proteasomal and Autophagic Degradation Systems.

Dikic I.

Annu Rev Biochem. 2017 Jun 20;86:193-224. doi: 10.1146/annurev-biochem-061516-044908. Epub 2017 May 1. Review.

PMID:
28460188
33.

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins.

Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I.

Sci Rep. 2017 Apr 25;7(1):1131. doi: 10.1038/s41598-017-01258-6.

34.

Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy.

Šprung M, Dikic I, Novak I.

Methods Mol Biol. 2018;1759:105-110. doi: 10.1007/7651_2017_14.

PMID:
28324488
35.

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.

Cell Res. 2017 May;27(5):657-674. doi: 10.1038/cr.2017.40. Epub 2017 Mar 21.

36.

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.

Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C.

Elife. 2017 Feb 14;6. pii: e23063. doi: 10.7554/eLife.23063.

37.

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I.

Nat Commun. 2017 Jan 13;8:14004. doi: 10.1038/ncomms14004.

38.

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.

Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR.

J Exp Med. 2017 Feb;214(2):423-437. doi: 10.1084/jem.20161867. Epub 2017 Jan 12.

39.

Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.

Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I.

EMBO J. 2017 Feb 15;36(4):549-564. doi: 10.15252/embj.201695063. Epub 2016 Dec 27.

40.

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.

Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I.

Cell. 2016 Dec 1;167(6):1636-1649.e13. doi: 10.1016/j.cell.2016.11.019.

41.

Autophagy Captures the Nobel Prize.

Tooze SA, Dikic I.

Cell. 2016 Dec 1;167(6):1433-1435. doi: 10.1016/j.cell.2016.11.023.

42.

In Silico Knockout Studies of Xenophagic Capturing of Salmonella.

Scheidel J, Amstein L, Ackermann J, Dikic I, Koch I.

PLoS Comput Biol. 2016 Dec 1;12(12):e1005200. doi: 10.1371/journal.pcbi.1005200. eCollection 2016 Dec.

43.

Removing the waste bags: how p97 drives autophagy of lysosomes.

Seczynska M, Dikic I.

EMBO J. 2017 Jan 17;36(2):129-131. doi: 10.15252/embj.201695950. Epub 2016 Nov 28. No abstract available.

44.

SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.

Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I.

Elife. 2016 Nov 17;5. pii: e21491. doi: 10.7554/eLife.21491.

45.

How the proteasome is degraded.

Hoeller D, Dikic I.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13266-13268. Epub 2016 Nov 11. No abstract available.

46.

CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.

Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M.

Diabetes. 2016 Dec;65(12):3667-3679. Epub 2016 Aug 16.

47.

Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Weishaupt JH, Hyman T, Dikic I.

Trends Mol Med. 2016 Sep;22(9):769-783. doi: 10.1016/j.molmed.2016.07.005. Epub 2016 Aug 4. Review.

PMID:
27498188
48.

Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection.

Fiskin E, Bionda T, Dikic I, Behrends C.

Mol Cell. 2016 Jun 16;62(6):967-981. doi: 10.1016/j.molcel.2016.04.015. Epub 2016 May 19.

49.

Cell biology: Ubiquitination without E1 and E2 enzymes.

Bhogaraju S, Dikic I.

Nature. 2016 May 5;533(7601):43-4. doi: 10.1038/nature17888. Epub 2016 Apr 20. No abstract available.

PMID:
27096359
50.

A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.

Suzuki N, Rohaim A, Kato R, Dikic I, Wakatsuki S, Kawasaki M.

FEBS J. 2016 Jun;283(11):2004-17. doi: 10.1111/febs.13734. Epub 2016 Apr 28.

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