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Items: 31


Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses.

Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stürzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, Neil SJD, Finzi A, Richard J.

MBio. 2019 Jun 18;10(3). pii: e01113-19. doi: 10.1128/mBio.01113-19.


Soluble CD93 is an apoptotic cell opsonin recognized by αx β2.

Blackburn JWD, Lau DHC, Liu EY, Ellins J, Vrieze AM, Pawlak EN, Dikeakos JD, Heit B.

Eur J Immunol. 2019 Apr;49(4):600-610. doi: 10.1002/eji.201847801. Epub 2019 Feb 7.


PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway.

Dirk BS, End C, Pawlak EN, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):519-525. doi: 10.1016/j.bbrc.2018.11.085. Epub 2018 Nov 17.


Bacterial Superantigens Expand and Activate, Rather than Delete or Incapacitate, Preexisting Antigen-Specific Memory CD8+ T Cells.

Meilleur CE, Wardell CM, Mele TS, Dikeakos JD, Bennink JR, Mu HH, McCormick JK, Haeryfar SMM.

J Infect Dis. 2019 Apr 8;219(8):1307-1317. doi: 10.1093/infdis/jiy647.


Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997).

Van Nynatten LR, Johnson AL, Dirk BS, Pawlak EN, Jacob RA, Haeryfar SMM, Dikeakos JD.

Viruses. 2018 Sep 13;10(9). pii: E493. doi: 10.3390/v10090493.


Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin.

Khadir F, Shaler CR, Oryan A, Rudak PT, Mazzuca DM, Taheri T, Dikeakos JD, Haeryfar SMM, Rafati S.

PLoS Negl Trop Dis. 2018 Aug 22;12(8):e0006701. doi: 10.1371/journal.pntd.0006701. eCollection 2018 Aug.


The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells.

Pawlak EN, Dirk BS, Jacob RA, Johnson AL, Dikeakos JD.

Retrovirology. 2018 Jan 12;15(1):6. doi: 10.1186/s12977-018-0388-3.


HIV-I Nef inhibitors: a novel class of HIV-specific immune adjuvants in support of a cure.

Dekaban GA, Dikeakos JD.

AIDS Res Ther. 2017 Sep 12;14(1):53. doi: 10.1186/s12981-017-0175-6. Review.


The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis.

Jacob RA, Johnson AL, Pawlak EN, Dirk BS, Van Nynatten LR, Haeryfar SMM, Dikeakos JD.

Virology. 2017 Sep;509:1-10. doi: 10.1016/j.virol.2017.05.018. Epub 2017 Jun 1.


Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function.

Evans AL, Blackburn JWD, Taruc K, Kipp A, Dirk BS, Hunt NR, Barr SD, Dikeakos JD, Heit B.

Mol Biol Evol. 2017 Jul 1;34(7):1613-1628. doi: 10.1093/molbev/msx102.


HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling.

Dirk BS, Pawlak EN, Johnson AL, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD.

Sci Rep. 2016 Nov 14;6:37021. doi: 10.1038/srep37021.


A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression.

Johnson AL, Dirk BS, Coutu M, Haeryfar SM, Arts EJ, Finzi A, Dikeakos JD.

mSphere. 2016 Nov 9;1(6). pii: e00288-16. eCollection 2016 Nov-Dec.


Where in the Cell Are You? Probing HIV-1 Host Interactions through Advanced Imaging Techniques.

Dirk BS, Van Nynatten LR, Dikeakos JD.

Viruses. 2016 Oct 19;8(10). pii: E288. Review.


Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein.

King CR, Cohen MJ, Fonseca GJ, Dirk BS, Dikeakos JD, Mymryk JS.

PLoS Pathog. 2016 May 3;12(5):e1005621. doi: 10.1371/journal.ppat.1005621. eCollection 2016 May.


MIiSR: Molecular Interactions in Super-Resolution Imaging Enables the Analysis of Protein Interactions, Dynamics and Formation of Multi-protein Structures.

Caetano FA, Dirk BS, Tam JH, Cavanagh PC, Goiko M, Ferguson SS, Pasternak SH, Dikeakos JD, de Bruyn JR, Heit B.

PLoS Comput Biol. 2015 Dec 11;11(12):e1004634. doi: 10.1371/journal.pcbi.1004634. eCollection 2015 Dec.


Visualizing Interactions Between HIV-1 Nef and Host Cellular Proteins Using Ground-State Depletion Microscopy.

Dirk BS, Heit B, Dikeakos JD.

AIDS Res Hum Retroviruses. 2015 Jul;31(7):671-2. doi: 10.1089/aid.2014.0333. Epub 2015 May 18. No abstract available.


Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways.

Dirk BS, Jacob RA, Johnson AL, Pawlak EN, Cavanagh PC, Van Nynatten L, Haeryfar SM, Dikeakos JD.

PLoS One. 2015 Apr 27;10(4):e0125619. doi: 10.1371/journal.pone.0125619. eCollection 2015.


HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion.

Pawlak EN, Dikeakos JD.

Biochim Biophys Acta. 2015 Apr;1850(4):733-41. doi: 10.1016/j.bbagen.2015.01.003. Epub 2015 Jan 10. Review.


Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal.

Cohen MJ, King CR, Dikeakos JD, Mymryk JS.

Virology. 2014 Nov;468-470:238-243. doi: 10.1016/j.virol.2014.08.014. Epub 2014 Sep 6.


The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.

Atkins KM, Thomas LL, Barroso-González J, Thomas L, Auclair S, Yin J, Kang H, Chung JH, Dikeakos JD, Thomas G.

Cell Rep. 2014 Sep 11;8(5):1545-57. doi: 10.1016/j.celrep.2014.07.049. Epub 2014 Aug 21.


Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export.

Woods MW, Tong JG, Tom SK, Szabo PA, Cavanagh PC, Dikeakos JD, Haeryfar SM, Barr SD.

Retrovirology. 2014 Apr 3;11:27. doi: 10.1186/1742-4690-11-27.


Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2).

Werneburg NW, Bronk SF, Guicciardi ME, Thomas L, Dikeakos JD, Thomas G, Gores GJ.

J Biol Chem. 2012 Jul 13;287(29):24427-37. doi: 10.1074/jbc.M112.342238. Epub 2012 May 29.


An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.

Dikeakos JD, Thomas L, Kwon G, Elferich J, Shinde U, Thomas G.

Mol Biol Cell. 2012 Jun;23(11):2184-97. doi: 10.1091/mbc.E11-11-0928. Epub 2012 Apr 11.


Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.

Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall TE, Thomas G.

Mol Biol Cell. 2010 Oct 1;21(19):3279-92. doi: 10.1091/mbc.E10-05-0470. Epub 2010 Aug 11.


Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease.

Dikeakos JD, Di Lello P, Lacombe MJ, Ghirlando R, Legault P, Reudelhuber TL, Omichinski JG.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7408-13. doi: 10.1073/pnas.0809576106. Epub 2009 Apr 17.


PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.

Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL.

FEBS J. 2007 Aug;274(16):4094-102. Epub 2007 Jul 20.


The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro.

Rabah N, Gauthier D, Dikeakos JD, Reudelhuber TL, Lazure C.

FEBS J. 2007 Jul;274(13):3482-91. Epub 2007 Jun 12.


Sending proteins to dense core secretory granules: still a lot to sort out.

Dikeakos JD, Reudelhuber TL.

J Cell Biol. 2007 Apr 23;177(2):191-6. Epub 2007 Apr 16. Review.


A hydrophobic patch in a charged alpha-helix is sufficient to target proteins to dense core secretory granules.

Dikeakos JD, Lacombe MJ, Mercure C, Mireuta M, Reudelhuber TL.

J Biol Chem. 2007 Jan 12;282(2):1136-43. Epub 2006 Nov 8.


Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.

Di Lello P, Jenkins LM, Jones TN, Nguyen BD, Hara T, Yamaguchi H, Dikeakos JD, Appella E, Legault P, Omichinski JG.

Mol Cell. 2006 Jun 23;22(6):731-40.


Modulation of secretory granule-targeting efficiency by cis and trans compounding of sorting signals.

Lacombe MJ, Mercure C, Dikeakos JD, Reudelhuber TL.

J Biol Chem. 2005 Feb 11;280(6):4803-7. Epub 2004 Nov 29.

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