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Items: 1 to 50 of 273

1.

Large-scale quantitative isolation of pure protein N-linked glycans.

Valk-Weeber RL, Dijkhuizen L, van Leeuwen SS.

Carbohydr Res. 2019 Jun 1;479:13-22. doi: 10.1016/j.carres.2019.04.011. Epub 2019 May 3.

2.

Synthesis and Characterization of Sialylated Lactose- and Lactulose-Derived Oligosaccharides by Trypanosoma cruzi Trans-sialidase.

Pham HTT, Ten Kate GA, Dijkhuizen L, van Leeuwen SS.

J Agric Food Chem. 2019 Mar 27;67(12):3469-3479. doi: 10.1021/acs.jafc.8b06974. Epub 2019 Mar 14.

PMID:
30836749
3.

Structural and functional characterization of a family GH53 β-1,4-galactanase from Bacteroides thetaiotaomicron that facilitates degradation of prebiotic galactooligosaccharides.

Böger M, Hekelaar J, van Leeuwen SS, Dijkhuizen L, Lammerts van Bueren A.

J Struct Biol. 2019 Jan 1;205(1):1-10. doi: 10.1016/j.jsb.2018.12.002. Epub 2018 Dec 13.

4.

Synthesis of novel α-glucans with potential health benefits through controlled glucose release in the human gastrointestinal tract.

Gangoiti J, Corwin SF, Lamothe LM, Vafiadi C, Hamaker BR, Dijkhuizen L.

Crit Rev Food Sci Nutr. 2018 Dec 11:1-24. doi: 10.1080/10408398.2018.1516621. [Epub ahead of print]

PMID:
30525940
5.

Regional variations in human milk oligosaccharides in Vietnam suggest FucTx activity besides FucT2 and FucT3.

van Leeuwen SS, Stoutjesdijk E, Ten Kate GA, Schaafsma A, Dijck-Brouwer J, Muskiet FAJ, Dijkhuizen L.

Sci Rep. 2018 Nov 14;8(1):16790. doi: 10.1038/s41598-018-34882-x.

6.

Stimulatory effects of novel glucosylated lactose derivatives GL34 on growth of selected gut bacteria.

Pham HTT, Boger MCL, Dijkhuizen L, van Leeuwen SS.

Appl Microbiol Biotechnol. 2019 Jan;103(2):707-718. doi: 10.1007/s00253-018-9473-8. Epub 2018 Nov 7.

7.

Mutational Analysis of the Role of the Glucansucrase Gtf180-ΔN Active Site Residues in Product and Linkage Specificity with Lactose as Acceptor Substrate.

Pham H, Pijning T, Dijkhuizen L, van Leeuwen SS.

J Agric Food Chem. 2018 Nov 28;66(47):12544-12554. doi: 10.1021/acs.jafc.8b04486. Epub 2018 Nov 15.

8.

Structural characterization of glucosylated GOS derivatives synthesized by the Lactobacillus reuteri GtfA and Gtf180 glucansucrase enzymes.

Pham HT, Dijkhuizen L, van Leeuwen SS.

Carbohydr Res. 2018 Dec;470:57-63. doi: 10.1016/j.carres.2018.10.003. Epub 2018 Oct 22.

9.

Trans-α-glucosylation of stevioside by the mutant glucansucrase enzyme Gtf180-ΔN-Q1140E improves its taste profile.

Devlamynck T, Te Poele EM, Quataert K, Gerwig GJ, Van de Walle D, Dewettinck K, Kamerling JP, Soetaert W, Dijkhuizen L.

Food Chem. 2019 Jan 30;272:653-662. doi: 10.1016/j.foodchem.2018.08.025. Epub 2018 Aug 10.

10.

Cross-Feeding among Probiotic Bacterial Strains on Prebiotic Inulin Involves the Extracellular exo-Inulinase of Lactobacillus paracasei Strain W20.

Boger MCL, Lammerts van Bueren A, Dijkhuizen L.

Appl Environ Microbiol. 2018 Oct 17;84(21). pii: e01539-18. doi: 10.1128/AEM.01539-18. Print 2018 Nov 1.

11.

Biochemical characterization of a GH70 protein from Lactobacillus kunkeei DSM 12361 with two catalytic domains involving branching sucrase activity.

Meng X, Gangoiti J, Wang X, Grijpstra P, van Leeuwen SS, Pijning T, Dijkhuizen L.

Appl Microbiol Biotechnol. 2018 Sep;102(18):7935-7950. doi: 10.1007/s00253-018-9236-6. Epub 2018 Jul 24.

PMID:
30043269
12.

Synthesis of galacto-oligosaccharides derived from lactulose by wild-type and mutant β-galactosidase enzymes from Bacillus circulans ATCC 31382.

Yin H, Dijkhuizen L, van Leeuwen SS.

Carbohydr Res. 2018 Jul 30;465:58-65. doi: 10.1016/j.carres.2018.06.009. Epub 2018 Jun 19.

13.

Biochemical characterization of two GH70 family 4,6-α-glucanotransferases with distinct product specificity from Lactobacillus aviarius subsp. aviarius DSM 20655.

Meng X, Gangoiti J, de Kok N, van Leeuwen SS, Pijning T, Dijkhuizen L.

Food Chem. 2018 Jul 1;253:236-246. doi: 10.1016/j.foodchem.2018.01.154. Epub 2018 Jan 31.

14.

Glucansucrase (mutant) enzymes from Lactobacillus reuteri 180 efficiently transglucosylate Stevia component rebaudioside A, resulting in a superior taste.

Te Poele EM, Devlamynck T, Jäger M, Gerwig GJ, Van de Walle D, Dewettinck K, Hirsch AKH, Kamerling JP, Soetaert W, Dijkhuizen L.

Sci Rep. 2018 Jan 24;8(1):1516. doi: 10.1038/s41598-018-19622-5.

15.

Molecular characterization of a Rhodococcus jostii RHA1 γ-butyrolactone(-like) signalling molecule and its main biosynthesis gene gblA.

Ceniceros A, Dijkhuizen L, Petrusma M.

Sci Rep. 2017 Dec 18;7(1):17743. doi: 10.1038/s41598-017-17853-6.

16.

Biotechnological potential of novel glycoside hydrolase family 70 enzymes synthesizing α-glucans from starch and sucrose.

Gangoiti J, Pijning T, Dijkhuizen L.

Biotechnol Adv. 2018 Jan - Feb;36(1):196-207. doi: 10.1016/j.biotechadv.2017.11.001. Epub 2017 Nov 10. Review.

PMID:
29133008
17.

Is there foul play in the leaf pocket? The metagenome of floating fern Azolla reveals endophytes that do not fix N2 but may denitrify.

Dijkhuizen LW, Brouwer P, Bolhuis H, Reichart GJ, Koppers N, Huettel B, Bolger AM, Li FW, Cheng S, Liu X, Wong GK, Pryer K, Weber A, Bräutigam A, Schluepmann H.

New Phytol. 2018 Jan;217(1):453-466. doi: 10.1111/nph.14843. Epub 2017 Oct 30.

18.

Dietary N-Glycans from Bovine Lactoferrin and TLR Modulation.

Figueroa-Lozano S, Valk-Weeber RL, van Leeuwen SS, Dijkhuizen L, de Vos P.

Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700389. Epub 2018 Jan 3.

19.

Mining novel starch-converting Glycoside Hydrolase 70 enzymes from the Nestlé Culture Collection genome database: The Lactobacillus reuteri NCC 2613 GtfB.

Gangoiti J, van Leeuwen SS, Meng X, Duboux S, Vafiadi C, Pijning T, Dijkhuizen L.

Sci Rep. 2017 Aug 30;7(1):9947. doi: 10.1038/s41598-017-07190-z.

20.

Genome-based exploration of the specialized metabolic capacities of the genus Rhodococcus.

Ceniceros A, Dijkhuizen L, Petrusma M, Medema MH.

BMC Genomics. 2017 Aug 9;18(1):593. doi: 10.1186/s12864-017-3966-1.

21.

Structural characterization of glucosylated lactose derivatives synthesized by the Lactobacillus reuteri GtfA and Gtf180 glucansucrase enzymes.

Pham HTT, Dijkhuizen L, van Leeuwen SS.

Carbohydr Res. 2017 Sep 8;449:59-64. doi: 10.1016/j.carres.2017.07.002. Epub 2017 Jul 8.

22.

Molecular and biochemical characteristics of the inulosucrase HugO from Streptomyces viridochromogenes DSM40736 (Tü494).

Frasch HJ, Leeuwen SSV, Dijkhuizen L.

Microbiology. 2017 Jul;163(7):1030-1041. doi: 10.1099/mic.0.000493. Epub 2017 Jul 21.

PMID:
28714842
23.

3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Contains a Phosphatidylinositol Cofactor.

Montersino S, Te Poele E, Orru R, Westphal AH, Barendregt A, Heck AJR, van der Geize R, Dijkhuizen L, Mattevi A, van Berkel WJH.

Front Microbiol. 2017 Jun 16;8:1110. doi: 10.3389/fmicb.2017.01110. eCollection 2017.

24.

Biochemical Characterization of the Functional Roles of Residues in the Active Site of the β-Galactosidase from Bacillus circulans ATCC 31382.

Yin H, Pijning T, Meng X, Dijkhuizen L, van Leeuwen SS.

Biochemistry. 2017 Jun 20;56(24):3109-3118. doi: 10.1021/acs.biochem.7b00207. Epub 2017 Jun 5.

25.

Characterization of the Paenibacillus beijingensis DSM 24997 GtfD and its glucan polymer products representing a new glycoside hydrolase 70 subfamily of 4,6-α-glucanotransferase enzymes.

Gangoiti J, Lamothe L, van Leeuwen SS, Vafiadi C, Dijkhuizen L.

PLoS One. 2017 Apr 11;12(4):e0172622. doi: 10.1371/journal.pone.0172622. eCollection 2017.

26.

A new group of glycoside hydrolase family 13 α-amylases with an aberrant catalytic triad.

Sarian FD, Janeček Š, Pijning T, Ihsanawati, Nurachman Z, Radjasa OK, Dijkhuizen L, Natalia D, van der Maarel MJ.

Sci Rep. 2017 Mar 13;7:44230. doi: 10.1038/srep44230.

27.

Draft Genome Sequence of Lactobacillus reuteri 121, a Source of α-Glucan and β-Fructan Exopolysaccharides.

Gangoiti J, Meng X, Lammerts van Bueren A, Dijkhuizen L.

Genome Announc. 2017 Mar 9;5(10). pii: e01691-16. doi: 10.1128/genomeA.01691-16.

28.

Catechol glucosides act as donor/acceptor substrates of glucansucrase enzymes of Lactobacillus reuteri.

Te Poele EM, Valk V, Devlamynck T, van Leeuwen SS, Dijkhuizen L.

Appl Microbiol Biotechnol. 2017 Jun;101(11):4495-4505. doi: 10.1007/s00253-017-8190-z. Epub 2017 Mar 3.

29.

Structural analysis of rebaudioside A derivatives obtained by Lactobacillus reuteri 180 glucansucrase-catalyzed trans-α-glucosylation.

Gerwig GJ, Te Poele EM, Dijkhuizen L, Kamerling JP.

Carbohydr Res. 2017 Feb 22;440-441:51-62. doi: 10.1016/j.carres.2017.01.008. Epub 2017 Jan 31.

30.

Reaction kinetics and galactooligosaccharide product profiles of the β-galactosidases from Bacillus circulans, Kluyveromyces lactis and Aspergillus oryzae.

Yin H, Bultema JB, Dijkhuizen L, van Leeuwen SS.

Food Chem. 2017 Jun 15;225:230-238. doi: 10.1016/j.foodchem.2017.01.030. Epub 2017 Jan 7.

PMID:
28193420
31.

Engineering of the Bacillus circulans β-Galactosidase Product Specificity.

Yin H, Pijning T, Meng X, Dijkhuizen L, van Leeuwen SS.

Biochemistry. 2017 Feb 7;56(5):704-711. doi: 10.1021/acs.biochem.7b00032. Epub 2017 Jan 25.

32.

Prebiotic galactooligosaccharides activate mucin and pectic galactan utilization pathways in the human gut symbiont Bacteroides thetaiotaomicron.

Lammerts van Bueren A, Mulder M, Leeuwen SV, Dijkhuizen L.

Sci Rep. 2017 Jan 16;7:40478. doi: 10.1038/srep40478.

33.

Crystal Structure of 4,6-α-Glucanotransferase Supports Diet-Driven Evolution of GH70 Enzymes from α-Amylases in Oral Bacteria.

Bai Y, Gangoiti J, Dijkstra BW, Dijkhuizen L, Pijning T.

Structure. 2017 Feb 7;25(2):231-242. doi: 10.1016/j.str.2016.11.023. Epub 2017 Jan 5.

34.

4,3-α-Glucanotransferase, a novel reaction specificity in glycoside hydrolase family 70 and clan GH-H.

Gangoiti J, van Leeuwen SS, Gerwig GJ, Duboux S, Vafiadi C, Pijning T, Dijkhuizen L.

Sci Rep. 2017 Jan 6;7:39761. doi: 10.1038/srep39761.

35.

Stevia Glycosides: Chemical and Enzymatic Modifications of Their Carbohydrate Moieties to Improve the Sweet-Tasting Quality.

Gerwig GJ, Te Poele EM, Dijkhuizen L, Kamerling JP.

Adv Carbohydr Chem Biochem. 2016;73:1-72. doi: 10.1016/bs.accb.2016.05.001. Epub 2016 Aug 29. Review.

PMID:
27816105
37.

Structural determinants of alternating (α1 → 4) and (α1 → 6) linkage specificity in reuteransucrase of Lactobacillus reuteri.

Meng X, Pijning T, Dobruchowska JM, Yin H, Gerwig GJ, Dijkhuizen L.

Sci Rep. 2016 Oct 17;6:35261. doi: 10.1038/srep35261.

38.

Characterization of the glucansucrase GTF180 W1065 mutant enzymes producing polysaccharides and oligosaccharides with altered linkage composition.

Meng X, Pijning T, Tietema M, Dobruchowska JM, Yin H, Gerwig GJ, Kralj S, Dijkhuizen L.

Food Chem. 2017 Feb 15;217:81-90. doi: 10.1016/j.foodchem.2016.08.087. Epub 2016 Aug 24.

PMID:
27664611
39.

Modification of linear (β1→3)-linked gluco-oligosaccharides with a novel recombinant β-glucosyltransferase (trans-β-glucosidase) enzyme from Bradyrhizobium diazoefficiens.

Dobruchowska JM, Jonsson JO, Fridjonsson OH, Aevarsson A, Kristjansson JK, Altenbuchner J, Watzlawick H, Gerwig GJ, Dijkhuizen L, Kamerling JP, Hreggvidsson GO.

Glycobiology. 2016 Nov;26(11):1157-1170. doi: 10.1093/glycob/cww074. Epub 2016 Aug 22.

PMID:
27550196
40.

Structural basis for the roles of starch and sucrose in homo-exopolysaccharide formation by Lactobacillus reuteri 35-5.

Bai Y, Dobruchowska JM, van der Kaaij RM, Gerwig GJ, Dijkhuizen L.

Carbohydr Polym. 2016 Oct 20;151:29-39. doi: 10.1016/j.carbpol.2016.05.048. Epub 2016 May 17.

PMID:
27474540
41.

Structure-function relationships of family GH70 glucansucrase and 4,6-α-glucanotransferase enzymes, and their evolutionary relationships with family GH13 enzymes.

Meng X, Gangoiti J, Bai Y, Pijning T, Van Leeuwen SS, Dijkhuizen L.

Cell Mol Life Sci. 2016 Jul;73(14):2681-706. doi: 10.1007/s00018-016-2245-7. Epub 2016 May 7. Review.

42.

Carbohydrate-binding module 74 is a novel starch-binding domain associated with large and multidomain α-amylase enzymes.

Valk V, Lammerts van Bueren A, van der Kaaij RM, Dijkhuizen L.

FEBS J. 2016 Jun;283(12):2354-68. doi: 10.1111/febs.13745. Epub 2016 May 11.

43.

Glucansucrase Gtf180-ΔN of Lactobacillus reuteri 180: enzyme and reaction engineering for improved glycosylation of non-carbohydrate molecules.

Devlamynck T, Te Poele EM, Meng X, van Leeuwen SS, Dijkhuizen L.

Appl Microbiol Biotechnol. 2016 Sep;100(17):7529-39. doi: 10.1007/s00253-016-7476-x. Epub 2016 Apr 6.

44.

Comparative structural characterization of 7 commercial galacto-oligosaccharide (GOS) products.

van Leeuwen SS, Kuipers BJ, Dijkhuizen L, Kamerling JP.

Carbohydr Res. 2016 Apr 29;425:48-58. doi: 10.1016/j.carres.2016.03.006. Epub 2016 Mar 16.

PMID:
27035911
45.

Lactobacillus reuteri Strains Convert Starch and Maltodextrins into Homoexopolysaccharides Using an Extracellular and Cell-Associated 4,6-α-Glucanotransferase.

Bai Y, Böger M, van der Kaaij RM, Woortman AJ, Pijning T, van Leeuwen SS, van Bueren AL, Dijkhuizen L.

J Agric Food Chem. 2016 Apr 13;64(14):2941-52. doi: 10.1021/acs.jafc.6b00714. Epub 2016 Mar 30.

PMID:
26996545
46.

Glucosylation of Catechol with the GTFA Glucansucrase Enzyme from Lactobacillus reuteri and Sucrose as Donor Substrate.

te Poele EM, Grijpstra P, van Leeuwen SS, Dijkhuizen L.

Bioconjug Chem. 2016 Apr 20;27(4):937-46. doi: 10.1021/acs.bioconjchem.6b00018. Epub 2016 Mar 8.

PMID:
26898769
47.

The Gram-negative bacterium Azotobacter chroococcum NCIMB 8003 employs a new glycoside hydrolase family 70 4,6-α-glucanotransferase enzyme (GtfD) to synthesize a reuteran like polymer from maltodextrins and starch.

Gangoiti J, van Leeuwen SS, Vafiadi C, Dijkhuizen L.

Biochim Biophys Acta. 2016 Jun;1860(6):1224-36. doi: 10.1016/j.bbagen.2016.02.005. Epub 2016 Feb 8.

PMID:
26868718
48.

Synthesis of New Hyperbranched α-Glucans from Sucrose by Lactobacillus reuteri 180 Glucansucrase Mutants.

Meng X, Dobruchowska JM, Pijning T, Gerwig GJ, Dijkhuizen L.

J Agric Food Chem. 2016 Jan 20;64(2):433-42. doi: 10.1021/acs.jafc.5b05161. Epub 2016 Jan 8.

PMID:
26688101
49.

The Exiguobacterium sibiricum 255-15 GtfC Enzyme Represents a Novel Glycoside Hydrolase 70 Subfamily of 4,6-α-Glucanotransferase Enzymes.

Gangoiti J, Pijning T, Dijkhuizen L.

Appl Environ Microbiol. 2015 Nov 20;82(2):756-66. doi: 10.1128/AEM.03420-15. Print 2016 Jan 15.

50.

Characterization of the Functional Roles of Amino Acid Residues in Acceptor-binding Subsite +1 in the Active Site of the Glucansucrase GTF180 from Lactobacillus reuteri 180.

Meng X, Pijning T, Dobruchowska JM, Gerwig GJ, Dijkhuizen L.

J Biol Chem. 2015 Dec 11;290(50):30131-41. doi: 10.1074/jbc.M115.687558. Epub 2015 Oct 27.

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