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Items: 24

1.

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.

Biehs B, Dijkgraaf GJP, Piskol R, Alicke B, Boumahdi S, Peale F, Gould SE, de Sauvage FJ.

Nature. 2018 Oct;562(7727):429-433. doi: 10.1038/s41586-018-0596-y. Epub 2018 Oct 8.

PMID:
30297801
2.

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer.

de Sousa e Melo F, Kurtova AV, Harnoss JM, Kljavin N, Hoeck JD, Hung J, Anderson JE, Storm EE, Modrusan Z, Koeppen H, Dijkgraaf GJ, Piskol R, de Sauvage FJ.

Nature. 2017 Mar 29;543(7647):676-680. doi: 10.1038/nature21713.

PMID:
28358093
3.

Complex regulation of ADAR-mediated RNA-editing across tissues.

Huntley MA, Lou M, Goldstein LD, Lawrence M, Dijkgraaf GJ, Kaminker JS, Gentleman R.

BMC Genomics. 2016 Jan 15;17:61. doi: 10.1186/s12864-015-2291-9.

4.

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.

Sharpe HJ, Pau G, Dijkgraaf GJ, Basset-Seguin N, Modrusan Z, Januario T, Tsui V, Durham AB, Dlugosz AA, Haverty PM, Bourgon R, Tang JY, Sarin KY, Dirix L, Fisher DC, Rudin CM, Sofen H, Migden MR, Yauch RL, de Sauvage FJ.

Cancer Cell. 2015 Mar 9;27(3):327-41. doi: 10.1016/j.ccell.2015.02.001.

5.

PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition.

Metcalfe C, Alicke B, Crow A, Lamoureux M, Dijkgraaf GJ, Peale F, Gould SE, de Sauvage FJ.

Cancer Res. 2013 Dec 1;73(23):7034-42. doi: 10.1158/0008-5472.CAN-13-1222. Epub 2013 Oct 23.

6.

A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway.

Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z.

Cell Stem Cell. 2013 Sep 5;13(3):300-13. doi: 10.1016/j.stem.2013.06.005. Epub 2013 Jul 18.

7.

Recurrent R-spondin fusions in colon cancer.

Seshagiri S, Stawiski EW, Durinck S, Modrusan Z, Storm EE, Conboy CB, Chaudhuri S, Guan Y, Janakiraman V, Jaiswal BS, Guillory J, Ha C, Dijkgraaf GJ, Stinson J, Gnad F, Huntley MA, Degenhardt JD, Haverty PM, Bourgon R, Wang W, Koeppen H, Gentleman R, Starr TK, Zhang Z, Largaespada DA, Wu TD, de Sauvage FJ.

Nature. 2012 Aug 30;488(7413):660-4. doi: 10.1038/nature11282.

8.

The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression.

Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z.

Cancer Discov. 2012 Jul;2(7):638-51. doi: 10.1158/2159-8290.CD-12-0093. Epub 2012 May 10.

9.

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.

Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E388-97. doi: 10.1073/pnas.1120421109. Epub 2012 Jan 20.

10.

Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).

Giannetti AM, Wong H, Dijkgraaf GJ, Dueber EC, Ortwine DF, Bravo BJ, Gould SE, Plise EG, Lum BL, Malhi V, Graham RA.

J Med Chem. 2011 Apr 28;54(8):2592-601. doi: 10.1021/jm1008924. Epub 2011 Mar 25.

PMID:
21438527
11.

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.

Dijkgraaf GJ, Alicke B, Weinmann L, Januario T, West K, Modrusan Z, Burdick D, Goldsmith R, Robarge K, Sutherlin D, Scales SJ, Gould SE, Yauch RL, de Sauvage FJ.

Cancer Res. 2011 Jan 15;71(2):435-44. doi: 10.1158/0008-5472.CAN-10-2876. Epub 2010 Dec 1.

12.

Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.

Pozniak CD, Langseth AJ, Dijkgraaf GJ, Choe Y, Werb Z, Pleasure SJ.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21795-800. doi: 10.1073/pnas.1016485107. Epub 2010 Nov 22.

13.

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway.

Castanedo GM, Wang S, Robarge KD, Blackwood E, Burdick D, Chang C, Dijkgraaf GJ, Gould S, Gunzner J, Guichert O, Halladay J, Khojasteh C, Lee L, Marsters JC Jr, Murray L, Peterson D, Plise E, Salphati L, de Sauvage FJ, Wong S, Sutherlin DP.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6748-53. doi: 10.1016/j.bmcl.2010.08.134. Epub 2010 Sep 15.

PMID:
20875741
14.

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ.

Science. 2009 Oct 23;326(5952):572-4. doi: 10.1126/science.1179386. Epub 2009 Sep 2.

15.

Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer.

Welm BE, Dijkgraaf GJ, Bledau AS, Welm AL, Werb Z.

Cell Stem Cell. 2008 Jan 10;2(1):90-102. doi: 10.1016/j.stem.2007.10.002.

16.

A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.

Pagé N, Gérard-Vincent M, Ménard P, Beaulieu M, Azuma M, Dijkgraaf GJ, Li H, Marcoux J, Nguyen T, Dowse T, Sdicu AM, Bussey H.

Genetics. 2003 Mar;163(3):875-94.

17.
18.

Involvement of protein N-glycosyl chain glucosylation and processing in the biosynthesis of cell wall beta-1,6-glucan of Saccharomyces cerevisiae.

Shahinian S, Dijkgraaf GJ, Sdicu AM, Thomas DY, Jakob CA, Aebi M, Bussey H.

Genetics. 1998 Jun;149(2):843-56.

19.

The yeast CWH41 gene encodes glucosidase I.

Romero PA, Dijkgraaf GJ, Shahinian S, Herscovics A, Bussey H.

Glycobiology. 1997 Oct;7(7):997-1004.

PMID:
9363442
20.

The KNH1 gene of Saccharomyces cerevisiae is a functional homolog of KRE9.

Dijkgraaf GJ, Brown JL, Bussey H.

Yeast. 1996 Jun 15;12(7):683-92.

21.

CWH41 encodes a novel endoplasmic reticulum membrane N-glycoprotein involved in beta 1,6-glucan assembly.

Jiang B, Sheraton J, Ram AF, Dijkgraaf GJ, Klis FM, Bussey H.

J Bacteriol. 1996 Feb;178(4):1162-71.

22.

Covalent association of beta-1,3-glucan with beta-1,6-glucosylated mannoproteins in cell walls of Candida albicans.

Kapteyn JC, Montijn RC, Dijkgraaf GJ, Van den Ende H, Klis FM.

J Bacteriol. 1995 Jul;177(13):3788-92.

23.

Glucosylation of cell wall proteins in regenerating spheroplasts of Candida albicans.

Kapteyn JC, Dijkgraaf GJ, Montijn RC, Klis FM.

FEMS Microbiol Lett. 1995 May 15;128(3):271-7.

PMID:
7781974
24.

Identification of beta-1,6-glucosylated cell wall proteins in yeast and hyphal forms of Candida albicans.

Kapteyn JC, Montijn RC, Dijkgraaf GJ, Klis FM.

Eur J Cell Biol. 1994 Dec;65(2):402-7.

PMID:
7536675

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