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Deep learning-enabled system for rapid pneumothorax screening on chest CT.

Li X, Thrall JH, Digumarthy SR, Kalra MK, Pandharipande PV, Zhang B, Nitiwarangkul C, Singh R, Khera RD, Li Q.

Eur J Radiol. 2019 Sep 26;120:108692. doi: 10.1016/j.ejrad.2019.108692. [Epub ahead of print]


Response to the Combination of Osimertinib and Trametinib in a Patient With EGFR-Mutant NSCLC Harboring an Acquired BRAF Fusion.

Dagogo-Jack I, Piotrowska Z, Cobb R, Banwait M, Lennerz JK, Hata AN, Digumarthy SR, Sequist LV.

J Thorac Oncol. 2019 Oct;14(10):e226-e228. doi: 10.1016/j.jtho.2019.05.046. No abstract available.


Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer.

Digumarthy SR, Mendoza DP, Padole A, Chen T, Peterson PG, Piotrowska Z, Sequist LV.

Cancers (Basel). 2019 Sep 13;11(9). pii: E1360. doi: 10.3390/cancers11091360.


Viewing Imaging Studies: How Patient Location and Imaging Site Affect Referring Physicians.

Homayounieh F, Singh R, Chen T, Sugarman EJ, Schultz TJ, Digumarthy SR, Dreyer KJ, Kalra MK.

J Digit Imaging. 2019 Sep 12. doi: 10.1007/s10278-019-00279-z. [Epub ahead of print]


Comparison of image quality and radiation doses between rapid kV-switching and dual-source DECT techniques in the chest.

Singh R, Sharma A, McDermott S, Homayounieh F, Rastogi S, Flores EJ, Shepard JAO, Gilman MD, Digumarthy SR.

Eur J Radiol. 2019 Oct;119:108639. doi: 10.1016/j.ejrad.2019.08.008. Epub 2019 Aug 13.


Outcomes to first-line pembrolizumab in patients with non-small cell lung cancer and very high PD-L1 expression.

Aguilar EJ, Ricciuti B, Gainor JF, Kehl KL, Kravets S, Dahlberg S, Nishino M, Sholl LM, Adeni A, Subegdjo S, Khosrowjerdi S, Peterson RI, Digumarthy S, Liu C, Sauter J, Rizvi H, Arbour KC, Carter BW, Heymach JV, Altan M, Hellmann MD, Awad MM.

Ann Oncol. 2019 Aug 21. pii: mdz288. doi: 10.1093/annonc/mdz288. [Epub ahead of print]


Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer.

Farago AF, Yeap BY, Stanzione M, Hung YP, Heist RS, Marcoux JP, Zhong J, Rangachari D, Barbie DA, Phat S, Myers DT, Morris R, Kem M, Dubash TD, Kennedy EA, Digumarthy SR, Sequist LV, Hata AN, Maheswaran S, Haber DA, Lawrence MS, Shaw AT, Mino-Kenudson M, Dyson NJ, Drapkin BJ.

Cancer Discov. 2019 Oct;9(10):1372-1387. doi: 10.1158/2159-8290.CD-19-0582. Epub 2019 Aug 15.


Deploying Clinical Process Improvement Strategies to Reduce Motion Artifacts and Expiratory Phase Scanning in Chest CT.

Doda Khera R, Singh R, Homayounieh F, Stone E, Redel T, Savage CA, Stockton K, Shepard JO, Kalra MK, Digumarthy SR.

Sci Rep. 2019 Aug 14;9(1):11858. doi: 10.1038/s41598-019-48423-7.


Radiation Dose for Multiregion CT Protocols: Challenges and Limitations.

Singh R, Szczykutowicz TP, Homayounieh F, Vining R, Kanal K, Digumarthy SR, Kalra MK.

AJR Am J Roentgenol. 2019 Nov;213(5):1100-1106. doi: 10.2214/AJR.19.21201. Epub 2019 Jul 24.


Predicting malignant potential of subsolid nodules: can radiomics preempt longitudinal follow up CT?

Digumarthy SR, Padole AM, Rastogi S, Price M, Mooradian MJ, Sequist LV, Kalra MK.

Cancer Imaging. 2019 Jun 10;19(1):36. doi: 10.1186/s40644-019-0223-7.


Computed Tomography Imaging Characteristics of Non-Small-Cell Lung Cancer With Anaplastic Lymphoma Kinase Rearrangements: A Systematic Review and Meta-Analysis.

Mendoza DP, Stowell J, Muzikansky A, Shepard JO, Shaw AT, Digumarthy SR.

Clin Lung Cancer. 2019 Sep;20(5):339-349. doi: 10.1016/j.cllc.2019.05.006. Epub 2019 May 11.


Postoperative Imaging After Lobectomy: Predicting the Displacement and Change in Orientation of Nonresected Lung Nodules.

Digumarthy SR, Shukla PK, Mendoza DP, Guo L, Chretien YR, Shepard JO, Kalra MK.

J Comput Assist Tomogr. 2019 Jul/Aug;43(4):592-598. doi: 10.1097/RCT.0000000000000871.


Type I Collagen-targeted Positron Emission Tomography Imaging in Idiopathic Pulmonary Fibrosis: First-in-Human Studies.

Montesi SB, Izquierdo-Garcia D, Désogère P, Abston E, Liang LL, Digumarthy S, Seethamraju R, Lanuti M, Caravan P, Catana C.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):258-261. doi: 10.1164/rccm.201903-0503LE. No abstract available.


Safety and Success of Repeat Lung Needle Biopsies in Patients with Epidermal Growth Factor Receptor-Mutant Lung Cancer.

Fintelmann FJ, Troschel FM, Kuklinski MW, McDermott S, Petranovic M, Digumarthy SR, Sharma A, Troschel AS, Price MC, Hariri LP, Gilman MD, Shepard JO, Sequist LV, Piotrowska Z.

Oncologist. 2019 May 31. pii: theoncologist.2019-0158. doi: 10.1634/theoncologist.2019-0158. [Epub ahead of print]


Determining malignancy in CT guided fine needle aspirate biopsy of subsolid lung nodules: Is core biopsy necessary?

Kiranantawat N, McDermott S, Petranovic M, Mino-Kenudson M, Muniappan A, Sharma A, Shepard JO, Digumarthy SR.

Eur J Radiol Open. 2019 May 4;6:175-181. doi: 10.1016/j.ejro.2019.04.006. eCollection 2019.


Quality of Documentation of Contrast Agent Allergies in Electronic Health Records.

Deng F, Li MD, Wong A, Kowalski LT, Lai KH, Digumarthy SR, Zhou L.

J Am Coll Radiol. 2019 Aug;16(8):1027-1035. doi: 10.1016/j.jacr.2019.01.027. Epub 2019 Mar 4.


Imaging characteristics of BRAF-mutant non-small cell lung cancer by functional class.

Mendoza DP, Dagogo-Jack I, Chen T, Padole A, Shepard JO, Shaw AT, Digumarthy SR.

Lung Cancer. 2019 Mar;129:80-84. doi: 10.1016/j.lungcan.2019.01.007. Epub 2019 Jan 16.


Clinical role, safety and diagnostic accuracy of percutaneous transthoracic needle biopsy in the evaluation of pulmonary consolidation.

Kiranantawat N, McDermott S, Fintelmann FJ, Montesi SB, Price MC, Digumarthy SR, Sharma A.

Respir Res. 2019 Jan 31;20(1):23. doi: 10.1186/s12931-019-0982-5.


Can CT radiomic analysis in NSCLC predict histology and EGFR mutation status?

Digumarthy SR, Padole AM, Gullo RL, Sequist LV, Kalra MK.

Medicine (Baltimore). 2019 Jan;98(1):e13963. doi: 10.1097/MD.0000000000013963.


Radiation dose reduction in chest dual-energy computed tomography: effect on image quality and diagnostic information.

Canellas R, Digumarthy S, Tabari A, Otrakji A, McDermott S, Flores EJ, Kalra M.

Radiol Bras. 2018 Nov-Dec;51(6):377-384. doi: 10.1590/0100-3984.2017.0136.


Efficacy of Alectinib in Patients with ALK-Positive NSCLC and Symptomatic or Large CNS Metastases.

Lin JJ, Jiang GY, Joshipura N, Ackil J, Digumarthy SR, Rincon SP, Yeap BY, Gainor JF, Shaw AT.

J Thorac Oncol. 2019 Apr;14(4):683-690. doi: 10.1016/j.jtho.2018.12.002. Epub 2018 Dec 7.


Heterogeneous Pulmonary Perfusion on Dual-Energy Computed Tomography: Faulty Postprocessing or New Artifact?

Borse R, Homayounieh F, Singh R, Digumarthy SR.

J Comput Assist Tomogr. 2018 Nov/Dec;42(6):885-886. doi: 10.1097/RCT.0000000000000797.


Clinical Utility of Rapid EGFR Genotyping in Advanced Lung Cancer.

Dagogo-Jack I, Azzolli CG, Fintelmann F, Mino-Kenudson M, Farago AF, Gainor JF, Jiang G, Piotrowska Z, Heist RS, Lennes IT, Temel JS, Mooradian MJ, Lin JJ, Digumarthy SR, Batten JM, Robinson H, Nose V, Rivera M, Nardi V, Dias-Santagata D, Le LP, Sequist LV, Pitman M, Shepard JO, Shaw AT, Iafrate AJ, Lennerz JK.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.17.00299. Epub 2018 Jul 24.


Deep learning in chest radiography: Detection of findings and presence of change.

Singh R, Kalra MK, Nitiwarangkul C, Patti JA, Homayounieh F, Padole A, Rao P, Putha P, Muse VV, Sharma A, Digumarthy SR.

PLoS One. 2018 Oct 4;13(10):e0204155. doi: 10.1371/journal.pone.0204155. eCollection 2018.


Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion.

Piotrowska Z, Isozaki H, Lennerz JK, Gainor JF, Lennes IT, Zhu VW, Marcoux N, Banwait MK, Digumarthy SR, Su W, Yoda S, Riley AK, Nangia V, Lin JJ, Nagy RJ, Lanman RB, Dias-Santagata D, Mino-Kenudson M, Iafrate AJ, Heist RS, Shaw AT, Evans EK, Clifford C, Ou SI, Wolf B, Hata AN, Sequist LV.

Cancer Discov. 2018 Dec;8(12):1529-1539. doi: 10.1158/2159-8290.CD-18-1022. Epub 2018 Sep 26.


Process improvement for reducing side discrepancies in radiology reports.

Digumarthy SR, Vining R, Tabari A, Nandimandalam S, Otrakji A, Shepard JO, Kalra MK.

Acta Radiol Open. 2018 Aug 20;7(7-8):2058460118794727. doi: 10.1177/2058460118794727. eCollection 2018 Jul.


Heterogeneity and Coexistence of T790M and T790 Wild-Type Resistant Subclones Drive Mixed Response to Third-Generation Epidermal Growth Factor Receptor Inhibitors in Lung Cancer.

Piotrowska Z, Hazar-Rethinam M, Rizzo C, Nadres B, Van Seventer EE, Shahzade HA, Lennes IT, Iafrate AJ, Dias-Santagata D, Leshchiner I, Jessop NA, Hu H, Digumarthy SR, Nagy RJ, Lanman RB, Moody S, Niederst MJ, Engelman JA, Hata AN, Corcoran RB, Sequist LV.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.17.00263. Epub 2018 Jul 16.


CT texture analysis of histologically proven benign and malignant lung lesions.

Digumarthy SR, Padole AM, Lo Gullo R, Singh R, Shepard JO, Kalra MK.

Medicine (Baltimore). 2018 Jun;97(26):e11172. doi: 10.1097/MD.0000000000011172.


Brigatinib in Patients With Alectinib-Refractory ALK-Positive NSCLC.

Lin JJ, Zhu VW, Schoenfeld AJ, Yeap BY, Saxena A, Ferris LA, Dagogo-Jack I, Farago AF, Taber A, Traynor A, Menon S, Gainor JF, Lennerz JK, Plodkowski AJ, Digumarthy SR, Ou SI, Shaw AT, Riely GJ.

J Thorac Oncol. 2018 Oct;13(10):1530-1538. doi: 10.1016/j.jtho.2018.06.005. Epub 2018 Jun 20.


Multifactorial Analysis of Mortality in Screening Detected Lung Cancer.

Digumarthy SR, De Man R, Canellas R, Otrakji A, Wang G, Kalra MK.

J Oncol. 2018 May 16;2018:1296246. doi: 10.1155/2018/1296246. eCollection 2018.


Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis.

Montesi SB, Rao R, Liang LL, Goulart HE, Sharma A, Digumarthy SR, Shea BS, Seethamraju RT, Caravan P, Tager AM.

Eur Respir J. 2018 May 17;51(5). pii: 1800171. doi: 10.1183/13993003.00171-2018. Print 2018 May. No abstract available.


Tracking the Evolution of Resistance to ALK Tyrosine Kinase Inhibitors through Longitudinal Analysis of Circulating Tumor DNA.

Dagogo-Jack I, Brannon AR, Ferris LA, Campbell CD, Lin JJ, Schultz KR, Ackil J, Stevens S, Dardaei L, Yoda S, Hubbeling H, Digumarthy SR, Riester M, Hata AN, Sequist LV, Lennes IT, Iafrate AJ, Heist RS, Azzoli CG, Farago AF, Engelman JA, Lennerz JK, Benes CH, Leary RJ, Shaw AT, Gainor JF.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.17.00160. Epub 2018 Jan 23.


Submillisievert chest dual energy computed tomography: a pilot study.

Canellas R, Ackman JB, Digumarthy SR, Price M, Otrakji A, McDermott S, Sharma A, Kalra MK.

Br J Radiol. 2018 Feb;91(1082):20170735. doi: 10.1259/bjr.20170735. Epub 2017 Dec 5.


Should Dual-Energy Computed Tomography Pulmonary Angiography Replace Single-Energy Computed Tomography Pulmonary Angiography in Pregnant and Postpartum Patients?

McDermott S, Otrakji A, Flores EJ, Kalra MK, Shepard JO, Digumarthy SR.

J Comput Assist Tomogr. 2018 Jan/Feb;42(1):25-32. doi: 10.1097/RCT.0000000000000655.


The pathology of pulmonary bacterial infection.

Kradin RL, Digumarthy S.

Semin Diagn Pathol. 2017 Nov;34(6):498-509. doi: 10.1053/j.semdp.2017.06.001. Epub 2017 Jun 7. Review. No abstract available.


Circulating Tumor DNA Identifies EGFR Coamplification as a Mechanism of Resistance to Crizotinib in a Patient with Advanced MET-Amplified Lung Adenocarcinoma.

Dagogo-Jack I, Fabrizio D, Lennerz J, Schrock AB, Young L, Mino-Kenudson M, Digumarthy SR, Heist RS, Ali SM, Miller VA, Shaw AT.

J Thorac Oncol. 2017 Oct;12(10):e155-e157. doi: 10.1016/j.jtho.2017.04.023. Epub 2017 May 9. No abstract available.


Lung Cancers Associated With Cystic Airspaces: Natural History, Pathologic Correlation, and Mutational Analysis.

Fintelmann FJ, Brinkmann JK, Jeck WR, Troschel FM, Digumarthy SR, Mino-Kenudson M, Shepard JO.

J Thorac Imaging. 2017 May;32(3):176-188. doi: 10.1097/RTI.0000000000000265.


Recent Advances in Computed Tomographic Technology: Cardiopulmonary Imaging Applications.

Tabari A, Lo Gullo R, Murugan V, Otrakji A, Digumarthy S, Kalra M.

J Thorac Imaging. 2017 Mar;32(2):89-100. doi: 10.1097/RTI.0000000000000258. Review.


Assessment of chest CT at CTDIvol less than 1 mGy with iterative reconstruction techniques.

Padole A, Digumarthy S, Flores E, Madan R, Mishra S, Sharma A, Kalra MK.

Br J Radiol. 2017 Mar;90(1071):20160625. doi: 10.1259/bjr.20160625. Epub 2017 Jan 5.


Clinical Activity of Alectinib in Advanced RET-Rearranged Non-Small Cell Lung Cancer.

Lin JJ, Kennedy E, Sequist LV, Brastianos PK, Goodwin KE, Stevens S, Wanat AC, Stober LL, Digumarthy SR, Engelman JA, Shaw AT, Gainor JF.

J Thorac Oncol. 2016 Nov;11(11):2027-2032. doi: 10.1016/j.jtho.2016.08.126. Epub 2016 Aug 17.


Primary Paratracheal Leiomyoma: Increased Preoperative Diagnostic Specificity With Magnetic Resonance Imaging.

Levesque MH, Aisagbonhi O, Digumarthy S, Wright CD, Ackman JB.

Ann Thorac Surg. 2016 Aug;102(2):e151-4. doi: 10.1016/j.athoracsur.2016.01.015.


Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer.

Gainor JF, Dardaei L, Yoda S, Friboulet L, Leshchiner I, Katayama R, Dagogo-Jack I, Gadgeel S, Schultz K, Singh M, Chin E, Parks M, Lee D, DiCecca RH, Lockerman E, Huynh T, Logan J, Ritterhouse LL, Le LP, Muniappan A, Digumarthy S, Channick C, Keyes C, Getz G, Dias-Santagata D, Heist RS, Lennerz J, Sequist LV, Benes CH, Iafrate AJ, Mino-Kenudson M, Engelman JA, Shaw AT.

Cancer Discov. 2016 Oct;6(10):1118-1133. Epub 2016 Jul 18.


EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer: A Retrospective Analysis.

Gainor JF, Shaw AT, Sequist LV, Fu X, Azzoli CG, Piotrowska Z, Huynh TG, Zhao L, Fulton L, Schultz KR, Howe E, Farago AF, Sullivan RJ, Stone JR, Digumarthy S, Moran T, Hata AN, Yagi Y, Yeap BY, Engelman JA, Mino-Kenudson M.

Clin Cancer Res. 2016 Sep 15;22(18):4585-93. doi: 10.1158/1078-0432.CCR-15-3101. Epub 2016 May 25.


Retained wire with intra-aortic migration presenting with hemoptysis: case studies of the Massachusetts General Hospital.

Nance JW, Hedgire SS, Digumarthy SR, Tolis G Jr, Melnitchouk S, Ghoshhajra BB.

Coron Artery Dis. 2016 Sep;27(6):521-2. doi: 10.1097/MCA.0000000000000384. No abstract available.


Impact of Nonvascular Thoracic MR Imaging on the Clinical Decision Making of Thoracic Surgeons: A 2-year Prospective Study.

Ackman JB, Gaissert HA, Lanuti M, Digumarthy SR, Shepard JA, Halpern EF, Wright CD.

Radiology. 2016 Aug;280(2):464-74. doi: 10.1148/radiol.2016152004. Epub 2016 Feb 24.


Percutaneous CT guided lung biopsy in patients with pulmonary hypertension: Assessment of complications.

Digumarthy SR, Kovacina B, Otrakji A, Lanuti M, Shepard JA, Sharma A.

Eur J Radiol. 2016 Feb;85(2):466-71. doi: 10.1016/j.ejrad.2015.12.007. Epub 2015 Dec 17.


Volumetric Tumor Response and Progression in EGFR-mutant NSCLC Patients Treated with Erlotinib or Gefitinib.

Nishino M, Dahlberg SE, Fulton LE, Digumarthy SR, Hatabu H, Johnson BE, Sequist LV.

Acad Radiol. 2016 Mar;23(3):329-36. doi: 10.1016/j.acra.2015.11.005. Epub 2016 Jan 8.


Dual-Energy CT: Spectrum of Thoracic Abnormalities.

Otrakji A, Digumarthy SR, Lo Gullo R, Flores EJ, Shepard JA, Kalra MK.

Radiographics. 2016 Jan-Feb;36(1):38-52. doi: 10.1148/rg.2016150081. Review.


Osimertinib Responses After Disease Progression in Patients Who Had Been Receiving Rociletinib.

Sequist LV, Piotrowska Z, Niederst MJ, Heist RS, Digumarthy S, Shaw AT, Engelman JA.

JAMA Oncol. 2016 Apr;2(4):541-3. doi: 10.1001/jamaoncol.2015.5009. No abstract available.


Quantification of interstitial fluid on whole body CT: comparison with whole body autopsy.

Lo Gullo R, Mishra S, Lira DA, Padole A, Otrakji A, Khawaja RD, Pourjabbar S, Singh S, Shepard JA, Digumarthy SR, Kalra MK, Stone JR.

Forensic Sci Med Pathol. 2015 Dec;11(4):488-96. doi: 10.1007/s12024-015-9728-y. Epub 2015 Nov 5.


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