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Number and molecular brightness analysis reveals Htt25Q protein aggregation upon the uptake of Htt97Q aggregates.

Sameni S, Zhang R, Digman MA.

Biochem Biophys Res Commun. 2020 Jan 29;522(1):133-137. doi: 10.1016/j.bbrc.2019.10.041. Epub 2019 Nov 19.


Label-free assessment of pre-implantation embryo quality by the Fluorescence Lifetime Imaging Microscopy (FLIM)-phasor approach.

Ma N, Mochel NR, Pham PD, Yoo TY, Cho KWY, Digman MA.

Sci Rep. 2019 Sep 13;9(1):13206. doi: 10.1038/s41598-019-48107-2.


The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex.

Trivedi P, Palomba F, Niedzialkowska E, Digman MA, Gratton E, Stukenberg PT.

Nat Cell Biol. 2019 Sep;21(9):1127-1137. doi: 10.1038/s41556-019-0376-4. Epub 2019 Sep 3.


NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival.

Murata MM, Kong X, Moncada E, Chen Y, Imamura H, Wang P, Berns MW, Yokomori K, Digman MA.

Mol Biol Cell. 2019 Sep 15;30(20):2584-2597. doi: 10.1091/mbc.E18-10-0650. Epub 2019 Aug 7.


Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer's Disease Neurons by Imposed External Cys/CySS Redox Shifts.

Dong Y, Sameni S, Digman MA, Brewer GJ.

Sci Rep. 2019 Aug 2;9(1):11274. doi: 10.1038/s41598-019-47582-x.


Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.

Planes N, Digman MA, Vanderheyden PPML, Gratton E, Caballero-George C.

Biochim Biophys Acta Gen Subj. 2019 May;1863(5):917-924. doi: 10.1016/j.bbagen.2019.03.004. Epub 2019 Mar 6.


Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy.

Dong Y, Digman MA, Brewer GJ.

Geroscience. 2019 Feb;41(1):51-67. doi: 10.1007/s11357-019-00052-8. Epub 2019 Feb 6.


Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy.

Ma N, Kamalakshakurup G, Aghaamoo M, Lee AP, Digman MA.

Cytometry A. 2019 Jan;95(1):93-100. doi: 10.1002/cyto.a.23673. Epub 2018 Dec 11.


Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility.

Mah EJ, Lefebvre AEYT, McGahey GE, Yee AF, Digman MA.

Sci Rep. 2018 Nov 20;8(1):17094. doi: 10.1038/s41598-018-35381-9.


Feasibility study on mouse live imaging after spinal cord injury and poly(lactide-co-glycolide) bridge implantation.

Anzalone A, Chacko JV, Nishi RA, Dumont C, Smith D, Shea LD, Digman MA, Cummings BJ, Anderson AJ.

J Biomed Opt. 2018 Jun;23(6):1-6. doi: 10.1117/1.JBO.23.6.065007.


Publisher Correction: Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis.

Sameni S, Malacrida L, Tan Z, Digman MA.

Sci Rep. 2018 Apr 11;8(1):6060. doi: 10.1038/s41598-018-24031-9.


PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.

Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL.

Cancer Discov. 2018 Jul;8(7):866-883. doi: 10.1158/2159-8290.CD-17-1215. Epub 2018 Mar 23.


Viral highway to nucleus exposed by image correlation analyses.

Mäntylä E, Chacko JV, Aho V, Parrish CR, Shahin V, Kann M, Digman MA, Gratton E, Vihinen-Ranta M.

Sci Rep. 2018 Jan 18;8(1):1152. doi: 10.1038/s41598-018-19582-w.


Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis.

Sameni S, Malacrida L, Tan Z, Digman MA.

Sci Rep. 2018 Jan 15;8(1):734. doi: 10.1038/s41598-018-19160-0. Erratum in: Sci Rep. 2018 Apr 11;8(1):6060.


Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells.

Kong L, Murata MM, Digman MA.

Biochem Biophys Res Commun. 2018 Jan 29;496(1):199-204. doi: 10.1016/j.bbrc.2018.01.026. Epub 2018 Jan 4.


Quantitative image mean squared displacement (iMSD) analysis of the dynamics of profilin 1 at the membrane of live cells.

Davey RJ, Digman MA, Gratton E, Moens PDJ.

Methods. 2018 May 1;140-141:119-125. doi: 10.1016/j.ymeth.2017.12.002. Epub 2017 Dec 11.


Tracking Functional Tumor Cell Subpopulations of Malignant Glioma by Phasor Fluorescence Lifetime Imaging Microscopy of NADH.

Trinh AL, Chen H, Chen Y, Hu Y, Li Z, Siegel ER, Linskey ME, Wang PH, Digman MA, Zhou YH.

Cancers (Basel). 2017 Dec 6;9(12). pii: E168. doi: 10.3390/cancers9120168.


An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles.

Digiacomo L, Cardarelli F, Pozzi D, Palchetti S, Digman MA, Gratton E, Capriotti AL, Mahmoudi M, Caracciolo G.

Nanoscale. 2017 Nov 16;9(44):17254-17262. doi: 10.1039/c7nr06437c.


Mechanoresponsive stem cells to target cancer metastases through biophysical cues.

Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W.

Sci Transl Med. 2017 Jul 26;9(400). pii: eaan2966. doi: 10.1126/scitranslmed.aan2966.


Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation.

Herrington KA, Trinh AL, Dang C, O'Shaughnessy E, Hahn KM, Gratton E, Digman MA, Sütterlin C.

Mol Biol Cell. 2017 Jul 15;28(15):2135-2145. doi: 10.1091/mbc.E16-09-0665. Epub 2017 May 24.


Elucidation of Exosome Migration across the Blood-Brain Barrier Model In Vitro.

Chen CC, Liu L, Ma F, Wong CW, Guo XE, Chacko JV, Farhoodi HP, Zhang SX, Zimak J, Ségaliny A, Riazifar M, Pham V, Digman MA, Pone EJ, Zhao W.

Cell Mol Bioeng. 2016 Dec;9(4):509-529. doi: 10.1007/s12195-016-0458-3. Epub 2016 Jul 7.


Self-assisted optothermal trapping of gold nanorods under two-photon excitation.

Chen H, Gratton E, Digman MA.

Methods Appl Fluoresc. 2016 Sep 6;4(3):035003. doi: 10.1088/2050-6120/4/3/035003.


Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography.

Liang EI, Mah EJ, Yee AF, Digman MA.

Integr Biol (Camb). 2017 Feb 20;9(2):145-155. doi: 10.1039/c6ib00193a.


The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease.

Sameni S, Syed A, Marsh JL, Digman MA.

Sci Rep. 2016 Oct 7;6:34755. doi: 10.1038/srep34755.


Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary.

Cinco R, Digman MA, Gratton E, Luderer U.

Biol Reprod. 2016 Dec;95(6):129. doi: 10.1095/biolreprod.116.142141. Epub 2016 Sep 28.


Highly Charged Particles Cause a Larger Current Blockage in Micropores Compared to Neutral Particles.

Qiu Y, Lin CY, Hinkle P, Plett TS, Yang C, Chacko JV, Digman MA, Yeh LH, Hsu JP, Siwy ZS.

ACS Nano. 2016 Sep 27;10(9):8413-22. doi: 10.1021/acsnano.6b03280. Epub 2016 Aug 22.


Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles.

Digiacomo L, Digman MA, Gratton E, Caracciolo G.

Acta Biomater. 2016 Sep 15;42:189-198. doi: 10.1016/j.actbio.2016.07.031. Epub 2016 Jul 20.


Measurements of absolute concentrations of NADH in cells using the phasor FLIM method.

Ma N, Digman MA, Malacrida L, Gratton E.

Biomed Opt Express. 2016 Jun 1;7(7):2441-52. doi: 10.1364/BOE.7.002441. eCollection 2016 Jul 1.


Digital quantification of miRNA directly in plasma using integrated comprehensive droplet digital detection.

Zhang K, Kang DK, Ali MM, Liu L, Labanieh L, Lu M, Riazifar H, Nguyen TN, Zell JA, Digman MA, Gratton E, Li J, Zhao W.

Lab Chip. 2015 Nov 7;15(21):4217-26. doi: 10.1039/c5lc00650c. Epub 2015 Sep 21.


Characterization of exogenous DNA mobility in live cells through fluctuation correlation spectroscopy.

Mieruszynski S, Digman MA, Gratton E, Jones MR.

Sci Rep. 2015 Sep 10;5:13848. doi: 10.1038/srep13848.


Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers.

Hendrix J, Baumgärtel V, Schrimpf W, Ivanchenko S, Digman MA, Gratton E, Kräusslich HG, Müller B, Lamb DC.

J Cell Biol. 2015 Aug 17;210(4):629-46. doi: 10.1083/jcb.201504006.


Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus.

Adu-Gyamfi E, Johnson KA, Fraser ME, Scott JL, Soni SP, Jones KR, Digman MA, Gratton E, Tessier CR, Stahelin RV.

J Virol. 2015 Sep;89(18):9440-53. doi: 10.1128/JVI.01087-15. Epub 2015 Jul 1.


Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin.

Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, Ringman JM, Parker I, Glabe C, Thompson LM, Chiu W, Potkin SG.

Mol Psychiatry. 2015 Nov;20(11):1286-93. doi: 10.1038/mp.2015.81. Epub 2015 Jun 23.


Live Cell Characterization of DNA Aggregation Delivered through Lipofection.

Mieruszynski S, Briggs C, Digman MA, Gratton E, Jones MR.

Sci Rep. 2015 May 27;5:10528. doi: 10.1038/srep10528.


Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium.

Olivera-Couto A, Salzman V, Mailhos M, Digman MA, Gratton E, Aguilar PS.

Biophys J. 2015 Apr 7;108(7):1633-1644. doi: 10.1016/j.bpj.2015.02.011.


Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis.

Moens PDJ, Digman MA, Gratton E.

Biophys J. 2015 Mar 24;108(6):1448-1458. doi: 10.1016/j.bpj.2015.02.003.


Spectral properties and dynamics of gold nanorods revealed by EMCCD-based spectral phasor method.

Chen H, Gratton E, Digman MA.

Microsc Res Tech. 2015 Apr;78(4):283-93. doi: 10.1002/jemt.22473. Epub 2015 Feb 13.


Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection.

Kang DK, Ali MM, Zhang K, Huang SS, Peterson E, Digman MA, Gratton E, Zhao W.

Nat Commun. 2014 Nov 13;5:5427. doi: 10.1038/ncomms6427.


Enhanced emission of fluorophores on shrink-induced wrinkled composite structures.

Sharma H, Digman MA, Felsinger N, Gratton E, Khine M.

Opt Mater Express. 2014;4(4):753-763.


A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress.

Adu-Gyamfi E, Soni SP, Jee CS, Digman MA, Gratton E, Stahelin RV.

Viruses. 2014 Oct 17;6(10):3837-54. doi: 10.3390/v6103837.


Nanoimaging of focal adhesion dynamics in 3D.

Chiu CL, Aguilar JS, Tsai CY, Wu G, Gratton E, Digman MA.

PLoS One. 2014 Jun 24;9(6):e99896. doi: 10.1371/journal.pone.0099896. eCollection 2014.


Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer.

Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML.

EMBO J. 2014 Jul 1;33(13):1454-73. doi: 10.15252/embj.201488598. Epub 2014 May 13.


Detecting Pyronin Y labeled RNA transcripts in live cell microenvironments by phasor-FLIM analysis.

Andrews LM, Jones MR, Digman MA, Gratton E.

Methods Appl Fluoresc. 2013 Mar 1;1(1):015001.


Quantitative measurement of intracellular transport of nanocarriers by spatio-temporal image correlation spectroscopy.

Coppola S, Pozzi D, De Sanctis SC, Digman MA, Gratton E, Caracciolo G.

Methods Appl Fluoresc. 2013;1(1). doi: 10.1088/2050-6120/1/1/015005.


Organic nitrogen uptake by arbuscular mycorrhizal fungi in a boreal forest.

Whiteside MD, Digman MA, Gratton E, Treseder KK.

Soil Biol Biochem. 2012 Dec;55. doi: 10.1016/j.soilbio.2012.06.001.


Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: interplay between nanostructure and composition.

Pozzi D, Marchini C, Cardarelli F, Salomone F, Coppola S, Montani M, Zabaleta ME, Digman MA, Gratton E, Colapicchioni V, Caracciolo G.

Biochim Biophys Acta. 2014 Mar;1838(3):957-67. doi: 10.1016/j.bbamem.2013.11.014. Epub 2013 Dec 1.


Measuring actin flow in 3D cell protrusions.

Chiu CL, Digman MA, Gratton E.

Biophys J. 2013 Oct 15;105(8):1746-55. doi: 10.1016/j.bpj.2013.07.057.


A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells.

James NG, Digman MA, Ross JA, Barylko B, Wang L, Li J, Chen Y, Mueller JD, Gratton E, Albanesi JP, Jameson DM.

Biochim Biophys Acta. 2014 Jan;1840(1):315-21. doi: 10.1016/j.bbagen.2013.09.001. Epub 2013 Sep 7.


Cell matrix remodeling ability shown by image spatial correlation.

Chiu CL, Digman MA, Gratton E.

J Biophys. 2013;2013:532030. doi: 10.1155/2013/532030. Epub 2013 Jul 14.

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