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Items: 24

1.

Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases.

Gril B, Paranjape AN, Woditschka S, Hua E, Dolan EL, Hanson J, Wu X, Kloc W, Izycka-Swieszewska E, Duchnowska R, Pęksa R, Biernat W, Jassem J, Nayyar N, Brastianos PK, Hall OM, Peer CJ, Figg WD, Pauly GT, Robinson C, Difilippantonio S, Bialecki E, Metellus P, Schneider JP, Steeg PS.

Nat Commun. 2018 Jul 13;9(1):2705. doi: 10.1038/s41467-018-05030-w.

2.

MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma.

Yohe ME, Gryder BE, Shern JF, Song YK, Chou HC, Sindiri S, Mendoza A, Patidar R, Zhang X, Guha R, Butcher D, Isanogle KA, Robinson CM, Luo X, Chen JQ, Walton A, Awasthi P, Edmondson EF, Difilippantonio S, Wei JS, Zhao K, Ferrer M, Thomas CJ, Khan J.

Sci Transl Med. 2018 Jul 4;10(448). pii: eaan4470. doi: 10.1126/scitranslmed.aan4470.

PMID:
29973406
3.

Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target.

Brooks D, Zimmer A, Wakefield L, Lyle LT, Difilippantonio S, Tucci FC, Illiano S, Annunziata CM, Steeg PS.

Oncotarget. 2018 May 4;9(34):23462-23481. doi: 10.18632/oncotarget.25231. eCollection 2018 May 4.

4.

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors.

Marzi L, Agama K, Murai J, Difilippantonio S, James A, Peer CJ, Figg WD, Beck D, Elsayed MSA, Cushman M, Pommier Y.

Mol Cancer Ther. 2018 Aug;17(8):1694-1704. doi: 10.1158/1535-7163.MCT-18-0028. Epub 2018 May 10.

PMID:
29748210
5.

Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.

Szabova L, Bupp S, Kamal M, Householder DB, Hernandez L, Schlomer JJ, Baran ML, Yi M, Stephens RM, Annunziata CM, Martin PL, Van Dyke TA, Weaver Ohler Z, Difilippantonio S.

PLoS One. 2014 Apr 18;9(4):e95649. doi: 10.1371/journal.pone.0095649. eCollection 2014.

6.

Evolutionary etiology of high-grade astrocytomas.

Song Y, Zhang Q, Kutlu B, Difilippantonio S, Bash R, Gilbert D, Yin C, O'Sullivan TN, Yang C, Kozlov S, Bullitt E, McCarthy KD, Kafri T, Louis DN, Miller CR, Hood L, Van Dyke T.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17933-8. doi: 10.1073/pnas.1317026110. Epub 2013 Oct 10.

7.

Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response.

Weaver Z, Difilippantonio S, Carretero J, Martin PL, El Meskini R, Iacovelli AJ, Gumprecht M, Kulaga A, Guerin T, Schlomer J, Baran M, Kozlov S, McCann T, Mena S, Al-Shahrour F, Alexander D, Wong KK, Van Dyke T.

Cancer Res. 2012 Nov 15;72(22):5921-33. doi: 10.1158/0008-5472.CAN-12-0736. Epub 2012 Sep 11.

8.

Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.

Szabova L, Yin C, Bupp S, Guerin TM, Schlomer JJ, Householder DB, Baran ML, Yi M, Song Y, Sun W, McDunn JE, Martin PL, Van Dyke T, Difilippantonio S.

Cancer Res. 2012 Aug 15;72(16):4141-53. doi: 10.1158/0008-5472.CAN-11-3834. Epub 2012 May 22.

9.

Mechanisms promoting translocations in editing and switching peripheral B cells.

Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.

Nature. 2009 Jul 9;460(7252):231-6. doi: 10.1038/nature08159.

10.

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.

Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M.

Mol Cell. 2009 May 15;34(3):285-97. doi: 10.1016/j.molcel.2009.04.025.

11.

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.

Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC.

Cell. 2008 Dec 12;135(6):1028-38. doi: 10.1016/j.cell.2008.09.062.

12.

53BP1 facilitates long-range DNA end-joining during V(D)J recombination.

Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A.

Nature. 2008 Nov 27;456(7221):529-33. doi: 10.1038/nature07476. Epub 2008 Oct 19.

13.

The NBS1-ATM connection revisited.

Difilippantonio S, Nussenzweig A.

Cell Cycle. 2007 Oct 1;6(19):2366-70. Epub 2007 Jul 18. Review.

PMID:
17881893
14.

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A.

Cell. 2007 Jul 13;130(1):63-75. Epub 2007 Jun 28.

15.

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis.

Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A.

J Exp Med. 2007 May 14;204(5):1003-11. Epub 2007 May 3.

16.

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.

Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A.

Nature. 2006 Sep 14;443(7108):222-5. Epub 2006 Aug 13.

PMID:
16906133
17.

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC.

Nature. 2006 Mar 2;440(7080):105-9. Epub 2006 Jan 8.

18.

53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice.

Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J.

Mol Cell Biol. 2005 Nov;25(22):10079-86.

19.

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A.

Nat Cell Biol. 2005 Jul;7(7):675-85. Epub 2005 Jun 19.

PMID:
15965469
20.

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

Reina-San-Martin B, Nussenzweig MC, Nussenzweig A, Difilippantonio S.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1590-5. Epub 2005 Jan 24.

21.

AID is required for c-myc/IgH chromosome translocations in vivo.

Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC.

Cell. 2004 Aug 20;118(4):431-8.

22.

Gene expression profiles in human non-small and small-cell lung cancers.

Difilippantonio S, Chen Y, Pietas A, Schlüns K, Pacyna-Gengelbach M, Deutschmann N, Padilla-Nash HM, Ried T, Petersen I.

Eur J Cancer. 2003 Sep;39(13):1936-47.

PMID:
12932674
23.

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.

Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.

Cell. 2003 Aug 8;114(3):371-383.

24.

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation.

Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC.

J Exp Med. 2003 Jun 16;197(12):1767-78.

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