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Items: 29


Correction to The Multiple Biological Targets of Hops and Bioactive Compounds.

Bolton JL, Dunlap TL, Hajirahimkhan A, Mbachu O, Chen SN, Chadwick L, Nikolic D, van Breemen RB, Pauli GF, Dietz BM.

Chem Res Toxicol. 2019 Aug 19;32(8):1732. doi: 10.1021/acs.chemrestox.9b00300. Epub 2019 Aug 8. No abstract available.


The Multiple Biological Targets of Hops and Bioactive Compounds.

Bolton JL, Dunlap TL, Hajirahimkhan A, Mbachu O, Chen SN, Chadwick L, Nikolic D, van Breemen RB, Pauli GF, Dietz BM.

Chem Res Toxicol. 2019 Feb 18;32(2):222-233. doi: 10.1021/acs.chemrestox.8b00345. Epub 2019 Jan 22. Review. Erratum in: Chem Res Toxicol. 2019 Aug 19;32(8):1732.


Evidence for Chemopreventive and Resilience Activity of Licorice: Glycyrrhiza Glabra and G. Inflata Extracts Modulate Estrogen Metabolism in ACI Rats.

Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantvit DD, Crosby J, Howell CE, Dong H, Chen SN, Pauli GF, van Breemen RB, Dietz BM, Bolton JL.

Cancer Prev Res (Phila). 2018 Dec;11(12):819-830. doi: 10.1158/1940-6207.CAPR-18-0178. Epub 2018 Oct 4.


Formation and biological targets of botanical o-quinones.

Bolton JL, Dunlap TL, Dietz BM.

Food Chem Toxicol. 2018 Oct;120:700-707. doi: 10.1016/j.fct.2018.07.050. Epub 2018 Jul 29. Review.


Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.

Hajirahimkhan A, Mbachu O, Simmler C, Ellis SG, Dong H, Nikolic D, Lankin DC, van Breemen RB, Chen SN, Pauli GF, Dietz BM, Bolton JL.

J Nat Prod. 2018 Apr 27;81(4):966-975. doi: 10.1021/acs.jnatprod.7b01070. Epub 2018 Apr 11.


Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.

Dunlap TL, Howell CE, Mukand N, Chen SN, Pauli GF, Dietz BM, Bolton JL.

Chem Res Toxicol. 2017 Nov 20;30(11):2084-2092. doi: 10.1021/acs.chemrestox.7b00237. Epub 2017 Oct 19.


Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats.

Keiler AM, Macejova D, Dietz BM, Bolton JL, Pauli GF, Chen SN, van Breemen RB, Nikolic D, Goerl F, Muders MH, Zierau O, Vollmer G.

J Steroid Biochem Mol Biol. 2017 Nov;174:234-241. doi: 10.1016/j.jsbmb.2017.09.020. Epub 2017 Sep 28.


A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus.

Keiler AM, Helle J, Bader MI, Ehrhardt T, Nestler K, Kretzschmar G, Bernhardt R, Vollmer G, Nikolić D, Bolton JL, Pauli GF, Chen SN, Dietz BM, van Breemen RB, Zierau O.

Phytomedicine. 2017 Oct 15;34:50-58. doi: 10.1016/j.phymed.2017.08.001. Epub 2017 Aug 2.


DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health.

Dietz BM, Chen SN, Alvarenga RFR, Dong H, Nikolić D, Biendl M, van Breemen RB, Bolton JL, Pauli GF.

J Nat Prod. 2017 Aug 25;80(8):2284-2294. doi: 10.1021/acs.jnatprod.7b00284. Epub 2017 Aug 16.


Botanicals and Their Bioactive Phytochemicals for Women's Health.

Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL.

Pharmacol Rev. 2016 Oct;68(4):1026-1073. Review.


Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation.

Wang S, Dunlap TL, Howell CE, Mbachu OC, Rue EA, Phansalkar R, Chen SN, Pauli GF, Dietz BM, Bolton JL.

Chem Res Toxicol. 2016 Jul 18;29(7):1142-50. doi: 10.1021/acs.chemrestox.6b00112. Epub 2016 Jun 22.


Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.

Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolić D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL.

Chem Res Toxicol. 2015 Nov 16;28(11):2130-41. doi: 10.1021/acs.chemrestox.5b00310. Epub 2015 Nov 5.


Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.

Dunlap TL, Wang S, Simmler C, Chen SN, Pauli GF, Dietz BM, Bolton JL.

Chem Res Toxicol. 2015 Aug 17;28(8):1584-94. doi: 10.1021/acs.chemrestox.5b00157. Epub 2015 Jul 16.


Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.

van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Qiu X, Alvarenga RF, Chen SN, Dietz BM, Bolton JL, Pauli GF, Krause E, Viana M, Nikolic D.

Mol Nutr Food Res. 2014 Oct;58(10):1962-9. doi: 10.1002/mnfr.201400245. Epub 2014 Sep 16.


Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement.

Krause E, Yuan Y, Hajirahimkhan A, Dong H, Dietz BM, Nikolic D, Pauli GF, Bolton JL, van Breemen RB.

Biomed Chromatogr. 2014 Jun;28(6):729-34. doi: 10.1002/bmc.3177.


Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.

Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikolić D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL.

PLoS One. 2013 Jul 12;8(7):e67947. doi: 10.1371/journal.pone.0067947. Print 2013.


Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.

Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic D, Guo J, Wright B, Chen SN, Pauli GF, van Breemen RB, Bolton JL.

Mol Nutr Food Res. 2013 Jun;57(6):1055-66. doi: 10.1002/mnfr.201200534. Epub 2013 Mar 20.


Botanical modulation of menopausal symptoms: mechanisms of action?

Hajirahimkhan A, Dietz BM, Bolton JL.

Planta Med. 2013 May;79(7):538-53. doi: 10.1055/s-0032-1328187. Epub 2013 Feb 13. Review.


Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).

Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen SN, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL.

Cancer Prev Res (Phila). 2012 Jan;5(1):73-81. doi: 10.1158/1940-6207.CAPR-11-0348. Epub 2011 Oct 13.


Integrated standardization concept for Angelica botanicals using quantitative NMR.

Gödecke T, Yao P, Napolitano JG, Nikolić D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen SN, Lankin DC, Pauli GF.

Fitoterapia. 2012 Jan;83(1):18-32. doi: 10.1016/j.fitote.2011.08.017. Epub 2011 Sep 1.


Biological reactive intermediates (BRIs) formed from botanical dietary supplements.

Dietz BM, Bolton JL.

Chem Biol Interact. 2011 Jun 30;192(1-2):72-80. doi: 10.1016/j.cbi.2010.10.007. Epub 2010 Oct 21. Review.


Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus.

Wang Z, Wijewickrama GT, Peng KW, Dietz BM, Yuan L, van Breemen RB, Bolton JL, Thatcher GR.

J Biol Chem. 2009 Mar 27;284(13):8633-42. doi: 10.1074/jbc.M807860200. Epub 2009 Jan 21.


Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.

Dietz BM, Liu D, Hagos GK, Yao P, Schinkovitz A, Pro SM, Deng S, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL.

Chem Res Toxicol. 2008 Oct;21(10):1939-48. doi: 10.1021/tx8001274. Epub 2008 Sep 23.


Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.

Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR.

Mol Cancer Ther. 2007 Sep;6(9):2418-28.


Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.

Gafner S, Dietz BM, McPhail KL, Scott IM, Glinski JA, Russell FE, McCollom MM, Budzinski JW, Foster BC, Bergeron C, Rhyu MR, Bolton JL.

J Nat Prod. 2006 Mar;69(3):432-5.


In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders.

Mahady GB, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR.

Phytother Res. 2005 Nov;19(11):988-91.


Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.

Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB.

Anal Chem. 2005 Oct 1;77(19):6407-14.


Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL.

Chem Res Toxicol. 2005 Aug;18(8):1296-305.


Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.

Dietz BM, Mahady GB, Pauli GF, Farnsworth NR.

Brain Res Mol Brain Res. 2005 Aug 18;138(2):191-7.

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