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Items: 1 to 50 of 56

1.

Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents.

Hernandez ED, Zheng L, Kim Y, Fang B, Liu B, Valdez RA, Dietrich WF, Rucker PV, Chianelli D, Schmeits J, Bao D, Zoll J, Dubois C, Federe GC, Chen L, Joseph SB, Klickstein LB, Walker J, Molteni V, McNamara P, Meeusen S, Tully DC, Badman MK, Xu J, Laffitte B.

Hepatol Commun. 2019 May 17;3(8):1085-1097. doi: 10.1002/hep4.1368. eCollection 2019 Aug.

2.

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

Cheung AK, Hurley B, Kerrigan R, Shu L, Chin DN, Shen Y, O'Brien G, Sung MJ, Hou Y, Axford J, Cody E, Sun R, Fazal A, Fridrich C, Sanchez CC, Tomlinson RC, Jain M, Deng L, Hoffmaster K, Song C, Van Hoosear M, Shin Y, Servais R, Towler C, Hild M, Curtis D, Dietrich WF, Hamann LG, Briner K, Chen KS, Kobayashi D, Sivasankaran R, Dales NA.

J Med Chem. 2018 Dec 27;61(24):11021-11036. doi: 10.1021/acs.jmedchem.8b01291. Epub 2018 Dec 13.

PMID:
30407821
3.

Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Palacino J, Swalley SE, Song C, Cheung AK, Shu L, Zhang X, Van Hoosear M, Shin Y, Chin DN, Keller CG, Beibel M, Renaud NA, Smith TM, Salcius M, Shi X, Hild M, Servais R, Jain M, Deng L, Bullock C, McLellan M, Schuierer S, Murphy L, Blommers MJ, Blaustein C, Berenshteyn F, Lacoste A, Thomas JR, Roma G, Michaud GA, Tseng BS, Porter JA, Myer VE, Tallarico JA, Hamann LG, Curtis D, Fishman MC, Dietrich WF, Dales NA, Sivasankaran R.

Nat Chem Biol. 2016 Apr;12(4):304. doi: 10.1038/nchembio0416-304c. No abstract available.

PMID:
26991088
4.

Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Palacino J, Swalley SE, Song C, Cheung AK, Shu L, Zhang X, Van Hoosear M, Shin Y, Chin DN, Keller CG, Beibel M, Renaud NA, Smith TM, Salcius M, Shi X, Hild M, Servais R, Jain M, Deng L, Bullock C, McLellan M, Schuierer S, Murphy L, Blommers MJ, Blaustein C, Berenshteyn F, Lacoste A, Thomas JR, Roma G, Michaud GA, Tseng BS, Porter JA, Myer VE, Tallarico JA, Hamann LG, Curtis D, Fishman MC, Dietrich WF, Dales NA, Sivasankaran R.

Nat Chem Biol. 2015 Sep;11(9):741. doi: 10.1038/nchembio0915-741a. No abstract available.

PMID:
26284678
5.

SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Palacino J, Swalley SE, Song C, Cheung AK, Shu L, Zhang X, Van Hoosear M, Shin Y, Chin DN, Keller CG, Beibel M, Renaud NA, Smith TM, Salcius M, Shi X, Hild M, Servais R, Jain M, Deng L, Bullock C, McLellan M, Schuierer S, Murphy L, Blommers MJ, Blaustein C, Berenshteyn F, Lacoste A, Thomas JR, Roma G, Michaud GA, Tseng BS, Porter JA, Myer VE, Tallarico JA, Hamann LG, Curtis D, Fishman MC, Dietrich WF, Dales NA, Sivasankaran R.

Nat Chem Biol. 2015 Jul;11(7):511-7. doi: 10.1038/nchembio.1837. Epub 2015 Jun 1. Erratum in: Nat Chem Biol. 2015 Sep;11(9):741. Nat Chem Biol. 2016 Apr;12(4):304.

PMID:
26030728
6.

The classical pink-eyed dilution mutation affects angiogenic responsiveness.

Rogers MS, Boyartchuk V, Rohan RM, Birsner AE, Dietrich WF, D'Amato RJ.

PLoS One. 2012;7(5):e35237. doi: 10.1371/journal.pone.0035237. Epub 2012 May 15.

7.

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin.

Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE.

Nat Immunol. 2008 Oct;9(10):1171-8. doi: 10.1038/ni.1646. Epub 2008 Aug 24.

8.

Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.

Coers J, Bernstein-Hanley I, Grotsky D, Parvanova I, Howard JC, Taylor GA, Dietrich WF, Starnbach MN.

J Immunol. 2008 May 1;180(9):6237-45.

9.

Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice.

Wang F, Paradkar PN, Custodio AO, McVey Ward D, Fleming MD, Campagna D, Roberts KA, Boyartchuk V, Dietrich WF, Kaplan J, Andrews NC.

Nat Genet. 2007 Aug;39(8):1025-32. Epub 2007 Jul 15.

PMID:
17632513
10.

Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways.

Coers J, Vance RE, Fontana MF, Dietrich WF.

Cell Microbiol. 2007 Oct;9(10):2344-57. Epub 2007 May 15.

PMID:
17506816
11.

The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice.

Bernstein-Hanley I, Coers J, Balsara ZR, Taylor GA, Starnbach MN, Dietrich WF.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14092-7. Epub 2006 Sep 7.

12.

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity.

Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE.

PLoS Pathog. 2006 Mar;2(3):e18. Epub 2006 Mar 17.

13.

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.

Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM, Flavell RA, Dietrich WF, Roy CR.

Nat Immunol. 2006 Mar;7(3):318-25. Epub 2006 Jan 29.

PMID:
16444259
14.

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin.

Boyden ED, Dietrich WF.

Nat Genet. 2006 Feb;38(2):240-4. Epub 2006 Jan 22.

PMID:
16429160
15.

Genetic analysis of susceptibility to Chlamydia trachomatis in mouse.

Bernstein-Hanley I, Balsara ZR, Ulmer W, Coers J, Starnbach MN, Dietrich WF.

Genes Immun. 2006 Mar;7(2):122-9.

PMID:
16395389
16.

The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.

Boyartchuk V, Rojas M, Yan BS, Jobe O, Hurt N, Dorfman DM, Higgins DE, Dietrich WF, Kramnik I.

J Immunol. 2004 Oct 15;173(8):5112-20.

17.

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity.

Shaw MH, Boyartchuk V, Wong S, Karaghiosoff M, Ragimbeau J, Pellegrini S, Muller M, Dietrich WF, Yap GS.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11594-9. Epub 2003 Sep 18.

18.

The origin and implications of the Human Genome Project: scientific overview.

Dietrich WF.

Natl Cathol Bioeth Q. 2001 Winter;1(4):489-95. No abstract available.

PMID:
12854559
19.

Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.

Wright EK, Goodart SA, Growney JD, Hadinoto V, Endrizzi MG, Long EM, Sadigh K, Abney AL, Bernstein-Hanley I, Dietrich WF.

Curr Biol. 2003 Jan 8;13(1):27-36.

20.
21.

Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locus.

Watarai M, Derre I, Kirby J, Growney JD, Dietrich WF, Isberg RR.

J Exp Med. 2001 Oct 15;194(8):1081-96.

22.

Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor.

Watters JW, Dewar K, Lehoczky J, Boyartchuk V, Dietrich WF.

Curr Biol. 2001 Oct 2;11(19):1503-11.

24.

Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11.

Watters JW, Dietrich WF.

Genomics. 2001 Apr 15;73(2):223-31. Erratum in: Genomics 2002 Mar;79(3):462.

PMID:
11318612
25.

Multigenic control of Listeria monocytogenes susceptibility in mice.

Boyartchuk VL, Broman KW, Mosher RE, D'Orazio SE, Starnbach MN, Dietrich WF.

Nat Genet. 2001 Mar;27(3):259-60.

PMID:
11242105
26.

Using mouse genetics to understand infectious disease pathogenesis.

Dietrich WF.

Genome Res. 2001 Mar;11(3):325-31. Review. No abstract available.

28.

Genomic sequence analysis of the mouse Naip gene array.

Endrizzi MG, Hadinoto V, Growney JD, Miller W, Dietrich WF.

Genome Res. 2000 Aug;10(8):1095-102.

29.

Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis.

Kramnik I, Dietrich WF, Demant P, Bloom BR.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8560-5.

30.

Loci influencing development of Th responses. Identification from in vitro analysis.

Guler ML, Gorham JD, Dietrich WF, Steen RG, Parvin C, Fenoglio D, Grupe A, Peltz G, Murphy KM.

Microbes Infect. 1999 Jan;1(1):79-88. Review. No abstract available.

PMID:
10847770
31.

Evolutionary divergence of the mouse and human Lgn1/SMA repeat structures.

Growney JD, Scharf JM, Kunkel LM, Dietrich WF.

Genomics. 2000 Feb 15;64(1):62-81.

PMID:
10708519
32.

The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts.

Huang S, Scharf JM, Growney JD, Endrizzi MG, Dietrich WF.

Mamm Genome. 1999 Oct;10(10):1032-5. No abstract available.

PMID:
10501978
33.

Comparative sequence analysis of the mouse and human Lgn1/SMA interval.

Endrizzi M, Huang S, Scharf JM, Kelter AR, Wirth B, Kunkel LM, Miller W, Dietrich WF.

Genomics. 1999 Sep 1;60(2):137-51.

PMID:
10486205
34.

Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma.

von Deimling F, Scharf JM, Liehr T, Rothe M, Kelter AR, Albers P, Dietrich WF, Kunkel LM, Wernert N, Wirth B.

Hum Genet. 1999 Jul-Aug;105(1-2):17-27.

PMID:
10480350
35.

A YAC-based physical map of the mouse genome.

Nusbaum C, Slonim DK, Harris KL, Birren BW, Steen RG, Stein LD, Miller J, Dietrich WF, Nahf R, Wang V, Merport O, Castle AB, Husain Z, Farino G, Gray D, Anderson MO, Devine R, Horton LT Jr, Ye W, Wu X, Kouyoumjian V, Zemsteva IS, Wu Y, Collymore AJ, Courtney DF, Tam J, Cadman M, Haynes AR, Heuston C, Marsland T, Southwell A, Trickett P, Strivens MA, Ross MT, Makalowski W, Xu Y, Boguski MS, Carter NP, Denny P, Brown SD, Hudson TJ, Lander ES.

Nat Genet. 1999 Aug;22(4):388-93.

PMID:
10431246
36.

Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism.

Guler ML, Gorham JD, Dietrich WF, Murphy TL, Steen RG, Parvin CA, Fenoglio D, Grupe A, Peltz G, Murphy KM.

J Immunol. 1999 Feb 1;162(3):1339-47.

37.

Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics.

Scharf JM, Endrizzi MG, Wetter A, Huang S, Thompson TG, Zerres K, Dietrich WF, Wirth B, Kunkel LM.

Nat Genet. 1998 Sep;20(1):83-6.

PMID:
9731538
39.

Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas.

Fazeli A, Steen RG, Dickinson SL, Bautista D, Dietrich WF, Bronson RT, Bresalier RS, Lander ES, Costa J, Weinberg RA.

Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10199-204.

40.

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.

Fleming MD, Trenor CC 3rd, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC.

Nat Genet. 1997 Aug;16(4):383-6.

PMID:
9241278
41.

DNA copy number changes associated with characteristic LOH in islet cell carcinomas of transgenic mice.

Shi YP, Naik P, Dietrich WF, Gray JW, Hanahan D, Pinkel D.

Genes Chromosomes Cancer. 1997 Jun;19(2):104-11.

PMID:
9172001
42.

The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5.

Scharf JM, Damron D, Frisella A, Bruno S, Beggs AH, Kunkel LM, Dietrich WF.

Genomics. 1996 Dec 15;38(3):405-17.

PMID:
8975718
43.

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.

Gould KA, Luongo C, Moser AR, McNeley MK, Borenstein N, Shedlovsky A, Dove WF, Hong K, Dietrich WF, Lander ES.

Genetics. 1996 Dec;144(4):1777-85.

44.

Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice.

Gould KA, Dietrich WF, Borenstein N, Lander ES, Dove WF.

Genetics. 1996 Dec;144(4):1769-76.

45.

Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.

Gorham JD, Güler ML, Steen RG, Mackey AJ, Daly MJ, Frederick K, Dietrich WF, Murphy KM.

Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12467-72.

46.

A comprehensive genetic map of the mouse genome.

Dietrich WF, Miller J, Steen R, Merchant MA, Damron-Boles D, Husain Z, Dredge R, Daly MJ, Ingalls KA, O'Connor TJ.

Nature. 1996 Mar 14;380(6570):149-52. Erratum in: Nature 1996 May 9;381(6578):172.

PMID:
8600386
47.

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.

Güler ML, Gorham JD, Hsieh CS, Mackey AJ, Steen RG, Dietrich WF, Murphy KM.

Science. 1996 Feb 16;271(5251):984-7.

PMID:
8584935
48.

New seizure frequency QTL and the complex genetics of epilepsy in EL mice.

Frankel WN, Valenzuela A, Lutz CM, Johnson EW, Dietrich WF, Coffin JM.

Mamm Genome. 1995 Dec;6(12):830-8.

PMID:
8747920
49.

Mapping the mouse genome: current status and future prospects.

Dietrich WF, Copeland NG, Gilbert DJ, Miller JC, Jenkins NA, Lander ES.

Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10849-53. Review.

50.

Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13.

Dietrich WF, Damron DM, Isberg RR, Lander ES, Swanson MS.

Genomics. 1995 Apr 10;26(3):443-50.

PMID:
7607666

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