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Items: 1 to 50 of 128

1.

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Krebs A, Waldmann T, Wilks MF, Van Vugt-Lussenburg BMA, Van der Burg B, Terron A, Steger-Hartmann T, Ruegg J, Rovida C, Pedersen E, Pallocca G, Luijten M, Leite SB, Kustermann S, Kamp H, Hoeng J, Hewitt P, Herzler M, Hengstler JG, Heinonen T, Hartung T, Hardy B, Gantner F, Fritsche E, Fant K, Ezendam J, Exner T, Dunkern T, Dietrich DR, Coecke S, Busquet F, Braeuning A, Bondarenko O, Bennekou SH, Beilmann M, Leist M.

ALTEX. 2019;36(4):682-699. doi: 10.14573/altex.1909271.

2.

Human MRP2 exports MC-LR but not the glutathione conjugate.

Kaur G, Fahrner R, Wittmann V, Stieger B, Dietrich DR.

Chem Biol Interact. 2019 Sep 25;311:108761. doi: 10.1016/j.cbi.2019.108761. Epub 2019 Jul 23.

PMID:
31348918
3.

Machine learning prediction of cyanobacterial toxin (microcystin) toxicodynamics in humans.

Altaner S, Jaeger S, Fotler R, Zemskov I, Wittmann V, Schreiber F, Dietrich DR.

ALTEX. 2019 Jul 2. doi: 10.14573/altex.1904031. [Epub ahead of print]

4.

Simultaneous Detection of 14 Microcystin Congeners from Tissue Samples Using UPLC- ESI-MS/MS and Two Different Deuterated Synthetic Microcystins as Internal Standards.

Altaner S, Puddick J, Fessard V, Feurstein D, Zemskov I, Wittmann V, Dietrich DR.

Toxins (Basel). 2019 Jul 2;11(7). pii: E388. doi: 10.3390/toxins11070388.

5.

Functional transepithelial transport measurements to detect nephrotoxicity in vitro using the RPTEC/TERT1 cell line.

Secker PF, Schlichenmaier N, Beilmann M, Deschl U, Dietrich DR.

Arch Toxicol. 2019 Jul;93(7):1965-1978. doi: 10.1007/s00204-019-02469-8. Epub 2019 May 10.

PMID:
31076804
6.

Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models.

Bastek H, Zubel T, Stemmer K, Mangerich A, Beneke S, Dietrich DR.

Toxicology. 2019 May 15;420:29-38. doi: 10.1016/j.tox.2019.03.013. Epub 2019 Mar 30.

PMID:
30940547
7.

Toxic Cyanobacteria in Svalbard: Chemical Diversity of Microcystins Detected Using a Liquid Chromatography Mass Spectrometry Precursor Ion Screening Method.

Kleinteich J, Puddick J, Wood SA, Hildebrand F, Laughinghouse HD IV, Pearce DA, Dietrich DR, Wilmotte A.

Toxins (Basel). 2018 Apr 3;10(4). pii: E147. doi: 10.3390/toxins10040147.

8.

Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect.

Secker PF, Beneke S, Schlichenmaier N, Delp J, Gutbier S, Leist M, Dietrich DR.

Cell Death Dis. 2018 Feb 14;9(2):226. doi: 10.1038/s41419-018-0273-y.

9.

Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy.

Maier MY, Luks L, Baudendistel OR, Wittmann V, Dietrich DR.

Chem Biol Interact. 2018 Feb 1;281:69-80. doi: 10.1016/j.cbi.2017.12.023. Epub 2017 Dec 19.

PMID:
29273565
10.

RPTEC/TERT1 cells form highly differentiated tubules when cultured in a 3D matrix.

Secker PF, Luks L, Schlichenmaier N, Dietrich DR.

ALTEX. 2018;35(2):223-234. doi: 10.14573/altex.1710181. Epub 2017 Dec 2.

11.

Further thoughts on limitations, uncertainties and competing interpretations regarding chemical exposures and diabetes.

Bond GG, Dietrich DR.

J Epidemiol Community Health. 2017 Sep;71(9):943. doi: 10.1136/jech-2017-209451. Epub 2017 Jul 8. No abstract available.

12.

Human cost burden of exposure to endocrine disrupting chemicals. A critical review.

Bond GG, Dietrich DR.

Arch Toxicol. 2017 Aug;91(8):2745-2762. doi: 10.1007/s00204-017-1985-y. Epub 2017 May 20. Review.

PMID:
28528477
13.

Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon.

Luks L, Maier MY, Sacchi S, Pollegioni L, Dietrich DR.

Arch Toxicol. 2017 Nov;91(11):3599-3611. doi: 10.1007/s00204-017-1970-5. Epub 2017 Apr 27.

PMID:
28451739
14.

Adsorption of Ten Microcystin Congeners to Common Laboratory-Ware Is Solvent and Surface Dependent.

Altaner S, Puddick J, Wood SA, Dietrich DR.

Toxins (Basel). 2017 Apr 6;9(4). pii: E129. doi: 10.3390/toxins9040129.

15.

Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.

Klaus V, Bastek H, Damme K, Collins LB, Frötschl R, Benda N, Lutter D, Ellinger-Ziegelbauer H, Swenberg JA, Dietrich DR, Stemmer K.

Arch Toxicol. 2017 Oct;91(10):3427-3438. doi: 10.1007/s00204-017-1953-6. Epub 2017 Mar 27.

16.

Total Synthesis of Microcystin-LF and Derivatives Thereof.

Zemskov I, Altaner S, Dietrich DR, Wittmann V.

J Org Chem. 2017 Apr 7;82(7):3680-3691. doi: 10.1021/acs.joc.7b00175. Epub 2017 Mar 27.

17.

Limitations, uncertainties and competing interpretations regarding chemical exposures and diabetes.

Bond GG, Dietrich DR.

J Epidemiol Community Health. 2017 Sep;71(9):941. doi: 10.1136/jech-2016-208711. Epub 2017 Mar 6. No abstract available.

18.

Trophic state and geographic gradients influence planktonic cyanobacterial diversity and distribution in New Zealand lakes.

Wood SA, Maier MY, Puddick J, Pochon X, Zaiko A, Dietrich DR, Hamilton DP.

FEMS Microbiol Ecol. 2017 Feb;93(2). pii: fiw234. Epub 2016 Nov 16.

PMID:
27856621
19.

Allowing pseudoscience into EU risk assessment processes is eroding public trust in science experts and in science as a whole: The bigger picture.

Dietrich DR, Dekant W, Greim H, Heslop-Harrison P, Berry SC, Boobis A, Hengstler J, Sharpe R.

Chem Biol Interact. 2016 Sep 25;257:1-3. doi: 10.1016/j.cbi.2016.07.023. Epub 2016 Jul 21. No abstract available.

20.

EU safety regulations: Don't mar legislation with pseudoscience.

Dietrich DR.

Nature. 2016 Jul 21;535(7612):355. doi: 10.1038/535355c. No abstract available.

PMID:
27443732
21.

Conflict of interest statements: current dilemma and a possible way forward.

Dietrich DR, Hengstler JG.

Arch Toxicol. 2016 Sep;90(9):2293-2295. doi: 10.1007/s00204-016-1783-y. No abstract available.

PMID:
27351767
22.

Novel insights into renal D-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo.

Luks L, Sacchi S, Pollegioni L, Dietrich DR.

Arch Toxicol. 2017 Jan;91(1):427-437. doi: 10.1007/s00204-016-1685-z. Epub 2016 Mar 9.

PMID:
26961980
23.

The Scent of Blood: A Driver of Human Behavior?

Moran JK, Dietrich DR, Elbert T, Pause BM, Kübler L, Weierstall R.

PLoS One. 2015 Sep 23;10(9):e0137777. doi: 10.1371/journal.pone.0137777. eCollection 2015.

24.

The effect of cyanobacterial biomass enrichment by centrifugation and GF/C filtration on subsequent microcystin measurement.

Rogers S, Puddick J, Wood SA, Dietrich DR, Hamilton DP, Prinsep MR.

Toxins (Basel). 2015 Mar 10;7(3):821-34. doi: 10.3390/toxins7030821.

25.

The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals.

van der Burg B, Wedebye EB, Dietrich DR, Jaworska J, Mangelsdorf I, Paune E, Schwarz M, Piersma AH, Kroese ED.

Reprod Toxicol. 2015 Aug 1;55:114-23. doi: 10.1016/j.reprotox.2015.01.008. Epub 2015 Feb 2.

PMID:
25656794
26.

Anatoxin-a producing Tychonema (Cyanobacteria) in European waterbodies.

Shams S, Capelli C, Cerasino L, Ballot A, Dietrich DR, Sivonen K, Salmaso N.

Water Res. 2015 Feb 1;69:68-79. doi: 10.1016/j.watres.2014.11.006. Epub 2014 Nov 18.

PMID:
25437339
27.

Molecular cloning and functional characterization of a rainbow trout liver Oatp.

Steiner K, Hagenbuch B, Dietrich DR.

Toxicol Appl Pharmacol. 2014 Nov 1;280(3):534-42. doi: 10.1016/j.taap.2014.08.031. Epub 2014 Sep 12.

28.

Comparison of two ELISA-based methods for the detection of microcystins in blood serum.

Heussner AH, Winter I, Altaner S, Kamp L, Rubio F, Dietrich DR.

Chem Biol Interact. 2014 Nov 5;223:10-7. doi: 10.1016/j.cbi.2014.08.014. Epub 2014 Sep 7.

PMID:
25204773
29.

Pitfalls in microcystin extraction and recovery from human blood serum.

Heussner AH, Altaner S, Kamp L, Rubio F, Dietrich DR.

Chem Biol Interact. 2014 Nov 5;223:87-94. doi: 10.1016/j.cbi.2014.08.010. Epub 2014 Sep 6.

PMID:
25196074
30.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, Aulock SV, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A, Barile FA.

Toxicon. 2013 Dec 15;76:A1-A2. doi: 10.1016/j.toxicon.2013.10.020. Epub 2013 Oct 24. No abstract available.

PMID:
24512766
31.

Experimental models of microcystin accumulation in Daphnia magna grazing on Planktothrix rubescens: implications for water management.

Shams S, Cerasino L, Salmaso N, Dietrich DR.

Aquat Toxicol. 2014 Mar;148:9-15. doi: 10.1016/j.aquatox.2013.12.020. Epub 2013 Dec 31.

PMID:
24440453
32.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A, Barile FA.

Toxicon. 2013 Dec 15;76:A1-A2. No abstract available.

PMID:
24409469
33.
34.

Editorial (for "The billboard").

Dietrich DR.

Chem Biol Interact. 2013 Nov 25;206(2):A1. doi: 10.1016/j.cbi.2013.10.001. Epub 2013 Oct 5. No abstract available.

PMID:
24103855
35.

Open letter: draft regulation on endocrine-active chemicals.

Dietrich DR.

Arch Toxicol. 2013 Oct;87(10):1869-72. doi: 10.1007/s00204-013-1125-2. Epub 2013 Sep 19. No abstract available.

PMID:
24048414
36.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Batta Gori G, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Wallace Hayes A, Gooderham N, Harvey A.

ALTEX. 2013;30(3):381-5. doi: 10.14573/altex.2013.3.381. No abstract available.

37.

Editorial.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A.

Regul Toxicol Pharmacol. 2013 Dec;67(3):317-20. doi: 10.1016/j.yrtph.2013.07.001. Epub 2013 Jul 9. No abstract available.

PMID:
23850959
38.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen OP, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes A, Gooderham N, Harvey A.

Toxicol In Vitro. 2013 Oct;27(7):2110-4. doi: 10.1016/j.tiv.2013.07.001. Epub 2013 Jul 9. No abstract available.

PMID:
23850741
39.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A.

Food Chem Toxicol. 2013 Dec;62:A1-4. doi: 10.1016/j.fct.2013.07.005. Epub 2013 Jul 5. No abstract available.

PMID:
23835284
40.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

Dietrich DR, Aulock Sv, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Gori GB, Pelkonen O, Lang F, Barile FA, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A.

Chem Biol Interact. 2013 Sep 5;205(1):A1-5. doi: 10.1016/j.cbi.2013.07.001. Epub 2013 Jul 4. No abstract available.

PMID:
23832050
41.

Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro.

Gauggel-Lewandowski S, Heussner AH, Steinberg P, Pieterse B, van der Burg B, Dietrich DR.

Chem Biol Interact. 2013 Nov 25;206(2):411-22. doi: 10.1016/j.cbi.2013.05.015. Epub 2013 Jun 21.

PMID:
23796820
42.

The cyanobacterial neurotoxin β-N-methylamino-l-alanine (BMAA) induces neuronal and behavioral changes in honeybees.

Okle O, Rath L, Galizia CG, Dietrich DR.

Toxicol Appl Pharmacol. 2013 Jul 1;270(1):9-15. doi: 10.1016/j.taap.2013.04.003. Epub 2013 Apr 13.

PMID:
23591064
43.

Site-directed spin-labeling of nucleotides and the use of in-cell EPR to determine long-range distances in a biologically relevant environment.

Azarkh M, Singh V, Okle O, Seemann IT, Dietrich DR, Hartig JS, Drescher M.

Nat Protoc. 2013 Jan;8(1):131-47. doi: 10.1038/nprot.2012.136. Epub 2012 Dec 20.

PMID:
23257982
44.

Toxin content and cytotoxicity of algal dietary supplements.

Heussner AH, Mazija L, Fastner J, Dietrich DR.

Toxicol Appl Pharmacol. 2012 Dec 1;265(2):263-71. doi: 10.1016/j.taap.2012.10.005. Epub 2012 Oct 12.

PMID:
23064102
45.

L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations.

Okle O, Stemmer K, Deschl U, Dietrich DR.

Toxicol Sci. 2013 Jan;131(1):217-24. doi: 10.1093/toxsci/kfs291. Epub 2012 Oct 9.

PMID:
23047912
46.

Characterization of biologically available wood combustion particles in cell culture medium.

Gauggel S, Derreza-Greeven C, Wimmer J, Wingfield M, van der Burg B, Dietrich DR.

ALTEX. 2012;29(2):183-200. doi: 10.14573/altex.2012.2.183.

47.

High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney.

Stemmer K, Perez-Tilve D, Ananthakrishnan G, Bort A, Seeley RJ, Tschöp MH, Dietrich DR, Pfluger PT.

Dis Model Mech. 2012 Sep;5(5):627-35. doi: 10.1242/dmm.009407. Epub 2012 Mar 15.

48.

Intracellular conformations of human telomeric quadruplexes studied by electron paramagnetic resonance spectroscopy.

Azarkh M, Singh V, Okle O, Dietrich DR, Hartig JS, Drescher M.

Chemphyschem. 2012 Apr 23;13(6):1444-7. doi: 10.1002/cphc.201100980. Epub 2012 Mar 6.

PMID:
22396158
49.

The human relevant potency threshold: reducing uncertainty by human calibration of cumulative risk assessments.

Borgert CJ, Sargent EV, Casella G, Dietrich DR, McCarty LS, Golden RJ.

Regul Toxicol Pharmacol. 2012 Mar;62(2):313-28. doi: 10.1016/j.yrtph.2011.10.012. Epub 2011 Oct 28.

50.

Microcystin congener- and concentration-dependent induction of murine neuron apoptosis and neurite degeneration.

Feurstein D, Stemmer K, Kleinteich J, Speicher T, Dietrich DR.

Toxicol Sci. 2011 Dec;124(2):424-31. doi: 10.1093/toxsci/kfr243. Epub 2011 Sep 20.

PMID:
21934130

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