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Differential modulation of transendothelial electrical resistance by TRPV4 agonists is mediated by apoptosis and/or necrosis.

Pairet N, Mang S, Kiechle T, Laufhäger N, Dietl P, Lamb DJ.

Biochem Biophys Rep. 2019 Sep 19;20:100672. doi: 10.1016/j.bbrep.2019.100672. eCollection 2019 Dec.


Retinoic acid signalling adjusts tight junction permeability in response to air-liquid interface conditions.

Lochbaum R, Schilpp C, Nonnenmacher L, Frick M, Dietl P, Wittekindt OH.

Cell Signal. 2020 Jan;65:109421. doi: 10.1016/j.cellsig.2019.109421. Epub 2019 Sep 16.


IL-13 Impairs Tight Junctions in Airway Epithelia.

Schmidt H, Braubach P, Schilpp C, Lochbaum R, Neuland K, Thompson K, Jonigk D, Frick M, Dietl P, Wittekindt OH.

Int J Mol Sci. 2019 Jun 30;20(13). pii: E3222. doi: 10.3390/ijms20133222.


Aquaporins in the lung.

Wittekindt OH, Dietl P.

Pflugers Arch. 2019 Apr;471(4):519-532. doi: 10.1007/s00424-018-2232-y. Epub 2018 Nov 5. Review.


Inflammation-induced upregulation of P2X4 expression augments mucin secretion in airway epithelia.

Winkelmann VE, Thompson KE, Neuland K, Jaramillo AM, Fois G, Schmidt H, Wittekindt OH, Han W, Tuvim MJ, Dickey BF, Dietl P, Frick M.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L58-L70. doi: 10.1152/ajplung.00157.2018. Epub 2018 Oct 25.


P2X4 receptor re-sensitization depends on a protonation/deprotonation cycle mediated by receptor internalization and recycling.

Fois G, Föhr KJ, Kling C, Fauler M, Wittekindt OH, Dietl P, Frick M.

J Physiol. 2018 Oct;596(20):4893-4907. doi: 10.1113/JP275448. Epub 2018 Sep 17.


TRPV4 inhibition attenuates stretch-induced inflammatory cellular responses and lung barrier dysfunction during mechanical ventilation.

Pairet N, Mang S, Fois G, Keck M, Kühnbach M, Gindele J, Frick M, Dietl P, Lamb DJ.

PLoS One. 2018 Apr 17;13(4):e0196055. doi: 10.1371/journal.pone.0196055. eCollection 2018.


Pulmonary surfactant protein SP-B promotes exocytosis of lamellar bodies in alveolar type II cells.

Martínez-Calle M, Olmeda B, Dietl P, Frick M, Pérez-Gil J.

FASEB J. 2018 Aug;32(8):4600-4611. doi: 10.1096/fj.201701462RR. Epub 2018 Mar 15.


Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.

Villeret B, Dieu A, Straube M, Solhonne B, Miklavc P, Hamadi S, Le Borgne R, Mailleux A, Norel X, Aerts J, Diallo D, Rouzet F, Dietl P, Sallenave JM, Garcia-Verdugo I.

ACS Nano. 2018 Feb 27;12(2):1188-1202. doi: 10.1021/acsnano.7b06934. Epub 2018 Jan 30.


Water Permeability Adjusts Resorption in Lung Epithelia to Increased Apical Surface Liquid Volumes.

Schmidt H, Michel C, Braubach P, Fauler M, Neubauer D, Thompson KE, Frick M, Mizaikoff B, Dietl P, Wittekindt OH.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):372-382. doi: 10.1165/rcmb.2016-0161OC.


A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies.

Hobi N, Giolai M, Olmeda B, Miklavc P, Felder E, Walther P, Dietl P, Frick M, Pérez-Gil J, Haller T.

Biochim Biophys Acta. 2016 Aug;1863(8):2124-34. doi: 10.1016/j.bbamcr.2016.04.028. Epub 2016 May 4.


A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca²⁺ release from acidic Ca²⁺ stores.

Fois G, Hobi N, Felder E, Ziegler A, Miklavc P, Walther P, Radermacher P, Haller T, Dietl P.

Cell Calcium. 2015 Dec;58(6):628-37. doi: 10.1016/j.ceca.2015.10.002. Epub 2015 Oct 27.


Glucocorticoids Regulate Tight Junction Permeability of Lung Epithelia by Modulating Claudin 8.

Kielgast F, Schmidt H, Braubach P, Winkelmann VE, Thompson KE, Frick M, Dietl P, Wittekindt OH.

Am J Respir Cell Mol Biol. 2016 May;54(5):707-17. doi: 10.1165/rcmb.2015-0071OC.


Physiological and immune-biological characterization of a long-term murine model of blunt chest trauma.

Hafner S, Wagner K, Wepler M, Matallo J, Gröger M, McCook O, Scheuerle A, Huber-Lang M, Frick M, Weber S, Stahl B, Jung B, Calzia E, Georgieff M, Möller P, Dietl P, Radermacher P, Wagner F.

Shock. 2015 Feb;43(2):140-7. doi: 10.1097/SHK.0000000000000277. Erratum in: Shock. 2015 Apr;43(4):425.


Hyperglycemia, oxidative stress, and the diaphragm: a link between chronic co-morbidity and acute stress?

Hafner S, Radermacher P, Frick M, Dietl P, Calzia E.

Crit Care. 2014 Jun 10;18(3):149. doi: 10.1186/cc13913.


Amiloride-sensitive fluid resorption in NCI-H441 lung epithelia depends on an apical Cl(-) conductance.

Korbmacher JP, Michel C, Neubauer D, Thompson K, Mizaikoff B, Frick M, Dietl P, Wittekindt OH.

Physiol Rep. 2014 Jan 16;2(1):e00201. doi: 10.1002/phy2.201. eCollection 2014 Jan 1.


Deuterium oxide dilution: a novel method to study apical water layers and transepithelial water transport.

Neubauer D, Korbmacher J, Frick M, Kiss J, Timmler M, Dietl P, Wittekindt OH, Mizaikoff B.

Anal Chem. 2013 May 7;85(9):4247-50. doi: 10.1021/ac4002723. Epub 2013 Apr 11.


Fusion-activated cation entry (FACE) via P2X₄ couples surfactant secretion and alveolar fluid transport.

Thompson KE, Korbmacher JP, Hecht E, Hobi N, Wittekindt OH, Dietl P, Kranz C, Frick M.

FASEB J. 2013 Apr;27(4):1772-83. doi: 10.1096/fj.12-220533. Epub 2013 Jan 10.


Effects of keratin phosphorylation on the mechanical properties of keratin filaments in living cells.

Fois G, Weimer M, Busch T, Felder ET, Oswald F, von Wichert G, Seufferlein T, Dietl P, Felder E.

FASEB J. 2013 Apr;27(4):1322-9. doi: 10.1096/fj.12-215632. Epub 2012 Dec 14.


Benzimidazolones enhance the function of epithelial Na⁺ transport.

Laube M, Kimpel SU, Dietl P, Thome UH, Wittekindt OH.

Br J Pharmacol. 2013 Mar;168(6):1329-40. doi: 10.1111/bph.12027.


Combining atomic force-fluorescence microscopy with a stretching device for analyzing mechanotransduction processes in living cells.

Hecht E, Knittel P, Felder E, Dietl P, Mizaikoff B, Kranz C.

Analyst. 2012 Nov 21;137(22):5208-14. doi: 10.1039/c2an36001b. Epub 2012 Sep 14.


Combined atomic force microscopy-fluorescence microscopy: analyzing exocytosis in alveolar type II cells.

Hecht E, Thompson K, Frick M, Wittekindt OH, Dietl P, Mizaikoff B, Kranz C.

Anal Chem. 2012 Jul 3;84(13):5716-22. doi: 10.1021/ac300775j. Epub 2012 Jun 22.


Spatio-temporal aspects, pathways and actions of Ca(2+) in surfactant secreting pulmonary alveolar type II pneumocytes.

Dietl P, Haller T, Frick M.

Cell Calcium. 2012 Sep-Oct;52(3-4):296-302. doi: 10.1016/j.ceca.2012.04.010. Epub 2012 May 14. Review.


Actin coating and compression of fused secretory vesicles are essential for surfactant secretion--a role for Rho, formins and myosin II.

Miklavc P, Hecht E, Hobi N, Wittekindt OH, Dietl P, Kranz C, Frick M.

J Cell Sci. 2012 Jun 1;125(Pt 11):2765-74. doi: 10.1242/jcs.105262. Epub 2012 Mar 16.


An ultra fast detection method reveals strain-induced Ca(2+) entry via TRPV2 in alveolar type II cells.

Fois G, Wittekindt O, Zheng X, Felder ET, Miklavc P, Frick M, Dietl P, Felder E.

Biomech Model Mechanobiol. 2012 Sep;11(7):959-71. doi: 10.1007/s10237-011-0365-4. Epub 2011 Dec 22.


Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins.

Usmani SM, von Einem J, Frick M, Miklavc P, Mayenburg M, Husmann M, Dietl P, Wittekindt OH.

Cell Microbiol. 2012 Mar;14(3):299-315. doi: 10.1111/j.1462-5822.2011.01724.x. Epub 2011 Dec 13.


Fusion-activated Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytes.

Miklavc P, Mair N, Wittekindt OH, Haller T, Dietl P, Felder E, Timmler M, Frick M.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14503-8. doi: 10.1073/pnas.1101039108. Epub 2011 Aug 15.


Nucleotide-mediated airway clearance.

Schmid A, Clunes LA, Salathe M, Verdugo P, Dietl P, Davis CW, Tarran R.

Subcell Biochem. 2011;55:95-138. doi: 10.1007/978-94-007-1217-1_5. Review.


Interfacial sensing by alveolar type II cells: a new concept in lung physiology?

Ravasio A, Hobi N, Bertocchi C, Jesacher A, Dietl P, Haller T.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1456-65. doi: 10.1152/ajpcell.00427.2010. Epub 2011 Jan 26.


Atomic force microscopy of microvillous cell surface dynamics at fixed and living alveolar type II cells.

Hecht E, Usmani SM, Albrecht S, Wittekindt OH, Dietl P, Mizaikoff B, Kranz C.

Anal Bioanal Chem. 2011 Mar;399(7):2369-78. doi: 10.1007/s00216-010-4407-z. Epub 2010 Nov 30.


Fusion-activated Ca(2+) entry: an "active zone" of elevated Ca(2+) during the postfusion stage of lamellar body exocytosis in rat type II pneumocytes.

Miklavc P, Frick M, Wittekindt OH, Haller T, Dietl P.

PLoS One. 2010 Jun 8;5(6):e10982. doi: 10.1371/journal.pone.0010982.


2-APB and capsazepine-induced Ca2+ influx stimulates clathrin-dependent endocytosis in alveolar epithelial cells.

Usmani SM, Fois G, Albrecht S, von Aulock S, Dietl P, Wittekindt OH.

Cell Physiol Biochem. 2010;25(1):91-102. doi: 10.1159/000272064. Epub 2009 Dec 22.


Plasma membrane trafficking in alveolar type II cells.

Albrecht S, Usmani SM, Dietl P, Wittekindt OH.

Cell Physiol Biochem. 2010;25(1):81-90. doi: 10.1159/000272053. Epub 2009 Dec 22.


Lamellar body exocytosis by cell stretch or purinergic stimulation: possible physiological roles, messengers and mechanisms.

Dietl P, Liss B, Felder E, Miklavc P, Wirtz H.

Cell Physiol Biochem. 2010;25(1):1-12. doi: 10.1159/000272046. Epub 2009 Dec 22. Review.


Existence of exocytotic hemifusion intermediates with a lifetime of up to seconds in type II pneumocytes.

Miklavc P, Albrecht S, Wittekindt OH, Schullian P, Haller T, Dietl P.

Biochem J. 2009 Oct 23;424(1):7-14. doi: 10.1042/BJ20091094.


A device for simultaneous live cell imaging during uni-axial mechanical strain or compression.

Gerstmair A, Fois G, Innerbichler S, Dietl P, Felder E.

J Appl Physiol (1985). 2009 Aug;107(2):613-20. doi: 10.1152/japplphysiol.00012.2009. Epub 2009 Jun 4.


Ca2+-dependent actin coating of lamellar bodies after exocytotic fusion: a prerequisite for content release or kiss-and-run.

Miklavc P, Wittekindt OH, Felder E, Dietl P.

Ann N Y Acad Sci. 2009 Jan;1152:43-52. doi: 10.1111/j.1749-6632.2008.03989.x.


Phosphatidylinositol-3-kinase regulates mast cell ion channel activity.

Lam RS, Shumilina E, Matzner N, Zemtsova IM, Sobiesiak M, Lang C, Felder E, Dietl P, Huber SM, Lang F.

Cell Physiol Biochem. 2008;22(1-4):169-76. doi: 10.1159/000149794. Epub 2008 Jul 25.


Mechanical strain of alveolar type II cells in culture: changes in the transcellular cytokeratin network and adaptations.

Felder E, Siebenbrunner M, Busch T, Fois G, Miklavc P, Walther P, Dietl P.

Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L849-57. doi: 10.1152/ajplung.00503.2007. Epub 2008 Aug 15.


New magnetic field dependence of Landau levels in a graphenelike structure.

Dietl P, Piéchon F, Montambaux G.

Phys Rev Lett. 2008 Jun 13;100(23):236405. Epub 2008 Jun 13.


Formation of cellular projections in neural progenitor cells depends on SK3 channel activity.

Liebau S, Vaida B, Proepper C, Grissmer S, Storch A, Boeckers TM, Dietl P, Wittekindt OH.

J Neurochem. 2007 Jun;101(5):1338-1350.


The assessment of repeated dose toxicity in vitro: a proposed approach. The report and recommendations of ECVAM workshop 56.

Prieto P, Baird AW, Blaauboer BJ, Castell Ripoll JV, Corvi R, Dekant W, Dietl P, Gennari A, Gribaldo L, Griffin JL, Hartung T, Heindel JJ, Hoet P, Jennings P, Marocchio L, Noraberg J, Pazos P, Westmoreland C, Wolf A, Wright J, Pfaller W.

Altern Lab Anim. 2006 Jun;34(3):315-41. No abstract available.


A fluorescent microplate assay for exocytosis in alveolar type II cells.

Wemhöner A, Frick M, Dietl P, Jennings P, Haller T.

J Biomol Screen. 2006 Apr;11(3):286-95.


Optical measurement of surface tension in a miniaturized air-liquid interface and its application in lung physiology.

Bertocchi C, Ravasio A, Bernet S, Putz G, Dietl P, Haller T.

Biophys J. 2005 Aug;89(2):1353-61. Epub 2005 Jun 10.


Exocytosis of lung surfactant: from the secretory vesicle to the air-liquid interface.

Dietl P, Haller T.

Annu Rev Physiol. 2005;67:595-621. Review.


Ca2+ induced surfactant secretion in alveolar type II cultures isolated from the H-2Kb-tsA58 transgenic mouse.

Jennings P, Bertocchi C, Frick M, Haller T, Pfaller W, Dietl P.

Cell Physiol Biochem. 2005;15(1-4):159-66.


Inhibition by cytoplasmic nucleotides of a new cation channel in freshly isolated human and rat type II pneumocytes.

Mair N, Frick M, Bertocchi C, Haller T, Amberger A, Weiss H, Margreiter R, Streif W, Dietl P.

Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1284-92. Epub 2004 Aug 20.


Pulmonary consequences of a deep breath revisited.

Dietl P, Frick M, Mair N, Bertocchi C, Haller T.

Biol Neonate. 2004;85(4):299-304. Epub 2004 Jun 8. Review.


Tracing surfactant transformation from cellular release to insertion into an air-liquid interface.

Haller T, Dietl P, Stockner H, Frick M, Mair N, Tinhofer I, Ritsch A, Enhorning G, Putz G.

Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L1009-15. Epub 2004 Jan 2.


Ca2+ entry is essential for cell strain-induced lamellar body fusion in isolated rat type II pneumocytes.

Frick M, Bertocchi C, Jennings P, Haller T, Mair N, Singer W, Pfaller W, Ritsch-Marte M, Dietl P.

Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L210-20. Epub 2003 Sep 22.

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