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Items: 1 to 50 of 55

1.

Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction.

Kurktschiev PD, Raziorrouh B, Schraut W, Backmund M, Wächtler M, Wendtner CM, Bengsch B, Thimme R, Denk G, Zachoval R, Dick A, Spannagl M, Haas J, Diepolder HM, Jung MC, Gruener NH.

J Exp Med. 2014 Sep 22;211(10):2047-59. doi: 10.1084/jem.20131333. Epub 2014 Sep 15.

2.

Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules.

Raziorrouh B, Heeg M, Kurktschiev P, Schraut W, Zachoval R, Wendtner C, Wächtler M, Spannagl M, Denk G, Ulsenheimer A, Bengsch B, Pircher H, Diepolder HM, Grüner NH, Jung MC.

PLoS One. 2014 Aug 21;9(8):e105703. doi: 10.1371/journal.pone.0105703. eCollection 2014.

3.

Clearance of HBV markers and HCC risk: who is safe?

Diepolder HM.

Gut. 2014 Oct;63(10):1532-3. doi: 10.1136/gutjnl-2013-306317. Epub 2014 Jan 7. No abstract available.

PMID:
24398880
4.

Lack of variant specific CD8+ T-cell response against mutant and pre-existing variants leads to outgrowth of particular clones in acute hepatitis C.

Ulsenheimer A, Paranhos-Baccalà G, Komurian-Pradel F, Raziorrouh B, Kurktschiev P, Diepolder HM, Zachoval R, Spannagl M, Jung MC, Gruener NH.

Virol J. 2013 Sep 28;10:295. doi: 10.1186/1743-422X-10-295.

5.

Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection.

Raziorrouh B, Ulsenheimer A, Schraut W, Heeg M, Kurktschiev P, Zachoval R, Jung MC, Thimme R, Neumann-Haefelin C, Horster S, Wächtler M, Spannagl M, Haas J, Diepolder HM, Grüner NH.

Gastroenterology. 2011 Oct;141(4):1422-31, 1431.e1-6. doi: 10.1053/j.gastro.2011.07.004. Epub 2011 Jul 18.

PMID:
21763239
6.

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity.

Pfafferott K, Gaudieri S, Ulsenheimer A, James I, Heeg M, Nolan D, John M, Rauch A, Mallal S, Lucas A, Klenerman P, Diepolder HM, Lucas M.

PLoS One. 2011 Feb 8;6(2):e16797. doi: 10.1371/journal.pone.0016797.

7.

Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus.

Diegelmann J, Beigel F, Zitzmann K, Kaul A, Göke B, Auernhammer CJ, Bartenschlager R, Diepolder HM, Brand S.

PLoS One. 2010 Dec 8;5(12):e15200. doi: 10.1371/journal.pone.0015200.

8.

The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function.

Raziorrouh B, Schraut W, Gerlach T, Nowack D, Grüner NH, Ulsenheimer A, Zachoval R, Wächtler M, Spannagl M, Haas J, Diepolder HM, Jung MC.

Hepatology. 2010 Dec;52(6):1934-47. doi: 10.1002/hep.23936. Epub 2010 Nov 9.

PMID:
21064032
9.

FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C.

Heeg MH, Ulsenheimer A, Grüner NH, Zachoval R, Jung MC, Gerlach JT, Raziorrouh B, Schraut W, Horster S, Kauke T, Spannagl M, Diepolder HM.

Gastroenterology. 2009 Oct;137(4):1280-8.e1-6. doi: 10.1053/j.gastro.2009.06.059. Epub 2009 Jul 29.

PMID:
19596013
10.

New insights into the immunopathogenesis of chronic hepatitis C.

Diepolder HM.

Antiviral Res. 2009 Jun;82(3):103-9. doi: 10.1016/j.antiviral.2009.02.203. Epub 2009 Mar 11. Review.

PMID:
19428600
11.

Can specific heterologous immunity boost hepatitis B vaccine responses?

Diepolder HM.

J Infect Dis. 2008 Aug 1;198(3):297-8. doi: 10.1086/589721. No abstract available.

PMID:
18544036
12.

The role of the novel Th17 cytokine IL-26 in intestinal inflammation.

Dambacher J, Beigel F, Zitzmann K, De Toni EN, Göke B, Diepolder HM, Auernhammer CJ, Brand S.

Gut. 2009 Sep;58(9):1207-17. doi: 10.1136/gut.2007.130112. Epub 2008 May 15.

PMID:
18483078
13.

Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells.

Barth H, Schnober EK, Neumann-Haefelin C, Thumann C, Zeisel MB, Diepolder HM, Hu Z, Liang TJ, Blum HE, Thimme R, Lambotin M, Baumert TF.

J Virol. 2008 Apr;82(7):3466-79. doi: 10.1128/JVI.02478-07. Epub 2008 Jan 23.

14.

The role of interleukin-22 in hepatitis C virus infection.

Dambacher J, Beigel F, Zitzmann K, Heeg MH, Göke B, Diepolder HM, Auernhammer CJ, Brand S.

Cytokine. 2008 Mar;41(3):209-16. doi: 10.1016/j.cyto.2007.11.016. Epub 2008 Jan 11.

PMID:
18191408
15.

Tracking virus-specific CD4+ T cells during and after acute hepatitis C virus infection.

Lucas M, Ulsenheimer A, Pfafferot K, Heeg MH, Gaudieri S, Grüner N, Rauch A, Gerlach JT, Jung MC, Zachoval R, Pape GR, Schraut W, Santantonio T, Nitschko H, Obermeier M, Phillips R, Scriba TJ, Semmo N, Day C, Weber JN, Fidler S, Thimme R, Haberstroh A, Baumert TF, Klenerman P, Diepolder HM.

PLoS One. 2007 Jul 25;2(7):e649.

16.

Characterization of sequence variations in immunodominant regions of the HBV-nucleocapsid protein as a prerequisite for the development of an epitope-based vaccine.

Gruener NH, Gerlach TJ, Ulsenheimer A, Diepolder HM, Wierenga E, Zachoval R, Heeg M, Pape GR, Jung MC.

Vaccine. 2007 Jun 21;25(26):4960-6. Epub 2006 Dec 22.

PMID:
17466417
17.

An unusual cause of intractable vomiting after cisplatin chemotherapy.

Storr M, Göke B, Diepolder HM.

Endoscopy. 2006;38 Suppl 2:E54. No abstract available.

PMID:
17366412
18.

Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity.

Rollier CS, Paranhos-Baccala G, Verschoor EJ, Verstrepen BE, Drexhage JA, Fagrouch Z, Berland JL, Komurian-Pradel F, Duverger B, Himoudi N, Staib C, Meyr M, Whelan M, Whelan JA, Adams VC, Larrea E, Riezu JI, Lasarte JJ, Bartosch B, Cosset FL, Spaan WJ, Diepolder HM, Pape GR, Sutter G, Inchauspe G, Heeney JL.

Hepatology. 2007 Mar;45(3):602-13. Erratum in: Hepatology. 2007 Jun;45(6):1590. Adams, Victoria A [corrected to Adams, Victoria C]; Lasarte, Juan José [corrected to Lasarte, Juan J].

PMID:
17326154
19.

Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses.

Ulsenheimer A, Lucas M, Seth NP, Tilman Gerlach J, Gruener NH, Loughry A, Pape GR, Wucherpfennig KW, Diepolder HM, Klenerman P.

J Viral Hepat. 2006 Oct;13(10):708-14.

20.

Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins.

Gerlach JT, Ulsenheimer A, Grüner NH, Jung MC, Schraut W, Schirren CA, Heeg M, Scholz S, Witter K, Zahn R, Vogler A, Zachoval R, Pape GR, Diepolder HM.

J Virol. 2005 Oct;79(19):12425-33.

21.

Leucocytapheresis with Adacolumn enhances HCV-specific proliferative responses in patients infected with hepatitis C virus genotype 1.

Diepolder HM, Kashiwagi N, Teuber G, Ulsenheimer A, Franz M, Yokoyama T, Zachoval R.

J Med Virol. 2005 Oct;77(2):209-15.

PMID:
16121358
22.

Plasmacytoid dendritic cells in acute and chronic hepatitis C virus infection.

Ulsenheimer A, Gerlach JT, Jung MC, Gruener N, Wächtler M, Backmund M, Santantonio T, Schraut W, Heeg MH, Schirren CA, Zachoval R, Pape GR, Diepolder HM.

Hepatology. 2005 Mar;41(3):643-51.

PMID:
15726647
23.

Uptake and presentation of hepatitis C virus-like particles by human dendritic cells.

Barth H, Ulsenheimer A, Pape GR, Diepolder HM, Hoffmann M, Neumann-Haefelin C, Thimme R, Henneke P, Klein R, Paranhos-Baccalà G, Depla E, Liang TJ, Blum HE, Baumert TF.

Blood. 2005 May 1;105(9):3605-14. Epub 2005 Jan 18.

PMID:
15657184
24.

Analysis of a successful HCV-specific CD8+ T cell response in patients with recurrent HCV-infection after orthotopic liver transplantation.

Gruener NH, Jung MC, Ulsenheimer A, Gerlach JT, Zachoval R, Diepolder HM, Baretton G, Schauer R, Pape GR, Schirren CA.

Liver Transpl. 2004 Dec;10(12):1487-96.

25.

Interferon-alpha for hepatitis C: antiviral or immunotherapy?

Diepolder HM.

J Hepatol. 2004 Jun;40(6):1030-1. Review. No abstract available.

PMID:
15158347
26.

[Prevention and therapy of viral hepatitis].

Diepolder HM.

Internist (Berl). 2004 Feb;45(2):197-209. German.

PMID:
14991162
27.

Antiviral treatment of recurrent hepatitis C virus (HCV) infection after liver transplantation: association of a strong, multispecific, and long-lasting CD4+ T cell response with HCV-elimination.

Schirren CA, Zachoval R, Gerlach JT, Ulsenheimer A, Gruener NH, Diepolder HM, Baretton G, Schraut W, Rau HG, Nitschko H, Pape GR, Jung MC.

J Hepatol. 2003 Sep;39(3):397-404.

PMID:
12927926
28.

Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance.

Gerlach JT, Diepolder HM, Zachoval R, Gruener NH, Jung MC, Ulsenheimer A, Schraut WW, Schirren CA, Waechtler M, Backmund M, Pape GR.

Gastroenterology. 2003 Jul;125(1):80-8.

PMID:
12851873
29.

Of chimps and men--finding the path to an HCV vaccine.

Diepolder HM, Gruener NH, Heeney J.

Hepatology. 2003 Jun;37(6):1472-4. No abstract available.

PMID:
12790129
30.

A subset of human dendritic cells in the T cell area of mucosa-associated lymphoid tissue with a high potential to produce TNF-alpha.

de Baey A, Mende I, Baretton G, Greiner A, Hartl WH, Baeuerle PA, Diepolder HM.

J Immunol. 2003 May 15;170(10):5089-94.

31.

Detection of functionally altered hepatitis C virus-specific CD4 T cells in acute and chronic hepatitis C.

Ulsenheimer A, Gerlach JT, Gruener NH, Jung MC, Schirren CA, Schraut W, Zachoval R, Pape GR, Diepolder HM.

Hepatology. 2003 May;37(5):1189-98.

PMID:
12717401
32.

Hepatitis C virus eradication associated with hepatitis B virus superinfection and development of a hepatitis B virus specific T cell response.

Gruener NH, Jung MC, Ulsenheimer A, Gerlach TJ, Diepolder HM, Schirren CA, Hoffmann R, Wächtler M, Backmund M, Pape GR.

J Hepatol. 2002 Dec;37(6):866-9.

PMID:
12445431
33.

Antibody responses against B-cell epitopes of the hypervariable region 1 of hepatitis C virus in self-limiting and chronic human hepatitis C followed-up using consensus peptides.

Isaguliants MG, Widell A, Zhang SM, Sidorchuk A, Levi M, Smirnov VD, Santantonio T, Diepolder HM, Pape GR, Nordenfelt E.

J Med Virol. 2002 Feb;66(2):204-17.

PMID:
11782929
34.
35.

Alloreactivity of natural killer cells in allogeneic liver transplantation.

Oertel M, Kohlhaw K, Diepolder HM, Schröder S, Schwarz R, Tannapfel A, Mössner J, Hauss J, Berr F.

Transplantation. 2001 Jul 15;72(1):116-22.

PMID:
11468545
36.

Vigorous peripheral blood cytotoxic T cell response during the acute phase of hepatitis C virus infection.

Cucchiarini M, Kammer AR, Grabscheid B, Diepolder HM, Gerlach TJ, Grüner N, Santantonio T, Reichen J, Pape GR, Cerny A.

Cell Immunol. 2000 Aug 1;203(2):111-23.

PMID:
11006009
37.

Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C.

Grüner NH, Gerlach TJ, Jung MC, Diepolder HM, Schirren CA, Schraut WW, Hoffmann R, Zachoval R, Santantonio T, Cucchiarini M, Cerny A, Pape GR.

J Infect Dis. 2000 May;181(5):1528-36. Epub 2000 May 5.

PMID:
10823750
38.

Role of the specific T-cell response for clearance and control of hepatitis C virus.

Pape GR, Gerlach TJ, Diepolder HM, Grüner N, Jung M, Santantonio T.

J Viral Hepat. 1999 Jul;6 Suppl 1:36-40.

PMID:
10760033
39.

Cytokine profile of liver- and blood-derived nonspecific T cells after liver transplantation: T helper cells type 1/0 lymphokines dominate in recurrent hepatitis C virus infection and rejection.

Schirren CA, Jung M, Worzfeld T, Mamin M, Baretton GB, Gruener NH, Gerlach JT, Diepolder HM, Zachoval R, Pape GR.

Liver Transpl. 2000 Mar;6(2):222-8.

PMID:
10719024
40.

Influence of HLA alleles on outcome of hepatitis C virus infection.

Diepolder HM, Scholz S, Pape GR.

Lancet. 1999 Dec 18-25;354(9196):2094-5. No abstract available.

PMID:
10609808
41.

Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C.

Gerlach JT, Diepolder HM, Jung MC, Gruener NH, Schraut WW, Zachoval R, Hoffmann R, Schirren CA, Santantonio T, Pape GR.

Gastroenterology. 1999 Oct;117(4):933-41.

PMID:
10500077
42.

Differential antigen-processing pathways of the hepatitis B virus e and core proteins.

Diepolder HM, Ries G, Jung MC, Schlicht HJ, Gerlach JT, Gr ner N, Caselmann WH, Pape GR.

Gastroenterology. 1999 Mar;116(3):650-7.

PMID:
10029624
43.

A vigorous virus-specific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B.

Diepolder HM, Jung MC, Keller E, Schraut W, Gerlach JT, Grüner N, Zachoval R, Hoffmann RM, Schirren CA, Scholz S, Pape GR.

Clin Exp Immunol. 1998 Aug;113(2):244-51.

44.

Images in hepatology: bile acid-induced diarrhea due to a choledochocolic fistula.

Sackmann M, Diepolder HM.

J Hepatol. 1998 Apr;28(4):727. No abstract available.

PMID:
9566844
45.

Immunopathogenesis of HCV infection.

Diepolder HM, Hoffmann RM, Gerlach JT, Zachoval R, Jung MC, Pape GR.

Curr Stud Hematol Blood Transfus. 1998;(62):135-51. Review. No abstract available.

PMID:
9507808
46.

Depletion of CD8+ T lymphocytes by murine monoclonal CD8 antibodies and restored specific T cell proliferation in vivo in a patient with chronic hepatitis C.

Kiefersauer S, Reiter C, Eisenburg J, Diepolder HM, Rieber EP, Riethmüller G, Gruber R.

J Immunol. 1997 Oct 15;159(8):4064-71.

PMID:
9378996
47.

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection.

Diepolder HM, Gerlach JT, Zachoval R, Hoffmann RM, Jung MC, Wierenga EA, Scholz S, Santantonio T, Houghton M, Southwood S, Sette A, Pape GR.

J Virol. 1997 Aug;71(8):6011-9.

48.

Anergic TH1 clones specific for hepatitis B virus (HBV) core peptides are inhibitory to other HBV core-specific CD4+ T cells in vitro.

Diepolder HM, Jung MC, Wierenga E, Hoffmann RM, Zachoval R, Gerlach TJ, Scholz S, Heavner G, Riethmüller G, Pape GR.

J Virol. 1996 Nov;70(11):7540-8.

49.

The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis C.

Diepolder HM, Zachoval R, Hoffmann RM, Jung MC, Gerlach T, Pape GR.

J Mol Med (Berl). 1996 Oct;74(10):583-8. Review.

PMID:
8912179
50.

Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection.

Diepolder HM, Zachoval R, Hoffmann RM, Wierenga EA, Santantonio T, Jung MC, Eichenlaub D, Pape GR.

Lancet. 1995 Oct 14;346(8981):1006-7.

PMID:
7475549

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